Sarah J Nelson

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi In vivo molecular imaging for planning radiation therapy of gliomas: an application of 1H MRSI
    Sarah J Nelson
    Mgnetic Resonance Science Center, Department of Radiology, University of California, San Francisco, California 94143, USA
    J Magn Reson Imaging 16:464-76. 2002
  2. ncbi Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM
    Forrest W Crawford
    Department of Radiology, University of California San Francisco, 1700 4th Street, San Francisco, CA 94143 2532, USA
    J Neurooncol 91:337-51. 2009
  3. ncbi (1)H spectroscopic imaging of human brain at 3 Tesla: comparison of fast three-dimensional magnetic resonance spectroscopic imaging techniques
    Matthew L Zierhut
    University of California, Joint Graduate Group in Bioengineering, San Francisco, CA, USA
    J Magn Reson Imaging 30:473-80. 2009
  4. ncbi Evaluation of MR markers that predict survival in patients with newly diagnosed GBM prior to adjuvant therapy
    Suja Saraswathy
    Department of Radiology and Biomedical Imaging, UCSF, Box 2532, Byers Hall, 1700 4th Street, San Francisco, CA, 94143 2532, USA
    J Neurooncol 91:69-81. 2009
  5. ncbi 3D 1H MRSI of brain tumors at 3.0 Tesla using an eight-channel phased-array head coil
    Joseph A Osorio
    UCSF UCB Joint Graduate Group in Bioengineering, University of California San Francisco, San Francisco, California 94158 2532, USA
    J Magn Reson Imaging 26:23-30. 2007
  6. ncbi Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice
    Matthew L Zierhut
    UCSF UCB Joint Graduate Group in Bioengineering, San Francisco, CA 94143 2532, USA
    J Magn Reson 202:85-92. 2010
  7. ncbi Survival analysis in patients with glioblastoma multiforme: predictive value of choline-to-N-acetylaspartate index, apparent diffusion coefficient, and relative cerebral blood volume
    Joonmi Oh
    Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco, California 94107, USA
    J Magn Reson Imaging 19:546-54. 2004
  8. ncbi Tumor regrowth between surgery and initiation of adjuvant therapy in patients with newly diagnosed glioblastoma
    Andrea Pirzkall
    Department of Radiology and Margaret Hart Surbeck Laboratory of Advanced Imaging, University of California, San Francisco, San Francisco, CA, USA
    Neuro Oncol 11:842-52. 2009
  9. ncbi High-resolution phased-array MRI of the human brain at 7 tesla: initial experience in multiple sclerosis patients
    Meredith Metcalf
    UCSF UC Berkeley Joint Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA 94017, USA
    J Neuroimaging 20:141-7. 2010
  10. ncbi Considerations in applying 3D PRESS H-1 brain MRSI with an eight-channel phased-array coil at 3 T
    Yan Li
    UCSF/UCB Joint Graduate Group in Bioengineering, San Francisco, CA 94720, USA
    Magn Reson Imaging 24:1295-302. 2006

Collaborators

Detail Information

Publications98

  1. ncbi In vivo molecular imaging for planning radiation therapy of gliomas: an application of 1H MRSI
    Sarah J Nelson
    Mgnetic Resonance Science Center, Department of Radiology, University of California, San Francisco, California 94143, USA
    J Magn Reson Imaging 16:464-76. 2002
    ..Further work is required to integrate the results of the H-MRSI examination into the treatment planning workstation, and to improve the quality of the data using more sensitive phased array coils and higher field strength magnets...
  2. ncbi Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM
    Forrest W Crawford
    Department of Radiology, University of California San Francisco, 1700 4th Street, San Francisco, CA 94143 2532, USA
    J Neurooncol 91:337-51. 2009
    ..These parameters may provide useful information for predicting outcome and for the stratification of patients into high or low risk groups for clinical trials...
  3. ncbi (1)H spectroscopic imaging of human brain at 3 Tesla: comparison of fast three-dimensional magnetic resonance spectroscopic imaging techniques
    Matthew L Zierhut
    University of California, Joint Graduate Group in Bioengineering, San Francisco, CA, USA
    J Magn Reson Imaging 30:473-80. 2009
    ..To investigate the signal-to-noise-ratio (SNR) and data quality of time-reduced three-dimensional (3D) proton magnetic resonance spectroscopic imaging ((1)H MRSI) techniques in the human brain at 3 Tesla...
  4. ncbi Evaluation of MR markers that predict survival in patients with newly diagnosed GBM prior to adjuvant therapy
    Suja Saraswathy
    Department of Radiology and Biomedical Imaging, UCSF, Box 2532, Byers Hall, 1700 4th Street, San Francisco, CA, 94143 2532, USA
    J Neurooncol 91:69-81. 2009
    ..This information may be important for stratifying patients to specific treatment protocols and for planning focal therapy...
  5. ncbi 3D 1H MRSI of brain tumors at 3.0 Tesla using an eight-channel phased-array head coil
    Joseph A Osorio
    UCSF UCB Joint Graduate Group in Bioengineering, University of California San Francisco, San Francisco, California 94158 2532, USA
    J Magn Reson Imaging 26:23-30. 2007
    ..To implement proton magnetic resonance spectroscopic imaging (1H MRSI) at 3 Tesla (3T) using an eight-channel phased-array head coil in a population of brain-tumor patients...
  6. ncbi Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice
    Matthew L Zierhut
    UCSF UCB Joint Graduate Group in Bioengineering, San Francisco, CA 94143 2532, USA
    J Magn Reson 202:85-92. 2010
    ....
  7. ncbi Survival analysis in patients with glioblastoma multiforme: predictive value of choline-to-N-acetylaspartate index, apparent diffusion coefficient, and relative cerebral blood volume
    Joonmi Oh
    Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco, California 94107, USA
    J Magn Reson Imaging 19:546-54. 2004
    ....
  8. ncbi Tumor regrowth between surgery and initiation of adjuvant therapy in patients with newly diagnosed glioblastoma
    Andrea Pirzkall
    Department of Radiology and Margaret Hart Surbeck Laboratory of Advanced Imaging, University of California, San Francisco, San Francisco, CA, USA
    Neuro Oncol 11:842-52. 2009
    ..The acquisition of metabolic and physiologic imaging data prior to adjuvant therapy may also be valuable in assessing regions of new CE and nonenhancing tumor...
  9. ncbi High-resolution phased-array MRI of the human brain at 7 tesla: initial experience in multiple sclerosis patients
    Meredith Metcalf
    UCSF UC Berkeley Joint Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA 94017, USA
    J Neuroimaging 20:141-7. 2010
    ..Clear involvement of the GM was observed with improved morphological detail in comparison to imaging at lower-field strength...
  10. ncbi Considerations in applying 3D PRESS H-1 brain MRSI with an eight-channel phased-array coil at 3 T
    Yan Li
    UCSF/UCB Joint Graduate Group in Bioengineering, San Francisco, CA 94720, USA
    Magn Reson Imaging 24:1295-302. 2006
    ..5 T with a quadrature head coil. This is expected to be critical for clinical applications of MRSI in patients with brain tumors because it can be used to either decrease acquisition time or improve spatial resolution...
  11. ncbi Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading
    Mark J Albers
    Department of Bioengineering, University of California San Francisco, San Francisco, California 94158 2330, USA
    Cancer Res 68:8607-15. 2008
    ....
  12. ncbi Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 63:582-91. 2010
    ..The results of this study demonstrated the potential of this new hyperpolarized MR dynamic method for improved cancer detection and characterization...
  13. ncbi In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized 13C-pyruvate
    Simon Hu
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158 2512, USA
    Mol Imaging Biol 11:399-407. 2009
    ....
  14. ncbi Flexible transceiver array for ultrahigh field human MR imaging
    Bing Wu
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 68:1332-8. 2012
    ..Seven Tesla parallel imaging with generalized autocalibrating partially parallel acquisitions (GRAPPA) performed using this flexible transceiver array was also presented...
  15. ncbi Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo
    David M Wilson
    Department of Radiology, University of California San Francisco UCSF, San Francisco, CA, United States
    J Magn Reson 205:141-7. 2010
    ....
  16. ncbi 3D sensitivity encoded ellipsoidal MR spectroscopic imaging of gliomas at 3T
    Esin Ozturk-Isik
    Margaret Hart Surbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    Magn Reson Imaging 27:1249-57. 2009
    ..The goal of this study was to implement time efficient data acquisition and reconstruction methods for 3D magnetic resonance spectroscopic imaging (MRSI) of gliomas at a field strength of 3T using parallel imaging techniques...
  17. ncbi Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging
    Ilwoo Park
    Surbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
    J Magn Reson Imaging 33:1284-90. 2011
    ..To demonstrate the feasibility of using DNP hyperpolarized [1-(13)C]-pyruvate to measure early response to temozolomide (TMZ) therapy using an orthotopic human glioblastoma xenograft model...
  18. ncbi 3D MRSI for resected high-grade gliomas before RT: tumor extent according to metabolic activity in relation to MRI
    Andrea Pirzkall
    Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA 94143 0226, USA
    Int J Radiat Oncol Biol Phys 59:126-37. 2004
    ....
  19. ncbi Analysis of hyperpolarized dynamic 13C lactate imaging in a transgenic mouse model of prostate cancer
    Janine M Lupo
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    Magn Reson Imaging 28:153-62. 2010
    ..The MLS was significantly higher in TRAMP mice that had advanced disease...
  20. ncbi GRAPPA-based susceptibility-weighted imaging of normal volunteers and patients with brain tumor at 7 T
    Janine M Lupo
    Department of Radiology, Surbeck Laboratory of Advanced Imaging, University of California, San Francisco, CA 94158 2532, USA
    Magn Reson Imaging 27:480-8. 2009
    ..GRAPPA-based SWI at 7 T revealed regions of microvascularity, hemorrhage and calcification within heterogeneous brain tumors that may aid in characterizing active or necrotic tumor and monitoring treatment effects...
  21. ncbi Serial analysis of imaging parameters in patients with newly diagnosed glioblastoma multiforme
    Yan Li
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158 2532, USA
    Neuro Oncol 13:546-57. 2011
    ..Our studies suggest that quantitative MRI variables derived from anatomic and physiological MRI provide useful information for predicting outcome in patients with GBM...
  22. ncbi 3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancer
    Simon Hu
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158 2512, USA
    Magn Reson Med 63:312-21. 2010
    ....
  23. ncbi Multi-channel microstrip transceiver arrays using harmonics for high field MR imaging in humans
    Bing Wu
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    IEEE Trans Med Imaging 31:183-91. 2012
    ..In addition, it also provides a simple approach to readily upgrade the channels of a conventional primary resonator microstrip array to a larger number for faster imaging...
  24. ncbi Regional variation in histopathologic features of tumor specimens from treatment-naive glioblastoma correlates with anatomic and physiologic MR Imaging
    Ramon F Barajas
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158 2330, USA
    Neuro Oncol 14:942-54. 2012
    ..Image-guided tissue acquisition and assessment of residual tumor from treatment-naive GBM should be guided by DSC in CE regions and by DWI in NE regions...
  25. ncbi Identifying malignant transformations in recurrent low grade gliomas using high resolution magic angle spinning spectroscopy
    Alexandra Constantin
    Electrical Engineering and Computer Science, Sutardja Dai Hall, University of California, Berkeley, Berkeley, CA 94709, USA
    Artif Intell Med 55:61-70. 2012
    ..This was achieved by exploring the use of multivariate pattern recognition methods to generate statistical models of the metabolic characteristics of recurrent LGGs that correlate with aggressive biology and poor clinical outcome...
  26. ncbi Hyperpolarized 13C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma
    Myriam M Chaumeil
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street Box 2532, San Francisco, CA 94158, USA
    Neuroimage 59:193-201. 2012
    ..It highlights the potential of HP lactate-to-pyruvate ratio as an early biomarker of response, thereby supporting further investigation of this non-invasive imaging approach for eventual clinical application...
  27. ncbi Dynamic susceptibility contrast perfusion imaging of radiation effects in normal-appearing brain tissue: changes in the first-pass and recirculation phases
    Michael C Lee
    Department of Radiology, University of California San Francisco, San Francisco, California 94143 2532, USA
    J Magn Reson Imaging 21:683-93. 2005
    ..To identify radiation-induced changes in the cerebral vasculature of healthy tissue in the first four months following radiotherapy through the analysis of dynamic-susceptibility contrast perfusion imaging...
  28. ncbi Design of cosine modulated very selective suppression pulses for MR spectroscopic imaging at 3T
    Joseph A Osorio
    UCSF UCB Joint Graduate Group in Bioengineering, San Francisco, California 94158 2532, USA
    Magn Reson Med 61:533-40. 2009
    ..This provided improved coverage and suppression of unwanted lipid signals with a smaller number of pulses. The use of the improved pulse sequence was validated in volunteer studies, and in clinical 3D MRSI exams of brain tumors...
  29. ncbi Compressed sensing for resolution enhancement of hyperpolarized 13C flyback 3D-MRSI
    Simon Hu
    Department of Radiology, University of California, Box 2512, 1700 4th Street, QB3 Building, Suite 102, San Francisco, CA 94158 2512, USA
    J Magn Reson 192:258-64. 2008
    ..Phantom tests validated the accuracy of the compressed sensing approach and initial mouse experiments demonstrated in vivo feasibility...
  30. ncbi Correlation of magnetic resonance spectroscopic and growth characteristics within Grades II and III gliomas
    Tracy R McKnight
    Department of Radiology, University of California, San Francisco 94107, USA
    J Neurosurg 106:660-6. 2007
    ....
  31. ncbi Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 65:610-9. 2011
    ..This approach has enabled the monitoring of perfusion and uptake of the pyruvate, and the conversion dynamics to lactate and alanine throughout a volume with high spatial and temporal resolution...
  32. ncbi Proton magnetic resonance spectroscopy imaging in the evaluation of patients undergoing gamma knife surgery for Grade IV glioma
    Antoinette A Chan
    Department of Radiology, University of California, San Francisco, California 94107-1739, USA
    J Neurosurg 101:467-75. 2004
    ..This difference was statistically significant (p < 0.01). CONCLUSIONS: Analysis of the results of this study indicates that patients undergoing GKS may benefit from the inclusion of 1H-MRS imaging in the treatment planning process...
  33. ncbi Implementation of 3 T lactate-edited 3D 1H MR spectroscopic imaging with flyback echo-planar readout for gliomas patients
    Ilwoo Park
    UCSF UCB Joint Graduate Group in Bioengineering, San Francisco, CA 94158, USA
    Ann Biomed Eng 39:193-204. 2011
    ..The implementation of this technique means that brain lactate can be evaluated in a routine clinical setting to study its potential as a marker for prognosis and response to therapy...
  34. ncbi MRI apparent diffusion coefficient reflects histopathologic subtype, axonal disruption, and tumor fraction in diffuse-type grade II gliomas
    Inas S Khayal
    UCSF UCB Joint Graduate Group in Bioengineering, University of California, San Francisco, CA, USA
    Neuro Oncol 13:1192-201. 2011
    ..Further, the ADC in grade II gliomas is associated with the fraction of tumor cells and degree of axonal disruption in tumor subregions...
  35. ncbi A practical multinuclear transceiver volume coil for in vivo MRI/MRS at 7 T
    Chunsheng Wang
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    Magn Reson Imaging 30:78-84. 2012
    ..Finite difference time domain method simulations for evaluating the design and 7-T MR experiment results acquired using the prototype coil are presented...
  36. ncbi Elliptical magnetic resonance spectroscopic imaging with GRAPPA for imaging brain tumors at 3 T
    Suchandrima Banerjee
    Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    Magn Reson Imaging 27:1319-25. 2009
    ..Metabolite concentrations measured from the accelerated acquisitions were in good agreement with measurements obtained from fully sampled MRSI scans...
  37. ncbi Comparison of T(1) and T(2) metabolite relaxation times in glioma and normal brain at 3T
    Yan Li
    University of California, San Francisco University of California, Berkeley UCSF UCB Joint Graduate Group in Bioengineering, San Francisco, California 94143 2532, USA
    J Magn Reson Imaging 28:342-50. 2008
    ..To measure T(1) and T(2) relaxation times of metabolites in glioma patients at 3T and to investigate how these values influence the observed metabolite levels...
  38. ncbi Relationship of MR-derived lactate, mobile lipids, and relative blood volume for gliomas in vivo
    Xiaojuan Li
    Center of Functional and Molecular Imaging and Department of Radiology, University of California, San Francisco, CA 94107, USA
    AJNR Am J Neuroradiol 26:760-9. 2005
    ..CONCLUSION: The in vivo distribution of rCBV, Lac, and Lip, as evaluated with three-dimensional MR spectroscopic imaging, may help in the diagnosis and selection of the most appropriate therapy for patients with gliomas...
  39. ncbi Potential value of MR spectroscopic imaging for the radiosurgical management of patients with recurrent high-grade gliomas
    Cynthia F Chuang
    Department of Radiation Oncology, University of California, San Francisco, Box 0226, San Francisco, CA 94143 0226, USA
    Technol Cancer Res Treat 6:375-82. 2007
    ....
  40. ncbi Characterization of low-grade gliomas using RGB color maps derived from ADC histograms
    Inas S Khayal
    UCSF UCB Joint Graduate Group in Bioengineering, University of California, San Francisco, California 94158 2330, USA
    J Magn Reson Imaging 30:209-13. 2009
    ....
  41. ncbi High-speed 3T MR spectroscopic imaging of prostate with flyback echo-planar encoding
    Albert P Chen
    Department of Radiology, University of California at San Francisco, San Francisco, CA 94143, USA
    J Magn Reson Imaging 25:1288-92. 2007
    ..The short acquisition time provided by this method reduces the 3T prostate MRI/MRSI exam time, allows longer repetition times, and/or allows the acquisition of additional MR acquisitions within the same exam...
  42. ncbi Phased array 3D MR spectroscopic imaging of the brain at 7 T
    Duan Xu
    Joint UCSF UC Berkeley Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA 94143, USA
    Magn Reson Imaging 26:1201-6. 2008
    ..The new 7 T MRSI sequence was tested in volunteer studies and demonstrated the feasibility of obtaining high-SNR phased-array 3D MRSI from the human brain...
  43. ncbi 7-Tesla susceptibility-weighted imaging to assess the effects of radiotherapy on normal-appearing brain in patients with glioma
    Janine M Lupo
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94158, USA
    Int J Radiat Oncol Biol Phys 82:e493-500. 2012
    ..To evaluate the intermediate- and long-term imaging manifestations of radiotherapy on normal-appearing brain tissue in patients with treated gliomas using 7T susceptibility-weighted imaging (SWI)...
  44. ncbi Feasibility of using hyperpolarized [1-13C]lactate as a substrate for in vivo metabolic 13C MRSI studies
    Albert P Chen
    Department of Radiology, University of California, Box 2512, San Francisco, CA 94158 2512, USA
    Magn Reson Imaging 26:721-6. 2008
    ..This study also demonstrated the potential value of this hyperpolarized agent to investigate in vivo lactate uptake and metabolism in preclinical animal models...
  45. ncbi Relationship between choline and apparent diffusion coefficient in patients with gliomas
    Inas S Khayal
    University of California, San Francisco, California, USA
    J Magn Reson Imaging 27:718-25. 2008
    ....
  46. ncbi Ex vivo MR spectroscopic measure differentiates tumor from treatment effects in GBM
    Radhika Srinivasan
    Department of Radiology and Biomedical Imaging, 1700 4th Street, Byers Hall, Suite 301, San Francisco, CA 94143 2532, USA
    Neuro Oncol 12:1152-61. 2010
    ..Low levels of MCI for tumor were associated with a reduced apparent diffusion coefficient and elevated choline-N-acetyl-aspartate index derived from in vivo MR images...
  47. ncbi Evaluation of diffusion parameters as early biomarkers of disease progression in glioblastoma multiforme
    Inas S Khayal
    UCSF UCB Joint Graduate Group in Bioengineering, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94158 2330, USA
    Neuro Oncol 12:908-16. 2010
    ..This is important because the mid-RT scan is currently not performed as part of the standard clinical care...
  48. ncbi Assessment of perfusion MRI-derived parameters in evaluating and predicting response to antiangiogenic therapy in patients with newly diagnosed glioblastoma
    Emma Essock-Burns
    Department of Radiology and Biomedical Imaging, University of California San Francisco, UCSF Mail Code 2532, Byers Hall Room 303, 1700 4th Street, San Francisco, CA 94158 0223, USA
    Neuro Oncol 13:119-31. 2011
    ....
  49. ncbi Development of a robust method for generating 7.0 T multichannel phase images of the brain with application to normal volunteers and patients with neurological diseases
    Kathryn E Hammond
    University of California San Francisco Berkeley Joint Graduate Group in Bioengineering, San Francisco, CA 94158 2532, USA
    Neuroimage 39:1682-92. 2008
    ..5 T. The clinical images showed novel contrast in MS plaques and depicted microhemorrhages and abnormal vasculature in brain tumors with unsurpassed resolution and contrast...
  50. ncbi Patterns of recurrence analysis in newly diagnosed glioblastoma multiforme after three-dimensional conformal radiation therapy with respect to pre-radiation therapy magnetic resonance spectroscopic findings
    Ilwoo Park
    Surbeck Laboratory of Advanced Imaging, Department of Radiology, University of California San Francisco, San Francisco, CA, USA
    Int J Radiat Oncol Biol Phys 69:381-9. 2007
    ....
  51. ncbi Partial-volume model for determining white matter and gray matter cerebral blood volume for analysis of gliomas
    Michael C Lee
    Department of Radiology, University of California San Francisco, UCSF Radiology Box 2532, 1700 4th Street, San Francisco, CA 94143, USA
    J Magn Reson Imaging 23:257-66. 2006
    ....
  52. ncbi Quantitative apparent diffusion coefficients and T2 relaxation times in characterizing contrast enhancing brain tumors and regions of peritumoral edema
    Joonmi Oh
    Center for Molecular and Functional Imaging, University of California, San Francisco, San Francisco, California 94107, USA
    J Magn Reson Imaging 21:701-8. 2005
    ..To investigate the potential value and relationship of in vivo quantification of apparent diffusion coefficients (ADCs) and T2 relaxation times for characterizing brain tumor cellularity and tumor-related edema...
  53. ncbi Magnetic resonance of 2-hydroxyglutarate in IDH1-mutated low-grade gliomas
    Adam Elkhaled
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94158, USA
    Sci Transl Med 4:116ra5. 2012
    ..Such information may augment the ability of clinicians to monitor therapeutic response and provide criteria for stratifying patients to specific treatment regimens...
  54. ncbi Apparent diffusion coefficient and fractional anisotropy of newly diagnosed grade II gliomas
    Inas S Khayal
    UCSF UCB Joint Graduate Group in Bioengineering, University of California, San Francisco, CA, USA
    NMR Biomed 22:449-55. 2009
    ..This suggests that ADC and FA may be helpful in directing tissue sampling to the most appropriate regions for taking biopsies in order to make a definitive diagnosis...
  55. ncbi Feasibility of dynamic susceptibility contrast perfusion MR imaging at 3T using a standard quadrature head coil and eight-channel phased-array coil with and without SENSE reconstruction
    Janine M Lupo
    Department of Radiology, University of California San Francisco, San Francisco, California 94158, USA
    J Magn Reson Imaging 24:520-9. 2006
    ..5t...
  56. ncbi 7T human spine imaging arrays with adjustable inductive decoupling
    Bing Wu
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    IEEE Trans Biomed Eng 57:397-403. 2010
    ..Preliminary results of human spine images acquired using the transceiver arrays demonstrate the feasibility of the design for ultrahigh-field MR applications and its robust performance for parallel imaging...
  57. ncbi Evaluation of lactate and alanine as metabolic biomarkers of prostate cancer using 1H HR-MAS spectroscopy of biopsy tissues
    May Britt Tessem
    Department of Radiology, University of California San Francisco, San Francisco, California 94158 2330, USA
    Magn Reson Med 60:510-6. 2008
    ..The significant increase in the concentration of both lactate and alanine in biopsy tissue containing as little as 5% cancer could be exploited in hyperpolarized (13)C spectroscopic imaging (SI) studies of prostate cancer patients...
  58. ncbi Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors
    Ilwoo Park
    Joint Graduate Group in Bioengineering, Surbeck Laboratory of Advanced Imaging, University of California San Francisco Berkeley, 1700 4th Street, Byers Hall, Room BH 303, San Francisco, CA 94158 2532, USA
    Neuro Oncol 12:133-44. 2010
    ..These results suggest that hyperpolarized MR metabolic imaging may be valuable for assessing prognosis and monitoring response to therapy for patients with brain tumors...
  59. ncbi Differentiation of low-grade oligodendrogliomas from low-grade astrocytomas by using quantitative blood-volume measurements derived from dynamic susceptibility contrast-enhanced MR imaging
    Soonmee Cha
    Department of Radiology, University of California-San Francisco, UCSF Medical Center, 505 Parnassus Avenue, San Francisco, CA 94143-0628, USA
    AJNR Am J Neuroradiol 26:266-73. 2005
    ..Our findings suggest that tumor rCBV(max) derived from DSC MR imaging can be used to distinguish between the two low-grade gliomas...
  60. ncbi Histopathological validation of a three-dimensional magnetic resonance spectroscopy index as a predictor of tumor presence
    Tracy R McKnight
    Department of Radiology, Biostatistics Core, Comprehensive Cancer Center, University of California, San Francisco 94143, USA
    J Neurosurg 97:794-802. 2002
    ..The information gleaned from the biopsy correlation study was used to test the hypothesis that there is metabolically active tumor in nonenhancing regions of the T2-hyperintense lesion that can be detected using MR spectroscopy...
  61. ncbi Unaliasing lipid contamination for MR spectroscopic imaging of gliomas at 3T using sensitivity encoding (SENSE)
    Esin Ozturk-Isik
    UCSF UCB Joint Graduate Group in Bioengineering, University of California San Francisco, San Francisco, California 94143 2532, USA
    Magn Reson Med 55:1164-9. 2006
    ....
  62. ncbi 1H-MRSI of radiation effects in normal-appearing white matter: dose-dependence and impact on automated spectral classification
    Michael C Lee
    Magnetic Resonance Science Center, Department of Radiology, University of California San Francisco, San Francisco, California 94107 1739, USA
    J Magn Reson Imaging 19:379-88. 2004
    ..To identify radiation-induced changes in healthy white-matter spectra in the first six months following radiotherapy, and assess the impact of these changes on an automated algorithm for detecting spectral abnormalities...
  63. ncbi MR spectroscopic imaging of glutathione in the white and gray matter at 7 T with an application to multiple sclerosis
    Radhika Srinivasan
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94107 1739, USA
    Magn Reson Imaging 28:163-70. 2010
    ..Reduced GSH was also observed in a MS WM lesion. This preliminary investigation demonstrates the potential of this marker to probe oxidative state in MS...
  64. ncbi Multiparametric characterization of grade 2 glioma subtypes using magnetic resonance spectroscopic, perfusion, and diffusion imaging
    Wei Bian
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
    Transl Oncol 2:271-80. 2009
    ....
  65. ncbi Fast magnetic resonance spectroscopic imaging at 3 Tesla using autocalibrating parallel technique
    Suchandrima Banerjee
    Joint Graduate Group in Bioeng, California Univ, Berkeley, San Francisco, CA, USA
    Conf Proc IEEE Eng Med Biol Soc 1:1866-9. 2006
    ..Employing two fold undersampling in two phase-encoding directions, a four fold reduction in scantime was simulated. Metabolic parameters showed close agreement between the full and GRAPPA reconstructed spectral data...
  66. ncbi Three-dimensional J-resolved H-1 magnetic resonance spectroscopic imaging of volunteers and patients with brain tumors at 3T
    Yan Li
    University of California, San Francisco University of California, Berkeley Joint Graduate Group in Bioengineering, San Francisco, California 94143 2532, USA
    Magn Reson Med 58:886-92. 2007
    ..17 Hz. This technique also enables the evaluation of the changes in metabolite T(2). Compared with the values in normal white matter, the T(2) values of Cho and Cr were statistically significantly increased in regions of glioma...
  67. ncbi Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis
    Sergio E Baranzini
    Department of Neurology, School of Medicine, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0435, USA
    Brain 133:2603-11. 2010
    ..Spectroscopy-based imaging provides a novel quantitative endophenotype for genetic association studies directed towards identifying new factors that contribute to the heterogeneity of clinical expression of multiple sclerosis...
  68. ncbi Challenges in dynamic contrast-enhanced MRI imaging of cervical lymph nodes to detect metastatic disease
    Susan M Noworolski
    The Magnetic Resonance Science Center, The University of California, San Francisco, California 94143 1290, USA
    J Magn Reson Imaging 17:455-62. 2003
    ..To identify and overcome challenges in using dynamic contrast-enhanced magnetic resonance imaging (MRI) to distinguish tumor from nontumor in the cervical lymph nodes of patients with squamous cell carcinoma of the head and neck...
  69. ncbi Partially parallel MR spectroscopic imaging of gliomas at 3T
    Esin Ozturk
    UCSF UCB Joint Graduate Group in Bioengineering, University of California, San Francisco, CA, USA
    Conf Proc IEEE Eng Med Biol Soc 1:493-6. 2006
    ....
  70. ncbi Generation of hyperpolarized substrates by secondary labeling with [1,1-13C] acetic anhydride
    David M Wilson
    Department of Radiology, University of California San Francisco, San Francisco, CA 94158 2330, USA
    Proc Natl Acad Sci U S A 106:5503-7. 2009
    ..This study demonstrates the feasibility of using prepolarized [1,1-(13)C] acetic anhydride and rapid chemical reactions to provide high SNR NMR spectra of amino acid derivatives and other biomolecules...
  71. ncbi Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T-initial experience
    Albert P Chen
    Department of Radiology, University of California San Francisco, San Francisco, California, USA
    Magn Reson Med 58:1099-106. 2007
    ..135 cm(3) nominal spatial resolution. Elevated (13)C lactate (lac) was observed in both primary and metastatic tumors, demonstrating the feasibility of studying cellular bioenergetics in vivo with DNP hyperpolarized (13)C MRSI...
  72. ncbi Supervised pattern recognition for the prediction of contrast-enhancement appearance in brain tumors from multivariate magnetic resonance imaging and spectroscopy
    Michael C Lee
    Surbeck Laboratory of Advanced Imaging, Department of Radiology, University of California, UCSF Radiology Box 2532, 1700 4th Street, San Francisco, CA 94143 2532, USA
    Artif Intell Med 43:61-74. 2008
    ..We also explore the use of feature selection or weighting in improving the accuracy of the pattern classifier...
  73. ncbi Identification of MRI and 1H MRSI parameters that may predict survival for patients with malignant gliomas
    Xiaojuan Li
    Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco, 1 Irving St, San Francisco, CA 94143, USA
    NMR Biomed 17:10-20. 2004
    ....
  74. ncbi Analysis of the spatial characteristics of metabolic abnormalities in newly diagnosed glioma patients
    Xiaojuan Li
    Department of Radiology, Magnetic Resonance Science Center, University of California-San Francisco, San Francisco, California 94143, USA
    J Magn Reson Imaging 16:229-37. 2002
    ..CONCLUSION: These 3D-MRSI data provide important additional information to conventional MRI for evaluating and characterizing gliomas...
  75. ncbi Imaging glioblastoma multiforme
    Sarah J Nelson
    Magnetic Resonance Science Center, Department of Radiology, University of California San Francisco, San Francisco, California 94143, USA
    Cancer J 9:134-45. 2003
    ....
  76. ncbi Combined magnetic resonance imaging and spectroscopic imaging approach to molecular imaging of prostate cancer
    John Kurhanewicz
    Magnetic Resonance Science Center, Department of Radiology, University of California San Francisco, San Francisco, California 94143 1290, USA
    J Magn Reson Imaging 16:451-63. 2002
    ....
  77. ncbi Directional diffusion in relapsing-remitting multiple sclerosis: a possible in vivo signature of Wallerian degeneration
    Roland G Henry
    Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco 94143 1290, USA
    J Magn Reson Imaging 18:420-6. 2003
    ..To examine the role of directional dependence of the apparent diffusion coefficients in the evaluation of normal-appearing brain regions of patients with relapsing-remitting multiple sclerosis...
  78. ncbi Improved spatial coverage for brain 3D PRESS MRSI by automatic placement of outer-volume suppression saturation bands
    Eugene Ozhinsky
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
    J Magn Reson Imaging 33:792-802. 2011
    ....
  79. ncbi Characterization of untreated gliomas by magnetic resonance spectroscopic imaging
    Sarah J Nelson
    Magnetic Resonance Science Center, Department of Radiology, University of California at San Francisco, One Irving Street, Box 1290, San Francisco, CA 94143, USA
    Neuroimaging Clin N Am 12:599-613. 2002
    ....
  80. ncbi Metabolic imaging of low-grade gliomas with three-dimensional magnetic resonance spectroscopy
    Andrea Pirzkall
    Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA 94143, USA
    Int J Radiat Oncol Biol Phys 53:1254-64. 2002
    ..We performed a study examining the impact MRSI would have on the routine addition of 2-3-cm margins around MRI T2-weighted hyperintensity to generate the treatment planning clinical target volume (CTV) for low-grade gliomas...
  81. ncbi Magnetic resonance spectroscopic imaging. Evaluating responses to therapy for gliomas
    Sarah J Nelson
    Department of Radiology, University of California, San Francisco 94143-0775, USA
    IEEE Eng Med Biol Mag 23:30-9. 2004
  82. ncbi Current and potential applications of clinical 13C MR spectroscopy
    John Kurhanewicz
    University of California San Francisco, San Francisco, California 94158 2330, USA
    J Nucl Med 49:341-4. 2008
    ..Preliminary preclinical studies in a model of prostate cancer have demonstrated the potential clinical utility of hyperpolarized (13)C MRS...
  83. ncbi Quantitative analysis of spatial distortions of diffusion techniques at 3T
    Duan Xu
    Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA
    Magn Reson Imaging 28:451-4. 2010
    ..These methods have confirmed the SSFSE based diffusion method is less distorted than the EPI based one, which is generally accepted through visual inspection...
  84. ncbi Spectroscopic imaging of the brain with phased-array coils at 3.0 T
    Duan Xu
    Joint UCSF UCB Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA 94143, USA
    Magn Reson Imaging 24:69-74. 2006
    ..The use of low peak power, dual-band spectral-spatial pulses was also investigated for application to 3 T MRSI of the brain using the body coil for radiofrequency excitation and PA coils for signal reception...
  85. ncbi Partially-parallel, susceptibility-weighted MR imaging of brain vasculature at 7 Tesla using sensitivity encoding and an autocalibrating parallel technique
    Janine M Lupo
    University of California San Francisco, CA, USA
    Conf Proc IEEE Eng Med Biol Soc 1:747-50. 2006
    ....
  86. ncbi Measurement of in vivo multi-component T2 relaxation times for brain tissue using multi-slice T2 prep at 1.5 and 3 T
    Joonmi Oh
    Department of Radiology, Center for Molecular and Functional Imaging, University of California, San Francisco, CA 94107, USA
    Magn Reson Imaging 24:33-43. 2006
    ..The use of the eight-channel head coil involved more accurate quantification of T2 relaxation times particularly when the number of echoes was limited...
  87. ncbi Perfusion, diffusion and spectroscopy values in newly diagnosed cerebral gliomas
    Isabelle Catalaa
    Service de Neuroradiologie, Hopital Rangueil, Toulouse, France
    NMR Biomed 19:463-75. 2006
    ..The non-enhancing region of grades II and III gliomas had MR parameters consistent with increased cellularity and/or membrane turnover...
  88. ncbi Multislice brain myelin water fractions at 3T in multiple sclerosis
    Joonmi Oh
    Department of Radiology, University of California, San Francisco, California 94117, USA
    J Neuroimaging 17:156-63. 2007
    ..To evaluate a multislice nonlinearly-spaced 12-echo imaging sequence at 3T covering the supratentorial brain for the quantification of myelin water fraction (MWF) in multiple sclerosis (MS) patients...
  89. ncbi Double spin-echo sequence for rapid spectroscopic imaging of hyperpolarized 13C
    Charles H Cunningham
    Department of Medical Biophysics, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada
    J Magn Reson 187:357-62. 2007
    ..Experiments in vivo showed three-dimensional coverage with excellent spectral quality and SNR...
  90. ncbi Pulse sequence for dynamic volumetric imaging of hyperpolarized metabolic products
    Charles H Cunningham
    Department of Medical Biophysics and Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ont, Canada M4N 3M5
    J Magn Reson 193:139-46. 2008
    ..5s. This high frame rate was used to measure the different lactate dynamics in different tissues in a normal rat model and a mouse model of prostate cancer...
  91. ncbi Assessment of metastatic cervical adenopathy using dynamic contrast-enhanced MR imaging
    Nancy J Fischbein
    Department of Radiology, University of California, San Francisco, San Francisco, CA 94143, USA
    AJNR Am J Neuroradiol 24:301-11. 2003
    ..05) in the tumor-involved nodes compared with the normal nodes. CONCLUSION: Analysis of dynamic contrast-enhanced MR imaging can differentiate normal from diseased lymph nodes in patients with squamous cell carcinoma of the head and neck...
  92. ncbi Dynamic susceptibility-weighted perfusion imaging of high-grade gliomas: characterization of spatial heterogeneity
    Janine M Lupo
    Department of Radiology, University of California, San Francisco, USA
    AJNR Am J Neuroradiol 26:1446-54. 2005
    ..Peak height and percent recovery parameters help to improve the specificity for characterization of the degree of angiogenesis and microvascular leakage in these tumors and may be useful in evaluating response to treatment...
  93. ncbi Quantification of prostate MRSI data by model-based time domain fitting and frequency domain analysis
    Pieter Pels
    ESAT SCD, Katholieke Universiteit Leuven, Leuven Heverlee, Belgium
    NMR Biomed 19:188-97. 2006
    ..Comparing the ratios estimated by the TDF and the FDA, the methods predicted the same spectrum type in 17 out of 18 voxels of the in vivo case study (94.4%)...
  94. ncbi Corpus callosum axonal injury in multiple sclerosis measured by proton magnetic resonance spectroscopic imaging
    Joonmi Oh
    Magnetic Resonance Science Center, Department of Radiology, University of California San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107, USA
    Arch Neurol 61:1081-6. 2004
    ..Axonal damage has been observed in normal-appearing white matter (NAWM) for patients with multiple sclerosis (MS)...
  95. ncbi Design of flyback echo-planar readout gradients for magnetic resonance spectroscopic imaging
    Charles H Cunningham
    Department of Electrical Engineering, Stanford University, Stanford, California, USA
    Magn Reson Med 54:1286-9. 2005
    ..3 min and 4096 voxels in 8.5 min). The trajectories were insensitive to errors in timing and require only a modest (10 to 30%) penalty in SNR relative to conventional phase encoding using the same acquisition time...
  96. ncbi Measurement of brain glutamate using TE-averaged PRESS at 3T
    Ralph Hurd
    GE Medical Systems, Menlo Park, California, USA
    Magn Reson Med 51:435-40. 2004
    ..A repeatibility error of <5%, and a coefficient of variation (CV) of <10% were observed for brain Glu levels in a study of six normal volunteers...
  97. ncbi Improved signal to noise in high-resolution magic angle spinning total correlation spectroscopy studies of prostate tissues using rotor-synchronized adiabatic pulses
    Andrew S Zektzer
    Center for Molecular and Functional Imaging, Department of Radiology, University of California, 185 Berry Street, San Francisco, CA 94017, USA
    Magn Reson Med 53:41-8. 2005
    ....
  98. ncbi Multivoxel magnetic resonance spectroscopy of brain tumors
    Sarah J Nelson
    Magnetic Resonance Science Center, University of California San Francisco, San Francisco, California 94143-1290, USA
    Mol Cancer Ther 2:497-507. 2003
    ....