Pratibha V Nerurkar

Summary

Affiliation: University of Hawaii
Country: USA

Publications

  1. ncbi request reprint In vitro toxicity of kava alkaloid, pipermethystine, in HepG2 cells compared to kavalactones
    Pratibha V Nerurkar
    Department of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA
    Toxicol Sci 79:106-11. 2004
  2. ncbi request reprint Microsomal triglyceride transfer protein gene expression and ApoB secretion are inhibited by bitter melon in HepG2 cells
    Pratibha V Nerurkar
    Laboratory of Metabolic Disorders and Alternative Medicine, Department of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources, University of Hawaii, Honolulu, HI, USA
    J Nutr 135:702-6. 2005
  3. pmc Lipid lowering effects of Momordica charantia (Bitter Melon) in HIV-1-protease inhibitor-treated human hepatoma cells, HepG2
    Pratibha V Nerurkar
    Laboratory of Metabolic Disorders and Alternative Medicine, Department of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources, Room 415H, East West Road, Honolulu, HI 96822, USA
    Br J Pharmacol 148:1156-64. 2006
  4. doi request reprint Regulation of glucose metabolism via hepatic forkhead transcription factor 1 (FoxO1) by Morinda citrifolia (noni) in high-fat diet-induced obese mice
    Pratibha V Nerurkar
    Department of Molecular Biosciences and Bioengineering MBBE, College of Tropical Agriculture and Human Resources CTAHR, University of Hawaii at Manoa, Honolulu, HI 96822, USA
    Br J Nutr 108:218-28. 2012
  5. doi request reprint Momordica charantia (bitter melon) reduces plasma apolipoprotein B-100 and increases hepatic insulin receptor substrate and phosphoinositide-3 kinase interactions
    Pratibha V Nerurkar
    Laboratory of Metabolic Disorders and Alternative Medicine, Department of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources, University of Hawaii at Manoa, Honolulu, HI 96816, USA
    Br J Nutr 100:751-9. 2008
  6. ncbi request reprint Highly active antiretroviral therapy (HAART)-associated lactic acidosis: in vitro effects of combination of nucleoside analogues and protease inhibitors on mitochondrial function and lactic acid production
    P V Nerurkar
    Laboratory of Metabolic Disorders and Alternative Medicine, Department of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources, Honolulu, Hawaii 96816, USA
    Cell Mol Biol (Noisy-le-grand) 49:1205-11. 2003
  7. pmc Momordica charantia (bitter melon) inhibits primary human adipocyte differentiation by modulating adipogenic genes
    Pratibha V Nerurkar
    Laboratory of Metabolic Disorders and Alternative Medicine, Department of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA
    BMC Complement Altern Med 10:34. 2010
  8. pmc Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation
    Pratibha V Nerurkar
    Laboratory of Metabolic Disorders and Alternative Medicine, Department of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources, University of Hawaii at Manoa, Honolulu, HI 96822, USA
    J Neuroinflammation 8:64. 2011
  9. ncbi request reprint Effects of kava alkaloid, pipermethystine, and kavalactones on oxidative stress and cytochrome P450 in F-344 rats
    Steven T S Lim
    Laboratory of Metabolic Disorders and Alternative Medicine, Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA
    Toxicol Sci 97:214-21. 2007
  10. pmc Strategies to improve palatability and increase consumption intentions for Momordica charantia (bitter melon): a vegetable commonly used for diabetes management
    Laura S Snee
    Laboratory of Metabolic Disorders and Alternative Medicine, Department of Molecular Biosciences and Bioengineering MBBE, CTAHR, University of Hawaii, Honolulu, USA
    Nutr J 10:78. 2011

Research Grants

Collaborators

Detail Information

Publications11

  1. ncbi request reprint In vitro toxicity of kava alkaloid, pipermethystine, in HepG2 cells compared to kavalactones
    Pratibha V Nerurkar
    Department of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA
    Toxicol Sci 79:106-11. 2004
    ..These observations suggest that PM, rather than kavalactones, is capable of causing cell death, probably in part by disrupting mitochondrial function. Thus, PM may contribute to rare but severe hepatotoxic reactions to kava...
  2. ncbi request reprint Microsomal triglyceride transfer protein gene expression and ApoB secretion are inhibited by bitter melon in HepG2 cells
    Pratibha V Nerurkar
    Laboratory of Metabolic Disorders and Alternative Medicine, Department of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources, University of Hawaii, Honolulu, HI, USA
    J Nutr 135:702-6. 2005
    ..05), involved in MTP secretion. Our data suggest that BMJ is a potent inhibitor of apoB secretion and TG synthesis and secretion that may be involved in the plasma lipid- and VLDL-lowering effects observed in animal studies...
  3. pmc Lipid lowering effects of Momordica charantia (Bitter Melon) in HIV-1-protease inhibitor-treated human hepatoma cells, HepG2
    Pratibha V Nerurkar
    Laboratory of Metabolic Disorders and Alternative Medicine, Department of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources, Room 415H, East West Road, Honolulu, HI 96822, USA
    Br J Pharmacol 148:1156-64. 2006
    ..4. Identifying molecular targets of BM may offer alternative dietary strategies to decrease PI-associated hyperlipidemia and improve quality of life among HIV-1-infected patients...
  4. doi request reprint Regulation of glucose metabolism via hepatic forkhead transcription factor 1 (FoxO1) by Morinda citrifolia (noni) in high-fat diet-induced obese mice
    Pratibha V Nerurkar
    Department of Molecular Biosciences and Bioengineering MBBE, College of Tropical Agriculture and Human Resources CTAHR, University of Hawaii at Manoa, Honolulu, HI 96822, USA
    Br J Nutr 108:218-28. 2012
    ..HepG2 cells demonstrated more than 80 % inhibition of PEPCK and G6P mRNA expression in cells treated with FoxO1 siRNA and fNJ. These data suggest that fNJ improves glucose metabolism via FoxO1 regulation in HFD-fed mice...
  5. doi request reprint Momordica charantia (bitter melon) reduces plasma apolipoprotein B-100 and increases hepatic insulin receptor substrate and phosphoinositide-3 kinase interactions
    Pratibha V Nerurkar
    Laboratory of Metabolic Disorders and Alternative Medicine, Department of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources, University of Hawaii at Manoa, Honolulu, HI 96816, USA
    Br J Nutr 100:751-9. 2008
    ..Investigating the biochemical and molecular mechanisms involved in amelioration of diabetic dyslipidaemia by BMJ may lead to identification of new molecular targets for dietary/alternative therapies...
  6. ncbi request reprint Highly active antiretroviral therapy (HAART)-associated lactic acidosis: in vitro effects of combination of nucleoside analogues and protease inhibitors on mitochondrial function and lactic acid production
    P V Nerurkar
    Laboratory of Metabolic Disorders and Alternative Medicine, Department of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources, Honolulu, Hawaii 96816, USA
    Cell Mol Biol (Noisy-le-grand) 49:1205-11. 2003
    ..Our findings suggested that not only NRTI but also PI are capable of increasing lactic acid production in vitro, and probably involve early biochemical changes in mitochondrial function such as loss of mitochondrial membrane potential...
  7. pmc Momordica charantia (bitter melon) inhibits primary human adipocyte differentiation by modulating adipogenic genes
    Pratibha V Nerurkar
    Laboratory of Metabolic Disorders and Alternative Medicine, Department of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA
    BMC Complement Altern Med 10:34. 2010
    ..The objective of our study was to investigate the effects of BM juice (BMJ) on lipid accumulation and adipocyte differentiation transcription factors in primary human differentiating preadipocytes and adipocytes...
  8. pmc Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation
    Pratibha V Nerurkar
    Laboratory of Metabolic Disorders and Alternative Medicine, Department of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources, University of Hawaii at Manoa, Honolulu, HI 96822, USA
    J Neuroinflammation 8:64. 2011
    ..The objective of our study was to investigate the neuroprotective effects of Momordica charantia (bitter melon) on high-fat diet (HFD)-associated BBB disruption, stress and neuroinflammatory cytokines...
  9. ncbi request reprint Effects of kava alkaloid, pipermethystine, and kavalactones on oxidative stress and cytochrome P450 in F-344 rats
    Steven T S Lim
    Laboratory of Metabolic Disorders and Alternative Medicine, Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA
    Toxicol Sci 97:214-21. 2007
    ....
  10. pmc Strategies to improve palatability and increase consumption intentions for Momordica charantia (bitter melon): a vegetable commonly used for diabetes management
    Laura S Snee
    Laboratory of Metabolic Disorders and Alternative Medicine, Department of Molecular Biosciences and Bioengineering MBBE, CTAHR, University of Hawaii, Honolulu, USA
    Nutr J 10:78. 2011
    ..The aim of this study was to develop bitter melon-containing recipes and test their palatability and acceptability in healthy individuals for future clinical studies...
  11. pmc Impaired virus clearance, compromised immune response and increased mortality in type 2 diabetic mice infected with West Nile virus
    Mukesh Kumar
    Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA
    PLoS ONE 7:e44682. 2012
    ..In conclusion, this study provides unique mechanistic insight into the immunopathogenesis of WNVE observed in diabetics and can be used to develop therapeutics for the management of WNVE among diabetic patients...

Research Grants1

  1. Longevity foods, SIRT activation and diabetic dyslipidemia.
    Pratibha Nerurkar; Fiscal Year: 2007
    ....