V Neugebauer

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. ncbi Non-pain-related CRF1 activation in the amygdala facilitates synaptic transmission and pain responses
    Guangchen Ji
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555 1069, USA
    Mol Pain 9:2. 2013
  2. ncbi Modulation of medial prefrontal cortical activity using in vivo recordings and optogenetics
    Guangchen Ji
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555 1069, USA
    Mol Brain 5:36. 2012
  3. ncbi Homer1a signaling in the amygdala counteracts pain-related synaptic plasticity, mGluR1 function and pain behaviors
    Anke Tappe-Theodor
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555 1069, USA
    Mol Pain 7:38. 2011
  4. ncbi Pain-related increase of excitatory transmission and decrease of inhibitory transmission in the central nucleus of the amygdala are mediated by mGluR1
    Wenjie Ren
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    Mol Pain 6:93. 2010
  5. ncbi Pain-related anxiety-like behavior requires CRF1 receptors in the amygdala
    Guangchen Ji
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    Mol Pain 3:13. 2007
  6. ncbi Molecular pain, a new era of pain research and medicine
    Jianguo Gu
    Mol Pain 1:1. 2005
  7. ncbi NR2B receptor blockade inhibits pain-related sensitization of amygdala neurons
    Guangchen Ji
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    Mol Pain 5:21. 2009
  8. ncbi Enhanced group II mGluR-mediated inhibition of pain-related synaptic plasticity in the amygdala
    Jeong S Han
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    Mol Pain 2:18. 2006
  9. ncbi PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior
    Yu Fu
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    Mol Pain 4:26. 2008
  10. ncbi Facilitation of synaptic transmission and pain responses by CGRP in the amygdala of normal rats
    Jeong S Han
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    Mol Pain 6:10. 2010

Research Grants

  1. Pain, Nociception, and the Amygdal
    Volker Neugebauer; Fiscal Year: 2010
  2. PAIN, NOCICEPTION AND THE AMYGDALA
    Volker Neugebauer; Fiscal Year: 2007
  3. PAIN, NOCICEPTION AND THE AMYGDALA
    Volker Neugebauer; Fiscal Year: 2002
  4. Pain, Nociception, and the Amygdal
    Volker Neugebauer; Fiscal Year: 2009

Detail Information

Publications43

  1. ncbi Non-pain-related CRF1 activation in the amygdala facilitates synaptic transmission and pain responses
    Guangchen Ji
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555 1069, USA
    Mol Pain 9:2. 2013
    ..Here we examined the synaptic and behavioral effects of CRF in the amygdala of normal animals in the absence of tissue injury or disease...
  2. ncbi Modulation of medial prefrontal cortical activity using in vivo recordings and optogenetics
    Guangchen Ji
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555 1069, USA
    Mol Brain 5:36. 2012
    ..abstract:..
  3. ncbi Homer1a signaling in the amygdala counteracts pain-related synaptic plasticity, mGluR1 function and pain behaviors
    Anke Tappe-Theodor
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555 1069, USA
    Mol Pain 7:38. 2011
    ..Using transgenic mice overexpressing Homer1a in the forebrain (H1a-mice), we analyzed synaptic plasticity, pain behavior and mGluR1 function in the basolateral amygdala (BLA) in a model of arthritis pain...
  4. ncbi Pain-related increase of excitatory transmission and decrease of inhibitory transmission in the central nucleus of the amygdala are mediated by mGluR1
    Wenjie Ren
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    Mol Pain 6:93. 2010
    ..In conclusion, mGluR1 rather than mGluR5 can account for the pain-related changes of excitatory and inhibitory synaptic transmission in the CeLC through a mechanism that involves inhibition of inhibitory transmission (disinhibition)...
  5. ncbi Pain-related anxiety-like behavior requires CRF1 receptors in the amygdala
    Guangchen Ji
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    Mol Pain 3:13. 2007
    ..The results are a direct demonstration that the clinically well-documented relationship between pain and anxiety involves the amygdala...
  6. ncbi Molecular pain, a new era of pain research and medicine
    Jianguo Gu
    Mol Pain 1:1. 2005
    ..Molecular Pain, an Open Access, peer-reviewed, online journal, will provide a forum for molecular pain scientists to communicate their research findings in a targeted manner to others in this important and growing field...
  7. ncbi NR2B receptor blockade inhibits pain-related sensitization of amygdala neurons
    Guangchen Ji
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    Mol Pain 5:21. 2009
    ..The differential effects of AP5 and Ro-256981 may suggest that NMDA receptors containing the NR2B subunit are important but not sole contributors to pain-related changes of CeA neurons...
  8. ncbi Enhanced group II mGluR-mediated inhibition of pain-related synaptic plasticity in the amygdala
    Jeong S Han
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    Mol Pain 2:18. 2006
    ..These pain-related changes involve presynaptic group I metabotropic glutamate receptors (mGluRs) and postsynaptic NMDA and calcitonin gene-related peptide (CGRP1) receptors. Here we address the role of group II mGluRs...
  9. ncbi PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior
    Yu Fu
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    Mol Pain 4:26. 2008
    ..The data suggest that in the amygdala PKA and ERK, but not PKC, contribute to pain-related synaptic facilitation and behavior by increasing NMDA receptor function through independent signaling pathways...
  10. ncbi Facilitation of synaptic transmission and pain responses by CGRP in the amygdala of normal rats
    Jeong S Han
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    Mol Pain 6:10. 2010
    ..Thus, increased CGRP levels in the amygdala might trigger pain in the absence of tissue injury...
  11. ncbi Pain-related synaptic plasticity in spinal dorsal horn neurons: role of CGRP
    Gary C Bird
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    Mol Pain 2:31. 2006
    ..Here we address the role of CGRP in synaptic plasticity in the spinal dorsal horn in a model of arthritic pain...
  12. ncbi Pain-related deactivation of medial prefrontal cortical neurons involves mGluR1 and GABA(A) receptors
    Guangchen Ji
    Dept of Neuroscience and Cell Biology, The Univ of Texas Medical Branch, 301 Univ Blvd, Galveston, TX 77555 1069, USA
    J Neurophysiol 106:2642-52. 2011
    ..Exogenous activation of mGluR1/5 produces GABAergic inhibition under normal conditions. Restoring normal activity in the mPFC may be a therapeutic strategy to improve cognitive deficits associated with persistent pain...
  13. ncbi Techniques for assessing knee joint pain in arthritis
    Volker Neugebauer
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    Mol Pain 3:8. 2007
    ..A discussion of pain assessment in humans with arthritis pain conditions concludes this review...
  14. ncbi Differential sensitization of amygdala neurons to afferent inputs in a model of arthritic pain
    Volker Neugebauer
    Department of Anatomy and Neurosciences and Marine Biomedical Institute, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    J Neurophysiol 89:716-27. 2003
    ..Recruitment of noSOM neurons increases the gain of amygdala processing. NS neurons preserve the distinction between nociceptive and nonnociceptive inputs...
  15. ncbi Forebrain pain mechanisms
    Volker Neugebauer
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1069, USA
    Brain Res Rev 60:226-42. 2009
    ....
  16. ncbi Synaptic plasticity in the amygdala in a model of arthritic pain: differential roles of metabotropic glutamate receptors 1 and 5
    Volker Neugebauer
    Department of Anatomy and Neurosciences and Marine Biomedical Institute, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    J Neurosci 23:52-63. 2003
    ..Our results show that plastic changes in the amygdala in an arthritis model that produces prolonged pain involve a critical switch of presynaptic mGluR1 expression and function...
  17. ncbi Processing of nociceptive mechanical and thermal information in central amygdala neurons with knee-joint input
    Volker Neugebauer
    Department of Anatomy and Neurosciences and Marine Biomedical Institute, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    J Neurophysiol 87:103-12. 2002
    ..Their large symmetrical receptive fields and sigmoid rather than monotonically increasing linear stimulus-response functions suggest a role of nociceptive central amygdala neurons in other than sensory-discriminative aspects of pain...
  18. ncbi Peripheral metabotropic glutamate receptors as drug targets for pain relief
    Volker Neugebauer
    Department of Anatomy and Neurosciences and Marine Biomedical Institute, University of Texas, Medical Branch, Galveston, TX 77555 1069, USA
    Expert Opin Ther Targets 6:349-61. 2002
    ....
  19. ncbi Peripheral metabotropic glutamate receptors: fight the pain where it hurts
    V Neugebauer
    Department of Anatomy and Neurosciences and Marine Biomedical Institute, The University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    Trends Neurosci 24:550-2. 2001
    ..They also alert us to the necessity of assessing drug effects at different levels of the nervous system: peripheral and central...
  20. ncbi Metabotropic glutamate receptors--important modulators of nociception and pain behavior
    Volker Neugebauer
    Department of Anatomy and Neurosciences and Marine Biomedical Institute, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-1069, USA
    Pain 98:1-8. 2002
  21. ncbi The amygdala and persistent pain
    Volker Neugebauer
    Department of Anatomy and Neurosciences, University of Texas Medical Branch, Galveston, 77555 1069, USA
    Neuroscientist 10:221-34. 2004
    ..It is conceivable, however, that amygdala plasticity plays an important role in emotional pain behavior and its modulation by affective state...
  22. ncbi Differential mechanisms of CRF1 and CRF2 receptor functions in the amygdala in pain-related synaptic facilitation and behavior
    Yu Fu
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    J Neurosci 28:3861-76. 2008
    ..Presynaptic CRF2 receptor-mediated inhibition does not reach behavioral significance...
  23. ncbi Pro- and anti-nociceptive effects of corticotropin-releasing factor (CRF) in central amygdala neurons are mediated through different receptors
    Guangchen Ji
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1069, USA
    J Neurophysiol 99:1201-12. 2008
    ..Inhibitory effects of CRF (10 microM) were reversed by astressin-2B. These data suggest that CRF has dual effects on amygdala neurons: CRF1 receptor-mediated PKA-dependent facilitation and CRF2 receptor-mediated inhibition...
  24. ncbi Group III mGluR7 and mGluR8 in the amygdala differentially modulate nocifensive and affective pain behaviors
    Enza Palazzo
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1069, USA
    Neuropharmacology 55:537-45. 2008
    ....
  25. ncbi Computerized analysis of audible and ultrasonic vocalizations of rats as a standardized measure of pain-related behavior
    Jeong S Han
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-1069, USA
    J Neurosci Methods 141:261-9. 2005
    ..The computerized analysis of audible and ultrasonic vocalizations is a valid, quantitative, reliable and convenient method to measure pain-related behavior...
  26. ncbi Differential changes of group II and group III mGluR function in central amygdala neurons in a model of arthritic pain
    Weidong Li
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    J Neurophysiol 96:1803-15. 2006
    ..The increased function and endogenous activation of group II mGluRs in the arthritis pain model appear more input-selective than the general changes of group III mGluRs...
  27. ncbi Block of NMDA and non-NMDA receptor activation results in reduced background and evoked activity of central amygdala neurons in a model of arthritic pain
    Weidong Li
    Department of Anatomy and Neurosciences, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-1069, USA
    Pain 110:112-22. 2004
    ....
  28. ncbi Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation
    Guangchen Ji
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    J Neurosci 30:5451-64. 2010
    ..The novel amygdalo-cortical pain mechanism has important implications for our understanding of amygdala functions and amygdalo-cortical interactions...
  29. ncbi Protein kinase A-dependent enhanced NMDA receptor function in pain-related synaptic plasticity in rat amygdala neurones
    Gary C Bird
    Department of Neuroscience and Cell Biology, Marine Biomedical Institute, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1069, USA
    J Physiol 564:907-21. 2005
    ..Our results suggest that pain-related synaptic plasticity in the amygdala involves a critical switch of postsynaptic NMDA receptor function through PKA-dependent NR1 phosphorylation...
  30. ncbi Differential effects of CRF1 and CRF2 receptor antagonists on pain-related sensitization of neurons in the central nucleus of the amygdala
    Guangchen Ji
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1069, USA
    J Neurophysiol 97:3893-904. 2007
    ..These data suggest that CRF1 receptors in the amygdala contribute to pain-related sensitization, whereas the normally inhibitory function of CRF2 receptors is lost in the arthritis pain model...
  31. ncbi mGluR1 and mGluR5 antagonists in the amygdala inhibit different components of audible and ultrasonic vocalizations in a model of arthritic pain
    Jeong Seok Han
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Blvd RT 1069, Galveston, TX 77555 1069, USA
    Pain 113:211-22. 2005
    ..Both mGluR1 and mGluR5 contribute to vocalizations generated in the amygdala whereas mGluR1, but not mGluR5, is involved in the amygdala-mediated modulation of vocalizations originating from activity in the brainstem...
  32. ncbi Synaptic plasticity in the amygdala in a visceral pain model in rats
    Jeong Seok Han
    Department of Anatomy and Neurosciences, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-1069, USA
    Neurosci Lett 361:254-7. 2004
    ..Our results provide novel evidence for an important role of the CeA in visceral pain...
  33. ncbi Hemispheric lateralization of pain processing by amygdala neurons
    Guangchen Ji
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    J Neurophysiol 102:2253-64. 2009
    ..Whereas both left and right amygdala neurons receive nociceptive inputs and can become sensitized in principle, a yet unknown mechanism prevents PKA activation and pain-related changes in the left amygdala...
  34. ncbi Corticotropin-releasing factor and Urocortin I modulate excitatory glutamatergic synaptic transmission
    Jie Liu
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555 1031, USA
    J Neurosci 24:4020-9. 2004
    ..The results also suggest that CRF receptors may provide novel targets in affective disorders and stress...
  35. ncbi Differential roles of mGluR1 and mGluR5 in brief and prolonged nociceptive processing in central amygdala neurons
    Weidong Li
    Department of Anatomy and Neurosciences and Marine Biomedical Institute, The University of Texas Medical Branch, Galveston, Texas 77555-1069, USA
    J Neurophysiol 91:13-24. 2004
    ..These data suggest a change of mGluR1 function and activation in the amygdala in pain-related sensitization, whereas mGluR5 is involved in brief as well as prolonged nociception...
  36. ncbi Enhanced group III mGluR-mediated inhibition of pain-related synaptic plasticity in the amygdala
    Jeong S Han
    Department of Anatomy and Neurosciences and Marine Biomedical Institute, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-1069, USA
    Neuropharmacology 46:918-26. 2004
    ..These data suggest that presynaptic group III mGluRs are involved in the regulation of synaptic plasticity in the amygdala in an arthritis pain model...
  37. ncbi Critical role of calcitonin gene-related peptide 1 receptors in the amygdala in synaptic plasticity and pain behavior
    Jeong S Han
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555-1069, USA
    J Neurosci 25:10717-28. 2005
    ..This study provides direct evidence for the critical dependence of pain behavior on CGRP1-mediated amygdala plasticity...
  38. ncbi Spinal CGRP1 receptors contribute to supraspinally organized pain behavior and pain-related sensitization of amygdala neurons
    Hita Adwanikar
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1069, USA
    Pain 132:53-66. 2007
    ..These data suggest that spinal CGRP1 receptors are not only important for spinal pain mechanisms but also contribute significantly to the transmission of nociceptive information to the amygdala and to higher integrated behavior...
  39. ncbi Activation of dopamine D1 receptors blocks phencyclidine-induced neurotoxicity by enhancing N-methyl-D-aspartate receptor-mediated synaptic strength
    Gang Lei
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555 1031, USA
    J Neurochem 109:1017-30. 2009
    ....
  40. ncbi Amyloid-beta oligomers impair fear conditioned memory in a calcineurin-dependent fashion in mice
    Kelly T Dineley
    Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555 1043, USA
    J Neurosci Res 88:2923-32. 2010
    ..Collectively, these results indicate that CaN activation may play a central role in mediating synaptic and memory disruption induced by acute oligomeric A beta treatment in mice...
  41. ncbi mGluR1, but not mGluR5, activates feed-forward inhibition in the medial prefrontal cortex to impair decision making
    Hao Sun
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    J Neurophysiol 106:960-73. 2011
    ..The results show that mGluR1 activates feed-forward inhibition of PFC pyramidal cells to impair cognitive functions...
  42. ncbi The amygdala: different pains, different mechanisms
    Volker Neugebauer
    Pain 127:1-2. 2007
  43. ncbi Visceral pain and the black box called brain
    Volker Neugebauer
    Pain 138:5-6. 2008

Research Grants13

  1. Pain, Nociception, and the Amygdal
    Volker Neugebauer; Fiscal Year: 2010
    ..The long-term goal of this project is the better understanding of higher brain functions involved in the different pain components to improve pain management strategies and decision making. ..
  2. PAIN, NOCICEPTION AND THE AMYGDALA
    Volker Neugebauer; Fiscal Year: 2007
    ....
  3. PAIN, NOCICEPTION AND THE AMYGDALA
    Volker Neugebauer; Fiscal Year: 2002
    ..In parallel experiments in vitro, the influence of glutamate receptor subtypes is analyzed for effects on synaptic transmission including pre- versus postsynaptic influences and membrane properties after inflammation. ..
  4. Pain, Nociception, and the Amygdal
    Volker Neugebauer; Fiscal Year: 2009
    ..The long-term goal of this project is the better understanding of higher brain functions involved in the different pain components to improve pain management strategies and decision making. ..