Richard A Neher

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Optimal flexibility for conformational transitions in macromolecules
    Richard A Neher
    Arnold Sommerfeld Center for Theoretical Physics ASC and Center for NanoScience CeNS, LMU Munich, Theresienstrasse 37, 80333 Munich, Germany
    Phys Rev Lett 99:178101. 2007
  2. pmc Recombination rate and selection strength in HIV intra-patient evolution
    Richard A Neher
    Kavli Institute for Theoretical Physics, University of California, Santa Barbara, California, United States of America
    PLoS Comput Biol 6:e1000660. 2010
  3. ncbi request reprint Kinetic accessibility of buried DNA sites in nucleosomes
    Wolfram Möbius
    Arnold Sommerfeld Center for Theoretical Physics and Center for NanoScience, LMU Munchen, Theresienstrasse 37, 80333 München, Germany
    Phys Rev Lett 97:208102. 2006
  4. pmc Dynamic mutation-selection balance as an evolutionary attractor
    Sidhartha Goyal
    Kavli Institute for Theoretical Physics, Department of Physics, University of California, Santa Barbara, CA 93106, USA
    Genetics 191:1309-19. 2012
  5. ncbi request reprint Target search on a dynamic DNA molecule
    Thomas Schötz
    Arnold Sommerfeld Center for Theoretical Physics and Center for Nano Science, University of Munich, Munchen, Germany
    Phys Rev E Stat Nonlin Soft Matter Phys 84:051911. 2011
  6. pmc Correlated evolution of nearby residues in Drosophilid proteins
    Benjamin Callahan
    Department of Applied Physics, Stanford University, Stanford, California, United States of America
    PLoS Genet 7:e1001315. 2011
  7. pmc Blind source separation techniques for the decomposition of multiply labeled fluorescence images
    Richard A Neher
    Kavli Institute for Theoretical Physics, University of California, Santa Barbara, California, USA
    Biophys J 96:3791-800. 2009
  8. pmc Competition between recombination and epistasis can cause a transition from allele to genotype selection
    Richard A Neher
    Kavli Institute for Theoretical Physics, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 106:6866-71. 2009
  9. ncbi request reprint Intermediate phase in DNA melting
    Richard A Neher
    Arnold Sommerfeld Center for Theoretical Physics and Center for NanoScience, LMU Munchen, Theresienstrasse 37, 80333 München, Germany
    Phys Rev E Stat Nonlin Soft Matter Phys 73:030902. 2006
  10. pmc DNA as a programmable viscoelastic nanoelement
    Richard A Neher
    Arnold Sommerfeld Center for Theoretical Physics and Center for NanoScience, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Biophys J 89:3846-55. 2005

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Optimal flexibility for conformational transitions in macromolecules
    Richard A Neher
    Arnold Sommerfeld Center for Theoretical Physics ASC and Center for NanoScience CeNS, LMU Munich, Theresienstrasse 37, 80333 Munich, Germany
    Phys Rev Lett 99:178101. 2007
    ..To explain this effect, we generalize the Kramers-Langer theory for multidimensional barrier crossing to configuration-dependent mobility matrices...
  2. pmc Recombination rate and selection strength in HIV intra-patient evolution
    Richard A Neher
    Kavli Institute for Theoretical Physics, University of California, Santa Barbara, California, United States of America
    PLoS Comput Biol 6:e1000660. 2010
    ..With the methods developed here, more precise and more detailed studies will be possible as soon as data with higher time resolution and greater sample sizes are available...
  3. ncbi request reprint Kinetic accessibility of buried DNA sites in nucleosomes
    Wolfram Möbius
    Arnold Sommerfeld Center for Theoretical Physics and Center for NanoScience, LMU Munchen, Theresienstrasse 37, 80333 München, Germany
    Phys Rev Lett 97:208102. 2006
    ..Close inspection reveals a surprising physical effect of flexibility-assisted barrier crossing, which we characterize within a toy model, the "semiflexible Brownian rotor."..
  4. pmc Dynamic mutation-selection balance as an evolutionary attractor
    Sidhartha Goyal
    Kavli Institute for Theoretical Physics, Department of Physics, University of California, Santa Barbara, CA 93106, USA
    Genetics 191:1309-19. 2012
    ..This may explain the maintenance of mitochondria and other asexual genomes...
  5. ncbi request reprint Target search on a dynamic DNA molecule
    Thomas Schötz
    Arnold Sommerfeld Center for Theoretical Physics and Center for Nano Science, University of Munich, Munchen, Germany
    Phys Rev E Stat Nonlin Soft Matter Phys 84:051911. 2011
    ..We also rationalize the slow exploration in the frozen limit as a subtle interplay between long jumps and long trapping times of the protein in "islands" within random DNA configurations in solution...
  6. pmc Correlated evolution of nearby residues in Drosophilid proteins
    Benjamin Callahan
    Department of Applied Physics, Stanford University, Stanford, California, United States of America
    PLoS Genet 7:e1001315. 2011
    ....
  7. pmc Blind source separation techniques for the decomposition of multiply labeled fluorescence images
    Richard A Neher
    Kavli Institute for Theoretical Physics, University of California, Santa Barbara, California, USA
    Biophys J 96:3791-800. 2009
    ....
  8. pmc Competition between recombination and epistasis can cause a transition from allele to genotype selection
    Richard A Neher
    Kavli Institute for Theoretical Physics, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 106:6866-71. 2009
    ..These haplotype blocks disappear in a second transition to pure allele selection. Our results demonstrate that the collective effect of many weak epistatic interactions can have dramatic effects on the population structure...
  9. ncbi request reprint Intermediate phase in DNA melting
    Richard A Neher
    Arnold Sommerfeld Center for Theoretical Physics and Center for NanoScience, LMU Munchen, Theresienstrasse 37, 80333 München, Germany
    Phys Rev E Stat Nonlin Soft Matter Phys 73:030902. 2006
    ..This continuous transition is in many aspects analogous to Bose-Einstein condensation. When the sequence is weakly disordered, the contour length changes discontinuously with temperature...
  10. pmc DNA as a programmable viscoelastic nanoelement
    Richard A Neher
    Arnold Sommerfeld Center for Theoretical Physics and Center for NanoScience, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Biophys J 89:3846-55. 2005
    ..Based on our findings, we suggest new dynamical roles for DNA in artificial nanoscale devices. The basepairing dynamics described here is also relevant for the extension of repetitive sequences inside genomic DNA...