ANDRE ELIAS NEL

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Toxic potential of materials at the nanolevel
    Andre Nel
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:622-7. 2006
  2. doi A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment
    Andre E Nel
    Department of Medicine, Division of NanoMedicine, University of California Center for Environmental Implications of Nanotechnology, University of California, Los Angeles, California 90095, United States
    ACS Nano 7:6422-33. 2013
  3. doi Nanomaterial toxicity testing in the 21st century: use of a predictive toxicological approach and high-throughput screening
    Andre Nel
    Department of Medicine, Division of NanoMedicine, University of California, Los Angeles, CA 90095, USA
    Acc Chem Res 46:607-21. 2013
  4. pmc Particulate matter and atherosclerosis: role of particle size, composition and oxidative stress
    Jesus A Araujo
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Part Fibre Toxicol 6:24. 2009
  5. pmc Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells
    Ke Wei Gong
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Genome Biol 8:R149. 2007
  6. doi Understanding biophysicochemical interactions at the nano-bio interface
    Andre E Nel
    Division of NanoMedicine, David Geffen School of Medicine and California NanoSystems Institute at UCLA, Los Angeles, California 90095, USA
    Nat Mater 8:543-57. 2009
  7. ncbi Atmosphere. Air pollution-related illness: effects of particles
    Andre Nel
    Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Science 308:804-6. 2005
  8. ncbi Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation
    Ray Chun Fai Chan
    Division of Clinical Immunology and Allergy, Department of Medicine, University of California Los Angeles, CA 90095, USA
    J Allergy Clin Immunol 118:455-65. 2006
  9. ncbi The University of California Center for the Environmental Implications of Nanotechnology
    Hilary A Godwin
    University of California, School of Public Health, Los Angeles, CA, USA
    Environ Sci Technol 43:6453-7. 2009
  10. pmc The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles
    Ning Li
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, CA 90095, USA
    Free Radic Biol Med 44:1689-99. 2008

Collaborators

Detail Information

Publications41

  1. ncbi Toxic potential of materials at the nanolevel
    Andre Nel
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:622-7. 2006
    ..The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable...
  2. doi A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment
    Andre E Nel
    Department of Medicine, Division of NanoMedicine, University of California Center for Environmental Implications of Nanotechnology, University of California, Los Angeles, California 90095, United States
    ACS Nano 7:6422-33. 2013
    ..After lively discussions, a short list of generally shared viewpoints on this topic was generated, including a general view that ATS approaches for ENMs can significantly benefit chemical safety analysis. ..
  3. doi Nanomaterial toxicity testing in the 21st century: use of a predictive toxicological approach and high-throughput screening
    Andre Nel
    Department of Medicine, Division of NanoMedicine, University of California, Los Angeles, CA 90095, USA
    Acc Chem Res 46:607-21. 2013
    ....
  4. pmc Particulate matter and atherosclerosis: role of particle size, composition and oxidative stress
    Jesus A Araujo
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Part Fibre Toxicol 6:24. 2009
    ..This article reviews the supporting epidemiological and animal data, possible pathogenic mechanisms and future perspectives...
  5. pmc Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells
    Ke Wei Gong
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Genome Biol 8:R149. 2007
    ..We hypothesize that these pro-oxidative chemicals could synergize with oxidized lipid components generated in low-density lipoprotein particles to enhance vascular inflammation and atherosclerosis...
  6. doi Understanding biophysicochemical interactions at the nano-bio interface
    Andre E Nel
    Division of NanoMedicine, David Geffen School of Medicine and California NanoSystems Institute at UCLA, Los Angeles, California 90095, USA
    Nat Mater 8:543-57. 2009
    ..This knowledge is important from the perspective of safe use of nanomaterials...
  7. ncbi Atmosphere. Air pollution-related illness: effects of particles
    Andre Nel
    Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Science 308:804-6. 2005
  8. ncbi Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation
    Ray Chun Fai Chan
    Division of Clinical Immunology and Allergy, Department of Medicine, University of California Los Angeles, CA 90095, USA
    J Allergy Clin Immunol 118:455-65. 2006
    ..Diesel exhaust particles (DEPs), a model pollutant, act as an adjuvant for allergic sensitization. Increasing evidence shows that this effect could be mediated by an effect on dendritic cells (DCs)...
  9. ncbi The University of California Center for the Environmental Implications of Nanotechnology
    Hilary A Godwin
    University of California, School of Public Health, Los Angeles, CA, USA
    Environ Sci Technol 43:6453-7. 2009
    ..Assessing nanomaterialsfor human health and ecotoxicological impact can be well aided by using high-throughput laboratory methods...
  10. pmc The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles
    Ning Li
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, CA 90095, USA
    Free Radic Biol Med 44:1689-99. 2008
    ..The importance of cellular antioxidant and detoxification pathways in protecting against particle-induced lung damage will also be discussed...
  11. doi Potential health impact of nanoparticles
    Tian Xia
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, USA
    Annu Rev Public Health 30:137-50. 2009
    ..This review discusses the toxicological potential of NMs by comparing the possible injury mechanisms and adverse health effects of engineered and ambient ultrafine particles...
  12. doi T-cell effector pathways in allergic diseases: transcriptional mechanisms and therapeutic targets
    Talal A Chatila
    Division of Immunology, Allergy and Rheumatology, Department of Pediatrics, University of California at Los Angeles, Los Angeles, CA, USA
    J Allergy Clin Immunol 121:812-23; quiz 824-5. 2008
    ....
  13. doi Importance of oxidative stress in the pathogenesis and treatment of asthma
    Marc A Riedl
    Section of Clinical Immunology and Allergy, Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, California 90095, USA
    Curr Opin Allergy Clin Immunol 8:49-56. 2008
    ..The purpose of the current review is to summarize recent evidence demonstrating the important role of oxidative stress in asthma pathogenesis. The therapeutic implications of these findings will be presented...
  14. ncbi Glutathione depletion inhibits dendritic cell maturation and delayed-type hypersensitivity: implications for systemic disease and immunosenescence
    Hyon Jeen Kim
    Department of Medicine, Division of Clinical Immunology and Allergy, University of California, Los Angeles, CA 90095, USA
    J Allergy Clin Immunol 119:1225-33. 2007
    ..This could affect the outcome of the immune response during systemic diseases and aging...
  15. pmc Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress
    Jesus A Araujo
    Department of Medicine, David Geffen School of Medicine, 10833 Le Conte Ave, CHS 52 175, Box 951680, Los Angeles, CA 90095, USA
    Circ Res 102:589-96. 2008
    ..We conclude that ultrafine particles concentrate the proatherogenic effects of ambient PM and may constitute a significant cardiovascular risk factor...
  16. pmc Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery
    Monty Liong
    Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA
    ACS Nano 2:889-96. 2008
    ..The highly versatile multifunctional nanoparticles could potentially be used for simultaneous imaging and therapeutic applications...
  17. ncbi Role of the Nrf2-mediated signaling pathway as a negative regulator of inflammation: implications for the impact of particulate pollutants on asthma
    Ning Li
    Division of Clinical Immunology and Allergy, Department of Medicine, University of California, Los Angeles, California 90095, USA
    Antioxid Redox Signal 8:88-98. 2006
    ..Moreover, chemopreventive Nrf2 inducers may be used for treating PM-exacerbated asthma...
  18. ncbi Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects
    Ning Li
    Department of Medicine Division of Clinical Immunology and Allergy, University of California, Los Angeles, CA 90095, USA
    Clin Immunol 109:250-65. 2003
    ..We review the biology of oxidative stress, including protective and injurious effects that explain the impact of particulate matter-induced oxidative stress in asthma...
  19. pmc Ambient ultrafine particles provide a strong adjuvant effect in the secondary immune response: implication for traffic-related asthma flares
    Ning Li
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, USA
    Am J Physiol Lung Cell Mol Physiol 299:L374-83. 2010
    ....
  20. ncbi Comparative toxicity of C60 aggregates toward mammalian cells: role of tetrahydrofuran (THF) decomposition
    Michael Kovochich
    Department of Medicine, Division of NanoMedicine, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Environ Sci Technol 43:6378-84. 2009
    ..Thus, the role of nC60 in the cellular responses is likely not due to the direct effect of the nC60 material surface on the cells but is related to the conversion of THF into a toxic byproduct during preparation of the suspension...
  21. ncbi Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization
    Michael J Whitekus
    Department of Pathology and Laboratory Medicine and Jonsson Comprehensive Cancer Center, University of California School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Immunol 168:2560-7. 2002
    ..Antioxidant treatment strategies may therefore serve to alleviate allergic inflammation and may provide a rational basis for treating the contribution of particulate matter to asthmatic disease...
  22. ncbi Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm
    Tian Xia
    Division of Clinical Immunology and Allergy, Department of Medicine, University of California, Los Angeles, California 90095, USA
    Nano Lett 6:1794-807. 2006
    ..Although not all materials have electronic configurations or surface properties to allow spontaneous ROS generation, particle interactions with cellular components are capable of generating oxidative stress...
  23. ncbi Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages
    Ning Li
    Division of Clinical Immunology and Allergy, Department of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Immunol 169:4531-41. 2002
    ..Moreover, epithelial cells are not able to convert N-acetylcysteine to cytoprotective glutathione...
  24. ncbi Nitrotyrosine-modified proteins and oxidative stress induced by diesel exhaust particles
    Gary Guishan Xiao
    Department of Medicine Clinical Immunology and Allergy, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Electrophoresis 26:280-92. 2005
    ..g., GAPDH and enolase), antioxidant defense (e.g., MnSOD) and inhibition of proteosomal activity (e.g., Hsp 90alpha). These oxidative proteins may serve as markers for oxidative stress generation in vivo...
  25. ncbi Use of proteomics to demonstrate a hierarchical oxidative stress response to diesel exhaust particle chemicals in a macrophage cell line
    Gary Guishan Xiao
    Keck Functional Proteomics Center, Department of Biochemistry and Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 278:50781-90. 2003
    ..These data suggest that DEP induce a hierarchical oxidative stress response in which some of these proteins may serve as markers for oxidative stress during PM exposures...
  26. ncbi Use of a fluorescent phosphoprotein dye to characterize oxidative stress-induced signaling pathway components in macrophage and epithelial cultures exposed to diesel exhaust particle chemicals
    Meiying Wang
    Department of Medicine, Division of Clinical Immunology and Allergy, and David Geffen School of Medicine, University of California Los Angeles, CA 90095, USA
    Electrophoresis 26:2092-108. 2005
    ....
  27. ncbi The role of phase II antioxidant enzymes in protecting memory T cells from spontaneous apoptosis in young and old mice
    Hyon Jeen Kim
    Division of Clinical Immunology and Allergy, Department of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 175:2948-59. 2005
    ..Taken together, we suggest that phase II enzyme expression and the accompanying increase in intracellular thiol levels protect memory T cells from mitochondrial dysfunction and spontaneous apoptosis...
  28. pmc Oxidative stress and asthma: proteome analysis of chitinase-like proteins and FIZZ1 in lung tissue and bronchoalveolar lavage fluid
    Lifeng Zhang
    Division of NanoMedicine, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    J Proteome Res 8:1631-8. 2009
    ..The oxidative stress proteins, Ym1/Ym2, FIZZ1, and SP-D, could play an important role in the pathogenesis of asthma and may be useful oxidative stress markers...
  29. pmc Innate immune responses during respiratory tract infection with a bacterial pathogen induce allergic airway sensitization
    Nicolas W J Schröder
    Pediatric Infectious Diseases, Cedars Sinai Medical Center, University of California, Los Angeles, CA, USA
    J Allergy Clin Immunol 122:595-602.e5. 2008
    ..A mechanistic reconciliation of these findings has not yet emerged. In particular, the role of innate immunity in this context is unclear...
  30. ncbi Pro-oxidative DEP chemicals induce heat shock proteins and an unfolding protein response in a bronchial epithelial cell line as determined by DIGE analysis
    EunMi Juliana Jung
    Department of Medicine, Division of Clinical Immunology and Allergy, and David Geffen School of Medicine, University of California Los Angeles, CA 90095, USA
    Proteomics 7:3906-18. 2007
    ..Our data suggest that pro-oxidative DEP chemicals induce protein unfolding/misfolding that lead to UPR and proinflammatory effects in a cell type that is targeted by PM in the lung...
  31. doi Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties
    Tian Xia
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, USA
    ACS Nano 2:2121-34. 2008
    ....
  32. ncbi Impairment of mitochondrial function by particulate matter (PM) and their toxic components: implications for PM-induced cardiovascular and lung disease
    Tian Xia
    Division of Clinical Immunology and Allergy, Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095 1680, USA
    Front Biosci 12:1238-46. 2007
    ..An understanding of the mitochondrial effects of PM is key in understanding the mechanisms of PM-induced adverse health effects...
  33. doi Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-glycoprotein siRNA to overcome drug resistance in a cancer cell line
    Huan Meng
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, USA
    ACS Nano 4:4539-50. 2010
    ..These results demonstrate that it is possible to use the MSNP platform to effectively deliver a siRNA that knocks down gene expression of a drug exporter that can be used to improve drug sensitivity to a chemotherapeutic agent...
  34. doi Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells
    Hyon Jeen Kim
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, CA 90095, USA
    J Allergy Clin Immunol 121:1255-1261.e7. 2008
    ..Recent studies suggest that the redox equilibrium of dendritic cells (DCs) is a key factor in maintaining protective cellular immunity and that a disturbance of this homeostatic mechanism could contribute to immune senescence...
  35. doi Adjuvant effects of ambient particulate matter monitored by proteomics of bronchoalveolar lavage fluid
    Xuedong Kang
    Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Proteomics 10:520-31. 2010
    ..These proteins may be the important specific elements targeted by PM in air pollution through the ability to generate ROS in the immune system, and may be involved in allergen sensitization and asthma pathogenesis...
  36. ncbi T-cell activation through the antigen receptor. Part 2: role of signaling cascades in T-cell differentiation, anergy, immune senescence, and development of immunotherapy
    Andre E Nel
    Division of Clinical Immunology Allergy, Department of Medicine, UCLA School of Medicine, University of California, Los Angeles 90095 1680, USA
    J Allergy Clin Immunol 109:901-15. 2002
    ..This includes a description of the mechanism of action of altered peptide ligands, CTLA-4Ig, and pharmacologic inhibitors of mitogen-activated protein kinases, nuclear factor kappaB, and protein kinase C cascades...
  37. doi Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs
    Tian Xia
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, USA
    ACS Nano 3:3273-86. 2009
    ..This novel use of a cationic MSNP extends its therapeutic use potential...
  38. ncbi Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals
    Ning Li
    Division of Clinical Immunology and Allergy, Department of Medicine, University of California, Los Angeles 90095, USA
    J Immunol 173:3467-81. 2004
    ..We propose that Nrf2-mediated phase II enzyme expression protects against the proinflammatory effects of particulate pollutants in the setting of allergic inflammation and asthma...
  39. pmc The adjuvant effect of ambient particulate matter is closely reflected by the particulate oxidant potential
    Ning Li
    Division of NanoMedicine, Department of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    Environ Health Perspect 117:1116-23. 2009
    ....
  40. pmc How exposure to environmental tobacco smoke, outdoor air pollutants, and increased pollen burdens influences the incidence of asthma
    M Ian Gilmour
    U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Environ Health Perspect 114:627-33. 2006
    ....
  41. ncbi Tracheobronchial particle dose considerations for in vitro toxicology studies
    Robert F Phalen
    Community and Environmental Medicine, School of Medicine, University of California Irvine, Irvine, CA 92697 1825, USA
    Toxicol Sci 92:126-32. 2006
    ..Local groups of TB cells in high-dose individuals are predicted to receive particle doses that are 3000-25,000 times higher than the doses averaged over the entire TB region...

Research Grants31

  1. Biological Analysis of Toxic DEP Chemicals
    Andre Nel; Fiscal Year: 2006
    ..We will determine if inhaled ambient PM induce apoptosis in induced sputum samples in humans. ..
  2. Lipids rafts in JNK and Nk-kB activation by TCR/CD28
    Andre Nel; Fiscal Year: 2006
    ..We will compare T-cells from young and elderly human subjects to determine how altered cytoskeletal assembly contributes to signaling decline by the TCR. ..
  3. Proteomics of DEP-induced Oxidative Stress
    Andre Nel; Fiscal Year: 2006
    ..They will also use a display of protein carbonyls to identity oxidatively modified proteins in the BAL fluid. ..
  4. Atherogenic Effects of Ambient PM In Susceptible Animals
    Andre Nel; Fiscal Year: 2007
    ..These mice will be exposed to CAPs as discussed in Aims 1 and 2, and select endpoints used to demonstrate the effect on atherosclerotic inflammation and apoptosis. ..
  5. Development of methods and models for nanoparticle toxicity screening: Applicatio
    Andre Nel; Fiscal Year: 2007
    ..A broader assessment of nanomaterial toxicity in the context of the hierarchical oxidative stress response is likely to yield a more sensitive paradigm for toxicity testing, perhaps resolving inconsistencies reported in the literature. ..
  6. Nano-Biological Interactions and Toxicity of Engineered Metal Oxide Particles
    Andre Nel; Fiscal Year: 2009
    ....
  7. MAPKINASE CASCADES AND T CELL DECISION MAKING
    Andre Nel; Fiscal Year: 2001
    ..The effects of stress stimuli on induction of apoptosis and expression of these genes will be compared in normal murine T-lymphocytes and lymphocytes from gld and c-rel knock-out (KO) mice. ..
  8. Nano-Biological Interactions and Toxicity of Engineered Metal Oxide Particles
    ANDRE ELIAS NEL; Fiscal Year: 2010
    ....