M E Nemergut

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Nuclear import of the ran exchange factor, RCC1, is mediated by at least two distinct mechanisms
    M E Nemergut
    Department of Microbiology, Markey Center for Cell Signaling, University of Virginia, Charlottesville, Virginia 22908, USA
    J Cell Biol 149:835-50. 2000
  2. ncbi Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B
    M E Nemergut
    Center for Cell Signaling, University of Virginia, Charlottesville, VA 22908, USA
    Science 292:1540-3. 2001
  3. ncbi CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration
    T L Gumienny
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11743, USA
    Cell 107:27-41. 2001

Collaborators

  • I G Macara
  • C A Mizzen
  • T L Gumienny
  • L Van Aelst
  • R Francis
  • Y Qin
  • T Schedl
  • M O Hengartner
  • K Nishiwaki
  • L B Haney
  • K S Ravichandran
  • A C Tosello-Trampont
  • J M Kinchen
  • S F Walk
  • E Brugnera

Detail Information

Publications3

  1. pmc Nuclear import of the ran exchange factor, RCC1, is mediated by at least two distinct mechanisms
    M E Nemergut
    Department of Microbiology, Markey Center for Cell Signaling, University of Virginia, Charlottesville, Virginia 22908, USA
    J Cell Biol 149:835-50. 2000
    ..Furthermore, the nuclear import of RCC1 does not require a preexisting Ran gradient or energy. We speculate that this second import pathway evolved to ensure that RCC1 never accumulates in the cytoplasm...
  2. ncbi Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B
    M E Nemergut
    Center for Cell Signaling, University of Virginia, Charlottesville, VA 22908, USA
    Science 292:1540-3. 2001
    ..We propose that the docking of RCC1 to H2A/H2B establishes the polarity of the Ran-GTP gradient that drives nuclear envelope assembly, nuclear transport, and other nuclear events...
  3. ncbi CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration
    T L Gumienny
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11743, USA
    Cell 107:27-41. 2001
    ..These studies identify CED-12/ELMO as an upstream regulator of Rac1 that affects engulfment and cell migration from C. elegans to mammals...