Susan L Neuhausen

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers
    Susan L Neuhausen
    Department of Epidemiology, University of California Irvine, 224 Irvine Hall, Irvine, CA 92697, USA
    Breast Cancer Res 11:R76. 2009
  2. pmc Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers
    Eitan Friedman
    The Suzanne Levy Gertner Oncogenetics Unit, The Chaim Sheba Medical Center, Tel Hashomer, Israel, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Breast Cancer Res 8:R15. 2006
  3. pmc The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancer
    Esther M John
    Clinical and Genetic Epidemiology Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA
    Breast Cancer Res 6:R375-89. 2004
  4. pmc Co-occurrence of celiac disease and other autoimmune diseases in celiacs and their first-degree relatives
    Susan L Neuhausen
    Department of Epidemiology, University of California Irvine, 224 Irvine Hall, Irvine, CA 92697 7550, USA
    J Autoimmun 31:160-5. 2008
  5. ncbi request reprint Prostate cancer risk and IRS1, IRS2, IGF1, and INS polymorphisms: strong association of IRS1 G972R variant and cancer risk
    Susan L Neuhausen
    Department of Medicine, Division of Epidemiology, University of California Irvine, Irvine, CA 92697 7550, USA
    Prostate 64:168-74. 2005
  6. pmc BRCA1 and BRCA2 mutation carriers in the Breast Cancer Family Registry: an open resource for collaborative research
    Susan L Neuhausen
    Department of Epidemiology, University of California Irvine, Irvine, CA 92697 7550, USA
    Breast Cancer Res Treat 116:379-86. 2009
  7. doi request reprint Genetic variation in IGFBP2 and IGFBP5 is associated with breast cancer in populations of African descent
    Chad P Garner
    Department of Epidemiology, University of California Irvine, 224 Irvine Hall, Irvine, CA, 92697 7550, USA
    Hum Genet 123:247-55. 2008
  8. pmc Meat consumption, nonsteroidal anti-inflammatory drug use, and mortality among colorectal cancer patients in the California Teachers Study
    Jason A Zell
    Genetic Epidemiology Research Institute, Department of Epidemiology, University of California at Irvine, 92697, USA
    Cancer Prev Res (Phila) 3:865-75. 2010
  9. ncbi request reprint Mortality after bilateral salpingo-oophorectomy in BRCA1 and BRCA2 mutation carriers: a prospective cohort study
    Susan M Domchek
    Abramson Cancer Centre, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Lancet Oncol 7:223-9. 2006
  10. pmc Genome-Wide Association Study of Celiac Disease in North America Confirms FRMD4B as New Celiac Locus
    Chad Garner
    Epidemiology Department, School of Medicine, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 9:e101428. 2014

Research Grants

  1. The IGF Signaling Pathway and Breast Cancer Risk
    Susan Neuhausen; Fiscal Year: 2007

Detail Information

Publications31

  1. pmc Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers
    Susan L Neuhausen
    Department of Epidemiology, University of California Irvine, 224 Irvine Hall, Irvine, CA 92697, USA
    Breast Cancer Res 11:R76. 2009
    ..In this study, we investigate the association of variants in genes involved in IGF signaling and risk of breast cancer in women who carry deleterious BRCA1 and BRCA2 mutations...
  2. pmc Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers
    Eitan Friedman
    The Suzanne Levy Gertner Oncogenetics Unit, The Chaim Sheba Medical Center, Tel Hashomer, Israel, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Breast Cancer Res 8:R15. 2006
    ....
  3. pmc The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancer
    Esther M John
    Clinical and Genetic Epidemiology Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA
    Breast Cancer Res 6:R375-89. 2004
    ....
  4. pmc Co-occurrence of celiac disease and other autoimmune diseases in celiacs and their first-degree relatives
    Susan L Neuhausen
    Department of Epidemiology, University of California Irvine, 224 Irvine Hall, Irvine, CA 92697 7550, USA
    J Autoimmun 31:160-5. 2008
    ..These results indicate that the presence of IDDM within our celiac disease families may be due to shared genetic susceptibility predisposing to these diseases or autoimmune diseases in general...
  5. ncbi request reprint Prostate cancer risk and IRS1, IRS2, IGF1, and INS polymorphisms: strong association of IRS1 G972R variant and cancer risk
    Susan L Neuhausen
    Department of Medicine, Division of Epidemiology, University of California Irvine, Irvine, CA 92697 7550, USA
    Prostate 64:168-74. 2005
    ..We hypothesized that functional polymorphisms in INS, IRS1, IRS2, and IGF1 may be associated with prostate cancer...
  6. pmc BRCA1 and BRCA2 mutation carriers in the Breast Cancer Family Registry: an open resource for collaborative research
    Susan L Neuhausen
    Department of Epidemiology, University of California Irvine, Irvine, CA 92697 7550, USA
    Breast Cancer Res Treat 116:379-86. 2009
    ..The value of the resource has been greatly enhanced by determining the germline BRCA1 and BRCA2 mutation statuses of nearly 6,000 probands...
  7. doi request reprint Genetic variation in IGFBP2 and IGFBP5 is associated with breast cancer in populations of African descent
    Chad P Garner
    Department of Epidemiology, University of California Irvine, 224 Irvine Hall, Irvine, CA, 92697 7550, USA
    Hum Genet 123:247-55. 2008
    ..0038 and P = 0.01 in African-Americans and Nigerians, respectively. This study is the first to report associations between genetic variants in IGFBP2 and IGFBP5 and breast cancer risk...
  8. pmc Meat consumption, nonsteroidal anti-inflammatory drug use, and mortality among colorectal cancer patients in the California Teachers Study
    Jason A Zell
    Genetic Epidemiology Research Institute, Department of Epidemiology, University of California at Irvine, 92697, USA
    Cancer Prev Res (Phila) 3:865-75. 2010
    ..These findings have implications for CRC survivorship and tertiary CRC prevention...
  9. ncbi request reprint Mortality after bilateral salpingo-oophorectomy in BRCA1 and BRCA2 mutation carriers: a prospective cohort study
    Susan M Domchek
    Abramson Cancer Centre, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Lancet Oncol 7:223-9. 2006
    ..However, the reduction in mortality after this surgery is unclear. We aimed to assess whether BPSO improves overall mortality or cancer-specific mortality in BRCA1 and BRCA2 mutation carriers...
  10. pmc Genome-Wide Association Study of Celiac Disease in North America Confirms FRMD4B as New Celiac Locus
    Chad Garner
    Epidemiology Department, School of Medicine, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 9:e101428. 2014
    ..Preliminary, suggestive statistical evidence for association with the two traits was found at chromosomes 3p21.31, 6q15, 6q25, 1q24.3 and 10p11.23, with future studies being required to validate the reported associations. ..
  11. pmc Association analysis of the extended MHC region in celiac disease implicates multiple independent susceptibility loci
    Richard Ahn
    Department of Epidemiology, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 7:e36926. 2012
    ..This study is the first comprehensive association analysis of the xMHC in celiac disease that specifically accounts for the known HLA disease genotypes and the genetic complexity of the region...
  12. pmc Nonsteroidal anti-inflammatory drugs: effects on mortality after colorectal cancer diagnosis
    Jason A Zell
    Genetic Epidemiology Research Institute and Department of Epidemiology, University of California at Irvine, Irvine, California 92697 7550, USA
    Cancer 115:5662-71. 2009
    ..The authors investigated the association between prediagnosis NSAID use and mortality after CRC diagnosis among women in the California Teachers Study cohort...
  13. ncbi request reprint Genetic testing in an ethnically diverse cohort of high-risk women: a comparative analysis of BRCA1 and BRCA2 mutations in American families of European and African ancestry
    Rita Nanda
    Center for Clinical Cancer Genetics, Section of Hematology Oncology, Department of Medicine, University of Chicago Medical Center, Chicago, Ill 60637 1470, USA
    JAMA 294:1925-33. 2005
    ..Ten years after BRCA1 and BRCA2 were first identified as major breast cancer susceptibility genes, the spectrum of mutations and modifiers of risk among many ethnic minorities remain undefined...
  14. pmc Recent breast cancer incidence trends according to hormone therapy use: the California Teachers Study cohort
    Sarah F Marshall
    Department of Epidemiology, School of Medicine, University of California, Irvine, 224 Irvine Hall, Irvine, CA 92697, USA
    Breast Cancer Res 12:R4. 2010
    ..Few data sources can address breast cancer incidence trends according to pertinent characteristics like hormone therapy use history...
  15. pmc Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival
    Jason A Zell
    Department of Epidemiology, University of California, Irvine, California 92697, USA
    Clin Cancer Res 15:6208-16. 2009
    ..We examined associations of the +316 ODC1 single nucleotide polymorphism (SNP) with colorectal cancer-specific survival among colorectal cancer cases, and then investigated its functional significance in colon cancer cells...
  16. pmc Mitochondrial DNA G10398A variant is not associated with breast cancer in African-American women
    Veronica Wendy Setiawan
    Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
    Cancer Genet Cytogenet 181:16-9. 2008
    ..18, 95% CI = 0.76-1.82, P = 0.46). Our results do not support the hypothesis that the mtDNA G10398A polymorphism is, as has previously been reported, a marker of breast cancer risk in African Americans...
  17. pmc Hormone therapy and the risk of breast cancer in BRCA1 mutation carriers
    Andrea Eisen
    Sunnybrook Regional Cancer Center, Toronto, Ontario, Canada
    J Natl Cancer Inst 100:1361-7. 2008
    ....
  18. pmc AURKA F31I polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a consortium of investigators of modifiers of BRCA1/2 study
    Fergus J Couch
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 16:1416-21. 2007
    ..In summary, the F31I polymorphism in AURKA is not associated with a modified risk of breast cancer in BRCA1 and BRCA2 carriers...
  19. ncbi request reprint Age at first birth and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
    Joanne Kotsopoulos
    Centre for Research in Women s Health, Women s College Hospital, University of Toronto, Room 750, 790 Bay Street, 7th Floor, Toronto, ON M5G 1N8, Canada
    Breast Cancer Res Treat 105:221-8. 2007
    ..Nonetheless, BRCA mutation carriers opting for a prophylactic oophorectomy as a breast and/or ovarian cancer risk-reducing strategy should complete childbearing prior to age 40 when this prevention modality is most effective...
  20. ncbi request reprint Oral contraceptives and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
    Steven A Narod
    The Centre for Research on Women s Health, University of Toronto, 790 Bay Street, Toronto, Ontario M5G 1N8, Canada
    J Natl Cancer Inst 94:1773-9. 2002
    ..We examined whether this association is seen in women at high risk of breast cancer because they carry a mutation in one of two breast cancer susceptibility genes, BRCA1 and BRCA2...
  21. ncbi request reprint Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group
    Timothy R Rebbeck
    Center for Clinical Epidemiology and Biostatistics, Abramson Family Cancer Research Institute, The University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    J Clin Oncol 22:1055-62. 2004
    ..Thus, we estimated the degree of breast cancer risk reduction after surgery in women who carry these mutations...
  22. ncbi request reprint Smoking and the risk of breast cancer among carriers of BRCA mutations
    Parviz Ghadirian
    Epidemiology Research Unit, Centre Hospitalier del Universite de Montreal Hotel Dieu, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Int J Cancer 110:413-6. 2004
    ..03; 95% CI 0.83 to l.28) or before the first pregnancy (OR = 1.09; 95% CI = 0.90 to 1.33). In conclusion, contrary to our previous report, smoking does not appear to be a risk factor for breast cancer among carriers of BRCA mutations...
  23. ncbi request reprint Dietary calcium, vitamin D, VDR genotypes and colorectal cancer
    Martha L Slattery
    Health Research Center, University of Utah, Salt Lake City, UT 84108, USA
    Int J Cancer 111:750-6. 2004
    ..The risk associated with VDR genotype seems to depend upon the level of dietary calcium and vitamin D and tumor site...
  24. ncbi request reprint Age at menarche and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
    Joanne Kotsopoulos
    Centre for Research in Women s Health, University of Toronto, Women s College Hospital, 790 Bay Street, 7th Floor, Totonto, Ontario M5G 1N8, Canada
    Cancer Causes Control 16:667-74. 2005
    ..46; 95% CI 0.30-0.69). This study implicates early age at menarche as a determinant of breast cancer among women with a BRCA1 mutation...
  25. ncbi request reprint Hormone replacement therapy and the risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers
    Joanne Kotsopoulos
    Centre for Research in Women s Health, 790 Bay Street, 7th Floor, Women s College Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1N8
    Gynecol Oncol 100:83-8. 2006
    ..This association has not been evaluated in BRCA1 or BRCA2 mutation carriers who face very high lifetime risks of both breast and ovarian cancers...
  26. ncbi request reprint Effect of short-term hormone replacement therapy on breast cancer risk reduction after bilateral prophylactic oophorectomy in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group
    Timothy R Rebbeck
    Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Clin Oncol 23:7804-10. 2005
    ..Thus, we evaluated whether the breast cancer risk reduction conferred by BPO in BRCA1/2 mutation carriers is altered by use of post-BPO HRT...
  27. ncbi request reprint Breast cancer risk following bilateral oophorectomy in BRCA1 and BRCA2 mutation carriers: an international case-control study
    Andrea Eisen
    Toronto Sunnybrook Regional Cancer Center, Toronto, ON, Canada
    J Clin Oncol 23:7491-6. 2005
    ....
  28. ncbi request reprint The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers
    Susan Colilla
    Department of Biostatistics and Epidemiology and Medicine and Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Carcinogenesis 27:599-605. 2006
    ....
  29. ncbi request reprint A role for XRCC4 in age at diagnosis and breast cancer risk
    Kristina Allen-Brady
    Genetic Epidemiology, Department of Medical Informatics, University of Utah, Salt Lake City, 84108, USA
    Cancer Epidemiol Biomarkers Prev 15:1306-10. 2006
    ..Our results suggest that XRCC4 may play a role in the age at diagnosis and risk of breast cancer in non-BRCA1/2, heritable breast cancer cases...
  30. ncbi request reprint Reproductive risk factors for ovarian cancer in carriers of BRCA1 or BRCA2 mutations: a case-control study
    John R McLaughlin
    Samuel Lunenfeld Research Institute, Toronto, ON, Canada
    Lancet Oncol 8:26-34. 2007
    ..We aimed to assess the effect of these three risk factors, and of tubal ligation, on the risk of ovarian cancer in women who carry a mutation in the BRCA1 or BRCA2 genes...
  31. ncbi request reprint Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations
    Timothy R Rebbeck
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    N Engl J Med 346:1616-22. 2002
    ..We investigated whether this procedure reduces the risk of cancers of the coelomic epithelium and breast in women who carry such mutations...

Research Grants2

  1. The IGF Signaling Pathway and Breast Cancer Risk
    Susan Neuhausen; Fiscal Year: 2007
    ..Currently, chemotherapies are being directed to the IGF pathway and the results of this study could provide further targets, as well as assist in identifying the group of women who could particularly benefit from these new drugs. ..