M E Nemergut
Affiliation: University of Virginia
- Nuclear import of the ran exchange factor, RCC1, is mediated by at least two distinct mechanismsM E Nemergut
Department of Microbiology, Markey Center for Cell Signaling, University of Virginia, Charlottesville, Virginia 22908, USA
J Cell Biol 149:835-50. 2000..Furthermore, the nuclear import of RCC1 does not require a preexisting Ran gradient or energy. We speculate that this second import pathway evolved to ensure that RCC1 never accumulates in the cytoplasm...
- Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2BM E Nemergut
Center for Cell Signaling, University of Virginia, Charlottesville, VA 22908, USA
Science 292:1540-3. 2001..We propose that the docking of RCC1 to H2A/H2B establishes the polarity of the Ran-GTP gradient that drives nuclear envelope assembly, nuclear transport, and other nuclear events...
- CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migrationT L Gumienny
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11743, USA
Cell 107:27-41. 2001..These studies identify CED-12/ELMO as an upstream regulator of Rac1 that affects engulfment and cell migration from C. elegans to mammals...