P S Nelson

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint An expressed-sequence-tag database of the human prostate: sequence analysis of 1168 cDNA clones
    P S Nelson
    Department of Molecular Biotechnology, University of Washington, Seattle 98195, USA
    Genomics 47:12-25. 1998
  2. pmc Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression
    P S Nelson
    Department of Molecular Biotechnology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 96:3114-9. 1999
  3. ncbi request reprint Negative selection: a method for obtaining low-abundance cDNAs using high-density cDNA clone arrays
    P S Nelson
    Department of Molecular Biotechnology, University of Washington, Seattle 98195, USA
    Genet Anal 15:209-15. 1999
  4. ncbi request reprint Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new member of the short-chain steroid dehydrogenase/reductase family highly expressed in normal and neoplastic prostate epithelium
    B Lin
    Departments of Molecular Biotechnology, University of Washington, Seattle 98195, USA
    Cancer Res 61:1611-8. 2001
  5. ncbi request reprint Comprehensive analyses of prostate gene expression: convergence of expressed sequence tag databases, transcript profiling and proteomics
    P S Nelson
    Fred Hutchinson Cancer Research Center, Department of Molecular Biotechnology, University of Washington, Seattle, USA
    Electrophoresis 21:1823-31. 2000
  6. ncbi request reprint PART-1: a novel human prostate-specific, androgen-regulated gene that maps to chromosome 5q12
    B Lin
    Department of Molecular Biotechnology, University of Washington, Seattle 98195, USA
    Cancer Res 60:858-63. 2000
  7. ncbi request reprint Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2
    B Lin
    Department of Molecular Biotechnology, University of Washington, Seattle 98195, USA
    Cancer Res 59:4180-4. 1999
  8. doi request reprint The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma
    J M Lucas
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Pathol 215:118-25. 2008
  9. pmc Cell-cell interaction in prostate gene regulation and cytodifferentiation
    A Y Liu
    Department of Urology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 94:10705-10. 1997
  10. pmc The prostate expression database (PEDB): status and enhancements in 2000
    P S Nelson
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Nucleic Acids Res 28:212-3. 2000

Collaborators

  • S Wang
  • W L Ng
  • A Y Liu
  • R L Baldwin
  • M Zhang
  • B J Trask
  • K Wang
  • L Hsu
  • G Liu
  • W J Ellis
  • P E Li
  • T Ideker
  • L Gan
  • Kazuo Fujikawa
  • B Lin
  • L Hood
  • A Rojas
  • R Vessella
  • C Ferguson
  • J M Lucas
  • J P Dean
  • J T White
  • M Matsumura
  • L H Grouse
  • C C Pritchard
  • D B Martin
  • A Akalin
  • T K Takayama
  • J D Wu
  • I Coleman
  • R Bumgarner
  • R Dash
  • P B Fisher
  • S R Plymate
  • L D True
  • C Morrissey
  • M Schummer
  • S Hawley
  • L True
  • P M Chaudhary
  • P J Munson
  • J Delrow
  • B A Amaker
  • E D McCollum
  • H L Forsythe
  • S E Holt
  • L W Elmore
  • J L Ware
  • B A McMullen
  • C Friedman
  • P Lange
  • D W Bednarski
  • R E Bumgarner
  • B Y Karlan
  • L Hassell
  • B Schummer
  • O Nguyen
  • H F Massa
  • V Nguyen
  • A Jasmin
  • M Eby

Detail Information

Publications20

  1. ncbi request reprint An expressed-sequence-tag database of the human prostate: sequence analysis of 1168 cDNA clones
    P S Nelson
    Department of Molecular Biotechnology, University of Washington, Seattle 98195, USA
    Genomics 47:12-25. 1998
    ..No novel transcripts were represented by more than one EST and thus are expressed at levels much lower than the known prostate-specific genes...
  2. pmc Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression
    P S Nelson
    Department of Molecular Biotechnology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 96:3114-9. 1999
    ....
  3. ncbi request reprint Negative selection: a method for obtaining low-abundance cDNAs using high-density cDNA clone arrays
    P S Nelson
    Department of Molecular Biotechnology, University of Washington, Seattle 98195, USA
    Genet Anal 15:209-15. 1999
    ....
  4. ncbi request reprint Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new member of the short-chain steroid dehydrogenase/reductase family highly expressed in normal and neoplastic prostate epithelium
    B Lin
    Departments of Molecular Biotechnology, University of Washington, Seattle 98195, USA
    Cancer Res 61:1611-8. 2001
    ..These results identify a new gene involved in the androgen receptor-regulated gene network of the human prostate that may play a role in the pathogenesis of prostate carcinoma...
  5. ncbi request reprint Comprehensive analyses of prostate gene expression: convergence of expressed sequence tag databases, transcript profiling and proteomics
    P S Nelson
    Fred Hutchinson Cancer Research Center, Department of Molecular Biotechnology, University of Washington, Seattle, USA
    Electrophoresis 21:1823-31. 2000
    ....
  6. ncbi request reprint PART-1: a novel human prostate-specific, androgen-regulated gene that maps to chromosome 5q12
    B Lin
    Department of Molecular Biotechnology, University of Washington, Seattle 98195, USA
    Cancer Res 60:858-63. 2000
    ..These results identify a new gene involved in the androgen receptor-regulated gene network of the human prostate that may play a role in the etiology of prostate carcinogenesis...
  7. ncbi request reprint Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2
    B Lin
    Department of Molecular Biotechnology, University of Washington, Seattle 98195, USA
    Cancer Res 59:4180-4. 1999
    ..These results suggest that TMPRSS2 may play a role in prostate carcinogenesis and should be investigated as a diagnostic or therapeutic target for the management of prostate cancers...
  8. doi request reprint The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma
    J M Lucas
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Pathol 215:118-25. 2008
    ..Based on studies with the related proteins matriptase and hepsin, TMPRSS2 should be investigated for causal roles in prostate carcinogenesis...
  9. pmc Cell-cell interaction in prostate gene regulation and cytodifferentiation
    A Y Liu
    Department of Urology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 94:10705-10. 1997
    ..Our studies show that cell-cell interaction plays an important role in prostatic cytodifferentiation and the maintenance of the differentiated state...
  10. pmc The prostate expression database (PEDB): status and enhancements in 2000
    P S Nelson
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Nucleic Acids Res 28:212-3. 2000
    ..PEDB may be accessed via the WWW at http://www.mbt.washington.edu/PEDB/..
  11. ncbi request reprint Characterization of hK4 (prostase), a prostate-specific serine protease: activation of the precursor of prostate specific antigen (pro-PSA) and single-chain urokinase-type plasminogen activator and degradation of prostatic acid phosphatase
    T K Takayama
    Departments of Biochemistry and Urology, University of Washington, Box 357350, Seattle, Washington 98195 7350, USA
    Biochemistry 40:15341-8. 2001
    ..These results indicate that hK4 may have a role in the physiologic processing of seminal plasma proteins such as pro-PSA, as well as in the pathogenesis of prostate cancer through its activation of pro-uPA...
  12. pmc IL-6 promotes prostate tumorigenesis and progression through autocrine cross-activation of IGF-IR
    A Rojas
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Oncogene 30:2345-55. 2011
    ..Our findings suggest that STAT3 and IGF-IR may represent potential effective targets for prevention or treatment of prostate cancer...
  13. ncbi request reprint Comparative hybridization of an array of 21,500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas
    M Schummer
    Department of Molecular Biotechnology, University of Washington, Seattle 98195, USA
    Gene 238:375-85. 1999
    ..These cDNAs were sequenced and compared to public sequence databases. One of these, the gene HE4, was found to be expressed primarily in some ovarian cancers, and is thus a potential marker of ovarian carcinoma...
  14. ncbi request reprint From genomics to proteomics: techniques and applications in cancer research
    D B Martin
    Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Trends Cell Biol 11:S60-5. 2001
    ..This review outlines the current status of these technologies and highlights recent studies in which they have been applied in the context of carcinogenesis...
  15. pmc Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis
    J P Dean
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Br J Cancer 98:245-9. 2008
    ..We further discuss senescent stromal gene expression changes, which may mediate these effects, and that may serve as therapeutic targets...
  16. ncbi request reprint Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans
    P M Chaudhary
    Department of Medicine and Molecular Biotechnology, University of Washington, Seattle, WA 98195, USA
    Blood 91:4020-7. 1998
    ..Together with human Toll, TIL3 and TIL4 encode a family of genes with conserved structural and functional features involved in immune modulation...
  17. pmc Project normal: defining normal variance in mouse gene expression
    C C Pritchard
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA
    Proc Natl Acad Sci U S A 98:13266-71. 2001
    ..These studies help to define the baseline level of variability in mouse gene expression and emphasize the importance of replicate microarray experiments...
  18. ncbi request reprint Prostate cancer genomics
    P E Li
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop D4 100, Seattle, WA 98109 1024, USA
    Curr Urol Rep 2:70-8. 2001
    ....
  19. ncbi request reprint Sequence databases and microarrays as tools for identifying prostate cancer biomarkers
    L H Grouse
    Office of Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Urology 57:154-9. 2001
    ....
  20. ncbi request reprint A novel mechanism for chaperone-mediated telomerase regulation during prostate cancer progression
    A Akalin
    Department of Pathology, Massey Cancer Center, Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Cancer Res 61:4791-6. 2001
    ....