Peter T Nelson

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology
    Peter T Nelson
    Department of Pathology, Division of Neuropathology, Rm 311, Sanders Brown Center on Aging, University of Kentucky, 800 S Limestone Avenue, Lexington, KY, 40536 0230, USA
    Acta Neuropathol 127:825-43. 2014
  2. pmc MicroRNA in Situ Hybridization in the Human Entorhinal and Transentorhinal Cortex
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center, Sanders Brown Center on Aging and Alzheimer s Disease Center, University of Kentucky Lexington, KY, USA
    Front Hum Neurosci 4:7. 2010
  3. pmc Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease
    Peter T Nelson
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA
    Acta Neuropathol 126:161-77. 2013
  4. pmc Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature
    Peter T Nelson
    Sanders Brown Center on Aging, Department of Pathology, University of Kentucky, Lexington 40536 0230, USA
    J Neuropathol Exp Neurol 71:362-81. 2012
  5. pmc In situ hybridization is a necessary experimental complement to microRNA (miRNA) expression profiling in the human brain
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center, University of Kentucky, Lexington, KY 40536, United States
    Neurosci Lett 466:69-72. 2009
  6. pmc Brains with medial temporal lobe neurofibrillary tangles but no neuritic amyloid plaques are a diagnostic dilemma but may have pathogenetic aspects distinct from Alzheimer disease
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, Univerisity of Kentucky, Lexington, Kentucky 40536 0230, USA
    J Neuropathol Exp Neurol 68:774-84. 2009
  7. pmc Low sensitivity in clinical diagnoses of dementia with Lewy bodies
    Peter T Nelson
    Division of Neuropathology, Department of Pathology, University of Kentucky Medical Center, University of Kentucky, Rm 311, Sanders Brown Building, 800 S Limestone, Lexington, KY 40536 0230, USA
    J Neurol 257:359-66. 2010
  8. pmc Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies
    P T Nelson
    Department of Pathology, Division of Neuropathology, University of Kentucky Medical Center, 800 S Limestone, University of Kentucky, Lexington, KY 40536 0230, USA
    Neurology 73:1127-33. 2009
  9. pmc Association between male gender and cortical Lewy body pathology in large autopsy series
    Peter T Nelson
    Division of Neuropathology, Department of Pathology, Sanders Brown Center on Aging, University of Kentucky, Rm 311, Sanders Brown Building, 800 S Limestone, Lexington, KY 40536 0230, USA
    J Neurol 257:1875-81. 2010
  10. pmc Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center, Sanders Brown Center on Aging, Lexington, KY 40536 0230, USA
    J Neuropathol Exp Neurol 68:1-14. 2009

Detail Information

Publications56

  1. pmc ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology
    Peter T Nelson
    Department of Pathology, Division of Neuropathology, Rm 311, Sanders Brown Center on Aging, University of Kentucky, 800 S Limestone Avenue, Lexington, KY, 40536 0230, USA
    Acta Neuropathol 127:825-43. 2014
    ..Controlling for important confounders such as diabetes itself, exposure to a sulfonylurea drug was associated with risk for HS-Aging pathology (p = 0.03). Thus, we describe a novel and targetable dementia risk factor. ..
  2. pmc MicroRNA in Situ Hybridization in the Human Entorhinal and Transentorhinal Cortex
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center, Sanders Brown Center on Aging and Alzheimer s Disease Center, University of Kentucky Lexington, KY, USA
    Front Hum Neurosci 4:7. 2010
    ..As with other areas of brain, the TEC and EC have characteristic miRNA expression patterns. MiRNA ISH is among the first methods to show special staining characteristics of cells and laminae of the human TEC...
  3. pmc Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease
    Peter T Nelson
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA
    Acta Neuropathol 126:161-77. 2013
    ..We conclude that the published literature on HS-Aging provides strong evidence of an important and under-appreciated brain disease of aging. Unfortunately, there is no therapy or preventive strategy currently available...
  4. pmc Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature
    Peter T Nelson
    Sanders Brown Center on Aging, Department of Pathology, University of Kentucky, Lexington 40536 0230, USA
    J Neuropathol Exp Neurol 71:362-81. 2012
    ..Although Aβ plaques may play a key role in AD pathogenesis, the severity of cognitive impairment correlates best with the burden of neocortical neurofibrillary tangles...
  5. pmc In situ hybridization is a necessary experimental complement to microRNA (miRNA) expression profiling in the human brain
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center, University of Kentucky, Lexington, KY 40536, United States
    Neurosci Lett 466:69-72. 2009
    ..Technical and theoretical aspects of this important technique are described, especially those pertinent to studying the human brain...
  6. pmc Brains with medial temporal lobe neurofibrillary tangles but no neuritic amyloid plaques are a diagnostic dilemma but may have pathogenetic aspects distinct from Alzheimer disease
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, Univerisity of Kentucky, Lexington, Kentucky 40536 0230, USA
    J Neuropathol Exp Neurol 68:774-84. 2009
    ..We conclude that NFT+/NP- cases comprise approximately 5% of aged individuals in multiple data sets; these cases are not necessarily within the spectrum of AD...
  7. pmc Low sensitivity in clinical diagnoses of dementia with Lewy bodies
    Peter T Nelson
    Division of Neuropathology, Department of Pathology, University of Kentucky Medical Center, University of Kentucky, Rm 311, Sanders Brown Building, 800 S Limestone, Lexington, KY 40536 0230, USA
    J Neurol 257:359-66. 2010
    ..Our data suggest that further work is needed to refine our ability to identify specific aging-related brain disease mechanisms, especially in DLB...
  8. pmc Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies
    P T Nelson
    Department of Pathology, Division of Neuropathology, University of Kentucky Medical Center, 800 S Limestone, University of Kentucky, Lexington, KY 40536 0230, USA
    Neurology 73:1127-33. 2009
    ..Recent studies raised questions about the severity of cognitive impairment associated with dementia with Lewy bodies (DLB). However, there have been few analyses of large, multicenter data registries for clinical-pathologic correlation...
  9. pmc Association between male gender and cortical Lewy body pathology in large autopsy series
    Peter T Nelson
    Division of Neuropathology, Department of Pathology, Sanders Brown Center on Aging, University of Kentucky, Rm 311, Sanders Brown Building, 800 S Limestone, Lexington, KY 40536 0230, USA
    J Neurol 257:1875-81. 2010
    ..05 for both). Males are far more likely than females to die with neocortical LB pathology. This phenomenon may help guide medical practice including clinical trial study design...
  10. pmc Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center, Sanders Brown Center on Aging, Lexington, KY 40536 0230, USA
    J Neuropathol Exp Neurol 68:1-14. 2009
    ..We argue that existing data strongly support the hypothesis that both amyloid plaques and NFTs contribute to cognitive impairment...
  11. pmc High-throughput experimental studies to identify miRNA targets directly, with special focus on the mammalian brain
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center and Sanders Brown Center on Aging, University of Kentucky, 800 S Limestone, Lexington, KY 40536, USA
    Brain Res 1338:122-30. 2010
    ..Topics related to experimentally identified miRNA targets are discussed, with special emphasis on studies pertinent to the mammalian brain...
  12. pmc MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center and Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536 0230, USA
    J Alzheimers Dis 21:75-9. 2010
    ..02) in adjacent brain tissue. Adjusted miR-107 and BACE1 mRNA levels tended to correlate negatively (trend with regression P< 0.07). In sum, miR-107 expression tends to be lower relative to other miRNAs as AD progresses...
  13. pmc Thinking outside the box: Alzheimer-type neuropathology that does not map directly onto current consensus recommendations
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center and Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40536 0230, USA
    J Neuropathol Exp Neurol 69:449-54. 2010
    ..02). We conclude that more explicit diagnostic categories and a better understanding of the pathology in earlier phases of the disease may be helpful for guiding neuropathologists in the diagnosis of Alzheimer disease...
  14. pmc Acetylcholinesterase inhibitor treatment is associated with relatively slow cognitive decline in patients with Alzheimer's disease and AD + DLB
    Peter T Nelson
    Department of Pathology, University of Kentucky Medical Center, University of Kentucky, Lexington, KY, USA
    J Alzheimers Dis 16:29-34. 2009
    ..In both diseases, treatment with acetylcholinesterase inhibitors was associated with a slower rate of cognitive decline...
  15. pmc Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies
    Peter T Nelson
    Department of Pathology, University of Kentucky, Lexington, KY 40536 0230, USA
    Acta Neuropathol 121:571-87. 2011
    ..In conclusion, it may be most fruitful to focus attention on specific pathways involved in AD rather than attributing it to an inevitable consequence of aging...
  16. pmc Modeling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center, Sanders Brown Center on Aging and Alzheimer s Disease Center, University of Kentucky, Lexington, KY, USA
    Brain Pathol 20:66-79. 2010
    ..There was no support for independent association between CILA severity and most evaluated indices including diffuse plaques, argyrophilic grains, heart disease, education level, apolipoprotein E alleles or diabetes...
  17. pmc MicroRNAs (miRNAs) in neurodegenerative diseases
    Peter T Nelson
    Department of Pathology, University of Kentucky, Lexington, KY, USA
    Brain Pathol 18:130-8. 2008
    ..Finally, a discussion is included with theoretical syntheses and possible future directions in exploring the nexus between miRNA and ND research...
  18. pmc Specific sequence determinants of miR-15/107 microRNA gene group targets
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Nucleic Acids Res 39:8163-72. 2011
    ..Future studies should take this important miRNA-to-miRNA variability into account...
  19. pmc Hippocampal sclerosis in advanced age: clinical and pathological features
    Peter T Nelson
    Department of Pathology, Division of Neuropathology and the Sanders Brown Centre on Ageing, University of Kentucky, 800 S Limestone, Lexington, KY 40536 0230, USA
    Brain 134:1506-18. 2011
    ..In summary, in the largest series of autopsy-verified patients with hippocampal sclerosis to date, we characterized the clinical and pathological features associated with hippocampal sclerosis associated with ageing...
  20. pmc Technical variables in high-throughput miRNA expression profiling: much work remains to be done
    Peter T Nelson
    Department of Pathology and Sanders Brown Center, University of Kentucky, Lexington, KY 40536, USA
    Biochim Biophys Acta 1779:758-65. 2008
    ..We conclude that greater focus on technical parameters is required to bolster the validity, reliability, and cultural credibility of miRNA gene expression profiling studies...
  21. pmc Human cerebral neuropathology of Type 2 diabetes mellitus
    Peter T Nelson
    Department of Pathology, Division of Neuropathology, University of Kentucky Medical Center, Sanders Brown Center on Aging and Alzheimer s Disease Center, University of Kentucky, Lexington, KY 40536 0230, USA
    Biochim Biophys Acta 1792:454-69. 2009
    ..These preliminary, correlative, and descriptive studies may help develop new hypotheses about CNDM2. We conclude that more work should be performed on human material in the context of CNDM2...
  22. pmc Alzheimer's-type neuropathology in the precuneus is not increased relative to other areas of neocortex across a range of cognitive impairment
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center, Sanders Brown Center on Aging and Alzheimer s Disease Center, University of Kentucky, Lexington, KY 40536, USA
    Neurosci Lett 450:336-9. 2009
    ..Our results are not consistent with the idea that the precuneus is involved in a special way with plaques or tangles relative to other areas of neocortex...
  23. pmc Adjusting for mortality when identifying risk factors for transitions to mild cognitive impairment and dementia
    Richard J Kryscio
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA
    J Alzheimers Dis 35:823-32. 2013
    ....
  24. pmc "End-stage" neurofibrillary tangle pathology in preclinical Alzheimer's disease: fact or fiction?
    Erin L Abner
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536 0230, USA
    J Alzheimers Dis 25:445-53. 2011
    ..There is no documented example of truly end-stage neurofibrillary pathology coexisting with intact cognition...
  25. pmc Arteriolosclerosis that affects multiple brain regions is linked to hippocampal sclerosis of ageing
    Janna H Neltner
    1 Department of Pathology, Division of Neuropathology, University of Kentucky, Lexington, KY 40536, USA
    Brain 137:255-67. 2014
    ..We conclude that there may be a pathogenetic change in aged human brain arterioles that impacts multiple brain areas and contributes to hippocampal sclerosis of ageing. ..
  26. pmc Prediction of preclinical Alzheimer's disease: longitudinal rates of change in cognition
    Kathryn P Riley
    Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    J Alzheimers Dis 25:707-17. 2011
    ..Longitudinal changes in slope of decline in specific cognitive test measures can serve as non-invasive methods for the detection of pAD...
  27. pmc Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, University of Kentucky, Lexington, Kentucky 40536 0230, USA
    J Neuropathol Exp Neurol 66:1136-46. 2007
    ..Our data show that there are many important contributory causes to cognitive decline in older persons. However, NFTs and NPs should not be dismissed as irrelevant in AD based on clinicopathologic correlation...
  28. pmc Preclinical AD Workgroup staging: pathological correlates and potential challenges
    Gregory A Jicha
    Neurology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Neurobiol Aging 33:622.e1-622.e16. 2012
    ..While the final recommendations from the PADW working group have not yet been released, this preliminary analysis provides a perspective on those recommendations from a neuropathological point of view...
  29. pmc miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease
    Wang Xia Wang
    Department of Pathology, Division of Neuropathology, and the Sanders Brown Center on Aging, Rm 311, Sanders Brown Center, 800 S Limestone, University of Kentucky, Lexington, KY 40536 0230, USA
    Am J Pathol 177:334-45. 2010
    ..These findings indicate that miR-107 contributes to GRN expression regulation with implications for brain disorders...
  30. pmc Patterns of microRNA expression in normal and early Alzheimer's disease human temporal cortex: white matter versus gray matter
    Wang Xia Wang
    Department of Pathology, Sanders Brown Center on Aging, University of Kentucky Medical Center, University of Kentucky, Lexington, 40536 0230, USA
    Acta Neuropathol 121:193-205. 2011
    ....
  31. pmc Individual microRNAs (miRNAs) display distinct mRNA targeting "rules"
    Wang Xia Wang
    Department of Pathology, University of Kentucky Medical Center, Lexington, KY, USA
    RNA Biol 7:373-80. 2010
    ....
  32. pmc The miR-15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseases
    John R Finnerty
    Division of Neuropathology, Department of Pathology, University of Kentucky Medical Center and Sanders BrownCenter on Aging, University of Kentucky, Lexington, KY 40536, USA
    J Mol Biol 402:491-509. 2010
    ..In conclusion, the miR-15/107 group of miRNA genes is a fascinating topic of study for evolutionary biologists, miRNA biochemists, and clinically oriented translational researchers alike...
  33. pmc Anti-Argonaute RIP-Chip shows that miRNA transfections alter global patterns of mRNA recruitment to microribonucleoprotein complexes
    Wang Xia Wang
    Department of Pathology and Laboratory Medicine, University of Kentucky Medical Center, Lexington, Kentucky, 40506 9983, USA
    RNA 16:394-404. 2010
    ..In summary, RIP-Chip assays constitute an optimized, validated, direct, and high-throughput biochemical assay that provides data about specific miRNA:mRNA interactions, as well as global patterns of regulation by miRNAs...
  34. pmc Focus on RNA isolation: obtaining RNA for microRNA (miRNA) expression profiling analyses of neural tissue
    Wang Xia Wang
    Sanders Brown Center on Aging and Department of Pathology, University of Kentucky, Lexington, Kentucky 40536 0230, USA
    Biochim Biophys Acta 1779:749-57. 2008
    ..Based on these data, recommendations for miRNA expression profiling in neural tissues, and considerations worthy of further study, are discussed...
  35. pmc The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1
    Wang Xia Wang
    Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 28:1213-23. 2008
    ....
  36. pmc Mild cognitive impairment: statistical models of transition using longitudinal clinical data
    Erin L Abner
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA
    Int J Alzheimers Dis 2012:291920. 2012
    ..Notably, APOE-4 increases the risk of transition to clinical MCI but does not affect the risk for a final transition to dementia, and baseline hypertension decreases the risk of transition to dementia from clinical MCI...
  37. pmc Self-reported head injury and risk of late-life impairment and AD pathology in an AD center cohort
    Erin L Abner
    University of Kentucky Alzheimer s Disease Center, Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, USA
    Dement Geriatr Cogn Disord 37:294-306. 2014
    ..To evaluate the relationship between self-reported head injury and cognitive impairment, dementia, mortality, and Alzheimer's disease (AD)-type pathological changes...
  38. pmc CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing
    Manasi Malik
    Department of Physiology, Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 33:13320-5. 2013
    ..Exon 2 encodes the CD33 IgV domain that typically mediates sialic acid binding in SIGLEC family members. In summary, these results suggest a novel model wherein SNP-modulated RNA splicing modulates CD33 function and, thereby, AD risk. ..
  39. pmc APOE-ε2 and APOE-ε4 correlate with increased amyloid accumulation in cerebral vasculature
    Peter T Nelson
    Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA
    J Neuropathol Exp Neurol 72:708-15. 2013
    ..These data demonstrate that APOE genotype correlations with Aβ deposition in CAA only incompletely correspond to other AD-linked brain pathologies...
  40. pmc Digital pathology and image analysis for robust high-throughput quantitative assessment of Alzheimer disease neuropathologic changes
    Janna Hackett Neltner
    Department of Pathology and Laboratory Medicine, University of Kentucky, 800 Rose St, MS 115A, Lexington, KY 40536, USA
    J Neuropathol Exp Neurol 71:1075-85. 2012
    ....
  41. pmc University of Kentucky Sanders-Brown healthy brain aging volunteers: donor characteristics, procedures and neuropathology
    Frederick A Schmitt
    Department of Neurology and the Sanders Brown Center on Aging, 303 Sanders Brown Building, 800 S Limestone, University of Kentucky, Lexington, USA
    Curr Alzheimer Res 9:724-33. 2012
    ..We also explain some of the evolving methodologies and the academic contributions that have been made due to this motivated group of older Kentuckians...
  42. pmc National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach
    Thomas J Montine
    Department of Pathology, University of Washington School of Medicine, Box 359791, Seattle, WA 98104, USA
    Acta Neuropathol 123:1-11. 2012
    ..Recommendations also are made for the minimum sampling of brain, preferred staining methods with acceptable alternatives, reporting of results, and clinico-pathologic correlations...
  43. pmc Dysregulation of the mitogen granulin in human cancer through the miR-15/107 microRNA gene group
    Wang Xia Wang
    Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center, University of Kentucky, Lexington, Kentucky 40536 0230, USA
    Cancer Res 70:9137-42. 2010
    ..These findings indicate for the first time that the mitogen and growth factor GRN is dysregulated via the miR-15/107 gene group in multiple human cancers, which may provide a potential common therapeutic target...
  44. pmc Is synaptic loss a unique hallmark of Alzheimer's disease?
    Stephen W Scheff
    Department of Anatomy and Neurobiology, University of Kentucky Medical Center, University of Kentucky, Lexington, KY 40536, United States Sanders Brown Center on Aging and Alzheimer s Disease Center, University of Kentucky Medical Center, University of Kentucky, Lexington, KY 40536, United States Electronic address
    Biochem Pharmacol 88:517-28. 2014
    ..These findings indicate that synapse loss is probably not a hallmark specific to AD but rather a change common to many diseases associated with dementia. ..
  45. pmc Expression of miR-15/107 family microRNAs in human tissues and cultured rat brain cells
    Wang Xia Wang
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA
    Genomics Proteomics Bioinformatics 12:19-30. 2014
    ..In summary, we provide a detailed study of the tissue and cell type-specific expression profile of this highly expressed and phylogenetically conserved family of miRNA genes. ..
  46. ncbi RNA in brain disease: no longer just "the messenger in the middle"
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, University of Kentucky, Sanders Brown Center on Aging, Lexington, Kentucky 40536 0230, USA
    J Neuropathol Exp Neurol 66:461-8. 2007
    ..Here we present an overview of new research highlighting functions for RNA that far surpass the "messenger in the middle" role and that identify RNA molecules as important agents in the human brain in health and in disease states...
  47. pmc A combined computational-experimental approach predicts human microRNA targets
    Marianthi Kiriakidou
    Department of Pathology, School of Medicine, Center for Bioinformatics, and Computer and Information Science, School of Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 18:1165-78. 2004
    ..We describe a computational program, "DIANA-microT", that identifies mRNA targets for animal miRNAs and predicts mRNA targets, bearing single MREs, for human and mouse miRNAs...
  48. pmc Six-month partial suppression of Huntingtin is well tolerated in the adult rhesus striatum
    Richard Grondin
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, 317 Whitney Hendrickson MRISC, Lexington, Kentucky 40536 0098, USA
    Brain 135:1197-209. 2012
    ....
  49. doi The effect of cigarette smoking on functional recovery following peripheral nerve ischemia/reperfusion injury
    Brian Rinker
    Department of Surgery, Division of Plastic Surgery, University of Kentucky, Lexington, KY 40536 0284, USA
    Microsurgery 31:59-65. 2011
    ..04). Exposure to cigarette smoke was associated with a slower functional recovery following peripheral nerve I/R injury...
  50. doi Balamuthia mandrillaris meningoencephalitis: survival of a pediatric patient
    Larry Curtis Cary
    University of Kentucky College of Medicine, Department of Pediatrics, Pediatric Residency Program, MN118 William R Willard Medical Education Building, 800 Rose St, Lexington, KY 40536 0298, USA
    Pediatrics 125:e699-703. 2010
    ..Our observations suggest that early diagnosis and treatment may significantly reduce mortality and morbidity rates from this highly virulent organism...
  51. pmc Neuroinflammatory phenotype in early Alzheimer's disease
    Tiffany L Sudduth
    Department of Physiology, University of Kentucky Sanders Brown Center on Aging, Lexington, KY 40536, USA
    Neurobiol Aging 34:1051-9. 2013
    ..We were able to detect differences in AD neuropathology, and changes in serum proteins that distinguished the individuals with apparent M1 versus M2 brain inflammatory polarization...
  52. pmc Energizing miRNA research: a review of the role of miRNAs in lipid metabolism, with a prediction that miR-103/107 regulates human metabolic pathways
    Bernard R Wilfred
    Sanders Brown Center on Aging and Department of Pathology, Division of Neuropathology, University of Kentucky, Lexington, KY 40536, USA
    Mol Genet Metab 91:209-17. 2007
    ..These predictions require experimental verification. In conclusion, a review of the literature on miRNA regulation of metabolism leads us believe that the future will provide researchers with many additional energizing revelations...
  53. pmc A novel monoclonal antibody against human Argonaute proteins reveals unexpected characteristics of miRNAs in human blood cells
    Peter T Nelson
    Department of Pathology, University of Kentucky, Lexington, KY 40536, USA
    RNA 13:1787-92. 2007
    ..We report the characterization of 2A8 and its use to clone miRNAs from human brain and from preparations of human polymorphonuclear leukocytes (neutrophils), which revealed a prevalent miRNA with unusual features...
  54. pmc White matter integrity is associated with cerebrospinal fluid markers of Alzheimer's disease in normal adults
    Brian T Gold
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY, USA Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, KY, USA Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, USA Electronic address
    Neurobiol Aging 35:2263-71. 2014
    ..Our results link lower WM microstructural integrity in CN older adults with CSF biomarkers of Alzheimer's disease and suggest that this association in the fornix may be independent of volumetric measures...
  55. pmc miRNP:mRNA association in polyribosomes in a human neuronal cell line
    Peter T Nelson
    Department of Pathology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    RNA 10:387-94. 2004
    ..These findings suggest that miRNP proteins may play important roles in target mRNA recognition and translational repression...
  56. ncbi Microglia in diseases of the central nervous system
    Peter T Nelson
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania, School of Medicine, 613 Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104 6100, USA
    Ann Med 34:491-500. 2002
    ..A recurrent theme is the perpetuation by MG of pathological cycles of monocyte recruitment, activation and cytopathic secretions, and/or auto antigen presentation...

Research Grants2

  1. A specific microRNA (Mir-107) is a potential therapeutic target in Alzheimer's di
    Peter T Nelson; Fiscal Year: 2010
    ..A research program is proposed which exploits this new discovery, in order to develop and evaluate a novel therapy for patients at risk for Alzheimer's disease. ..
  2. A specific microRNA (Mir-107) is a potential therapeutic target in Alzheimer's di
    Peter Nelson; Fiscal Year: 2009
    ..A research program is proposed which exploits this new discovery, in order to develop and evaluate a novel therapy for patients at risk for Alzheimer's disease. ..