Thomas Neufeld

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Role and regulation of starvation-induced autophagy in the Drosophila fat body
    Ryan C Scott
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis 55455 USA
    Dev Cell 7:167-78. 2004
  2. pmc TOR-dependent control of autophagy: biting the hand that feeds
    Thomas P Neufeld
    Department of Genetics, Cell Biology and Development, University of Minnesota, 6 160 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    Curr Opin Cell Biol 22:157-68. 2010
  3. pmc Eating on the fly: function and regulation of autophagy during cell growth, survival and death in Drosophila
    Thomas P Neufeld
    University of Minnesota, Department of Genetics, Cell Biology and Development, Minneapolis, Minnesota 55455, USA
    Autophagy 4:557-62. 2008
  4. pmc The phosphatase subunit tap42 functions independently of target of rapamycin to regulate cell division and survival in Drosophila
    Katherine D Cygnar
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, 55455, USA
    Genetics 170:733-40. 2005
  5. ncbi request reprint Inhibition of cellular growth and proliferation by dTOR overexpression in Drosophila
    Krista M Hennig
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Genesis 34:107-10. 2002
  6. pmc Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death
    Ryan C Scott
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Curr Biol 17:1-11. 2007
  7. pmc An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation
    Yu Yun Chang
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Biol Cell 20:2004-14. 2009
  8. pmc Autophagy takes flight in Drosophila
    Yu Yun Chang
    University of Minnesota, Department of Genetics, Cell Biology, and Development, Minneapolis, MN 55455, USA
    FEBS Lett 584:1342-9. 2010
  9. pmc Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila
    Gabor Juhasz
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Genes Dev 21:3061-6. 2007
  10. ncbi request reprint Contribution of Atg1-dependent autophagy to TOR-mediated cell growth and survival
    Thomas P Neufeld
    Department of Genetics, Cell Biology and Development, University of Minnesota, Mineapolis, Minnesota 55455, USA
    Autophagy 3:477-9. 2007

Detail Information

Publications26

  1. ncbi request reprint Role and regulation of starvation-induced autophagy in the Drosophila fat body
    Ryan C Scott
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis 55455 USA
    Dev Cell 7:167-78. 2004
    ..Thus, in cells lacking TOR, autophagy plays a protective role that is dominant over its potential role as a growth suppressor...
  2. pmc TOR-dependent control of autophagy: biting the hand that feeds
    Thomas P Neufeld
    Department of Genetics, Cell Biology and Development, University of Minnesota, 6 160 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    Curr Opin Cell Biol 22:157-68. 2010
    ....
  3. pmc Eating on the fly: function and regulation of autophagy during cell growth, survival and death in Drosophila
    Thomas P Neufeld
    University of Minnesota, Department of Genetics, Cell Biology and Development, Minneapolis, Minnesota 55455, USA
    Autophagy 4:557-62. 2008
    ..We discuss genetic screening approaches that are being used to identify novel regulators and effectors of autophagy, and speculate about areas of research in this system likely to bear fruit in future studies...
  4. pmc The phosphatase subunit tap42 functions independently of target of rapamycin to regulate cell division and survival in Drosophila
    Katherine D Cygnar
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, 55455, USA
    Genetics 170:733-40. 2005
    ..Our results demonstrate that the role of Tap42 in TOR signaling has not been conserved in higher eukaryotes, indicating fundamental differences in the mechanisms of TOR signaling between yeast and higher eukaryotes...
  5. ncbi request reprint Inhibition of cellular growth and proliferation by dTOR overexpression in Drosophila
    Krista M Hennig
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Genesis 34:107-10. 2002
  6. pmc Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death
    Ryan C Scott
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Curr Biol 17:1-11. 2007
    ..Here, we circumvent this difficulty by directly manipulating autophagy rates in Drosophila through the autophagy-specific protein kinase Atg1...
  7. pmc An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation
    Yu Yun Chang
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Biol Cell 20:2004-14. 2009
    ..Atg1-Atg13 complexes thus function at multiple levels to mediate and adjust nutrient-dependent autophagic signaling...
  8. pmc Autophagy takes flight in Drosophila
    Yu Yun Chang
    University of Minnesota, Department of Genetics, Cell Biology, and Development, Minneapolis, MN 55455, USA
    FEBS Lett 584:1342-9. 2010
    ..This review summarizes key studies in Drosophila autophagy research and discusses potential questions that may lead to better understanding of the roles and regulation of autophagy in higher eukaryotes...
  9. pmc Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila
    Gabor Juhasz
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Genes Dev 21:3061-6. 2007
    ..Thus, normal levels of autophagy are crucial for stress survival and continuous cellular renewal, but not metamorphosis...
  10. ncbi request reprint Contribution of Atg1-dependent autophagy to TOR-mediated cell growth and survival
    Thomas P Neufeld
    Department of Genetics, Cell Biology and Development, University of Minnesota, Mineapolis, Minnesota 55455, USA
    Autophagy 3:477-9. 2007
    ..Atg1 also has an inhibitory effect on TOR signaling, indicating the existence of a positive feedback mechanism that may amplify the nutrient-dependent signals that control autophagy...
  11. pmc The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila
    Gabor Juhasz
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    J Cell Biol 181:655-66. 2008
    ..Our results suggest that Vps34 is regulated by TOR-dependent nutrient signals directly at sites of autophagosome formation...
  12. ncbi request reprint TOR regulation: sorting out the answers
    Thomas P Neufeld
    Department of Genetics, Cell Biology and Development, University of Minnesota, 6 160 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Cell Metab 5:3-5. 2007
    ..A recent report by now implicates Pmr1, a secretory pathway Ca(2+)/Mn(2+) ATPase located in the Golgi apparatus, as a novel regulator of TOR and its downstream targets in yeast...
  13. ncbi request reprint Body building: regulation of shape and size by PI3K/TOR signaling during development
    Thomas P Neufeld
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Mech Dev 120:1283-96. 2003
    ..This review focuses on the cellular activities regulated by PI3K and TOR during development, and discusses how changes in different aspects of cellular metabolism may interact to regulate growth...
  14. pmc Shrinkage control: regulation of insulin-mediated growth by FOXO transcription factors
    Thomas P Neufeld
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    J Biol 2:18. 2003
    ..Recent studies in Drosophila have shown how transcriptional responses to reduced insulin and nutrient levels can act to inhibit growth...
  15. pmc Autophagy: a forty-year search for a missing membrane source
    Gabor Juhasz
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota, USA
    PLoS Biol 4:e36. 2006
  16. pmc TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growth
    Krista M Hennig
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    J Cell Biol 173:963-74. 2006
    ..Our data indicate that endocytosis acts both as an effector function downstream of TOR and as a physiologically relevant regulator of TOR signaling...
  17. ncbi request reprint Drosophila Atg7: required for stress resistance, longevity and neuronal homeostasis, but not for metamorphosis
    Gabor Juhasz
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Autophagy 4:357-8. 2008
    ..These results suggest that in Drosophila, normal levels of autophagy may play a more important role in the homeostasis of certain terminally differentiated cells and stress survival than during development...
  18. pmc Drosophila target of rapamycin kinase functions as a multimer
    Yong Zhang
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Genetics 172:355-62. 2006
    ..TOR multimerization thus partially accounts for the high apparent molecular weight of TOR complexes and offers novel therapeutic strategies for pathologies stemming from TOR hyperactivity...
  19. ncbi request reprint Thinking globally and acting locally with TOR
    Andrew M Arsham
    Department of Genetics, Cell Biology, and Development, University of Minnesota, 6 160 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Curr Opin Cell Biol 18:589-97. 2006
    ..TOR thus functions to coordinate growth-permitting inputs with growth-promoting outputs on both a cellular and an organismal level...
  20. doi request reprint Genetic manipulation and monitoring of autophagy in Drosophila
    Thomas P Neufeld
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA
    Methods Enzymol 451:653-67. 2008
    ....
  21. pmc A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway
    Andrew M Arsham
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN, USA
    PLoS ONE 4:e6068. 2009
    ....
  22. doi request reprint Nutrient-dependent regulation of autophagy through the target of rapamycin pathway
    Yu Yun Chang
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Biochem Soc Trans 37:232-6. 2009
    ..Further insight into these TOR-dependent control mechanisms may support development of autophagy-based therapies for a number of pathological conditions...
  23. pmc Regulation of TORC1 by Rag GTPases in nutrient response
    Eunjung Kim
    Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093 081, USA
    Nat Cell Biol 10:935-45. 2008
    ..Genetic studies in Drosophila also show that Rag GTPases regulate cell growth, autophagy and animal viability during starvation. Our studies establish a function of Rag GTPases in TORC1 activation in response to amino acid signals...
  24. pmc The cell biology of autophagy in metazoans: a developing story
    Alicia Melendez
    Department of Biology, Queens College, Flushing, NY 11367, USA
    Development 135:2347-60. 2008
    ..Insights gained from investigating the functions of autophagy in normal development should increase our understanding of its roles in human disease and its potential as a target for therapeutic intervention...
  25. doi request reprint Experimental control and characterization of autophagy in Drosophila
    Gabor Juhasz
    Department of General Zoology, Eotvos Lorand University, Budapest, Hungary
    Methods Mol Biol 445:125-33. 2008
    ..We also describe methods for experimentally activating and inhibiting autophagy in this system and discuss the potential for genetic analysis in Drosophila to identify novel genes involved in autophagy...
  26. pmc Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
    Daniel J Klionsky
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Autophagy 4:151-75. 2008
    ..In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to verify an autophagic response...

Research Grants11

  1. Regulation of TOR Signaling and Autophagy in Drosophila
    Thomas P Neufeld; Fiscal Year: 2010
    ..Potential therapeutic approaches that involve inhibiting or potentiating autophagy will benefit from greater understanding of how regulators and effectors of autophagy interact to control this process. ..
  2. REGULATION OF GROWTH AND PROLIFERATION BY DROSOPHILA TOR
    Thomas Neufeld; Fiscal Year: 2009
    ..By helping to reveal the molecular basis of TOR,Aos effects on cell growth and metabolism, this work will advance our basic understanding of these processes. ..
  3. REGULATION OF GROWTH AND PROLIFERATION BY DROSOPHILA TOR
    Thomas Neufeld; Fiscal Year: 2007
    ..By helping to reveal the molecular basis of TOR,Aos effects on cell growth and metabolism, this work will advance our basic understanding of these processes. ..
  4. REGULATION OF GROWTH AND PROLIFERATION BY DROSOPHILA TOR
    Thomas Neufeld; Fiscal Year: 2005
    ....
  5. Regulation of TOR Signaling and Autophagy in Drosophila
    Thomas P Neufeld; Fiscal Year: 2010
    ..Potential therapeutic approaches that involve inhibiting or potentiating autophagy will benefit from greater understanding of how regulators and effectors of autophagy interact to control this process. ..