John K Neubert

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint Use of a novel thermal operant behavioral assay for characterization of orofacial pain sensitivity
    John K Neubert
    Department of Orthodontics, College of Dentistry, University of Florida, 1600 SW Archer Road, P O Box 100444, Gainesville, FL 32610 0444, USA
    Pain 116:386-95. 2005
  2. ncbi request reprint Differentiation between capsaicin-induced allodynia and hyperalgesia using a thermal operant assay
    John K Neubert
    College of Dentistry, Department of Orthodontics, University of Florida, Gainesville, FL, USA
    Behav Brain Res 170:308-15. 2006
  3. pmc Perineural resiniferatoxin selectively inhibits inflammatory hyperalgesia
    John K Neubert
    College of Dentistry Department of Orthodontics, University of Florida, Gainesville, FL, USA
    Mol Pain 4:3. 2008
  4. pmc Effects of mu- and kappa-2 opioid receptor agonists on pain and rearing behaviors
    John K Neubert
    Department of Orthodontics, College of Dentistry, University of Florida, Gainesville, FL, USA
    Behav Brain Funct 3:49. 2007
  5. pmc Characterization of mouse orofacial pain and the effects of lesioning TRPV1-expressing neurons on operant behavior
    John K Neubert
    Department of Orthodontics, College of Dentistry, University of Florida, Gainesville, FL, USA
    Mol Pain 4:43. 2008
  6. ncbi request reprint Peripheral targeting of the trigeminal ganglion via the infraorbital foramen as a therapeutic strategy
    John K Neubert
    Department of Orthodontics, College of Dentistry, University of Florida, 1600 S W Archer Road, P O Box 100444, Gainesville, FL 32610 0444, USA
    Brain Res Brain Res Protoc 15:119-26. 2005
  7. pmc Central sensitization in the trigeminal nucleus caudalis produced by a conjugate of substance P and the A subunit of cholera toxin
    Robert M Caudle
    Department of Oral and Maxillofacial Surgery, University of Florida College of Dentistry, Gainesville, Florida, USA
    J Pain 11:838-46. 2010
  8. pmc Sex differences in thermal pain sensitivity and sympathetic reactivity for two strains of rat
    Charles J Vierck
    Department of Neuroscience, University of Florida, Gainesville, Florida 332601 0244, USA
    J Pain 9:739-49. 2008
  9. pmc Dose-dependent effects of icilin on thermal preference in the hindpaw and face of rats
    Heather L Rossi
    Department of Orthodontics, College of Dentistry, University of Florida, Gainesville, Florida, USA
    J Pain 10:646-53. 2009
  10. pmc Adaptation of a novel operant orofacial testing system to characterize both mechanical and thermal pain
    Todd A Nolan
    Center for Comprehensive Pain Research, University of Florida, Gainesville, FL, USA
    Behav Brain Res 217:477-80. 2011

Research Grants

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Use of a novel thermal operant behavioral assay for characterization of orofacial pain sensitivity
    John K Neubert
    Department of Orthodontics, College of Dentistry, University of Florida, 1600 SW Archer Road, P O Box 100444, Gainesville, FL 32610 0444, USA
    Pain 116:386-95. 2005
    ..These data reflect an orofacial pain behavior profile that was based on an animal's responses in an operant escape paradigm. This technique allows evaluation of nociceptive processing and modulation throughout the neuraxis...
  2. ncbi request reprint Differentiation between capsaicin-induced allodynia and hyperalgesia using a thermal operant assay
    John K Neubert
    College of Dentistry, Department of Orthodontics, University of Florida, Gainesville, FL, USA
    Behav Brain Res 170:308-15. 2006
    ..This technique provides an alternative to reflex tests of orofacial sensitivity, and it presents a pivotal link for translating basic pain research into clinic trial strategies...
  3. pmc Perineural resiniferatoxin selectively inhibits inflammatory hyperalgesia
    John K Neubert
    College of Dentistry Department of Orthodontics, University of Florida, Gainesville, FL, USA
    Mol Pain 4:3. 2008
    ..We propose that this method could represent a beneficial treatment for a range of chronic pain problems, including neuropathic and inflammatory pain not responding to other therapies...
  4. pmc Effects of mu- and kappa-2 opioid receptor agonists on pain and rearing behaviors
    John K Neubert
    Department of Orthodontics, College of Dentistry, University of Florida, Gainesville, FL, USA
    Behav Brain Funct 3:49. 2007
    ..abstract:..
  5. pmc Characterization of mouse orofacial pain and the effects of lesioning TRPV1-expressing neurons on operant behavior
    John K Neubert
    Department of Orthodontics, College of Dentistry, University of Florida, Gainesville, FL, USA
    Mol Pain 4:43. 2008
    ..During the reward-conflict task, mice accessed a sweetened milk reward solution by voluntarily position their face against a neutral or heated thermode (37-55 degrees C)...
  6. ncbi request reprint Peripheral targeting of the trigeminal ganglion via the infraorbital foramen as a therapeutic strategy
    John K Neubert
    Department of Orthodontics, College of Dentistry, University of Florida, 1600 S W Archer Road, P O Box 100444, Gainesville, FL 32610 0444, USA
    Brain Res Brain Res Protoc 15:119-26. 2005
    ..This technique minimizes trauma to brain structures that may have an impact on pain perception...
  7. pmc Central sensitization in the trigeminal nucleus caudalis produced by a conjugate of substance P and the A subunit of cholera toxin
    Robert M Caudle
    Department of Oral and Maxillofacial Surgery, University of Florida College of Dentistry, Gainesville, Florida, USA
    J Pain 11:838-46. 2010
    ..The data also demonstrate that the intracisternal administration of SP-CTA in rodents is a useful model for studying central sensitization as a disease process without having to induce a peripheral injury...
  8. pmc Sex differences in thermal pain sensitivity and sympathetic reactivity for two strains of rat
    Charles J Vierck
    Department of Neuroscience, University of Florida, Gainesville, Florida 332601 0244, USA
    J Pain 9:739-49. 2008
    ..Female escape responses to heat were more variable than males, but L/G responding of males to the same stimulus was more variable than for females...
  9. pmc Dose-dependent effects of icilin on thermal preference in the hindpaw and face of rats
    Heather L Rossi
    Department of Orthodontics, College of Dentistry, University of Florida, Gainesville, Florida, USA
    J Pain 10:646-53. 2009
    ..In contrast, systemic icilin at the high concentration produces peripheral and/or central effects that diminish cold sensitivity, while WDS is maintained at a persistent rate...
  10. pmc Adaptation of a novel operant orofacial testing system to characterize both mechanical and thermal pain
    Todd A Nolan
    Center for Comprehensive Pain Research, University of Florida, Gainesville, FL, USA
    Behav Brain Res 217:477-80. 2011
    ..We demonstrate that the operant system is able to detect painful and analgesic responses to mechanical stimuli. These findings allow comparison of both mechanical and thermal stimuli using the same outcome measures...
  11. pmc Anti-nociceptive effect of a conjugate of substance P and light chain of botulinum neurotoxin type A
    Golam Mustafa
    Department of Oral and Maxillofacial Surgery, University of Florida College of Dentistry, Gainesville, FL, USA
    Pain 154:2547-53. 2013
    ....
  12. pmc Effect of caloric and non-caloric sweet reward solutions on thermal facial operant conditioning
    Todd A Nolan
    Center for Comprehensive Pain Research, University of Florida, Gainesville, FL, United States
    Behav Brain Res 216:723-5. 2011
    ..Our findings demonstrate that across a range of sucrose solutions some produce a success ratio which could mistakenly be labeled allodynic demonstrating the importance of choosing the correct reward solution...
  13. pmc Effects of hot and cold stimulus combinations on the thermal preference of rats
    Heather L Rossi
    College of Dentistry Department of Orthodontics, University of Florida, Gainesville, FL, United States
    Behav Brain Res 203:240-6. 2009
    ..The findings in this study will allow us to evaluate experimental pain states and analgesic treatments in a manner more relatable to the experience of the patient...
  14. pmc Characterization of cold sensitivity and thermal preference using an operant orofacial assay
    Heather L Rossi
    College of Dentistry Department of Orthodontics, University of Florida, Gainesville, FL 32610 0444, USA
    Mol Pain 2:37. 2006
    ..Male and female rats were trained to drink sweetened milk while pressing their shaved faces against a thermode. This presents a conflict paradigm between milk reward and thermal stimulation...
  15. pmc Effects of environmental enrichment on thermal sensitivity in an operant orofacial pain assay
    Heather L Rossi
    College of Dentistry, Department of Orthodontics, University of Florida, Gainesville, FL 32610 0459, USA
    Behav Brain Res 187:478-82. 2008
    ..These findings indicate that environmental enrichment can significantly affect temperature perception, likely through stress-related mechanisms...
  16. pmc Sensitization of spinal cord nociceptive neurons with a conjugate of substance P and cholera toxin
    Robert M Caudle
    Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, FL 32610, USA
    BMC Neurosci 8:30. 2007
    ..This conjugate should be taken up selectively by neurokinin receptor expressing neurons resulting in enhanced adenylate cyclase activity and neuronal firing...
  17. pmc The effects of a co-application of menthol and capsaicin on nociceptive behaviors of the rat on the operant orofacial pain assessment device
    Ethan M Anderson
    Department of Oral and Maxillofacial Surgery, University of Florida College of Dentistry, Gainesville, Florida, United States of America Department of Neuroscience, University of Florida College of Medicine, McKnight Brain Institute, Gainesville, Florida, United States of America
    PLoS ONE 9:e89137. 2014
    ..We hypothesized that agonists of TRPV1 and TRPM8/TRPA1, capsaicin and menthol, would alter nociceptive behaviors in the rat, but their opposite effects on temperature detection would attenuate one another if combined...
  18. pmc Placebo-induced analgesia in an operant pain model in rats
    Todd A Nolan
    College of Dentistry, Department of Orthodontics, University of Florida, Gainesville, FL, USA
    Pain 153:2009-16. 2012
    ..This finding may provide opportunities for invasive preclinical studies allowing greater understanding of placebo-induced analgesia, thus paving the way for avenues to harness its benefits...
  19. ncbi request reprint Comparison of experimental and acute clinical pain responses in humans as pain phenotypes
    Hyungsuk Kim
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Pain 5:377-84. 2004
    ..The predictive value of experimental pain for clinically induced pain is weak and not reliable...
  20. ncbi request reprint Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament
    Hyungsuk Kim
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 10 center Dr Building 10 Rm 1N103, Bethesda, MD 20892 1197, USA
    Pain 109:488-96. 2004
    ..Our observations demonstrate that gender, ethnicity and temperament contribute to individual variation in thermal and cold pain sensitivity by interactions with TRPV1 and OPRD1 single nucleotide polymorphisms...
  21. pmc Deletion of vanilloid receptor 1-expressing primary afferent neurons for pain control
    Laszlo Karai
    National Institute of Dental and Craniofacial Research, Bethesda, Maryland 20892, USA
    J Clin Invest 113:1344-52. 2004
    ..The results suggest that nociceptive neuronal or nerve terminal deletion will be effective and broadly applicable as strategies for pain management...
  22. ncbi request reprint Peripherally induced resiniferatoxin analgesia
    John K Neubert
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Pain 104:219-28. 2003
    ..The results demonstrate the efficacy and therapeutic potential of reversible, peripheral C-fiber 'inactivation' for intermediate duration pain control...
  23. ncbi request reprint Microdialysis in trigeminal ganglia
    John K Neubert
    Pain Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Brain Res Brain Res Protoc 10:102-8. 2002
    ..Microdialysis performed in the TG thus provides a valuable site for recovery and measurement of a variety of extracellular substances that may be integral in the processing of trigeminal sensory information...
  24. doi request reprint Toothache or trigeminal neuralgia: treatment dilemmas
    Christopher J Spencer
    J Pain 9:767-70. 2008

Research Grants2

  1. Molecular Targeting of the Vanilloid-1 Receptor
    JOHN NEUBERT; Fiscal Year: 2006
    ..These outcomes are expected to have significant positive effects on a wide spectrum of pain relating to tissue damage and injury. ..
  2. Novel Operant Thermal Assessments of Orofacial Pain
    JOHN NEUBERT; Fiscal Year: 2007
    ....