J S Nelson

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Imaging blood flow in human port-wine stain in situ and in real time using optical Doppler tomography
    J S Nelson
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, 1002 Health Sciences Rd E, Irvine, CA 92612, USA
    Arch Dermatol 137:741-4. 2001
  2. ncbi What is nonablative photorejuvenation of human skin?
    J Stuart Nelson
    Department of Surgery, Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612, USA
    Semin Cutan Med Surg 21:238-50. 2002
  3. ncbi Nd:YAG laser irradiation in conjunction with cryogen spray cooling induces deep and spatially selective photocoagulation in animal models
    B Anvari
    Beckman Laser Institute and Medical Clinic, University of California, Irvine 92715, USA
    Phys Med Biol 42:265-82. 1997
  4. ncbi Er:YAG laser skin resurfacing using repetitive long-pulse exposure and cryogen spray cooling: II. Theoretical analysis
    B Majaron
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, California 92612, USA
    Lasers Surg Med 28:131-7. 2001
  5. ncbi Cryogen spray cooling during Nd:YAG laser treatment of hemangiomas. A preliminary animal model study
    W L Hoffman
    Department of Dermatology, University of California, Irvine 92612, USA
    Dermatol Surg 23:635-41. 1997
  6. ncbi Feedback-controlled laser-mediated cartilage reshaping
    B J Wong
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, USA
    Arch Facial Plast Surg 1:282-7. 1999
  7. ncbi Photochemotherapy of hypervascular dermal lesions: a possible alternative to photothermal therapy?
    A Orenstein
    Beckman Laser Institute and Medical Clinic, University of California, Irvine
    Lasers Surg Med 10:334-43. 1990
  8. ncbi Cryogen spray cooling in laser dermatology: effects of ambient humidity and frost formation
    B Majaron
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612, USA
    Lasers Surg Med 28:469-76. 2001
  9. ncbi Er:YAG laser skin resurfacing using repetitive long-pulse exposure and cryogen spray cooling: I. Histological study
    B Majaron
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, California 92612, USA
    Lasers Surg Med 28:121-30. 2001
  10. ncbi Deep coagulation of dermal collagen with repetitive Er:YAG laser irradiation
    B Majaron
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, California 92612, USA
    Lasers Surg Med 26:215-22. 2000

Collaborators

Detail Information

Publications86

  1. ncbi Imaging blood flow in human port-wine stain in situ and in real time using optical Doppler tomography
    J S Nelson
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, 1002 Health Sciences Rd E, Irvine, CA 92612, USA
    Arch Dermatol 137:741-4. 2001
    ..Optical Doppler tomography (ODT) combines laser Doppler flowmetry with optical coherence tomography to obtain high-resolution images of blood flow in human skin in situ and in real time...
  2. ncbi What is nonablative photorejuvenation of human skin?
    J Stuart Nelson
    Department of Surgery, Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612, USA
    Semin Cutan Med Surg 21:238-50. 2002
    ....
  3. ncbi Nd:YAG laser irradiation in conjunction with cryogen spray cooling induces deep and spatially selective photocoagulation in animal models
    B Anvari
    Beckman Laser Institute and Medical Clinic, University of California, Irvine 92715, USA
    Phys Med Biol 42:265-82. 1997
    ....
  4. ncbi Er:YAG laser skin resurfacing using repetitive long-pulse exposure and cryogen spray cooling: II. Theoretical analysis
    B Majaron
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, California 92612, USA
    Lasers Surg Med 28:131-7. 2001
    ..To analyze the effects of laser pulse duration and cryogen spray cooling (CSC) on epidermal damage and depth of collagen coagulation in skin resurfacing with repetitive Er:YAG laser irradiation...
  5. ncbi Cryogen spray cooling during Nd:YAG laser treatment of hemangiomas. A preliminary animal model study
    W L Hoffman
    Department of Dermatology, University of California, Irvine 92612, USA
    Dermatol Surg 23:635-41. 1997
    ..Delivering a short cryogen spurt, on the order of milliseconds, has been shown to result in localized cooling of the superficial skin structures during laser irradiation...
  6. ncbi Feedback-controlled laser-mediated cartilage reshaping
    B J Wong
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, USA
    Arch Facial Plast Surg 1:282-7. 1999
    ..To demonstrate feedback-controlled laser-mediated cartilage reshaping using dynamic measurements of tissue optical properties and radiometric surface temperatures...
  7. ncbi Photochemotherapy of hypervascular dermal lesions: a possible alternative to photothermal therapy?
    A Orenstein
    Beckman Laser Institute and Medical Clinic, University of California, Irvine
    Lasers Surg Med 10:334-43. 1990
    ..The current study demonstrates, in the chicken comb model, that photochemotherapy can be used to treat hypervascular dermal lesions while leaving the normal overlying epidermis completely intact...
  8. ncbi Cryogen spray cooling in laser dermatology: effects of ambient humidity and frost formation
    B Majaron
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612, USA
    Lasers Surg Med 28:469-76. 2001
    ..Dynamics of cryogen spray deposition, water condensation and frost formation is studied in relationship to cooling rate and efficiency of cryogen spray cooling (CSC) in combination with laser dermatologic surgery...
  9. ncbi Er:YAG laser skin resurfacing using repetitive long-pulse exposure and cryogen spray cooling: I. Histological study
    B Majaron
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, California 92612, USA
    Lasers Surg Med 28:121-30. 2001
    ..Application of CSC does not offer significant epidermal protection for a given dermal coagulation depth...
  10. ncbi Deep coagulation of dermal collagen with repetitive Er:YAG laser irradiation
    B Majaron
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, California 92612, USA
    Lasers Surg Med 26:215-22. 2000
    ..We have investigated whether deep coagulation of dermal collagen, similar to that observed with the CO(2) laser, could be achieved with repetitive Er:YAG laser exposures...
  11. ncbi Combining two excitation wavelengths for pulsed photothermal profiling of hypervascular lesions in human skin
    B Majaron
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612 1475, USA
    Phys Med Biol 45:1913-22. 2000
    ..Such information provides the physician with guidance in selecting the optimal parameters for laser therapy on an individual patient basis...
  12. ncbi Optimal cryogen spray cooling parameters for pulsed laser treatment of port wine stains
    W Verkruysse
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, California, USA
    Lasers Surg Med 27:165-70. 2000
    ..The purpose of this study was to determine optimal spurt duration, tau(s), and optimal delay, tau(d), between the cryogen spurt and laser pulse when using CSC in treatment of port wine stain birthmarks...
  13. ncbi Three-dimensional reconstruction of port wine stain vascular anatomy from serial histological sections
    D J Smithies
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, USA
    Phys Med Biol 42:1843-7. 1997
    ....
  14. ncbi Mechanism of tumor destruction following photodynamic therapy with hematoporphyrin derivative, chlorin, and phthalocyanine
    J S Nelson
    Beckman Laser Institute and Medical Clinic, Irvine, CA 92715
    J Natl Cancer Inst 80:1599-605. 1988
    ..Binding of photosensitizers to the elements in this zone as well as altered permeability and transport through the endothelial cell layer because of the increased intraluminal pressure may be key features of tumor destruction...
  15. ncbi Modelling multiple laser pulses for port wine stain treatment
    W Verkruysse
    Beckman Laser Institute and Medical Clinic, University of California Irvine, USA
    Phys Med Biol 45:N197-203. 2000
    ..Therefore, it may be a means of enhancing PWS therapy for lesions that fail to respond to single-pulse dye laser treatment...
  16. ncbi Optical coherence tomography of the rat cochlea
    B J Wong
    University of California Irvine, Beckman Laser Institute and Medical Clinic, 92612, USA
    J Biomed Opt 5:367-70. 2000
    ....
  17. ncbi Angioresistance of thermally modified cartilage grafts in the chick chorioallantoic membrane model
    B J Wong
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, 1002 Health Sciences Rd E, Irvine, CA 92612, USA
    Arch Facial Plast Surg 3:24-7. 2001
    ..In vivo, angioinvasion of the tissue matrix does not occur in viable cartilage tissue, whereas denatured or nonviable grafts are readily vascularized and/or resorbed...
  18. ncbi Proteoglycan synthesis in porcine nasal cartilage grafts following Nd:YAG (lambda = 1.32 microns) laser-mediated reshaping
    B J Wong
    Beckman Laser Institute and Medical Clinic, University of California, Irvine 92612, USA
    Photochem Photobiol 71:218-24. 2000
    ....
  19. ncbi Optical Doppler tomography: imaging in vivo blood flow dynamics following pharmacological intervention and photodynamic therapy
    Z Chen
    Beckman Laser Institute and Medical Clinic, University of California, Irvine 92612, USA
    Photochem Photobiol 67:56-60. 1998
    ..Applications of this technique for monitoring changes in blood flow dynamics and vessel structure following pharmacological intervention and photodynamic therapy are demonstrated...
  20. ncbi The porcine and lagomorph septal cartilages: models for tissue engineering and morphologic cartilage research
    B J Wong
    Beckman Laser Institute and Medical Clinic, University of California-Irvine 92612, USA
    Am J Rhinol 15:109-16. 2001
    ..Our selective evaluation of key tissue properties establishes these species as appropriate animal models for nasal septal cartilaginous surgery...
  21. ncbi Laser-mediated cartilage reshaping with feedback-controlled cryogen spray cooling: biophysical properties and viability
    A M Karamzadeh
    Beckman Laser Institute and Medical Clinic, University of California Irvine, 92697, USA
    Lasers Surg Med 28:1-10. 2001
    ..Laser irradiation with CSC can be used to effectively reshape cartilage tissue with the additional advantage of increasing chondrocyte viability...
  22. ncbi In vivo burn depth determination by high-speed fiber-based polarization sensitive optical coherence tomography
    B H Park
    Beckman Laser Institute and Medical Clinic, University of California, 1002 Health Sciences Road East, Irvine, CA 92612, USA
    J Biomed Opt 6:474-9. 2001
    ..In conclusion, PS-OCT has potential use for noninvasive assessment of burn depth...
  23. ncbi Influence of nozzle-to-skin distance in cryogen spray cooling for dermatologic laser surgery
    G Aguilar
    Whitaker Center for Biomedical Engineering, University of California, Irvine, California 92697, USA
    Lasers Surg Med 28:113-20. 2001
    ..CONCLUSIONS: Sprayed areas and heat extraction efficiencies produced by current commercial nozzles may be significantly modified by varying the distance between the nozzle and the sprayed surface...
  24. ncbi Ultrahigh-resolution optical coherence tomography by broadband continuum generation from a photonic crystal fiber
    Yimin Wang
    Beckman Laser Institute and Department of Biomedical Engineering, University of California, Irvine, Irvine, California 92612, USA
    Opt Lett 28:182-4. 2003
    ..The system employed a dynamic-focusing tracking method to maintain high lateral resolution over a large imaging depth. Subcellular imaging is demonstrated...
  25. ncbi Use of laser photocoagulation for treatment of cutaneous angiomatosis in one dog and two cats
    G M Peavy
    Beckman Laser Institute and Medical Clinic, College of Medicine, University of California, Irvine 92612, USA
    J Am Vet Med Assoc 219:1094-7, 1073. 2001
    ..Laser treatment may provide an alternative to wide surgical resection or limb amputation for management of this condition in veterinary patients...
  26. ncbi Thermal depth profiling of vascular lesions: automated regularization of reconstruction algorithms
    Wim Verkruysse
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612, USA
    Phys Med Biol 53:1463-74. 2008
    ..Similar, or better, accuracy reconstructions can be achieved with an automated regularization procedure which enhances prospects for user friendly implementation of PPTR to optimize laser therapy on an individual patient basis...
  27. ncbi Hemoglobin contrast in magnetomotive optical Doppler tomography
    Jeehyun Kim
    Beckman Laser Institute and Medical Clinic, University of California at Irvine, 1002 Health Sciences Road East, Irvine, California 92612, USA
    Opt Lett 31:778-80. 2006
    ..Results suggest that MM-ODT may be a promising technique with which to image blood flow...
  28. ncbi Thermal responses of ex vivo human skin during multiple cryogen spurts and 1,450 nm laser pulses
    Rong Zhang
    Beckman Laser Institute, University of California, Irvine, 92612, USA
    Lasers Surg Med 38:137-41. 2006
    ..The objective of this study is to measure temperature variations at the epidermal-dermal junction in ex vivo human skin during three clinically relevant multiple cryogen spurt-laser pulse sequences (MCS-LPS)...
  29. ncbi Improvement of port wine stain laser therapy by skin preheating prior to cryogen spray cooling: a numerical simulation
    Wangcun Jia
    Beckman Laser Institute, University of California, Irvine, 92612, USA 92612, USA
    Lasers Surg Med 38:155-62. 2006
    ....
  30. ncbi Effect of ambient humidity on light transmittance through skin phantoms during cryogen spray cooling
    Julio C Ramirez-San-Juan
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612, USA
    Phys Med Biol 51:113-20. 2006
    ..The reduced light transmittance immediately after spurt termination was most likely because of scattering of light caused by condensation of water vapour due to aggressive cooling of ambient air in the wake of the cryogen spurt...
  31. ncbi Comparison of diffusion approximation and Monte Carlo based finite element models for simulating thermal responses to laser irradiation in discrete vessels
    Rong Zhang
    Beckman Laser Institute, University of California, Irvine, CA 92612, USA
    Phys Med Biol 50:4075-86. 2005
    ..The disadvantage is that a multidimensional ISF table is needed for DA-FEM-ISF to be a practical modelling tool...
  32. ncbi Use of erythema index imaging for systematic analysis of port wine stain skin response to laser therapy
    Byungjo Jung
    Beckman Laser Institute, University of California, Irvine, CA, USA
    Lasers Surg Med 37:186-91. 2005
    ....
  33. ncbi Description and analysis of treatments for port-wine stain birthmarks
    Kristen M Kelly
    Beckman Laser Institute, Irvine, CA 92612, USA
    Arch Facial Plast Surg 7:287-94. 2005
    ....
  34. ncbi Low-noise broadband light generation from optical fibers for use in high-resolution optical coherence tomography
    Yimin Wang
    Beckman Laser Institute and Department of Biomedical Engineering, University of California, Irvine, California 92612, USA
    J Opt Soc Am A Opt Image Sci Vis 22:1492-9. 2005
    ..The results showed that a single-mode fiber with a small core diameter is a useful way to generate low-noise, broadband light for high-resolution OCT imaging...
  35. ncbi Determination of human skin optical properties from spectrophotometric measurements based on optimization by genetic algorithms
    Rong Zhang
    University of California, Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California 92612, USA
    J Biomed Opt 10:024030. 2005
    ..Furthermore, the GA approach can lead to a reasonable understanding of the blood volume fraction and other skin properties, provided that the applicability of the diffusion approximation is satisfied...
  36. ncbi Determination of optimal view angles for quantitative facial image analysis
    Byungjo Jung
    Yonsei University, Department of Biomedical Engineering, Korea, 220 710
    J Biomed Opt 10:024002. 2005
    ..From these results, we propose that optimal view angles can be identified using the mannequin head model to image specific regions of interest on the face of human subjects...
  37. ncbi Influence of laser wavelength and pulse duration on gas bubble formation in blood filled glass capillaries
    Sol Kimel
    Beckman Laser Institute, University of California, Irvine, California 92612, USA
    Lasers Surg Med 36:281-8. 2005
    ..CONCLUSIONS: For laser treatment of HVSL it appears that lambda is of secondary importance and that the choice of t(p) is a more important factor...
  38. ncbi Radial and temporal variations in surface heat transfer during cryogen spray cooling
    Walfre Franco
    Department of Mechanical Engineering, University of California, Riverside, CA 92521, USA
    Phys Med Biol 50:387-97. 2005
    ..The study shows that radial and temporal variations of boundary conditions must be taken into account and ideally controlled to guarantee uniform protection during CSC of human skin...
  39. ncbi A library based fitting method for visual reflectance spectroscopy of human skin
    Wim Verkruysse
    Beckman Laser Institute, University of California, Irvine, CA 92612, USA
    Phys Med Biol 50:57-70. 2005
    ..The method is demonstrated using both simulated and measured reflectance spectra. An additional advantage of the method is that the fitting procedure is very fast...
  40. ncbi Microvascular blood flow dynamics associated with photodynamic therapy, pulsed dye laser irradiation and combined regimens
    Tia K Smith
    Beckman Laser Institute, University of California, Irvine, California 92612, USA
    Lasers Surg Med 38:532-9. 2006
    ..PDT/PDL can enhance diminution of microvascular blood flow. Our results suggest that PDT and PDT/PDL should be evaluated as alternative therapeutic options for treatment of hypervascular skin lesions including port wine stain birthmarks...
  41. ncbi Cutaneous effects of cryogen spray cooling on in vivo human skin
    Nicole Datrice
    Beckman Laser Institute, Irvine, California 92612, USA
    Dermatol Surg 32:1007-12. 2006
    ..CONCLUSION: Acute erythema, urticaria, and, less commonly, transient hyperpigmentation were observed after CSC exposure. Permanent skin injury was not observed and is unlikely...
  42. ncbi Infrared measurement of human skin temperature to predict the individual maximum safe radiant exposure (IMSRE)
    Wim Verkruysse
    Beckman Laser Institute and Medical Clinic, University of California Irvine, 1002 Health Sciences Road East, Irvine, CA 92612, USA
    Lasers Surg Med 39:757-66. 2007
    ..An objective and quantitative method to assess the individual maximum safe radiant exposure (IMSRE) would help clinicians optimize LHR while at the same time providing the safest possible laser therapy...
  43. ncbi Noninvasive blood flow imaging for real-time feedback during laser therapy of port wine stain birthmarks
    Yu Chih Huang
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, California 92612, USA
    Lasers Surg Med 40:167-73. 2008
    ..To address this need, we propose use of laser speckle imaging (LSI) to provide real-time, quantitative feedback during laser surgery. Herein, we present in vitro and in vivo data collected with a clinic-based LSI instrument...
  44. ncbi Dynamic skin cooling with an environmentally compatible alternative cryogen during laser surgery
    Wangcun Jia
    Beckman Laser Institute, University of California Irvine, 1002 Health Sciences Road East, Irvine, CA 92612, USA
    Lasers Surg Med 39:776-81. 2007
    ..However, R134a has a very high global warming potential (GWP = 1300). Our objective was to evaluate the cooling effectiveness of an alternative cryogen with a much lower GWP, namely liquid carbon dioxide (CO(2), GWP = 1)...
  45. ncbi Polarization color imaging system for on-line quantitative evaluation of facial skin lesions
    Heesung Kang
    Department of Biomedical Engineering, Yonsei University, Wonju, Korea
    Dermatol Surg 33:1350-6. 2007
    ..Quantitative methods have limitations for widely distributed skin lesions due to poor spatial resolution, potential skin blanching, and difficulty in relocating identical sites for subsequent measurements and analysis...
  46. ncbi Treatment of cutaneous vascular lesions using multiple-intermittent cryogen spurts and two-wavelength laser pulses: numerical and animal studies
    Wangcun Jia
    Beckman Laser Institute, University of California, Irvine, California 92612 1475, USA
    Lasers Surg Med 39:494-503. 2007
    ..In this study, the feasibility of applying multiple cryogen spurts intermittently with multiple two-wavelength laser pulses (MCS-MTWLP) was studied using numerical and animal models...
  47. ncbi Extent of lateral epidermal protection afforded by a cryogen spray against laser irradiation
    Walfre Franco
    Department of Mechanical Engineering, University of California, Riverside, California 92521, USA
    Lasers Surg Med 39:414-21. 2007
    ..The objective of the present study is to investigate the extent of lateral epidermal protection afforded by a cryogen spray during laser irradiation...
  48. ncbi Enhancement of optical skin clearing efficacy using a microneedle roller
    Jinhee Yoon
    Yonsei University, Department of Biomedical Engineering, Wonju, Korea
    J Biomed Opt 13:021103. 2008
    ..In conclusion, our data suggest that the microneedle roller can be a good physical method to enhance transdermal delivery of optical clearing agents, and hence their optical clearing potential over large regions of skin...
  49. ncbi Pulsed photothermal temperature profiling of agar tissue phantoms
    Matija Milanic
    Jozef Stefan Institute, Jamova 39, 1000, Ljubljana, Slovenia
    Lasers Med Sci 22:279-84. 2007
    ..g., with two absorbing layers). The average full width at half maximum (FWHM) of the temperature peaks equals 23% of the layer depth...
  50. ncbi Analysis of facial sebum distribution using a digital fluorescent imaging system
    Byungkwan Han
    Yonsei University, Department of Biomedical Engineering, Wonju, Korea
    J Biomed Opt 12:014006. 2007
    ....
  51. ncbi Laser surgery of port wine stains using local vacuum [corrected] pressure: changes in calculated energy deposition (Part II)
    Walfre Franco
    Beckman Laser Institute, University of California, Irvine, California 92612, USA
    Lasers Surg Med 39:118-27. 2007
    ....
  52. ncbi Laser surgery of port wine stains using local vacuum pressure: changes in skin morphology and optical properties (Part I)
    Michael A Childers
    Department of Mechanical Engineering, University of California, Riverside, CA, USA
    Lasers Surg Med 39:108-17. 2007
    ....
  53. ncbi Hand-held pulsed photothermal radiometry system to estimate epidermal temperature rise during laser therapy
    Byungjo Jung
    Beckman Laser Institute, Irvine, CA, USA
    Skin Res Technol 12:292-7. 2006
    ..In order to measure DeltaT(epi) on a specific PWS skin site, we developed an AC-coupled hand-held pulsed photothermal radiometry (PPTR) system, which overcomes the in vivo measurement limitations of bench-top systems...
  54. ncbi Collagen solubility correlates with skin optical clearing
    Jason Hirshburg
    J Biomed Opt 11:040501. 2006
    ..Herein we show that a chemical agent's tissue optical clearing potential is directly related to its collagen solubility, providing a rational design basis for effective, percutaneous formulations...
  55. ncbi Effects of hypobaric pressure on human skin: implications for cryogen spray cooling (part II)
    Guillermo Aguilar
    Department of Mechanical Engineering, University of California, Riverside, California 92521, USA
    Lasers Surg Med 36:130-5. 2005
    ..The objective of the present study (Part II) is to investigate the effects of hypobaric pressures on the efficiency of cryogen spray cooling (CSC), a technique that assists laser therapy of PWS and other dermatoses...
  56. ncbi Comparison of 585 and 595 nm laser-induced vascular response of normal in vivo human skin
    Brian M Pikkula
    Department of Bioengineering, Rice University, Houston, Texas 77251, USA
    Lasers Surg Med 36:117-23. 2005
    ....
  57. ncbi Effects of hypobaric pressure on human skin: feasibility study for port wine stain laser therapy (part I)
    Guillermo Aguilar
    Department of Mechanical Engineering, University of California, Riverside, California 92521, USA
    Lasers Surg Med 36:124-9. 2005
    ..The aim of this feasibility study is to demonstrate that with the aid of a local vacuum applied to the lesion site prior to laser exposure, photocoagulation of the smaller PWS blood vessels may be successfully achieved...
  58. ncbi Influence of wavelength on response to laser photothermolysis of blood vessels: implications for port wine stain laser therapy
    Sol Kimel
    Beckman Laser Institute, University of California, Irvine, CA 92612, USA
    Lasers Surg Med 33:288-95. 2003
    ..To ensure deposition of sufficient laser energy, irradiation at 585 nm, characterized by lower optical penetration depth in blood, may be preferable for PWS therapy...
  59. ncbi Reversible dissociation of collagen in tissues
    Alvin T Yeh
    Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, California, USA
    J Invest Dermatol 121:1332-5. 2003
    ..These results reveal the assembly process of high-order collagen structures and propose a molecular mechanism for the increase in tissue transparency observed after glycerol application...
  60. ncbi Prospective study of pulsed dye laser in conjunction with cryogen spray cooling for treatment of port wine stains in Chinese patients
    Chun-Hung Chiu
    Department of Medicine, Division of Dermatology, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, ROC
    Dermatol Surg 29:909-15; discussion 915. 2003
    ..CONCLUSIONS: PDL-CSC was more effective than PDL alone for blanching of PWS in Chinese patients. Moreover, PDL-CSC was better tolerated and resulted in a lower incidence of acute adverse effects such as blistering...
  61. ncbi Effect of spurt duration on the heat transfer dynamics during cryogen spray cooling
    Guillermo Aguilar
    Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA
    Phys Med Biol 48:2169-81. 2003
    ..Based on the results of this model skin phantom, it is shown that spurts longer than 40 ms have a negligible impact on both q and Q within clinically relevant cooling times (10-100 ms)...
  62. ncbi Experimental study of cryogen spray properties for application in dermatologic laser surgery
    Guillermo Aguilar
    Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA
    IEEE Trans Biomed Eng 50:863-9. 2003
    ..5-0.8-mm-diameter nozzles (narrow nozzles). These results complement and support previously reported studies, indicating that wide nozzles induce more efficient heat extraction than the narrow nozzles...
  63. ncbi In vivo port-wine stain depth determination with a photoacoustic probe
    John A Viator
    Beckman Laser Institute, University of California, Irvine, 1002 Health Sciences Road East, Irvine, Calfornia 92612, USA
    Appl Opt 42:3215-24. 2003
    ..In vivo measurements of PWS skin with different epidermal melanin concentrations correlated with the phantoms. Thus the photoacoustic probe can be used to determine PWS depth for most patients receiving laser therapy...
  64. ncbi Spectra from 2.5-15 microm of tissue phantom materials, optical clearing agents and ex vivo human skin: implications for depth profiling of human skin
    John A Viator
    Beckman Laser Institute, University of California, 1002 Health Sciences Road East, Irvine, CA 92612, USA
    Phys Med Biol 48:N15-24. 2003
    ..In such cases, overestimating mu(ir) will underestimate chromophore depth and vice versa, although the effect is dependent on actual chromophore depth...
  65. ncbi Effects of mass flow rate and droplet velocity on surface heat flux during cryogen spray cooling
    Emil Karapetian
    Department of Chemical Engineering and Material Sciences, University of California, Irvine, CA 92697, USA
    Phys Med Biol 48:N1-6. 2003
    ..However, for fully atomized sprays with small flow rates, droplet velocity can make a substantial difference in the surface heat flux...
  66. ncbi Dynamic behavior of cryogen spray cooling: effects of spurt duration and spray distance
    Guillermo Aguilar
    Department of Biomedical Engineering, University of California, Irvine, California 92697, USA
    Lasers Surg Med 32:152-9. 2003
    ..The objective of this study is to measure accurately temperature variations at the sprayed surface and the effects of spurt duration (deltat) and nozzle-to-sprayed surface distance (L) on cooling dynamics during CSC...
  67. ncbi Measurements of laser light attenuation following cryogen spray cooling spurt termination
    Ahmad Edris
    College of Medicine, University of California, Irvine, California 92697, USA
    Lasers Surg Med 32:143-7. 2003
    ..CONCLUSIONS: For the typical clinical use of a 30 milliseconds spurt duration and 30 milliseconds delay between spurt termination and delivery of the laser pulse, a minimum average transmittance value of approximately 97% was measured...
  68. ncbi Intermittent cryogen spray cooling for optimal heat extraction during dermatologic laser treatment
    Boris Majaron
    Jozef Stefan Institute, Ljubljana, Slovenia
    Phys Med Biol 47:3275-88. 2002
    ..On the other hand, lower duty cycles allow a substantial reduction in the average rate of heat extraction, enabling less aggressive and more efficient CSC for treatment of deeper targets, such as hair follicles...
  69. ncbi Cryogen spray cooling efficiency: improvement of port wine stain laser therapy through multiple-intermittent cryogen spurts and laser pulses
    Guillermo Aguilar
    Center for Biomedical Engineering, Beckman Laser Institute and Medical Clinic, University of California Irvine, 1002 Health Sciences Road East, Irvine, CA 92697, USA
    Lasers Surg Med 31:27-35. 2002
    ....
  70. ncbi Spectral variation of the infrared absorption coefficient in pulsed photothermal profiling of biological samples
    Boris Majaron
    Jozef Stefan Institute, Jamova, Ljubljana, Slovenia
    Phys Med Biol 47:1929-46. 2002
    ..Implementation of the latter approach for depth profiling of port wine stain birthmarks in vivo is presented and discussed...
  71. ncbi Evaluation of cryogen spray cooling exposure on in vitro model human skin
    Bunsho Kao
    Beckman Laser Institute and Medical Clinic, Irvine, California 92612, USA
    Lasers Surg Med 34:146-54. 2004
    ..CONCLUSIONS: Continuous CSC spurts of 80 milliseconds or less induce minimal, if any, epidermal or dermal damage and are unlikely to produce cryo-injury when used during dermatologic laser surgery...
  72. ncbi Effect of skin indentation on heat transfer during cryogen spray cooling
    Brooke Basinger
    Beckman Laser Institute, University of California, Irvine, California 92612, USA
    Lasers Surg Med 34:155-63. 2004
    ..This suggests that higher momentum sprays (which produce larger skin indentations for identical spurts) than those in current clinical use may improve CSC efficiency...
  73. ncbi Skin model surface temperatures during single and multiple cryogen spurts used in laser dermatologic surgery
    Julio C Ramirez-San-Juan
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, California 92612, USA
    Lasers Surg Med 36:141-6. 2005
    ....
  74. ncbi Removal of a mirror image and enhancement of the signal-to-noise ratio in Fourier-domain optical coherence tomography using an electro-optic phase modulator
    Jun Zhang
    Beckman Laser Institute and the Center for Biomedical Engineering, University of California, Irvine, Irvine, California 92612, USA
    Opt Lett 30:147-9. 2005
    ..The imaging range was doubled by cancellation of the mirror image. The elimination of low-frequency noises resulting from dc and autocorrelation terms increased the sensitivity by 20 dB...
  75. ncbi Determination of chemical agent optical clearing potential using in vitro human skin
    Bernard Choi
    Beckman Laser Institute, University of California, Irvine, California 92612, USA
    Lasers Surg Med 36:72-5. 2005
    ..Optical clearing is a method that temporarily reduces the optical scattering of biological tissues...
  76. ncbi Heat-transfer dynamics during cryogen spray cooling of substrate at different initial temperatures
    Wangcun Jia
    Beckman Laser Institute, University of California, Irvine, CA 92612 1475, USA
    Phys Med Biol 49:5295-308. 2004
    ..It is concluded that heat transfer between the cryogen spray and skin phantom remains in the nucleate boiling region even if T0 is 80 degrees C...
  77. ncbi Compensation of polarization-dependent loss in transmission fiber gratings by use of a Sagnac loop interferometer
    Chang Seok Kim
    Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA
    Opt Lett 30:20-2. 2005
    ..The result is verified experimentally for a fiber acousto-optic tunable filter and cascaded long-period fiber gratings with either intrinsic or process-induced polarization-dependent filtering characteristics...
  78. ncbi Depth-resolved birefringence and differential optical axis orientation measurements with fiber-based polarization-sensitive optical coherence tomography
    Shuguang Guo
    Beckman Laser Institute, Department of Biomedical Engineering, University of California, Irvine, Irvine, California 92612, USA
    Opt Lett 29:2025-7. 2004
    ..Experimental results with beef tendon and rabbit tendon and muscle show that this technique has promising potential for imaging the birefringent structure of multiple-layer samples with varying optical axes...
  79. ncbi Accurate measurement of blood vessel depth in port wine stained human skin in vivo using pulsed photothermal radiometry
    Bincheng Li
    University of California at Irvine, Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Road East, Irvine, California 92612, USA
    J Biomed Opt 9:961-6. 2004
    ..The most superficial PWS depths determined in vivo by PPTR are in good agreement with those measured using optical Doppler tomography (ODT)...
  80. ncbi Laser speckle imaging for monitoring blood flow dynamics in the in vivo rodent dorsal skin fold model
    Bernard Choi
    Beckman Laser Institute, University of California, Irvine, 92612, USA
    Microvasc Res 68:143-6. 2004
  81. ncbi Combined photodynamic and photothermal induced injury enhances damage to in vivo model blood vessels
    Kristen M Kelly
    Beckman Laser Institute, University of California, Irvine, California 92612, USA
    Lasers Surg Med 34:407-13. 2004
    ..The objective was to evaluate a novel methodology for selective vascular damage, combined photodynamic (PDT) and photothermal (PDL) treatment, using the in vivo chick chorioallantoic membrane (CAM) model...
  82. ncbi Influence of angle between the nozzle and skin surface on the heat flux and overall heat extraction during cryogen spray cooling
    Guillermo Aguilar
    Department of Mechanical Engineering, University of California, Riverside, CA 92521, USA
    Phys Med Biol 49:N147-53. 2004
    ..This study proves that the slight angle that many commercial nozzles have does not affect significantly the CSC efficiency...
  83. ncbi On the physics of laser-induced selective photothermolysis of hair follicles: Influence of wavelength, pulse duration, and epidermal cooling
    Lars O Svaasand
    Norwegian University of Science and Technology, NO 7491 Trondheim, Norway
    J Biomed Opt 9:353-61. 2004
    ..Thermal quenching of laser induced epidermal temperature rise after pulsed exposure can most efficiently be done with a 20 ms cryogen spurt applied immediately after irradiation...
  84. ncbi Use of optical coherence tomography to monitor biological tissue freezing during cryosurgery
    Bernard Choi
    Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA
    J Biomed Opt 9:282-6. 2004
    ..OCT can be used as a feedback tool during cryosurgical procedures to monitor progression of the freezing front...
  85. ncbi Imaging wound healing using optical coherence tomography and multiphoton microscopy in an in vitro skin-equivalent tissue model
    Alvin T Yeh
    University of California, Beckman Laser Institute, Laser Microbeam and Medical Program, 1002 Health Sciences Road East, Irvine, California 92612, USA
    J Biomed Opt 9:248-53. 2004
    ..This study illustrates the complementary features of linear and nonlinear light-tissue interaction in intrinsic signal optical imaging and their use for noninvasive, serial monitoring of wound healing processes in biological tissues...
  86. ncbi Coherent thermal wave imaging of subsurface chromophores in biological materials
    Sergev A Telenko
    Biomedical Engineering Program, University of Texas at Austin, 78712, USA
    Phys Med Biol 47:657-71. 2002
    ....