E J Nestler

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi The influence of DeltaFosB in the nucleus accumbens on natural reward-related behavior
    Deanna L Wallace
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 28:10272-7. 2008
  2. ncbi Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
    Olivier Berton
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Science 311:864-8. 2006
  3. ncbi DeltaFosB: a sustained molecular switch for addiction
    E J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 98:11042-6. 2001
  4. ncbi Psychogenomics: opportunities for understanding addiction
    E J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 21:8324-7. 2001
  5. ncbi The mesolimbic dopamine reward circuit in depression
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Biol Psychiatry 59:1151-9. 2006
  6. ncbi Molecular neurobiology of addiction
    E J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
    Am J Addict 10:201-17. 2001
  7. ncbi Is there a common molecular pathway for addiction?
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 9070, USA
    Nat Neurosci 8:1445-9. 2005
  8. ncbi From neurobiology to treatment: progress against addiction
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 9070, USA
    Nat Neurosci 5:1076-9. 2002
  9. ncbi Molecular basis of long-term plasticity underlying addiction
    E J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5, 323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Rev Neurosci 2:119-28. 2001
  10. ncbi Learning about addiction from the genome
    E J Nestler
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas 75390 9070, USA
    Nature 409:834-5. 2001

Research Grants

  1. MOLECULAR STUDIES OF OPIATE AND COCAINE ACTION IN BRAIN
    Eric Nestler; Fiscal Year: 2007
  2. MOLECULAR STUDIES OF COCAINE ACTION IN BRAIN
    Eric Nestler; Fiscal Year: 2007
  3. Basic Science Training Program in the Neurobiology of Mental Illness
    Carol Tamminga; Fiscal Year: 2007
  4. BASIC SCIENCE TRAINING PROGRAM IN DRUG ABUSE
    Eric Nestler; Fiscal Year: 2007
  5. Neural Substrates of Appetitive Behavior in Mood and Motivation
    Eric Nestler; Fiscal Year: 2007

Detail Information

Publications94

  1. ncbi The influence of DeltaFosB in the nucleus accumbens on natural reward-related behavior
    Deanna L Wallace
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 28:10272-7. 2008
    ..Additionally, our findings show that chronic exposure to stimuli that induce DeltaFosB in the NAc can increase consumption of other natural rewards...
  2. ncbi Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
    Olivier Berton
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Science 311:864-8. 2006
    ..These results establish an essential role for BDNF in mediating long-term neural and behavioral plasticity in response to aversive social experiences...
  3. ncbi DeltaFosB: a sustained molecular switch for addiction
    E J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 98:11042-6. 2001
    ....
  4. ncbi Psychogenomics: opportunities for understanding addiction
    E J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 21:8324-7. 2001
    ..The ultimate goal is to use this information to develop more effective treatments for these disorders as well as objective diagnostic tools, preventive measures, and eventually cures...
  5. ncbi The mesolimbic dopamine reward circuit in depression
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Biol Psychiatry 59:1151-9. 2006
    ....
  6. ncbi Molecular neurobiology of addiction
    E J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
    Am J Addict 10:201-17. 2001
    ..Knowledge of these mechanisms could lead to more effective treatments for addictive disorders...
  7. ncbi Is there a common molecular pathway for addiction?
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 9070, USA
    Nat Neurosci 8:1445-9. 2005
    ..A major goal for future research is to determine whether such common underpinnings of addiction can be exploited for the development of more effective treatments for a wide range of addictive disorders...
  8. ncbi From neurobiology to treatment: progress against addiction
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 9070, USA
    Nat Neurosci 5:1076-9. 2002
    ..The latter approach is the most speculative, but also the most promising in terms of translating basic knowledge of addiction into clinical progress...
  9. ncbi Molecular basis of long-term plasticity underlying addiction
    E J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5, 323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Rev Neurosci 2:119-28. 2001
    ....
  10. ncbi Learning about addiction from the genome
    E J Nestler
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas 75390 9070, USA
    Nature 409:834-5. 2001
    ..We illustrate this potential impact by searching a draft sequence of the human genome for genes related to desensitization of receptors that mediate the actions of drugs of abuse on the nervous system...
  11. ncbi Genes and addiction
    E J Nestler
    Department of Psychiatry and Center for Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Genet 26:277-81. 2000
    ..Whereas recent advances in this latter effort are heartening, a major challenge remains: to understand how the many genes implicated in rodent models interact to yield as complex a phenotype as addiction...
  12. ncbi The neurobiology of cocaine addiction
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Sci Pract Perspect 3:4-10. 2005
    ..Further pursuit of this and similar leads are first steps toward a complete understanding of the transition from cocaine abuse to addiction -- and, ultimately, more effective treatments for those who are addicted...
  13. ncbi Common molecular and cellular substrates of addiction and memory
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas 75390 9070, USA
    Neurobiol Learn Mem 78:637-47. 2002
    ..A better understanding of the molecular and cellular adaptations that occur in these neural circuits may lead to novel interventions to improve memory and combat addiction in humans...
  14. ncbi Molecular mechanisms of drug addiction
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Neuropharmacology 47:24-32. 2004
    ....
  15. ncbi Historical review: Molecular and cellular mechanisms of opiate and cocaine addiction
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience The University of Texas Southwestern Medical Center 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
    Trends Pharmacol Sci 25:210-8. 2004
    ..In this article, I present a historical review of basic research on opiate and cocaine addiction...
  16. ncbi Neurobiology of depression
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Neuron 34:13-25. 2002
    ..A neurobiologic understanding of depression also requires identification of the genes that make individuals vulnerable or resistant to the syndrome. These advances will fundamentally improve the treatment and prevention of depression...
  17. ncbi Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal
    Dan Georgescu
    Department of Psychiatry, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 23:3106-11. 2003
    ..Together, these studies support a role for the orexin system in molecular adaptations to morphine, and demonstrate dramatic differences in molecular responses among different populations of LH neurons...
  18. ncbi The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance
    Dan Georgescu
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9070, USA
    J Neurosci 25:2933-40. 2005
    ..This work identifies a novel hypothalamic-AcSh circuit that influences appetitive behavior and mediates the antidepressant activity of MCH1R antagonists...
  19. ncbi Regional and cellular mapping of cAMP response element-mediated transcription during naltrexone-precipitated morphine withdrawal
    Tamara Z Shaw-Lutchman
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, USA
    J Neurosci 22:3663-72. 2002
    ..CRE-mediated transcription may itself contribute to re-establishing homeostasis in the organism through target gene regulation in these regions...
  20. ncbi The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress
    Michael Lutter
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 9077, USA
    Nat Neurosci 11:752-3. 2008
    ..Together, these findings demonstrate a previously unknown function for ghrelin in defending against depressive-like symptoms of chronic stress...
  21. ncbi Regulation of drug reward by cAMP response element-binding protein: evidence for two functionally distinct subregions of the ventral tegmental area
    Valerie G Olson
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, USA
    J Neurosci 25:5553-62. 2005
    ..These results suggest a novel role for CREB in mediating drug-induced plasticity in the VTA and establish two functionally distinct subregions of the VTA in which CREB differentially regulates drug reward...
  22. ncbi Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression
    Amelia J Eisch
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Texas, Dallas 75390-9070, USA
    Biol Psychiatry 54:994-1005. 2003
    ..This interpretation is intriguing in that it suggests a role for BDNF in the VTA-NAc that is opposite of the proposed role for BDNF in the hippocampus...
  23. ncbi Induction of deltaFosB in reward-related brain structures after chronic stress
    Linda I Perrotti
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 24:10594-602. 2004
    ..These findings establish that chronic stress induces DeltaFosB in several discrete regions of the brain. Such induction could contribute to the long-term effects of stress on the brain...
  24. ncbi Molecular and cellular basis of addiction
    E J Nestler
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06508, USA
    Science 278:58-63. 1997
    ..Understanding the molecular and cellular basis of addictive states will lead to major changes in how addiction is viewed and ultimately treated...
  25. ncbi Brain region specific actions of regulator of G protein signaling 4 oppose morphine reward and dependence but promote analgesia
    Ming Hi Han
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, Texas, USA
    Biol Psychiatry 67:761-9. 2010
    ..Earlier evidence suggests dynamic regulation of RGS4 levels in neuronal networks mediating actions of opiates and other drugs of abuse, but the consequences of RGS4 actions in vivo are largely unknown...
  26. ncbi AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuli
    Vaishnav Krishnan
    Department of Psychiatry and Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Biol Psychiatry 64:691-700. 2008
    ..Recent evidence suggests that dopaminergic neurons of the ventral tegmental area (VTA) play a key role in the manifestation of stress vulnerability...
  27. ncbi Calcium-sensitive adenylyl cyclases in depression and anxiety: behavioral and biochemical consequences of isoform targeting
    Vaishnav Krishnan
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Biol Psychiatry 64:336-43. 2008
    ..This study examines the contribution of these AC isoforms to emotional behavior...
  28. ncbi Distinct roles of adenylyl cyclases 1 and 8 in opiate dependence: behavioral, electrophysiological, and molecular studies
    Venetia Zachariou
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, Texas, USA
    Biol Psychiatry 63:1013-21. 2008
    ..Earlier work revealed the selective induction of two calmodulin-dependent AC isoforms, AC1 and AC8, after chronic morphine, but their role in opiate dependence has remained unknown...
  29. ncbi Regulation of dopaminergic transmission and cocaine reward by the Clock gene
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 102:9377-81. 2005
    ..These findings demonstrate the involvement of a circadian-associated gene, Clock, in regulating dopamine function and cocaine reward...
  30. ncbi Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum
    Arvind Kumar
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Neuron 48:303-14. 2005
    ..Furthermore, modulating histone deacetylase activity alters locomotor and rewarding responses to cocaine. Thus, chromatin remodeling is an important regulatory mechanism underlying cocaine-induced neural and behavioral plasticity...
  31. ncbi An essential role for DeltaFosB in the nucleus accumbens in morphine action
    Venetia Zachariou
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9070, USA
    Nat Neurosci 9:205-11. 2006
    ..Together, these experiments demonstrated that DeltaFosB in the NAc, partly through the repression of dynorphin expression, mediates several major features of opiate addiction...
  32. ncbi Phospholipase Cgamma in distinct regions of the ventral tegmental area differentially modulates mood-related behaviors
    Carlos A Bolanos
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 23:7569-76. 2003
    ..Moreover, these data also support a role for drug-induced elevations in PLCgamma1 expression in the VTA in mediating long-term adaptations to drugs of abuse and aversive stimuli...
  33. ncbi Strain-selective effects of corticosterone on locomotor sensitization to cocaine and on levels of tyrosine hydroxylase and glucocorticoid receptor in the ventral tegmental area
    J Ortiz
    Department of Psychiatry, Yale University School of Medicine, Connecticut, Mental Health Center, New Haven 06508, USA
    Neuroscience 67:383-97. 1995
    ....
  34. ncbi IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates
    Scott J Russo
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Neurosci 10:93-9. 2007
    ..These findings directly implicate the IRS2-Akt signaling pathway as a critical regulator of dopamine cell morphology and opiate reward...
  35. ncbi Regulation of gene expression and cocaine reward by CREB and DeltaFosB
    Colleen A McClung
    The University of Texas Southwestern Medical Center, Department of Psychiatry and Center for Basic Neuroscience, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9070, USA
    Nat Neurosci 6:1208-15. 2003
    ..These findings help define the molecular functions of CREB and DeltaFosB and identify clusters of genes that contribute to cocaine addiction...
  36. ncbi Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions
    Vaishnav Krishnan
    Department of Psychiatry, The University of Texas Southwestern Medical Center UTSWMC, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Cell 131:391-404. 2007
    ....
  37. ncbi Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
    Nadia M Tsankova
    The University of Texas Southwestern Medical Center, Department of Psychiatry and Center for Basic Neuroscience, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9070, USA
    Nat Neurosci 9:519-25. 2006
    ..These experiments underscore an important role for histone remodeling in the pathophysiology and treatment of depression and highlight the therapeutic potential for histone methylation and deacetylation inhibitors in depression...
  38. ncbi Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli
    William Renthal
    Department of Psychiatry and Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Neuron 56:517-29. 2007
    ....
  39. ncbi Distinct patterns of DeltaFosB induction in brain by drugs of abuse
    L I Perrotti
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Synapse 62:358-69. 2008
    ....
  40. ncbi Acquisition and maintenance of intravenous cocaine self-administration in Lewis and Fischer inbred rat strains
    T A Kosten
    Department of Psychiatry, Yale University School of Medicine, and Connecticut Mental Health Center, New Haven 06508, USA
    Brain Res 778:418-29. 1997
    ..Further, because acquisition of drug self-administration is an animal model of vulnerability to drug addiction, these inbred strains may be useful to study factors underlying such vulnerability...
  41. ncbi RGS9 modulates dopamine signaling in the basal ganglia
    Zia Rahman
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 38:941-52. 2003
    ....
  42. ncbi Induction of activating transcription factors (ATFs) ATF2, ATF3, and ATF4 in the nucleus accumbens and their regulation of emotional behavior
    Thomas A Green
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 28:2025-32. 2008
    ....
  43. ncbi Induction of deltaFosB in the periaqueductal gray by stress promotes active coping responses
    Olivier Berton
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Neuron 55:289-300. 2007
    ..These results indicate that IS-induced accumulation of DeltaFosB in the vlPAG desensitizes substance P neurons enriched in this area and opposes behavioral despair by promoting active defense responses...
  44. ncbi Blockade of melanocortin transmission inhibits cocaine reward
    Richard Hsu
    Laboratory of Molecular Psychiatry, Center for Genes and Behaviour, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Eur J Neurosci 21:2233-42. 2005
    ..Modulation of cocaine reward is a novel action of the melanocortin-MC4-R system and could be targeted for the development of new medications for cocaine addiction...
  45. ncbi Environmental enrichment produces a behavioral phenotype mediated by low cyclic adenosine monophosphate response element binding (CREB) activity in the nucleus accumbens
    Thomas A Green
    Departments of Psychiatry and Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Biol Psychiatry 67:28-35. 2010
    ..The present study used cocaine to further explore this environmental enrichment behavioral phenotype, as well as the underlying molecular mechanisms involved...
  46. ncbi The addicted brain
    Eric J Nestler
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, USA
    Sci Am 290:78-85. 2004
  47. ncbi Essential role for RGS9 in opiate action
    Venetia Zachariou
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 100:13656-61. 2003
    ....
  48. ncbi Methylphenidate treatment during pre- and periadolescence alters behavioral responses to emotional stimuli at adulthood
    Carlos A Bolanos
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Biol Psychiatry 54:1317-29. 2003
    ..Data examining other potential long-term behavioral consequences of early MPH administration are lacking, however...
  49. ncbi Essential role of the cAMP-cAMP response-element binding protein pathway in opiate-induced homeostatic adaptations of locus coeruleus neurons
    Jun Li Cao
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 107:17011-6. 2010
    ....
  50. ncbi Behavioral interactions caused by combined administration of morphine and MK-801 in rats
    W A Carlezon
    Department of Psychiatry, McLean Hospital, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 151:261-72. 2000
    ..However, evidence in the existing literature suggests that some of MK-801's effects are additive (or synergistic) with those of morphine...
  51. ncbi Distinct roles for spinophilin and neurabin in dopamine-mediated plasticity
    P B Allen
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Neuroscience 140:897-911. 2006
    ..These data establish a requirement for synaptic scaffolding in dopamine-mediated responses, and further indicate that spinophilin and neurabin play distinct roles in dopaminergic signal transduction and psychostimulant response...
  52. ncbi Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens
    A M Pliakas
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 21:7397-403. 2001
    ..Exposure to the FST itself dramatically increased CREB function in the NAc. These findings raise the possibility that CREB-mediated transcription within the NAc regulates dysphoric states...
  53. ncbi Phosphorylation of DeltaFosB mediates its stability in vivo
    P G Ulery-Reynolds
    Department of Neurology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Neuroscience 158:369-72. 2009
    ..We show here that this phosphorylation reaction is also important for DeltaFosB's stability in the brain in vivo and for the unique behavioral plasticity mediated by this transcription factor...
  54. ncbi Downregulation of the CCAAT-enhancer binding protein beta in deltaFosB transgenic mice and by electroconvulsive seizures
    Jingshan Chen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Neuropsychopharmacology 29:23-31. 2004
    ....
  55. ncbi Role of cAMP response element-binding protein in the rat locus ceruleus: regulation of neuronal activity and opiate withdrawal behaviors
    Ming Hu Han
    Department of Psychiatry, Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 26:4624-9. 2006
    ....
  56. ncbi Regulation of gene expression by chronic morphine and morphine withdrawal in the locus ceruleus and ventral tegmental area
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, USA
    J Neurosci 25:6005-15. 2005
    ..Inhibition of either protein profoundly affects withdrawal responses, demonstrating that the genes identified in this study have important functional roles in mediating opiate-induced behaviors...
  57. ncbi Striatal regulation of ΔFosB, FosB, and cFos during cocaine self-administration and withdrawal
    Erin B Larson
    The Seay Center for Basic and Applied Research in Psychiatric Illness, UT Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurochem 115:112-22. 2010
    ....
  58. ncbi Altered sensitivity to rewarding and aversive drugs in mice with inducible disruption of cAMP response element-binding protein function within the nucleus accumbens
    Jennifer A DiNieri
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 29:1855-9. 2009
    ..Together with previous findings, these studies raise the possibility that disruption of CREB in the NAc influences motivation by simultaneously facilitating reward and reducing depressive-like states such as anhedonia and dysphoria...
  59. ncbi Phosphorylation of DARPP-32 at Threonine-34 is required for cocaine action
    Venetia Zachariou
    Department of Psychiatry, Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Neuropsychopharmacology 31:555-62. 2006
    ..These findings highlight distinct roles of the Thr-34 and Thr-75 phosphorylation sites of DARPP-32 in mediating short- and long-term behavioral and biochemical actions of cocaine...
  60. ncbi Cocaine regulates MEF2 to control synaptic and behavioral plasticity
    Suprabha Pulipparacharuvil
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9127, USA
    Neuron 59:621-33. 2008
    ....
  61. ncbi Molecular mechanisms of opiate and cocaine addiction
    E J Nestler
    Laboratory of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Curr Opin Neurobiol 7:713-9. 1997
    ..In addition, recent work has focused on a role for transcription factors, and the associated alterations in gene expression, in mediating part of this long-lasting, drug-induced molecular and behavioral plasticity...
  62. ncbi Long-term memory is facilitated by cAMP response element-binding protein overexpression in the amygdala
    S A Josselyn
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, Connecticut 06508, USA
    J Neurosci 21:2404-12. 2001
    ..These results suggest that CREB activity in the amygdala serves as a molecular switch for the formation of LTM in fear conditioning...
  63. ncbi CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits
    Deanna L Wallace
    Department of Psychiatry and Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Neurosci 12:200-9. 2009
    ....
  64. ncbi Linking molecules to mood: new insight into the biology of depression
    Vaishnav Krishnan
    Department of Psychiatry, University of Texas Southwestern Medical Center, USA
    Am J Psychiatry 167:1305-20. 2010
    ..The authors provide recommendations for future research, with a focus on translating today's discoveries into improved diagnostic tests and treatments...
  65. ncbi Increased impulsivity during withdrawal from cocaine self-administration: role for DeltaFosB in the orbitofrontal cortex
    Catharine A Winstanley
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Cereb Cortex 19:435-44. 2009
    ..Our findings suggest that induction of DeltaFosB within the OFC is one mediator of these effects and, thereby, increases vulnerability to addiction...
  66. ncbi Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure
    William Renthal
    Department of Psychiatry and Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 28:7344-9. 2008
    ..This study reveals a novel epigenetic pathway through which DeltaFosB mediates distinct transcriptional programs that may ultimately alter behavioral plasticity to chronic amphetamine exposure...
  67. ncbi Homeostatic and hedonic signals interact in the regulation of food intake
    Michael Lutter
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Nutr 139:629-32. 2009
    ..Finally, we discuss the clinical implications of these neuronal adaptations in the context of obesity and neuropsychiatric syndromes such as bulimia nervosa and Prader-Willi syndrome...
  68. ncbi Regulation of morphine reward and feeding by CREB in the lateral hypothalamus
    Valerie G Olson
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, USA
    Synapse 61:110-3. 2007
  69. ncbi Stimulation of protein kinase a activity in the rat amygdala enhances reward-related learning
    J David Jentsch
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 52:111-8. 2002
    ....
  70. ncbi CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli
    Michel Barrot
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 99:11435-40. 2002
    ..This control appears to be independent of the intrinsic appetitive or aversive value of the stimulus. The potential relevance of these data to addiction and mood disorders is discussed...
  71. ncbi The many faces of CREB
    William A Carlezon
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont MA 02478, USA
    Trends Neurosci 28:436-45. 2005
    ....
  72. ncbi Regulation of regulators of G protein signaling mRNA expression in rat brain by acute and chronic electroconvulsive seizures
    Stephen J Gold
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center at Dallas, Texas 75390, USA
    J Neurochem 82:828-38. 2002
    ..These studies demonstrate subtype-, time-, and region-specific regulation of RGS proteins by ECS, adaptations that may contribute to the antidepressant effects of this treatment...
  73. ncbi Regulation of RGS proteins by chronic morphine in rat locus coeruleus
    Stephen J Gold
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas TX 75390, USA
    Eur J Neurosci 17:971-80. 2003
    ....
  74. ncbi Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures
    Nadia M Tsankova
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, USA
    J Neurosci 24:5603-10. 2004
    ....
  75. ncbi The presynaptic active zone protein RIM1alpha is critical for normal learning and memory
    Craig M Powell
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 42:143-53. 2004
    ....
  76. ncbi Lateral hypothalamic neuropeptides in reward and drug addiction
    Ralph J DiLeone
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas 75390 9070, USA
    Life Sci 73:759-68. 2003
    ..Regulation of LH intracellular signaling pathways in response to drugs of abuse supports a role for the LH neuropeptides in addiction...
  77. ncbi New approaches to antidepressant drug discovery: beyond monoamines
    Olivier Berton
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9070, USA
    Nat Rev Neurosci 7:137-51. 2006
    ..This review summarizes the obstacles that have hindered the development of non-monoamine-based antidepressants, and provides a progress report on some of the most promising current strategies...
  78. ncbi Regulation of anxiety and initiation of sexual behavior by CREB in the nucleus accumbens
    Michel Barrot
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 102:8357-62. 2005
    ..The results also provide insight into the molecular mechanisms by which social interactions affect brain plasticity and behavior...
  79. ncbi Induction of nuclear factor-kappaB in nucleus accumbens by chronic cocaine administration
    E Ang
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    J Neurochem 79:221-4. 2001
    ..These results establish NF-kappaB as a putative target for DeltaFosB and implicate NF-kappaB signaling pathways in the long-term adaptations of nucleus accumbens neurons to cocaine...
  80. ncbi FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects
    N Hiroi
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06508, USA
    Proc Natl Acad Sci U S A 94:10397-402. 1997
    ..This finding demonstrates that a Fos family member protein plays a functional role in behavioral responses to drugs of abuse and implicates fosB gene products as important determinants of cocaine abuse...
  81. ncbi Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein
    Shin Nakagawa
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 22:3673-82. 2002
    ..The results suggest that the cAMP-CREB cascade could contribute to the actions of neurotransmitters and neurotrophic factors on adult neurogenesis...
  82. ncbi Neural mechanisms of addiction: the role of reward-related learning and memory
    Steven E Hyman
    Office of the Provost, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Neurosci 29:565-98. 2006
    ..Here we review progress in identifying candidate mechanisms of addiction...
  83. ncbi Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice
    Michel A Steiner
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 33:54-67. 2008
    ..We conclude that pharmacological blockade of CB1 signaling shares antidepressant-like behavioral effects with desipramine, but reveals opposite effects on HPA axis activity...
  84. ncbi Pathological gambling: focusing on the addiction, not the activity
    Carol A Tamminga
    Am J Psychiatry 163:180-1. 2006
  85. ncbi Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect
    Samuel S Newton
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 22:10883-90. 2002
    ..Together, the results demonstrate that nucleus accumbens CREB-dynorphin influence behavior in the learned helplessness model and suggest that this signaling cascade may contribute to symptoms of depression...
  86. ncbi Characterization of the mouse adenylyl cyclase type VIII gene promoter: regulation by cAMP and CREB
    Jennifer R Chao
    Laboratory of Molecular Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Eur J Neurosci 16:1284-94. 2002
    ..These results suggest that the ACVIII gene is regulated by CREB in vitro and in vivo and that this regulation may contribute to CREB-dependent neural plasticity...
  87. ncbi Striatal cell type-specific overexpression of DeltaFosB enhances incentive for cocaine
    Christina R Colby
    Division of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, Connecticut 06508, USA
    J Neurosci 23:2488-93. 2003
    ..These data suggest that accumulation of DeltaFosB contributes to drug addiction by increasing the incentive properties of cocaine, an effect that could increase the risk for relapse long after cocaine use ceases...
  88. ncbi Delta FosB regulates wheel running
    Martin Werme
    Department of Neuroscience, Karolinska Institutet, Stockholm, S 171 77 Sweden
    J Neurosci 22:8133-8. 2002
    ....
  89. ncbi Adenylyl cyclase type 5 (AC5) is an essential mediator of morphine action
    Kyoung Shim Kim
    Department of Neuroscience, Medical Research Institute, Ewha Womans University School of Medicine, Seoul 110 783, Korea
    Proc Natl Acad Sci U S A 103:3908-13. 2006
    ....
  90. ncbi Review. Transcriptional mechanisms of addiction: role of DeltaFosB
    Eric J Nestler
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Philos Trans R Soc Lond B Biol Sci 363:3245-55. 2008
    ....
  91. ncbi Multiple actions of spinophilin regulate mu opioid receptor function
    Joanna J Charlton
    Department of Pharmacology, University of Crete, 71409 Heraklion, Crete, Greece
    Neuron 58:238-47. 2008
    ..Our findings support a potent physiological role of spinophilin in regulating MOR function and provide a potential new target for the treatment of opiate addiction...
  92. ncbi CREB modulates excitability of nucleus accumbens neurons
    Yan Dong
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California 94304, USA
    Nat Neurosci 9:475-7. 2006
    ....
  93. ncbi Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons
    Schahram Akbarian
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    J Neurosci 22:4153-62. 2002
    ..Therefore, a BDNF-signaling pathway originating from non-noradrenergic sources is essential for opiate-induced molecular adaptations of the noradrenergic system...
  94. ncbi Adenylyl cyclase-5 activity in the nucleus accumbens regulates anxiety-related behavior
    Kyoung Shim Kim
    Division of Nano Sciences and Brain Disease Research Institute, Ewha Womans University, Seoul, Korea
    J Neurochem 107:105-15. 2008
    ..Taken together, these results suggest an essential role of AC5 in the NAc for maintaining normal levels of anxiety...

Research Grants5

  1. MOLECULAR STUDIES OF OPIATE AND COCAINE ACTION IN BRAIN
    Eric Nestler; Fiscal Year: 2007
    ..These experimental approaches, made possible by this K05 Award, promise to reveal new insight into the mechanisms by which repeated drug exposure leads to the behavioral plasticity of drug addiction. ..
  2. MOLECULAR STUDIES OF COCAINE ACTION IN BRAIN
    Eric Nestler; Fiscal Year: 2007
    ..This work will contribute to our growing knowledge of drug-induced neuroadaptations in the brain at the molecular level. ..
  3. Basic Science Training Program in the Neurobiology of Mental Illness
    Carol Tamminga; Fiscal Year: 2007
    ....
  4. BASIC SCIENCE TRAINING PROGRAM IN DRUG ABUSE
    Eric Nestler; Fiscal Year: 2007
    ..Finally, drug abuse trainees benefit enormously from the outstanding basic molecular and cell biology training programs at UT Southwestern, which helps build our drug abuse research on the strongest molecular and cellular foundations. ..
  5. Neural Substrates of Appetitive Behavior in Mood and Motivation
    Eric Nestler; Fiscal Year: 2007
    ..g., BDNF in Project 2, CCK in Project 4) and help control CREB activity (e.g., MCH in Project 3), and by characterizing their role in mediating CREB's complex behavioral phenotype related to depression and its treatment. ..