Elizabeta Nemeth

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Targeting the hepcidin-ferroportin axis in the diagnosis and treatment of anemias
    Elizabeta Nemeth
    David Geffen School of Medicine at UCLA, CHS 37 131, 10833 LeConte Avenue, Los Angeles, CA 90095 1690, USA
    Adv Hematol 2010:750643. 2010
  2. pmc Cellular catabolism of the iron-regulatory peptide hormone hepcidin
    Gloria Cuevas Preza
    Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 8:e58934. 2013
  3. pmc Manipulation of the hepcidin pathway for therapeutic purposes
    Eileen Fung
    Haematologica 98:1667-76. 2013
  4. ncbi request reprint Regulation of iron metabolism by hepcidin
    Elizabeta Nemeth
    Departments of Medicine and Pathology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    Annu Rev Nutr 26:323-42. 2006
  5. pmc Hepcidin in beta-thalassemia
    Elizabeta Nemeth
    Department of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Ann N Y Acad Sci 1202:31-5. 2010
  6. ncbi request reprint Hepcidin biology and therapeutic applications
    Elizabeta Nemeth
    David Geffen School of Medicine, UCLA, 10833 LeConte Ave, CHS 37 131, Los Angeles, CA 90095, USA
    Expert Rev Hematol 3:153-5. 2010
  7. doi request reprint Iron regulation and erythropoiesis
    Elizabeta Nemeth
    David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Curr Opin Hematol 15:169-75. 2008
  8. pmc The role of hepcidin in iron metabolism
    Elizabeta Nemeth
    David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Acta Haematol 122:78-86. 2009
  9. pmc Reduction of serum hepcidin by hemodialysis in pediatric and adult patients
    Joshua Zaritsky
    Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Clin J Am Soc Nephrol 5:1010-4. 2010
  10. pmc Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload
    Gloria C Preza
    Department of Pathology, UCLA, Los Angeles, California, USA
    J Clin Invest 121:4880-8. 2011

Collaborators

Detail Information

Publications64

  1. pmc Targeting the hepcidin-ferroportin axis in the diagnosis and treatment of anemias
    Elizabeta Nemeth
    David Geffen School of Medicine at UCLA, CHS 37 131, 10833 LeConte Avenue, Los Angeles, CA 90095 1690, USA
    Adv Hematol 2010:750643. 2010
    ..The diagnosis of different forms of anemia will be facilitated by improved hepcidin assays, and the treatment will be enhanced by the development of hepcidin agonists and antagonists...
  2. pmc Cellular catabolism of the iron-regulatory peptide hormone hepcidin
    Gloria Cuevas Preza
    Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 8:e58934. 2013
    ..Together these results show that the hormone hepcidin and its receptor ferroportin are internalized together and trafficked to lysosomes where both are degraded...
  3. pmc Manipulation of the hepcidin pathway for therapeutic purposes
    Eileen Fung
    Haematologica 98:1667-76. 2013
    ..In this review, we will summarize the strategies and development programs that have been devised for agonizing or antagonizing hepcidin and its receptor ferroportin. ..
  4. ncbi request reprint Regulation of iron metabolism by hepcidin
    Elizabeta Nemeth
    Departments of Medicine and Pathology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    Annu Rev Nutr 26:323-42. 2006
    ..The emergence of hepcidin as the pathogenic factor in most systemic iron disorders should provide important opportunities for improving their diagnosis and treatment...
  5. pmc Hepcidin in beta-thalassemia
    Elizabeta Nemeth
    Department of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Ann N Y Acad Sci 1202:31-5. 2010
    ..Hepcidin diagnostics and future therapeutic agonists may help in management of patients with beta-thalassemia...
  6. ncbi request reprint Hepcidin biology and therapeutic applications
    Elizabeta Nemeth
    David Geffen School of Medicine, UCLA, 10833 LeConte Ave, CHS 37 131, Los Angeles, CA 90095, USA
    Expert Rev Hematol 3:153-5. 2010
    ..The session included three 30-min presentations...
  7. doi request reprint Iron regulation and erythropoiesis
    Elizabeta Nemeth
    David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Curr Opin Hematol 15:169-75. 2008
    ..Major advances have been made in understanding the regulation of hepcidin production, and consequently the availability of iron for erythropoiesis...
  8. pmc The role of hepcidin in iron metabolism
    Elizabeta Nemeth
    David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Acta Haematol 122:78-86. 2009
    ..Diagnostic and therapeutic applications of this new knowledge are beginning to emerge. Dr. Ernest Beutler played a significant role in advancing our understanding of the function of hepcidin. This review is dedicated to his memory...
  9. pmc Reduction of serum hepcidin by hemodialysis in pediatric and adult patients
    Joshua Zaritsky
    Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Clin J Am Soc Nephrol 5:1010-4. 2010
    ....
  10. pmc Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload
    Gloria C Preza
    Department of Pathology, UCLA, Los Angeles, California, USA
    J Clin Invest 121:4880-8. 2011
    ..Moreover, liver iron concentrations were lower in mice chronically treated with minihepcidins than those in mice treated with solvent alone. Minihepcidins may be useful for the treatment of iron overload disorders...
  11. pmc Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination
    Bo Qiao
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Metab 15:918-24. 2012
    ..Our study demonstrates that ubiquitination is the functionally relevant signal for hepcidin-induced ferroportin endocytosis...
  12. pmc Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis
    Emilio Ramos
    Department of Chemistry and Biochemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1690, USA
    Blood 120:3829-36. 2012
    ..Our study demonstrates that minihepcidins could be beneficial in iron overload disorders either used alone for prevention or possibly as adjunctive therapy with phlebotomy or chelation...
  13. pmc Iron sequestration and anemia of inflammation
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Semin Hematol 46:387-93. 2009
    ..The supply of iron to hemoglobin synthesis becomes limiting, eventually resulting in anemia. Depending on the details of the underlying disease, other inflammation-related mechanisms may also contribute to anemia...
  14. pmc Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs
    Seth Rivera
    UCLA Department of Medicine, 10833 Le Conte Ave, CHS 37 131, Los Angeles, CA 90095, USA
    Blood 106:2196-9. 2005
    ..The rapid and sustained action of a single dose of hepcidin makes it an appealing agent for the prevention of iron accumulation in hereditary hemochromatosis...
  15. pmc Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4
    Lan Lin
    Departments of Pathology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1690, USA
    Blood 110:2182-9. 2007
    ..Fresh primary hepatocytes constitute a sufficient system for the regulation of hepcidin by physiologic iron stimuli and will greatly facilitate studies of major disorders of iron homeostasis...
  16. ncbi request reprint Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    Elizabeta Nemeth
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Science 306:2090-3. 2004
    ..The posttranslational regulation of ferroportin by hepcidin may thus complete a homeostatic loop: Iron regulates the secretion of hepcidin, which in turn controls the concentration of ferroportin on the cell surface...
  17. pmc High-throughput screening of small molecules identifies hepcidin antagonists
    Eileen Fung
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Mol Pharmacol 83:681-90. 2013
    ..Fursultiamine is a unique antagonist of hepcidin in vitro that could serve as a template for the development of drug candidates that inhibit the hepcidin-ferroportin interaction...
  18. pmc Hepcidin and iron homeostasis
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Biochim Biophys Acta 1823:1434-43. 2012
    ..Hepcidin, ferroportin and their regulators represent potential targets for the diagnosis and treatment of iron disorders and anemias. This article is part of a Special Issue entitled: Cell Biology of Metals...
  19. pmc Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice
    Emilio Ramos
    Chemistry and Biochemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    Hepatology 53:1333-41. 2011
    ..BMP6, whose expression is also regulated by iron, may mediate hepcidin regulation by iron stores. None of the mutant strains (except Bmp6(-/-) mice) had impaired BMP6 mRNA response to chronic iron loading...
  20. doi request reprint Hepcidin and disorders of iron metabolism
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Annu Rev Med 62:347-60. 2011
    ..The hepcidin-ferroportin axis is the principal regulator of extracellular iron homeostasis in health and disease, and is a promising target for the diagnosis and treatment of iron disorders and anemias...
  21. pmc The molecular basis of hepcidin-resistant hereditary hemochromatosis
    Augustine Fernandes
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Blood 114:437-43. 2009
    ..Our observations explain why the mutations in C326 Fpn residue produce a severe form of hemochromatosis with iron overload at an early age...
  22. pmc IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    Elizabeta Nemeth
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles UCLA, Los Angeles, California, USA
    J Clin Invest 113:1271-6. 2004
    ....
  23. pmc Inhibition of hepcidin transcription by growth factors
    Julia B Goodnough
    Department of Pathology, University of California, Los Angeles, CA 90095 1690, USA
    Hepatology 56:291-9. 2012
    ....
  24. doi request reprint Involvement of hepcidin in the anemia of multiple myeloma
    Sanjai Sharma
    West Los Angeles VA University of California Los Angeles Medical Center, Los Angeles, CA 90073, USA
    Clin Cancer Res 14:3262-7. 2008
    ..Because interleukin (IL)-6 is a potent inducer of hepcidin expression and its levels are elevated in multiple myeloma, we studied the role of hepcidin in the anemia of multiple myeloma...
  25. pmc Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6
    Richard Rodriguez
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Infect Immun 82:745-52. 2014
    ..Our results support the key role of IL-6 in hepcidin regulation in response to a variety of infectious and inflammatory stimuli. ..
  26. pmc Iron metabolism: interactions with normal and disordered erythropoiesis
    Tomas Ganz
    Department of Medicine and Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Cold Spring Harb Perspect Med 2:a011668. 2012
    ..Finally, we discuss iron disorders that affect erythropoiesis as well as erythroid disorders that cause iron dysregulation...
  27. pmc Hepcidin--a potential novel biomarker for iron status in chronic kidney disease
    Joshua Zaritsky
    Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    Clin J Am Soc Nephrol 4:1051-6. 2009
    ..Hepcidin is a key regulator of iron homeostasis, but its study in the setting of chronic kidney disease (CKD) has been hampered by the lack of validated serum assays...
  28. pmc Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site
    Lan Lin
    Department of Pathology, David Geffen School of Medicine, University of California, Los Angeles UCLA, Los Angeles, CA 90095, USA
    Blood Cells Mol Dis 40:122-31. 2008
    ..In this report, we investigate the proteinase involved in the release of s-hemojuvelin and show that s-hemojuvelin is released by a proprotein convertase through the cleavage at a conserved polybasic RNRR site...
  29. ncbi request reprint Regulation of iron acquisition and iron distribution in mammals
    Tomas Ganz
    Department of Medicine and Pathology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1690, USA
    Biochim Biophys Acta 1763:690-9. 2006
    ..Deficiency of hepcidin is the unifying cause of hereditary hemochromatoses, and excessive cytokine-stimulated hepcidin production causes hypoferremia and contributes to anemia of inflammation...
  30. pmc The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study
    Elizabeta Nemeth
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    Blood 107:328-33. 2006
    ..G71D and K83R, substitutions previously described in humans, did not affect hepcidin activity. Apart from the essential nature of the N-terminus, hepcidin structure appears permissive for mutations...
  31. ncbi request reprint Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia
    Seth Rivera
    Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Blood 105:1797-802. 2005
    ..Hepcidin contributes to AI by shunting iron away from erythropoiesis and sequestering it in the liver, predominantly in hepatocytes...
  32. ncbi request reprint Iron imports. IV. Hepcidin and regulation of body iron metabolism
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1690, USA
    Am J Physiol Gastrointest Liver Physiol 290:G199-203. 2006
    ..Hepcidin deficiency due to the dysregulation of its synthesis causes most known forms of hemochromatosis...
  33. pmc Testing the iron hypothesis in a mouse model of atherosclerosis
    Léon Kautz
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Rep 5:1436-42. 2013
    ..Our results strongly argue against any significant role of macrophage iron in atherosclerosis progression in mice. ..
  34. pmc The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders
    Tomas Ganz
    Department of Pulmonary and Critical Care Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Hematology Am Soc Hematol Educ Program 2011:538-42. 2011
    ....
  35. ncbi request reprint Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    Elizabeta Nemeth
    Department of Medicine, David Geffen School of Medicine, and the West Los Angeles Veterans Administration Hospital, University of California, Los Angeles 90095, USA
    Blood 101:2461-3. 2003
    ..The linkage of hepcidin induction to inflammation in humans supports its proposed role as a key mediator of anemia of inflammation...
  36. pmc Identification of erythroferrone as an erythroid regulator of iron metabolism
    Léon Kautz
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Nat Genet 46:678-84. 2014
    ..ERFE expression is greatly increased in Hbb(th3/+) mice with thalassemia intermedia, where it contributes to the suppression of hepcidin and the systemic iron overload characteristic of this disease. ..
  37. pmc The pathophysiology and pharmacology of hepcidin
    Piotr Ruchala
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Trends Pharmacol Sci 35:155-61. 2014
    ..This review summarizes hepcidin biology and discusses the current landscape for hepcidin-targeting therapeutic strategies. ..
  38. doi request reprint Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6
    Richard Rodriguez
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Infect Immun 82:745-52. 2014
    ..Our results support the key role of IL-6 in hepcidin regulation in response to a variety of infectious and inflammatory stimuli. ..
  39. ncbi request reprint Iron homeostasis and its disorders in mice and men: potential lessons for rhinos
    Tomas Ganz
    Departments of Medicine, David Geffen School of Medicine, 10833 Le Conte Avenue, Los Angeles, California 90095 1690 USA
    J Zoo Wildl Med 43:S19-26. 2012
    ..This review summarizes the current knowledge in humans and mice regarding the physiology and molecular basis of iron overload, and it explores how it can be applied to the problem of iron overload in captive rhino populations...
  40. doi request reprint Immunoassay for human serum hepcidin
    Tomas Ganz
    Intrinsic LifeSciences LLC, La Jolla, CA, USA
    Blood 112:4292-7. 2008
    ..The new serum hepcidin enzyme-linked immunosorbent assay yields accurate and reproducible measurements that appropriately reflect physiologic, pathologic, and genetic influences, and is informative about the etiology of iron disorders...
  41. pmc Mouse models of anemia of cancer
    Airie Kim
    Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 9:e93283. 2014
    ..Hepcidin-independent mechanisms play an important role in these murine models of AC. ..
  42. ncbi request reprint Hepcidin is decreased in TFR2 hemochromatosis
    Elizabeta Nemeth
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Blood 105:1803-6. 2005
    ..The only 2 cases with normal hepcidin values had concomitant inflammatory conditions. Our data indicate that TFR2 is a modulator of hepcidin production in response to iron...
  43. doi request reprint Hepcidin is a key mediator of anemia of inflammation in Crohn's disease
    Robert J Basseri
    Department of Gastroenterology, Cedars Sinai Medical Center, Los Angeles, CA, USA
    J Crohns Colitis 7:e286-91. 2013
    ..We hypothesized that hepcidin is significantly elevated in anemic CD patients and that hepcidin may cause iron restriction and, therefore, mediate ACD...
  44. doi request reprint Anti-hepcidin therapy for iron-restricted anemias
    Elizabeta Nemeth
    University of California, Los Angeles
    Blood 122:2929-31. 2013
    ....
  45. ncbi request reprint Hepcidin and β-thalassemia major
    Elizabeta Nemeth
    University of California, Los Angeles, CA, USA
    Blood 122:3-4. 2013
    ....
  46. pmc The hepcidin-binding site on ferroportin is evolutionarily conserved
    Ivana De Domenico
    Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Cell Metab 8:146-56. 2008
    ..The affinity of hepcidin for the HBD permits a rapid, sensitive assay of hepcidin from all species and yields insights into the evolution of hepcidin...
  47. ncbi request reprint Effects of plasma transfusion on hepcidin production in human congenital hypotransferrinemia
    Paola Trombini
    Department of Clinical Medicine and Centre for Diagnosis and Therapy of Hemochromatosis, University of Milano Bicocca, San Gerardo Hospital, Monza, Milan, Italy
    Haematologica 92:1407-10. 2007
    ..Time-course of urinary hepcidin and serum transferrin concentration suggests that hepcidin production is regulated by the combination of marrow iron requirements and iron supply by transferrin...
  48. ncbi request reprint Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis
    Alberto Piperno
    Department of Clinical Medicine and Prevention, Milano Bicocca University, San Gerardo Hospital, Monza, Italy
    Blood 110:4096-100. 2007
    ..The hepcidin response to oral iron is blunted in HFE-related hemochromatosis and not improved after iron depletion. The findings support the involvement of HFE in iron sensing and subsequent regulation of hepcidin...
  49. ncbi request reprint Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS
    Erwin Kemna
    Department of Clinical Chemistry 564, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Blood 106:1864-6. 2005
    ..These in vivo human results confirm the importance of the IL-6-hepcidin axis in the development of hypoferremia in inflammation and highlight the rapid responsiveness of this iron regulatory system...
  50. pmc The molecular basis of ferroportin-linked hemochromatosis
    Ivana De Domenico
    Dipartimento di Scienze Microbiologiche Genetiche e Molecolari, Universita di Messina, 98166 Messina, Italy
    Proc Natl Acad Sci U S A 102:8955-60. 2005
    ..The behavior of mutant Fpn in cell culture and the ability of mutant Fpn to act as a dominant negative explain the dominant inheritance of the disease as well as the different patient phenotypes...
  51. ncbi request reprint Liver iron concentrations and urinary hepcidin in beta-thalassemia
    Raffaella Origa
    Dipartimento di Scienze Biomediche e Biotecnologie, Universita di Cagliari, Ospedale Microcitemico ASL8 Cagliari, Italy
    Haematologica 92:583-8. 2007
    ..Hepcidin deficiency is the cause of iron overload in most forms of hereditary hemochromatosis. We sought to determine hepcidin's role in the pathogenesis of iron overload in b-thalassemia...
  52. pmc The molecular mechanism of hepcidin-mediated ferroportin down-regulation
    Ivana De Domenico
    Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Mol Biol Cell 18:2569-78. 2007
    ..Depletion of proteins involved in multivesicular body trafficking (Endosome Sorting Complex Required for Transport proteins), by small-interfering RNA, reduces the trafficking of Fpn-green fluorescent to the lysosome...
  53. ncbi request reprint Primary iron overload with inappropriate hepcidin expression in V162del ferroportin disease
    Heinz Zoller
    Clinical Division of Gastroenterology and Hepatology, Innsbruck Medical University, Innsbruck, Austria
    Hepatology 42:466-72. 2005
    ..Finally, macrophage iron storage in ferroportin disease is associated with elevated serum pro-hepcidin levels...
  54. ncbi request reprint Hepcidin and iron-related gene expression in subjects with Dysmetabolic Hepatic Iron Overload
    Donatella Barisani
    Department of Experimental Medicine, University of Milano Bicocca, Via Cadore 48, Monza 20052, Milan, Italy
    J Hepatol 49:123-33. 2008
    ..Since the pathophysiology of Dysmetabolic Hepatic Iron Overload (DHIO) is still obscure, the aim of this study was to evaluate, in these patients, possible alterations in iron-related molecule expression...
  55. ncbi request reprint Hepcidin and iron-loading anemias
    Elizabeta Nemeth
    Haematologica 91:727-32. 2006
  56. pmc DMT1 mutation: response of anemia to darbepoetin administration and implications for iron homeostasis
    Dagmar Pospisilova
    Blood 108:404-5. 2006
  57. doi request reprint Measurement of urinary hepcidin levels by SELDI-TOF-MS in HFE-hemochromatosis
    Claudia Bozzini
    Department of Clinical and Experimental Medicine, University of Verona, Policlinico G B Rossi, 37134 Verona, Italy
    Blood Cells Mol Dis 40:347-52. 2008
    ..This study measured urinary hepcidin levels by SELDI-TOF-MS in a large group of HH patients at diagnosis and during treatment, including both C282Y homozygous and C282Y/H63D compound heterozygotes...
  58. ncbi request reprint Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis
    George Papanikolaou
    First Department of Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, Laikon General Hospital, Athens 11527, Greece
    Nat Genet 36:77-82. 2004
    ..Urinary hepcidin levels were depressed in individuals with juvenile hemochromatosis, suggesting that hemojuvelin is probably not the hepcidin receptor. Rather, HFE2 seems to modulate hepcidin expression...
  59. pmc Molecular and clinical correlates in iron overload associated with mutations in ferroportin
    Ivana De Domenico
    Dipartimento di Scienze Microbiologiche Genetiche e Molecolari, Universita di Messina, 98166 Messina, Italia
    Haematologica 91:1092-5. 2006
    ..We suggest that FpnG80S represents a class of Fpn mutants whose behavior in vitro does not explain the patients' phenotype...
  60. pmc Hepcidin in iron overload disorders
    George Papanikolaou
    First Department of Medicine, National and Kapodistrian University of Athens, Greece
    Blood 105:4103-5. 2005
    ..These findings extend the spectrum of iron disorders with hepcidin deficiency and underscore the critical importance of the hepcidin-ferroportin interaction in iron homeostasis...
  61. ncbi request reprint Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function
    Lenaick Detivaud
    Institut National de la Sante et de la Recherche Medicale, Rennes, France
    Blood 106:746-8. 2005
    ..Moreover, we found in humans that hepcidin levels correlated with hepatic iron stores and hemoglobin levels and may also be affected by hepatic dysfunction...
  62. pmc Impaired intestinal iron absorption in Crohn's disease correlates with disease activity and markers of inflammation
    Gaith Semrin
    Center for Inflammatory Bowel Disease and Divisions of Gastroenterology and Nutrition, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Inflamm Bowel Dis 12:1101-6. 2006
    ..We sought to elucidate alterations in iron absorption in pediatric patients with active and inactive CD...
  63. ncbi request reprint Urinary hepcidin in congenital chronic anemias
    Susan L Kearney
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts, USA
    Pediatr Blood Cancer 48:57-63. 2007
    ..Hepcidin, a regulator for iron homeostasis, is induced by inflammation and iron burden and suppressed by anemia and hypoxia. This study was conducted to determine the hepcidin levels in patients with congenital chronic anemias...
  64. ncbi request reprint Novel urine hepcidin assay by mass spectrometry
    Erwin Kemna
    Department of Clinical Chemistry 564, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Blood 106:3268-70. 2005
    ..In conclusion, this novel MS urine hepcidin assay is easy to perform and available to a wide audience. This enables the implementation of hepcidin measurements in large clinical studies...

Research Grants5

  1. The Hepcidin-Ferroportin Axis in Anemia of Inflammation: Mechanisms and Targets
    Elizabeta Nemeth; Fiscal Year: 2009
    ..PUBLIS HEALTH RELEVANCE: The proposed project will help understand and treat a common form of anemia which develops in infections and inflammatory disorders. ..
  2. The Hepcidin-Ferroportin Axis in Anemia of Inflammation: Mechanisms and Targets
    Elizabeta Nemeth; Fiscal Year: 2010
    ..PUBLIS HEALTH RELEVANCE: The proposed project will help understand and treat a common form of anemia which develops in infections and inflammatory disorders. ..
  3. REGULATION OF HEPCIDIN BY IRON AND OXYGEN
    Elizabeta Nemeth; Fiscal Year: 2007
    ....