Jean A Nemzek

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Development of a murine model of blunt hepatic trauma
    Jean A Nemzek-Hamlin
    Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Comp Med 63:398-408. 2013
  2. pmc Adoptive transfer of fibrocytes enhances splenic T-cell numbers and survival in septic peritonitis
    Jean A Nemzek
    Unit for Laboratory Animal Medicine and Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Shock 40:106-14. 2013
  3. pmc Pulmonary inflammation and airway hyperresponsiveness in a mouse model of asthma complicated by acid aspiration
    Jean A Nemzek
    Unit for Laboratory Animal Medicine and Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
    Comp Med 59:321-30. 2009
  4. pmc Modeling sepsis in the laboratory: merging sound science with animal well-being
    Jean A Nemzek
    Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI, USA
    Comp Med 58:120-8. 2008
  5. ncbi request reprint Humane endpoints in shock research
    Jean A Nemzek
    Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Shock 21:17-25. 2004
  6. pmc Functional contribution of CXCR2 to lung injury after aspiration of acid and gastric particulates
    Jean A Nemzek
    Unit for Laboratory Animal Medicine, Department of Pathology, University of Michigan, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    Am J Physiol Lung Cell Mol Physiol 298:L382-91. 2010
  7. doi request reprint Low-dose carbon monoxide treatment attenuates early pulmonary neutrophil recruitment after acid aspiration
    Jean A Nemzek
    University of Michigan, Unit for Laboratory Animal Medicine, Ann Arbor, MI 48109, USA
    Am J Physiol Lung Cell Mol Physiol 294:L644-53. 2008
  8. ncbi request reprint Effects of tramadol and buprenorphine on select immunologic factors in a cecal ligation and puncture model
    Kelly M S Hugunin
    University of Michigan, Ann Arbor, MI, USA
    Shock 34:250-60. 2010
  9. ncbi request reprint Keratinocyte growth factor pretreatment is associated with decreased macrophage inflammatory protein-2alpha concentrations and reduced neutrophil recruitment in acid aspiration lung injury
    Jean A Nemzek
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109 0602, USA
    Shock 18:501-6. 2002
  10. ncbi request reprint An essential role for lipopolysaccharide-binding protein in pulmonary innate immune responses
    Ming Hui Fan
    Department of General Surgery, University of Michigan, Ann Arbor 48109, USA
    Shock 18:248-54. 2002

Research Grants

  1. Role of Cytokines in Two Hit Organ Injury
    Jean Nemzek; Fiscal Year: 2006

Collaborators

Detail Information

Publications15

  1. pmc Development of a murine model of blunt hepatic trauma
    Jean A Nemzek-Hamlin
    Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Comp Med 63:398-408. 2013
    ..In summary, this technique produced a reliable, low mortality, murine model that recreates features of blunt abdominal liver injury in human subjects with similar acute inflammatory response. ..
  2. pmc Adoptive transfer of fibrocytes enhances splenic T-cell numbers and survival in septic peritonitis
    Jean A Nemzek
    Unit for Laboratory Animal Medicine and Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Shock 40:106-14. 2013
    ..These results confirm the immunomodulatory effects of exogenous, tissue-derived fibrocytes in sepsis and suggest their potential in cell therapy...
  3. pmc Pulmonary inflammation and airway hyperresponsiveness in a mouse model of asthma complicated by acid aspiration
    Jean A Nemzek
    Unit for Laboratory Animal Medicine and Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
    Comp Med 59:321-30. 2009
    ..These results are consistent with an effective model of the acute effects of aspiration on the allergic lung. Further studies could examine how various forms of aspiration influence the severity of asthma...
  4. pmc Modeling sepsis in the laboratory: merging sound science with animal well-being
    Jean A Nemzek
    Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI, USA
    Comp Med 58:120-8. 2008
    ..A balance between the needs of sepsis research and animal welfare can only be achieved through knowledge of the strengths and weaknesses of and alternatives to in vivo sepsis models...
  5. ncbi request reprint Humane endpoints in shock research
    Jean A Nemzek
    Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Shock 21:17-25. 2004
    ..Equipped with the basic principles of humane endpoints, investigators can make informed decisions that meet current standards of animal care while still achieving the scientific goals of their research studies...
  6. pmc Functional contribution of CXCR2 to lung injury after aspiration of acid and gastric particulates
    Jean A Nemzek
    Unit for Laboratory Animal Medicine, Department of Pathology, University of Michigan, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    Am J Physiol Lung Cell Mol Physiol 298:L382-91. 2010
    ..However, CXCR2-independent mechanisms recruit neutrophils into areas of cellular aggregation after aspiration of acidified gastric particulates...
  7. doi request reprint Low-dose carbon monoxide treatment attenuates early pulmonary neutrophil recruitment after acid aspiration
    Jean A Nemzek
    University of Michigan, Unit for Laboratory Animal Medicine, Ann Arbor, MI 48109, USA
    Am J Physiol Lung Cell Mol Physiol 294:L644-53. 2008
    ..Although these effects were eventually overwhelmed, the results suggest that CO may have efficacy during the initial treatment of aspiration lung injury...
  8. ncbi request reprint Effects of tramadol and buprenorphine on select immunologic factors in a cecal ligation and puncture model
    Kelly M S Hugunin
    University of Michigan, Ann Arbor, MI, USA
    Shock 34:250-60. 2010
    ..However, when different analgesics are used, comparisons between studies may be complicated...
  9. ncbi request reprint Keratinocyte growth factor pretreatment is associated with decreased macrophage inflammatory protein-2alpha concentrations and reduced neutrophil recruitment in acid aspiration lung injury
    Jean A Nemzek
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109 0602, USA
    Shock 18:501-6. 2002
    ..23 +/- 1.19) at 8 h. In this study, KGF pretreatment after acid aspiration was associated with reduced neutrophil recruitment into the lung and a decrease in MIP-2alpha gradients between BAL fluid and plasma...
  10. ncbi request reprint An essential role for lipopolysaccharide-binding protein in pulmonary innate immune responses
    Ming Hui Fan
    Department of General Surgery, University of Michigan, Ann Arbor 48109, USA
    Shock 18:248-54. 2002
    ..Together, our findings suggest that LBP is essential in local pulmonary innate immune responses against bacteria...
  11. ncbi request reprint Quantification of TNF-alpha and IL-6 bioactivity in response to lipopolysaccharide in the degu (Octodon degus)
    Jean A Nemzek
    Unit for Laboratory Animal Medicine, University of Michigan, 018 Animal Research Facility, 1150 W Medical Center Drive, Ann Arbor, Michigan 48109 0614, USA
    Contemp Top Lab Anim Sci 42:39-42. 2003
    ....
  12. ncbi request reprint Six at six: interleukin-6 measured 6 h after the initiation of sepsis predicts mortality over 3 days
    Daniel G Remick
    Department of Pathology, University of Michigan, Ann Arbor 48109 0602, USA
    Shock 17:463-7. 2002
    ..This measurement may be determined quickly so that therapy may be targeted only to those individuals at significant risk of dying and initiated within sufficient time to be effective...
  13. pmc Evaluation of saphenous venipuncture and modified tail-clip blood collection in mice
    Omorodola I Abatan
    Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI, USA
    J Am Assoc Lab Anim Sci 47:8-15. 2008
    ..Overall, the effects of modified tail-clip method were similar to those of the saphenous venipuncture method in unanesthetized mice...
  14. ncbi request reprint Comparison of body surface temperature measurement and conventional methods for measuring temperature in the mouse
    Denise M Newsom
    Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Contemp Top Lab Anim Sci 43:13-8. 2004
    ..These results suggest that the surface probe could provide an efficient means for obtaining valuable physiological data and determining humane endpoints...
  15. ncbi request reprint Mechanistic approaches to acid aspiration and pneumonia must look beyond tumor necrosis factor-alpha levels
    Jean A Nemzek
    Crit Care Med 33:1877-8. 2005

Research Grants1

  1. Role of Cytokines in Two Hit Organ Injury
    Jean Nemzek; Fiscal Year: 2006
    ..Successful completion of these aims could impact current two hit theories and use of immune therapy in septic patients exposed to additional inflammatory insults. ..