David R Nelson

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc Hepatitis C virus: a critical appraisal of new approaches to therapy
    David R Nelson
    Clinical and Translational Science Institute, University of Florida, 1600 SW Archer Road, Room M440, Medical Science Building, Gainesville, FL 32610, USA
    Hepat Res Treat 2012:138302. 2012
  2. doi request reprint The role of triple therapy with protease inhibitors in hepatitis C virus genotype 1 naïve patients
    David R Nelson
    Clinical and Translational Science Institute, University of Florida, FL 32610, USA
    Liver Int 31:53-7. 2011
  3. pmc CC genotype donors for the interleukin-28B single nucleotide polymorphism are associated with better outcomes in hepatitis C after liver transplant
    Roberto J Firpi
    Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition Section of Hepatobiliary Diseases and Liver Transplantation, University of Florida, Gainesville, Florida 32610 0214, USA
    Liver Int 33:72-8. 2013
  4. doi request reprint The use of cyclosporine for recurrent hepatitis C after liver transplant: a randomized pilot study
    Roberto J Firpi
    Division of Gastroenterology, Hepatology and Nutrition, Section of Hepatobiliary Diseases and Liver Transplantation, Department of Medicine, University of Florida, Gainesville, FL 32610 0214, USA
    Dig Dis Sci 55:196-203. 2010
  5. doi request reprint The natural history of hepatitis C cirrhosis after liver transplantation
    Roberto J Firpi
    Section of Hepatobiliary Diseases, Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, FL 32610 0214, USA
    Liver Transpl 15:1063-71. 2009
  6. ncbi request reprint Sustained viral response to interferon and ribavirin in liver transplant recipients with recurrent hepatitis C
    Manal F Abdelmalek
    Department of Medicine, Section of Hepatobiliary Diseases University of Florida, Gainesville, FL 32610 0214, USA
    Liver Transpl 10:199-207. 2004
  7. ncbi request reprint Hepatitis C virus triggers apoptosis of a newly developed hepatoma cell line through antiviral defense system
    Haizhen Zhu
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
    Gastroenterology 133:1649-59. 2007
  8. ncbi request reprint Cyclosporine suppresses hepatitis C virus in vitro and increases the chance of a sustained virological response after liver transplantation
    Roberto J Firpi
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Section of Hepatobiliary Diseases, University of Florida, Gainesville, FL 32610 0214, USA
    Liver Transpl 12:51-7. 2006
  9. ncbi request reprint Long-term interleukin 10 therapy in chronic hepatitis C patients has a proviral and anti-inflammatory effect
    David R Nelson
    Department of Medicine, University of Florida, 1600 S W Archer Road, PO Box 100214, Gainesville, FL 32610 0214, USA
    Hepatology 38:859-68. 2003
  10. pmc Albinterferon Alfa-2b was not inferior to pegylated interferon-α in a randomized trial of patients with chronic hepatitis C virus genotype 2 or 3
    David R Nelson
    University of Florida, Gainesville, Florida, USA
    Gastroenterology 139:1267-76. 2010

Detail Information

Publications49

  1. pmc Hepatitis C virus: a critical appraisal of new approaches to therapy
    David R Nelson
    Clinical and Translational Science Institute, University of Florida, 1600 SW Archer Road, Room M440, Medical Science Building, Gainesville, FL 32610, USA
    Hepat Res Treat 2012:138302. 2012
    ..In this new era of DAAs, a comprehensive and critical analysis of the literature is needed to equip clinicians with the knowledge necessary to design, monitor, and modify treatment regimens in order to optimize patient outcomes...
  2. doi request reprint The role of triple therapy with protease inhibitors in hepatitis C virus genotype 1 naïve patients
    David R Nelson
    Clinical and Translational Science Institute, University of Florida, FL 32610, USA
    Liver Int 31:53-7. 2011
    ..However, these dramatic gains will be partially offset by new challenges in viral resistance and increased adverse events...
  3. pmc CC genotype donors for the interleukin-28B single nucleotide polymorphism are associated with better outcomes in hepatitis C after liver transplant
    Roberto J Firpi
    Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition Section of Hepatobiliary Diseases and Liver Transplantation, University of Florida, Gainesville, Florida 32610 0214, USA
    Liver Int 33:72-8. 2013
    ..We sought to examine the role of IL-28B polymorphisms of donor and recipients in liver transplant patients with recurrent HCV and its impact on the response to interferon-based therapy...
  4. doi request reprint The use of cyclosporine for recurrent hepatitis C after liver transplant: a randomized pilot study
    Roberto J Firpi
    Division of Gastroenterology, Hepatology and Nutrition, Section of Hepatobiliary Diseases and Liver Transplantation, Department of Medicine, University of Florida, Gainesville, FL 32610 0214, USA
    Dig Dis Sci 55:196-203. 2010
    ..We performed a pilot study to prospectively determine the antiviral effect of cyclosporine during therapy with PEGalfa-2a and ribavirin in liver transplant recipients with recurrent HCV infection...
  5. doi request reprint The natural history of hepatitis C cirrhosis after liver transplantation
    Roberto J Firpi
    Section of Hepatobiliary Diseases, Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, FL 32610 0214, USA
    Liver Transpl 15:1063-71. 2009
    ..The Model for End-Stage Liver Disease can stratify risk for decompensation and survival, whereas successful antiviral therapy may be protective...
  6. ncbi request reprint Sustained viral response to interferon and ribavirin in liver transplant recipients with recurrent hepatitis C
    Manal F Abdelmalek
    Department of Medicine, Section of Hepatobiliary Diseases University of Florida, Gainesville, FL 32610 0214, USA
    Liver Transpl 10:199-207. 2004
    ..05). In conclusion, loss of HCV after treatment of recurrent chronic hepatitis C with interferon and ribavirin is durable, and the durability of the SVR is associated with improvement in hepatic inflammation and regression of fibrosis...
  7. ncbi request reprint Hepatitis C virus triggers apoptosis of a newly developed hepatoma cell line through antiviral defense system
    Haizhen Zhu
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
    Gastroenterology 133:1649-59. 2007
    ..However, the interaction between HCV and hepatocyte innate antiviral defense systems is not understood. The aim of this study was to examine how human hepatocytes respond to HCV infection...
  8. ncbi request reprint Cyclosporine suppresses hepatitis C virus in vitro and increases the chance of a sustained virological response after liver transplantation
    Roberto J Firpi
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Section of Hepatobiliary Diseases, University of Florida, Gainesville, FL 32610 0214, USA
    Liver Transpl 12:51-7. 2006
    ..In conclusion, Cyclosporine may offer an advantage to Tacrolimus in those patients undergoing interferon-based therapy and should be studied in a prospective randomized trial...
  9. ncbi request reprint Long-term interleukin 10 therapy in chronic hepatitis C patients has a proviral and anti-inflammatory effect
    David R Nelson
    Department of Medicine, University of Florida, 1600 S W Archer Road, PO Box 100214, Gainesville, FL 32610 0214, USA
    Hepatology 38:859-68. 2003
    ..In conclusion, long-term rIL-10 therapy appears to decrease disease activity, but also leads to increased HCV viral burden via alterations in immunologic viral surveillance...
  10. pmc Albinterferon Alfa-2b was not inferior to pegylated interferon-α in a randomized trial of patients with chronic hepatitis C virus genotype 2 or 3
    David R Nelson
    University of Florida, Gainesville, Florida, USA
    Gastroenterology 139:1267-76. 2010
    ....
  11. ncbi request reprint Defective Jak-Stat activation in hepatoma cells is associated with hepatitis C viral IFN-alpha resistance
    Haizhen Zhu
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, 32610, USA
    J Interferon Cytokine Res 25:528-39. 2005
    ..Our study implies that long-term IFN stimulation in vitro selects cells that exhibit alterations in the host Jak-Stat signaling pathway, thereby representing a potential mechanism by which HCV resists IFN therapy...
  12. pmc Immune modulation of effector CD4+ and regulatory T cell function by sorafenib in patients with hepatocellular carcinoma
    Roniel Cabrera
    Department of Medicine, Section of Hepatobiliary Diseases, University of Florida, 1600 SW Archer Rd, P O Box 100214, Gainesville, FL 32610 0214, USA
    Cancer Immunol Immunother 62:737-46. 2013
    ..In conclusion, this study describes novel immune activating properties of low doses of sorafenib by promoting immune responsiveness in patients with HCC...
  13. ncbi request reprint One-year protocol liver biopsy can stratify fibrosis progression in liver transplant recipients with recurrent hepatitis C infection
    Roberto J Firpi
    Division of Gastroenterology, Hepatology, and Nutrition Section of Hepatobiliary Diseases, University of Florida, Gainesville, FL 32610 0214, USA
    Liver Transpl 10:1240-7. 2004
    ..A liver biopsy performed at 1 year posttransplant can help identify those patients more likely to develop progressive disease and may allow better targeting of antiviral therapy...
  14. pmc Treatment outcomes and prognostic factors of intrahepatic cholangiocarcinoma
    Renumathy Dhanasekaran
    Department of Medicine, University of Florida, Gainesville, FL, USA
    Oncol Rep 29:1259-67. 2013
    ..The overriding factors influencing outcome were stage and the presence of microvascular invasion on pathology...
  15. ncbi request reprint Impact of implementation of the MELD scoring system on the prevalence and incidence of chronic renal disease following liver transplantation
    Victor I Machicao
    Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, FL 32610 0214, USA
    Liver Transpl 12:754-61. 2006
    ..In conclusion, the implementation of the MELD allocation system is not associated with increased mortality or occurrence of CRD-3 or CRD-4 in the first 2 years after LT...
  16. pmc Novel type I interferon IL-28A suppresses hepatitis C viral RNA replication
    Haizhen Zhu
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida 32610, USA
    Virol J 2:80. 2005
    ..The effectiveness of IL-28A antiviral activity and its synergistic effect on IFN-alpha indicate that IL-28A may be potentially used to treat HCV chronic infection...
  17. ncbi request reprint An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection
    Roniel Cabrera
    Section of Hepatobiliary Diseases, Department of Medicine, University of Florida, Gainesville, FL 32610 0214, USA
    Hepatology 40:1062-71. 2004
    ..In conclusion, CD4(+)CD25(+) T lymphocytes constitute a highly differentiated population and appear to play a role in viral persistence by suppressing HCV-specific T cell responses in a cell-cell contact manner...
  18. pmc Hepatocellular carcinoma immunopathogenesis: clinical evidence for global T cell defects and an immunomodulatory role for soluble CD25 (sCD25)
    Roniel Cabrera
    Section of Hepatobiliary Diseases, Department of Medicine, University of Florida, 1600 SW Archer Rd, PO Box 100214, Gainesville, FL 32610 0214, USA
    Dig Dis Sci 55:484-95. 2010
    ..The mechanisms involved in hepatocellular carcinoma (HCC) establishing an immunologically tolerogenic tumor environment remain poorly characterized...
  19. doi request reprint Safety and antiviral activity of albinterferon alfa-2b in prior interferon nonresponders with chronic hepatitis C
    David R Nelson
    University of Florida College of Medicine, Box 100214, Room M 440, Gainesville, Florida 32610 0214, USA
    Clin Gastroenterol Hepatol 7:212-8. 2009
    ..This phase 2 study evaluated the safety/efficacy of albinterferon in CHC patients who had not responded to interferon-based regimens...
  20. doi request reprint New therapeutic strategies in HCV: second-generation protease inhibitors
    Virginia C Clark
    University of Florida, FL, USA
    Liver Int 33:80-4. 2013
    ..The true second-generation protease inhibitors are in earlier stages of development and efficacy data are anxiously awaited as they may provide pan-genotypic antiviral activity and a high genetic barrier to resistance...
  21. doi request reprint Is early recurrence of hepatitis C associated with biliary anastomotic stricture after liver transplantation?
    Shiro Fujita
    Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610 0286, USA
    Transplantation 84:1631-5. 2007
    ..The aim of the current study is to determine if recurrence of hepatitis C affects biliary complications after LT, with special reference to late biliary anastomotic strictures (LBAS)...
  22. pmc Low prevalence of HBV DNA in the liver allograft from anti-HBc-positive donors: a single-center experience
    Jen Jung Pan
    Section of Hepatobiliary Diseases, Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Florida, FL, USA
    Clin Transplant 25:164-70. 2011
    ..Prophylaxis for HBV is important for seronegative recipients receiving a liver from an anti-HBc(+) donor. Such prophylaxis may not be necessary for recipients who do not have detectable HBV DNA in the liver allograft...
  23. pmc OPA1 downregulation is involved in sorafenib-induced apoptosis in hepatocellular carcinoma
    Xiangxuan Zhao
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA
    Lab Invest 93:8-19. 2013
    ..Our results provide new insights into the pathogenesis of HCC and suggest that OPA1 is a novel therapeutic target in patients with HCC...
  24. pmc Balapiravir plus peginterferon alfa-2a (40KD)/ribavirin in a randomized trial of hepatitis C genotype 1 patients
    David R Nelson
    Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainsville, USA
    Ann Hepatol 11:15-31. 2012
    ..This phase 2, double-blind international trial evaluated the optimal treatment regimen of balapiravir plus peginterferon alfa-2a (40KD)/ribavirin...
  25. ncbi request reprint Hepatocellular carcinoma cell supernatants increase expansion and function of CD4(+)CD25(+) regulatory T cells
    Mengde Cao
    Section of Hepatobiliary Diseases, Department of Medicine, University of Florida, Gainesville, FL 32610 0214, USA
    Lab Invest 87:582-90. 2007
    ..In conclusion, these results strongly suggest that tumor-related factors not only induce and expand CD4(+)CD25(+) cells, but also enhance their suppressor ability...
  26. pmc Kinase inhibitor Sorafenib modulates immunosuppressive cell populations in a murine liver cancer model
    Mengde Cao
    Department of Medicine, University of Florida, Gainesville, FL 32610, USA
    Lab Invest 91:598-608. 2011
    ..In conclusion, our study strongly suggests that Sorafenib can enhance anti-tumor immunity via modulating immunosuppressive cell populations in the murine liver cancer model...
  27. doi request reprint Factors predicting survival after transjugular intrahepatic portosystemic shunt creation: 15 years' experience from a single tertiary medical center
    Jen Jung Pan
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, 1600 Southwest Archer Road, Room M 440, Gainesville, FL 32610, USA
    J Vasc Interv Radiol 19:1576-81. 2008
    ..This retrospective analysis was conducted to identify factors predictive of survival after transjugular intrahepatic portosystemic shunt (TIPS) creation...
  28. ncbi request reprint Late presentation of a biliary tract complication after right hepatic donation resulting in secondary biliary cirrhosis
    Giuseppe Morelli
    Division of Gastroenterology and Hepatology and Nutrition Section of Biliary Diseases and Liver Transplantation, University of Florida, Gainesville, FL 32610 0214, USA
    Liver Transpl 12:306-9. 2006
  29. doi request reprint Novel interferons for treatment of hepatitis C virus
    Virginia Clark
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Florida, Gainesville, FL 32610, USA
    Clin Liver Dis 13:351-63. 2009
    ..This review highlights novel interferons under development that may offer therapeutic advantages over the formulations currently available...
  30. pmc Deep sequencing analysis of HCV NS3 resistance-associated variants and mutation linkage in liver transplant recipients
    Mariana E Kirst
    College of Medicine, Department of Medicine, Division of Infectious Diseases and Global Medicine, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 8:e69698. 2013
    ..The methods described here should facilitate the analysis of low frequency HCV drug resistance, mutation linkage and evolution, which may inform future therapeutic strategies in patients undergoing direct acting antiviral therapies. ..
  31. pmc Neutrophil-lymphocyte ratio predicts overall and recurrence-free survival after liver transplantation for hepatocellular carcinoma
    Alpna R Limaye
    Section of Hepatobiliary Diseases, Department of Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, Florida, USA
    Hepatol Res 43:757-64. 2013
    ..We hypothesize that the NLR is predictive of overall survival (OS) and recurrence-free survival (RFS) in patients with HCC who undergo LT...
  32. ncbi request reprint Current and future hepatitis C therapies
    Roberto J Firpi
    Section of Hepatobiliary Diseases and Liver Transplantation, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, Gainesville, Florida 32610 0214, USA
    Arch Med Res 38:678-90. 2007
    ..This review will focus on current therapies for hepatitis C and the most recent advances in the search for new therapies...
  33. pmc The role of ribavirin in direct acting antiviral drug regimens for chronic hepatitis C
    Virginia Clark
    University of Florida, College of Medicine, Gainesville, FL 32610, USA
    Liver Int 32:103-7. 2012
    ..It is remarkable that the age-old question of the role of RBV in the future of HCV therapy remains as real today as it was two decades ago...
  34. ncbi request reprint Short recovery time after percutaneous liver biopsy: should we change our current practices?
    Roberto J Firpi
    Division of Gastroenterology, Hepatology and Nutrition Section of Hepatobiliary Diseases, University of Florida, 1600 SW Archer Road, PO Box 100214, Gainesville, FL 32610 0214, USA
    Clin Gastroenterol Hepatol 3:926-9. 2005
    ..The aim of this study was to determine whether ambulatory patients requiring percutaneous liver biopsy can be safely discharged after a short recovery time period...
  35. pmc Characterization of Anti-HCV Antibodies in IL-10-Treated Patients
    Erika A Eksioglu
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
    Viral Immunol 23:359-68. 2010
    ..We have found that IL-10-treated patients have significantly lower HCV antibodies, but maintain the total anti-HCV antibody titer, suggesting a novel mechanism by which IL-10 treatment increases viral load in patients...
  36. ncbi request reprint Combination of interferon alfa-2b and ribavirin in liver transplant recipients with histological recurrent hepatitis C
    Roberto J Firpi
    Department of Medicine, Section of Hepatobiliary Diseases, University of Florida, Gainesville, FL 32610, USA
    Liver Transpl 8:1000-6. 2002
    ..In summary, combination therapy is a reasonable antiviral option for recurrent HCV infection for established post-LT hepatitis and appears to prevent histological progression of disease if viral eradication is successful...
  37. ncbi request reprint Betaine resolves severe alcohol-induced hepatitis and steatosis following liver transplantation
    Karim Samara
    Department of Internal Medicine, University of Florida, Gainesville, Florida 32608 0214, USA
    Dig Dis Sci 51:1226-9. 2006
  38. ncbi request reprint Stabilized beta-catenin promotes hepatocyte proliferation and inhibits TNFalpha-induced apoptosis
    Xian Zhang Shang
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida, P O Box 100275, Gainesville, FL 32610, USA
    Lab Invest 84:332-41. 2004
    ..Our study suggests that mutant beta-catenin can promote cell proliferation and cell survival ability, but the stabilized beta-catenin alone is insufficient for completely oncogenic transformation...
  39. doi request reprint Management of viral hepatitis in hematologic malignancies
    Roberto J Firpi
    Division of Gastroenterology, Hepatology and Nutrition Section of Hepatobiliary Diseases and Liver Transplantation, University of Florida Gainesville, FL 32610 0214, USA
    Blood Rev 22:117-26. 2008
    ..In this review we will highlight the mechanisms of virus reactivation, clinical manifestations, and management strategies to minimize acute and chronic morbidity in this population...
  40. ncbi request reprint Tobacco use before and after liver transplantation: a single center survey and implications for clinical practice and research
    Shawna L Ehlers
    Department of Clinical and Health Psychology, University of Florida Health Science Center, Gainesville FL 32610 0165, USA
    Liver Transpl 10:412-7. 2004
    ....
  41. pmc Trends in the prevalence of thrombocytopenia among individuals infected with hepatitis C virus in the United States, 1999-2008
    Teresa L Kauf
    Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, Florida, USA
    BMC Res Notes 5:142. 2012
    ..Bi-yearly data from the 1999-2000 to 2007-2008 National Health and Nutrition Examination Surveys (NHANES) were used to examine the prevalence of thrombocytopenia among HCV-infected individuals in the United States...
  42. pmc Liver test results do not identify liver disease in adults with α(1)-antitrypsin deficiency
    Virginia C Clark
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, Gainesville, Florida 32610 0214, USA
    Clin Gastroenterol Hepatol 10:1278-83. 2012
    ..We evaluated this recommendation in a large group of adults with A-AT deficiency to determine the prevalence of increased levels of alanine aminotransferase (ALT) and identify risk factors for liver disease...
  43. ncbi request reprint CD8+ T-cell interaction with HCV replicon cells: evidence for both cytokine- and cell-mediated antiviral activity
    Chen Liu
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA
    Hepatology 37:1335-42. 2003
    ..This T-cell/HCV subgenomic replicon system represents a model for the investigation of CD8 cell interaction with HCV-infected hepatocytes...
  44. ncbi request reprint Anti-hepatitis C virus activity of albinterferon alfa-2b in cell culture
    Chen Liu
    Department of Pathology, University of Florida, Gainesville, Florida, USA
    Hepatol Res 37:941-7. 2007
    ..Conclusion: The present study indicates that alb-IFN has a potent, direct anti-HCV activity in both liver and non-liver cells...
  45. ncbi request reprint Familial aggregation of insulin resistance in first-degree relatives of patients with nonalcoholic fatty liver disease
    Manal F Abdelmalek
    Division of Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, Florida, USA
    Clin Gastroenterol Hepatol 4:1162-9. 2006
    ..An association between nonalcoholic fatty liver disease (NAFLD) and the insulin resistance (IR) syndrome exists. Familial clustering of IR may support a genetic predisposition to NAFLD or cryptogenic cirrhosis (CC)...
  46. pmc Diagnosis and management of patients with α1-antitrypsin (A1AT) deficiency
    David R Nelson
    Department of Medicine, University of Florida, Gainesville, Florida, USA
    Clin Gastroenterol Hepatol 10:575-80. 2012
    ..We sought to present a rational approach for hepatologists to manage adult patients with A1AT deficiency...
  47. ncbi request reprint A brief psychological intervention to improve adherence following transplantation
    Gail L Lisson
    Department of Clinical and Health Psychology, University of Florida, Gainesville, FL 32610 0165, USA
    Ann Transplant 10:52-7. 2005
    ..This intervention has been very favorably received by patients, caregivers, transplant physicians, and nurse coordinators...
  48. doi request reprint New therapies in the management of hepatitis C virus
    Anthony J Michaels
    Division of Hepatology and Liver Transplantation, Shands Hospital, University of Florida, Gainesville, Florida, USA
    Curr Opin Gastroenterol 26:196-201. 2010
    ..This article will discuss the most promising up-to-date hepatitis C virus antiviral therapies in clinical investigation as well as the associated clinical trial results...
  49. ncbi request reprint Lack of antiviral effect of a short course of mycophenolate mofetil in patients with chronic hepatitis C virus infection
    Roberto J Firpi
    Section of Hepatobiliary Diseases, Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, PO Box 100214, JHMHC, Gainesville, FL 32610 0214, USA
    Liver Transpl 9:57-61. 2003
    ..The most common side effects were headache, nausea, and diarrhea. Mycophenolate alone does not appear to have a significant antiviral or biochemical effect in patients with chronic hepatitis C...