Maiken Nedergaard

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Artifact versus reality--how astrocytes contribute to synaptic events
    Maiken Nedergaard
    Division of Glia Disease and Therapeutics, Department of Neurosurgery, Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, NY 14580, USA
    Glia 60:1013-23. 2012
  2. doi request reprint Glial calcium and diseases of the nervous system
    Maiken Nedergaard
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Calcium 47:140-9. 2010
  3. pmc Astrocytes modulate neural network activity by Ca²+-dependent uptake of extracellular K+
    Fushun Wang
    Division of Glia Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical School, Rochester, NY 14640, USA
    Sci Signal 5:ra26. 2012
  4. doi request reprint Loss of astrocytic domain organization in the epileptic brain
    Nancy Ann Oberheim
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 28:3264-76. 2008
  5. pmc Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity
    Ditte Lovatt
    Center for Translational Neuromedicine, Departments of Neurosurgery and Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 109:6265-70. 2012
  6. pmc Extracellular Ca²⁺ acts as a mediator of communication from neurons to glia
    Arnulfo Torres
    Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Sci Signal 5:ra8. 2012
  7. pmc Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering
    Vinita Rangroo Thrane
    1 Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, New York, USA 2 Letten Centre, Institute for Basic Medical Sciences, University of Oslo, Oslo, Norway 3 Centre for Molecular Medicine Norway, University of Oslo, Oslo, Norway 4 Department of Ophthalmology, Haukeland University Hospital, Bergen, Norway 5
    Nat Med 19:1643-8. 2013
  8. pmc Glutamate-dependent neuroglial calcium signaling differs between young and adult brain
    Wei Sun
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA
    Science 339:197-200. 2013
  9. ncbi request reprint Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo
    Xiaohai Wang
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:816-23. 2006
  10. pmc Photolysis of caged Ca2+ but not receptor-mediated Ca2+ signaling triggers astrocytic glutamate release
    Fushun Wang
    Center for Translational Neuromedicine, Division of Glia Disease and Therapeutics, University of Rochester Medical School, Rochester, New York 14642
    J Neurosci 33:17404-12. 2013

Research Grants

  1. Calcium Signalling Among Non-Neuronal Brain Cells
    Maiken Nedergaard; Fiscal Year: 2004
  2. Antiapoptotic Actions of Connexin
    Maiken Nedergaard; Fiscal Year: 2003
  3. CONTROL OF ASTROCYTIC SIGNALING
    Maiken Nedergaard; Fiscal Year: 2006
  4. Mediators of Functional Hyperemia and Its Dysregulation in Post-Traumatic Brain
    Maiken Nedergaard; Fiscal Year: 2006
  5. The Role of Astrocytes in Ischemic Stroke
    Maiken Nedergaard; Fiscal Year: 2007
  6. Mediators of Functional Hyperemia and Its Dysregulation in Post-Traumatic Brain
    Maiken Nedergaard; Fiscal Year: 2007
  7. Astrocyte Dysfunction in Epilepsy
    Maiken Nedergaard; Fiscal Year: 2007
  8. Mediators of Functional Hyperemia and Its Dysregulation in Post-Traumatic Brain
    Maiken Nedergaard; Fiscal Year: 2009
  9. Astrocyte Dysfunction in Epilepsy
    Maiken Nedergaard; Fiscal Year: 2009
  10. Mediators of Functional Hyperemia and Its Dysregulation in Post-Traumatic Brain
    Maiken Nedergaard; Fiscal Year: 2010

Collaborators

Detail Information

Publications89

  1. pmc Artifact versus reality--how astrocytes contribute to synaptic events
    Maiken Nedergaard
    Division of Glia Disease and Therapeutics, Department of Neurosurgery, Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, NY 14580, USA
    Glia 60:1013-23. 2012
    ....
  2. doi request reprint Glial calcium and diseases of the nervous system
    Maiken Nedergaard
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Calcium 47:140-9. 2010
    ..In this review we summarise the role of glial calcium signalling in various forms of pathological processes including neurological and psychiatric disorders and neurodegeneration...
  3. pmc Astrocytes modulate neural network activity by Ca²+-dependent uptake of extracellular K+
    Fushun Wang
    Division of Glia Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical School, Rochester, NY 14640, USA
    Sci Signal 5:ra26. 2012
    ..Active control of the extracellular K+ concentration thus provides astrocytes with a simple yet powerful mechanism to rapidly modulate network activity...
  4. doi request reprint Loss of astrocytic domain organization in the epileptic brain
    Nancy Ann Oberheim
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 28:3264-76. 2008
    ..Reorganization of astrocytes may, in concert with dendritic sprouting and new synapse formation, form the structural basis for recurrent excitation in the epileptic brain...
  5. pmc Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity
    Ditte Lovatt
    Center for Translational Neuromedicine, Departments of Neurosurgery and Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 109:6265-70. 2012
    ..This study shows that adenosine-mediated synaptic depression is not a consequence of astrocytic ATP release, but is instead an autonomic feedback mechanism that suppresses excitatory transmission during prolonged activity...
  6. pmc Extracellular Ca²⁺ acts as a mediator of communication from neurons to glia
    Arnulfo Torres
    Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Sci Signal 5:ra8. 2012
    ..Thus, astrocytic ATP release evoked by an activity-associated decrease in [Ca(2+)](e) may provide a negative feedback mechanism that potentiates inhibitory transmission in response to local hyperexcitability...
  7. pmc Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering
    Vinita Rangroo Thrane
    1 Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, New York, USA 2 Letten Centre, Institute for Basic Medical Sciences, University of Oslo, Oslo, Norway 3 Centre for Molecular Medicine Norway, University of Oslo, Oslo, Norway 4 Department of Ophthalmology, Haukeland University Hospital, Bergen, Norway 5
    Nat Med 19:1643-8. 2013
    ..Instead, our findings identify failure of potassium buffering in astrocytes as a crucial mechanism in ammonia neurotoxicity and demonstrate the therapeutic potential of blocking this pathway by inhibiting NKCC1. ..
  8. pmc Glutamate-dependent neuroglial calcium signaling differs between young and adult brain
    Wei Sun
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA
    Science 339:197-200. 2013
    ..Neuroglial signaling in the adult brain may therefore occur in a manner fundamentally distinct from that exhibited during development...
  9. ncbi request reprint Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo
    Xiaohai Wang
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:816-23. 2006
    ..These findings indicate that astrocytes respond to synaptic input, by means of spillover or ectopic release of glutamate, and that increases in astrocytic Ca(2+) occur independently of postsynaptic excitatory activity...
  10. pmc Photolysis of caged Ca2+ but not receptor-mediated Ca2+ signaling triggers astrocytic glutamate release
    Fushun Wang
    Center for Translational Neuromedicine, Division of Glia Disease and Therapeutics, University of Rochester Medical School, Rochester, New York 14642
    J Neurosci 33:17404-12. 2013
    ..Combined, these studies show that photolysis but not by agonists induced astrocytic Ca(2+) signaling triggers glutamate release. ..
  11. pmc Sleep drives metabolite clearance from the adult brain
    Lulu Xie
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    Science 342:373-7. 2013
    ..Thus, the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system. ..
  12. pmc Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice
    Xiaoning Han
    Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Stem Cell 12:342-53. 2013
    ..Mice allografted with murine GPCs showed no enhancement of either LTP or learning. These findings indicate that human glia differentially enhance both activity-dependent plasticity and learning in mice...
  13. pmc Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain
    Vinita Rangroo Thrane
    1 Division of Glia Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642 2 Letten Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway 3 Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo, 0318 Oslo, Norway 4
    Sci Rep 3:2582. 2013
    ..As the central nervous system is devoid of lymphatic vessels, the paravascular space may serve as a lymphatic equivalent that represents a separate highway for the transport of lipids and signaling molecules. ..
  14. pmc Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain
    Jeffrey J Iliff
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, and Department of Neurology, Tongii Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan, China 430030
    J Neurosci 33:18190-9. 2013
    ....
  15. pmc In vivo NADH fluorescence imaging indicates effect of aquaporin-4 deletion on oxygen microdistribution in cortical spreading depression
    Alexander S Thrane
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York, USA
    J Cereb Blood Flow Metab 33:996-9. 2013
    ....
  16. pmc 'Hit & Run' model of closed-skull traumatic brain injury (TBI) reveals complex patterns of post-traumatic AQP4 dysregulation
    Zeguang Ren
    Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York, USA
    J Cereb Blood Flow Metab 33:834-45. 2013
    ..These findings suggest that changes in AQP4 expression and localization may not contribute to cerebral edema formation, but rather may represent a compensatory mechanism to facilitate its resolution...
  17. pmc Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury
    Michael J Chen
    Department of Neurosurgery, Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York, USA
    Glia 60:1660-70. 2012
    ..Since Cx43/Cx30 is expressed by astrocytes, these findings also support an important role of astrocytes in the development of chronic pain...
  18. pmc Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury
    Weiguo Peng
    Department of Neurosurgery, Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 106:12489-93. 2009
    ..1), which crosses the blood-brain barrier. Systemic administration of BBG may thus comprise a readily feasible approach by which to treat traumatic SCI in humans...
  19. ncbi request reprint Cortical spreading depression causes and coincides with tissue hypoxia
    Takahiro Takano
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Box 645, Rochester, New York 14642, USA
    Nat Neurosci 10:754-62. 2007
    ..Increasing O2 availability shortens the duration of CSD and improves local redox state. Our results indicate that tissue hypoxia associated with CSD is caused by a transient increase in O2 demand exceeding vascular O2 supply...
  20. ncbi request reprint Adenosine is crucial for deep brain stimulation-mediated attenuation of tremor
    Lane Bekar
    Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester, Rochester, New York 14642, USA
    Nat Med 14:75-80. 2008
    ....
  21. pmc Bergmann glia modulate cerebellar Purkinje cell bistability via Ca2+-dependent K+ uptake
    Fushun Wang
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 109:7911-6. 2012
    ..Thus, Bergmann glia play a previously unappreciated role in controlling the membrane potential and thereby the activity of adjacent Purkinje cells...
  22. pmc Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions
    Karl A Kasischke
    Department of Neurology, Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Cereb Blood Flow Metab 31:68-81. 2011
    ..Thus, two-photon NADH imaging can be applied to expose vascular supply regions and to localize functionally relevant microregional cortical hypoxia with micrometer spatial resolution...
  23. pmc Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema
    Alexander S Thrane
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 108:846-51. 2011
    ....
  24. ncbi request reprint Astrocyte-mediated control of cerebral blood flow
    Takahiro Takano
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:260-7. 2006
    ..These observations implicate astrocytes in the control of local microcirculation and suggest that one of their physiological roles is to mediate vasodilation in response to increased neural activity...
  25. pmc General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex
    Alexander Stanley Thrane
    Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 109:18974-9. 2012
    ..We propose that these glial effects may constitute a nonneuronal mechanism for sedative action of anesthetic drugs...
  26. pmc Cultured astrocytes do not release adenosine during hypoxic conditions
    Takumi Fujita
    Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York, USA
    J Cereb Blood Flow Metab 32:e1-7. 2012
    ..These results show that cultured astrocytes do not release adenosine during mild hypoxia, an observation consistent with their high resistance to hypoxia...
  27. pmc Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury
    Chunlan Huang
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, New York 14642, USA
    J Neurosci 32:3333-8. 2012
    ..Connexins may thereby constitute a new therapeutic target in spinal cord injury...
  28. ncbi request reprint Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord
    Neeta S Roy
    Department of Neurology and Neuroscience, Cornell University Medical Center, New York, New York 10021, USA
    Nat Biotechnol 22:297-305. 2004
    ..The cells have survived >168 doublings in vitro, with karyotypic normalcy and without replicative senescence. hTERT overexpression thus permits the generation of progenitor lines able to give rise to phenotypically restricted neurons...
  29. pmc Astrocytes and ischemic injury
    Takahiro Takano
    Divison of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Stroke 40:S8-12. 2009
    ..Neuroprotective efforts targeting the functional integrity of astrocytes may constitute a superior strategy for future neuroprotection...
  30. pmc Receptor-mediated glutamate release from volume sensitive channels in astrocytes
    Takahiro Takano
    Center for Aging and Developmental Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 102:16466-71. 2005
    ..Our observations indicate that volume-sensitive channel may constitute a previously uncharacterized target for modulation of astrocyte-neuronal interactions...
  31. pmc The locus coeruleus-norepinephrine network optimizes coupling of cerebral blood volume with oxygen demand
    Lane K Bekar
    Division of Glia Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York, USA
    J Cereb Blood Flow Metab 32:2135-45. 2012
    ..As LC neuron loss is prominent in Alzheimer and Parkinson diseases, the diminished ability to couple blood volume to oxygen demand may contribute to their pathogenesis...
  32. pmc Heterogeneity of astrocytic form and function
    Nancy Ann Oberheim
    Center for Translational Neuromedicine, Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA
    Methods Mol Biol 814:23-45. 2012
    ....
  33. pmc Locus coeruleus alpha-adrenergic-mediated activation of cortical astrocytes in vivo
    Lane K Bekar
    Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester, Rochester, NY 14642, USA
    Cereb Cortex 18:2789-95. 2008
    ..Future investigations of LC function must therefore consider the possibility that LC neuromodulatory effects are in part derived from activation of astrocytes...
  34. pmc Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture
    Nanna Goldman
    Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York, USA
    Nat Neurosci 13:883-8. 2010
    ..These observations indicate that adenosine mediates the effects of acupuncture and that interfering with adenosine metabolism may prolong the clinical benefit of acupuncture...
  35. ncbi request reprint The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex
    Ditte Lovatt
    Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 27:12255-66. 2007
    ....
  36. pmc α1-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice
    Fengfei Ding
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, United States
    Cell Calcium 54:387-94. 2013
    ..Instead astrocytes appear to be the primary target for NE, with astrocytic Ca2+ signaling being triggered by the α1-adrenergic receptor. In turn, astrocytes may coordinate the broad effects of neuromodulators on neuronal activity...
  37. ncbi request reprint Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices
    Takahiro Takano
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York
    Glia 62:78-95. 2014
    ..These observations suggest that the functional properties and the fine structure of astrocytes in slices may be reflective of early stages of reactive gliosis and should be confirmed in vivo when possible...
  38. ncbi request reprint Imaging of cortical astrocytes using 2-photon laser scanning microscopy in the intact mouse brain
    Guo Feng Tian
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    Adv Drug Deliv Rev 58:773-87. 2006
    ....
  39. pmc A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β
    Jeffrey J Iliff
    Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    Sci Transl Med 4:147ra111. 2012
    ..Clearance through paravenous flow may also regulate extracellular levels of proteins involved with neurodegenerative conditions, its impairment perhaps contributing to the mis-accumulation of soluble proteins...
  40. pmc Brain connexins in demyelinating diseases: therapeutic potential of glial targets
    Maria Luisa Cotrina
    Division of Glia Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, NY 14640, USA
    Brain Res 1487:61-8. 2012
    ..This article is part of a Special Issue entitled Electrical Synapses...
  41. pmc Cognitive deficits and delayed neuronal loss in a mouse model of multiple microinfarcts
    Minghuan Wang
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 32:17948-60. 2012
    ..The long-lasting gliosis, delayed neuronal loss, and demyelination suggest that the therapeutic window for microinfarcts may be much wider (perhaps days to weeks) than for larger strokes...
  42. ncbi request reprint Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease
    Takahiro Takano
    Department of Neurosurgery, Center for Aging and Developmental Biology, University of Rochester Medical Center, 601 Elmwood Ave, Box 645, Rochester, NY 14642, USA
    Ann N Y Acad Sci 1097:40-50. 2007
    ....
  43. pmc Resolving vesicle fusion from lysis to monitor calcium-triggered lysosomal exocytosis in astrocytes
    Jyoti K Jaiswal
    The Rockefeller University, 1230 York Avenue, Box 304, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 104:14151-6. 2007
    ..We have used this approach to demonstrate that lysosomes undergo calcium-triggered exocytosis in astrocytes...
  44. pmc Uniquely hominid features of adult human astrocytes
    Nancy Ann Oberheim
    Center for Translational Neuromedicine, Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 29:3276-87. 2009
    ..On this basis, we posit that this astrocytic complexity has permitted the increased functional competence of the adult human brain...
  45. pmc An astrocytic basis of epilepsy
    Guo Feng Tian
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Med 11:973-81. 2005
    ..Our results show an unanticipated key role for astrocytes in seizure activity. As such, these findings identify astrocytes as a proximal target for the treatment of epileptic disorders...
  46. pmc Traditional acupuncture triggers a local increase in adenosine in human subjects
    Takahiro Takano
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, NY, USA
    J Pain 13:1215-23. 2012
    ..This study strengthens the role of adenosine in acupuncture-mediated antinociception by directly providing such evidence in humans...
  47. pmc Brain-wide pathway for waste clearance captured by contrast-enhanced MRI
    Jeffrey J Iliff
    Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York, USA
    J Clin Invest 123:1299-309. 2013
    ..We propose that this MRI approach may provide the basis for a wholly new strategy to evaluate Alzheimer's disease susceptibility and progression in the live human brain...
  48. ncbi request reprint P2X7 receptor inhibition improves recovery after spinal cord injury
    Xiaohai Wang
    Department of Neurosurgery, Center for Aging and Developmental Biology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Nat Med 10:821-7. 2004
    ..P2X7R antagonists inhibit this process, reducing both the histological extent and functional sequelae of acute SCI...
  49. pmc A novel technique for morphometric quantification of subarachnoid hemorrhage-induced microglia activation
    Benjamin A Plog
    University of Rochester School of Medicine and Dentistry, Rochester, NY, USA Department of Neurosurgery, Center for Translation Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA Department of Pathology, University of Rochester Medical Center, Rochester, NY, USA Electronic address
    J Neurosci Methods 229:44-52. 2014
    ..SAH causes activation of microglia, but the time course and degree of microglial activation after SAH and its link to poor patient outcome and vasospasm remains unknown...
  50. pmc Purine receptor mediated actin cytoskeleton remodeling of human fibroblasts
    Nanna Goldman
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, United States
    Cell Calcium 53:297-301. 2013
    ..These observations indicate that purine signaling induces transient changes in fibroblast cytoarchitecture that could be related to the beneficial effects of acupuncture...
  51. pmc Glial progenitor cell-based treatment and modeling of neurological disease
    Steven A Goldman
    Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Science 338:491-5. 2012
    ....
  52. ncbi request reprint Glial regulation of the cerebral microvasculature
    Costantino Iadecola
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, New York 10021, USA
    Nat Neurosci 10:1369-76. 2007
    ..The involvement of astrocytes in neurovascular coupling has broad implications for the interpretation of functional imaging signals and for the understanding of brain diseases that are associated with neurovascular dysfunction...
  53. pmc Astrocytic calcium signaling: mechanism and implications for functional brain imaging
    Xiaohai Wang
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY, USA
    Methods Mol Biol 489:93-109. 2009
    ....
  54. doi request reprint Two-photon in vivo imaging of cells
    Daniel J Christensen
    The Institute of Optics, University of Rochester, Rochester, NY, USA
    Pediatr Nephrol 26:1483-9. 2011
    ..This review focuses on providing the reader with a short history of, and impetus behind, two-photon imaging, its working mechanics, and emerging technologies related to biological multiphoton imaging...
  55. pmc The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: a novel mouse model of chronic traumatic encephalopathy
    Anthony L Petraglia
    1 Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York
    J Neurotrauma 31:1211-24. 2014
    ..We describe the neurological sequelae of repetitive mTBI in a novel mouse model, which resemble several of the neuropsychiatric behaviors observed clinically in patients sustaining repetitive mild head injury. ..
  56. pmc Deciphering migraine
    Takahiro Takano
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, New York 14642, USA
    J Clin Invest 119:16-9. 2009
    ....
  57. pmc Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's disease
    Abdellatif Benraiss
    Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Stem Cell 12:787-99. 2013
    ..In addition, squirrel monkeys given ICV injections of adenoviral BDNF/noggin showed similar addition of striatal neurons. Induced neuronal addition may therefore represent a promising avenue for disease amelioration in HD...
  58. pmc Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse
    Martha S Windrem
    Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Stem Cell 2:553-65. 2008
    ..These data demonstrate that the neonatal transplantation of human glial progenitor cells can effectively treat disorders of congenital and perinatal hypomyelination...
  59. ncbi request reprint Astrocytic complexity distinguishes the human brain
    Nancy Ann Oberheim
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Trends Neurosci 29:547-53. 2006
    ..We propose that human cortical evolution has been accompanied by increasing complexity in the form and function of astrocytes, which reflects an expansion of their functional roles in synaptic modulation and cortical circuitry...
  60. pmc Norepinephrine: a neuromodulator that boosts the function of multiple cell types to optimize CNS performance
    John O'Donnell
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Neurochem Res 37:2496-512. 2012
    ....
  61. ncbi request reprint Signaling at the gliovascular interface
    Marie Simard
    Department of Neurosurgery, New York Medical College, Valhalla, New York 10590, USA
    J Neurosci 23:9254-62. 2003
    ..It is speculated that calcium signaling may play a role in astrocytic functions related to the blood-brain barrier, including blood flow regulation, metabolic trafficking, and water homeostasis...
  62. ncbi request reprint Role of glial cells in cerebral ischemia
    Maiken Nedergaard
    Department of Neurosurgery, Center for Aging and Developmental Biology, University of Rochester Medical Center, Rochester, New York, USA
    Glia 50:281-6. 2005
    ..By emphasizing open issues in this field, we hope to stimulate further research into this relatively unexplored aspect of brain pathophysiology...
  63. ncbi request reprint Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain
    Marta C Nunes
    Department of Neurology and Neuroscience, Cornell University Medical College, New York, New York, USA
    Nat Med 9:439-47. 2003
    ..These experiments indicate that an abundant pool of mitotically competent neurogenic progenitor cells resides in the adult human white matter...
  64. pmc Physiological and pathological functions of P2X7 receptor in the spinal cord
    Maria Luisa Cotrina
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY, 14642, USA
    Purinergic Signal 5:223-32. 2009
    ..We will discuss the mechanisms for P2X7R actions and the potential that manipulating the P2X7R signaling pathway may have for therapeutic intervention in pathological events, specifically in the spinal cord...
  65. ncbi request reprint Astrocytic glutamate release-induced transient depolarization and epileptiform discharges in hippocampal CA1 pyramidal neurons
    Ning Kang
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, 10595, USA
    J Neurophysiol 94:4121-30. 2005
    ..Our study provides a novel mechanism, astrocytic release of glutamate, for seizure initiation...
  66. pmc Astrocyte-mediated activation of neuronal kainate receptors
    Qing Song Liu
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 101:3172-7. 2004
    ..By modulating the activity of interneurons, astrocytes may play a critical role in circuit function of hippocampus...
  67. ncbi request reprint Astrocyte-mediated control of cerebral microcirculation
    Christopher M Anderson
    Department of Neurology, University of California San Francisco, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Trends Neurosci 26:340-4; author reply 344-5. 2003
    ..This finding represents a breakthrough in our knowledge both of astrocyte function and of the mechanism of activity-dependent cerebral blood flow regulation...
  68. ncbi request reprint New roles for astrocytes: redefining the functional architecture of the brain
    Maiken Nedergaard
    Department of Cell Biology, New York Medical College, Valhalla, NY 10595, USA
    Trends Neurosci 26:523-30. 2003
    ..By these means, astrocytes might establish the functional as well as the structural architecture of the adult brain...
  69. ncbi request reprint DM-nitrophen provides physiologically significant increases of intracellular [Ca2+] in the presence of Mg2+
    Takahiro Takano
    Cell Calcium 41:503-4. 2007
  70. doi request reprint A central role of connexin 43 in hypoxic preconditioning
    Jane H C Lin
    Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 28:681-95. 2008
    ..Thus, adaptive modulation of Cx43 can offset environmental stress by adenosine-mediated elevation of cellular resistance...
  71. pmc Intercellular calcium signaling mediated by point-source burst release of ATP
    Gregory Arcuino
    Department of Cell Biology, Anatomy, and Pathology, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 99:9840-5. 2002
    ....
  72. ncbi request reprint Astrocytes in the aging brain
    Maria Luisa Cotrina
    Department of Anatomy and Cell Biology, New York Medical College, Valhalla, NY 10595, USA
    J Neurosci Res 67:1-10. 2002
  73. ncbi request reprint Development of tight junction molecules in blood vessels of germinal matrix, cerebral cortex, and white matter
    Praveen Ballabh
    Department of Pediatrics, Westchester Medicak Center New York Medical College, Valhalla, 10595, USA
    Pediatr Res 58:791-8. 2005
    ....
  74. ncbi request reprint Erythropoietin strikes a new cord
    Steven A Goldman
    Nat Med 8:785-7. 2002
  75. ncbi request reprint Connexin mediates gap junction-independent resistance to cellular injury
    Jane H C Lin
    Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 23:430-41. 2003
    ..Moreover, cells expressing nonfunctional mutant connexins also acquired a high resistance to injury. These observations identify Cx proteins as active players in cell survival...
  76. ncbi request reprint Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cells
    Jane H C Lin
    Departments of Pathology and Anatomy and Cell Biology, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 22:4302-11. 2002
    ....
  77. pmc Connexin 43 hemichannels are permeable to ATP
    Jian Kang
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 28:4702-11. 2008
    ..Furthermore, a putative Cx43 hemichannel with characteristics identical to the Cx43 hemichannel in C6 cells was identified in the membrane of hippocampal astrocytes in acutely prepared slices...
  78. ncbi request reprint Beyond the role of glutamate as a neurotransmitter
    Maiken Nedergaard
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    Nat Rev Neurosci 3:748-55. 2002
    ..Here, we review the current knowledge on glutamatergic signalling in non-neuronal cells, with a special emphasis on astrocytes...
  79. ncbi request reprint Paucity of pericytes in germinal matrix vasculature of premature infants
    Alex Braun
    Department of Pathology, New York Medical College, Westchester Medical Center, Valhalla, New York 10595, USA
    J Neurosci 27:12012-24. 2007
    ..Hence, a paucity of pericytes in the GM vasculature may contribute to its propensity to hemorrhage, and a lower expression of TGF-beta1 could be a basis of reduced pericyte density in its vasculature...
  80. ncbi request reprint Activity-dependent long-term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neurons
    Jun Xu
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 25:1750-60. 2005
    ..This new form of hippocampal neuronal plasticity could be a cellular correlate of learning and memory besides synaptic LTP...
  81. ncbi request reprint Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons
    Christopher M Anderson
    Department of Pharmacology and Therapeutics, University of Manitoba and Division of Neurodegenerative Disorders, St Boniface Hospital Research Center, Winnipeg, Canada R2H 2A6
    Trends Neurosci 29:257-62. 2006
    ....
  82. ncbi request reprint Anatomic analysis of blood vessels in germinal matrix, cerebral cortex, and white matter in developing infants
    Praveen Ballabh
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
    Pediatr Res 56:117-24. 2004
    ..of the GM compared with gray and white matter may play a role in GM hemorrhage, whereas a relatively low vascularity of white matter may increase the propensity for the occurrence of periventricular leukomalacia in premature infants..
  83. ncbi request reprint Astrocyte end-feet in germinal matrix, cerebral cortex, and white matter in developing infants
    Nadine El-Khoury
    Department of Pediatrics, Westchester Medical Center, New York Medical College, Valhalla, New York 10595, USA
    Pediatr Res 59:673-9. 2006
    ....
  84. ncbi request reprint Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cells
    Neeta Singh Roy
    Department of Neurology, Cornell University Medical College, NYC, NY 10021, USA
    Exp Neurol 196:224-34. 2005
    ..These results suggest the utility of promoter/enhancer-based FACS for the isolation of specific phenotypes from hES cell populations as a means of purifying clinically appropriate vectors for cell therapy...
  85. ncbi request reprint Presynaptic inactivation of action potentials and postsynaptic inhibition of GABAA currents contribute to KA-induced disinhibition in CA1 pyramidal neurons
    Ning Kang
    Dept of Cell Biology and Anatomy, New York Medical College, Basic Science Bldg, Rm 220, Valhalla, NY 10595, USA
    J Neurophysiol 92:873-82. 2004
    ..Thus the postsynaptic KAR-mediated inhibition of GABA(A) currents may contribute to the KAR agonist-induced decrease in the potency of uIPSCs and KA-induced disinhibition...
  86. doi request reprint Maturational changes in laminin, fibronectin, collagen IV, and perlecan in germinal matrix, cortex, and white matter and effect of betamethasone
    Hongmin Xu
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
    J Neurosci Res 86:1482-500. 2008
    ..Because fibronectin provides structural stability to the blood vessels, its reduced expression in the germinal matrix may contribute to the fragility of germinal matrix vasculature and the propensity to hemorrhage in premature neonates...
  87. pmc Purinergic signaling regulates neural progenitor cell expansion and neurogenesis
    Jane H C Lin
    Department of Cell Biology, New York Medical College, Valhalla, NY, USA
    Dev Biol 302:356-66. 2007
    ..As a result, progenitor cell-derived neurogenesis is thus associated with regions of both active purinergic signaling and modulation thereof...
  88. ncbi request reprint New roles for astrocytes (stars at last)
    Bruce Ransom
    Department of Neurology, University of Washington, 1959 NE Pacific, Room RR650, Box 356465, Seattle, WA 98195, USA
    Trends Neurosci 26:520-2. 2003
    ..But now, at last, astrocytes have our attention...

Research Grants38

  1. Calcium Signalling Among Non-Neuronal Brain Cells
    Maiken Nedergaard; Fiscal Year: 2004
    ..The long-distance multicellular calcium signaling pathway that we propose, and its attendant hormonal regulation, suggests immediately testable strategies for its abrogation. ..
  2. Antiapoptotic Actions of Connexin
    Maiken Nedergaard; Fiscal Year: 2003
    ..Defining the pathways, by which connexin proteins increase cellular resistance to injury, may provide a potential new therapeutic target for preventing cell death in acute pathologies as stroke and head trauma. ..
  3. CONTROL OF ASTROCYTIC SIGNALING
    Maiken Nedergaard; Fiscal Year: 2006
    ..abstract_text> ..
  4. Mediators of Functional Hyperemia and Its Dysregulation in Post-Traumatic Brain
    Maiken Nedergaard; Fiscal Year: 2006
    ....
  5. The Role of Astrocytes in Ischemic Stroke
    Maiken Nedergaard; Fiscal Year: 2007
    ..Our hope is that these studies ultimately will result in new treatment options for patients with acute ischemic stroke. ..
  6. Mediators of Functional Hyperemia and Its Dysregulation in Post-Traumatic Brain
    Maiken Nedergaard; Fiscal Year: 2007
    ....
  7. Astrocyte Dysfunction in Epilepsy
    Maiken Nedergaard; Fiscal Year: 2007
    ..By more specifically targeting the glial cause of neuronal excitability, we might be able to achieve more specific, less variable and less toxic treatment options for patients with epilepsy. ..
  8. Mediators of Functional Hyperemia and Its Dysregulation in Post-Traumatic Brain
    Maiken Nedergaard; Fiscal Year: 2009
    ....
  9. Astrocyte Dysfunction in Epilepsy
    Maiken Nedergaard; Fiscal Year: 2009
    ..By more specifically targeting the glial cause of neuronal excitability, we might be able to achieve more specific, less variable and less toxic treatment options for patients with epilepsy. ..
  10. Mediators of Functional Hyperemia and Its Dysregulation in Post-Traumatic Brain
    Maiken Nedergaard; Fiscal Year: 2010
    ....
  11. Astrocyte Dysfunction in Epilepsy
    Maiken Nedergaard; Fiscal Year: 2010
    ..By more specifically targeting the glial cause of neuronal excitability, we might be able to achieve more specific, less variable and less toxic treatment options for patients with epilepsy. ..
  12. Astrocyte Dysfunction in Epilepsy
    Maiken Nedergaard; Fiscal Year: 2009
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  13. Antiapoptotic Actions of Connexin
    Maiken Nedergaard; Fiscal Year: 2004
    ..Defining the pathways, by which connexin proteins increase cellular resistance to injury, may provide a potential new therapeutic target for preventing cell death in acute pathologies as stroke and head trauma. ..
  14. CONTROL OF ASTROCYTIC SIGNALING
    Maiken Nedergaard; Fiscal Year: 1999
    ..abstract_text> ..
  15. ASTROCYTE MEDIATED PROPAGATION OF ISCHEMIC BRAIN DAMAGE
    Maiken Nedergaard; Fiscal Year: 1999
    ..Is focal ischemia associated with a decrease in gap junctional function intake live rat brain? 4. Will manipulations of junctional conductance affect the outcome of ischemia? ..
  16. CONTROL OF ASTROCYTIC SIGNALING
    Maiken Nedergaard; Fiscal Year: 1999
    ..abstract_text> ..
  17. CONTROL OF ASTROCYTIC SIGNALING
    Maiken Nedergaard; Fiscal Year: 2000
    ..abstract_text> ..
  18. ASTROCYTE MEDIATED PROPAGATION OF ISCHEMIC BRAIN DAMAGE
    Maiken Nedergaard; Fiscal Year: 2000
    ..Is focal ischemia associated with a decrease in gap junctional function intake live rat brain? 4. Will manipulations of junctional conductance affect the outcome of ischemia? ..
  19. MULTI-PHOTON CONFOCAL MICROSCOPE SYSTEM
    Maiken Nedergaard; Fiscal Year: 2001
    ..The multi-photon confocal microscope system will become a core facility at New York Medical College, serving the entire medical science community. ..
  20. CONTROL OF ASTROCYTIC SIGNALING
    Maiken Nedergaard; Fiscal Year: 2001
    ..abstract_text> ..
  21. CONTROL OF ASTROCYTIC SIGNALING
    Maiken Nedergaard; Fiscal Year: 2000
    ..abstract_text> ..
  22. Antiapoptotic Actions of Connexin
    Maiken Nedergaard; Fiscal Year: 2001
    ..Defining the pathways, by which connexin proteins increase cellular resistance to injury, may provide a potential new therapeutic target for preventing cell death in acute pathologies as stroke and head trauma. ..
  23. Calcium Signalling Among Non-Neuronal Brain Cells
    Maiken Nedergaard; Fiscal Year: 2001
    ..The long-distance multicellular calcium signaling pathway that we propose, and its attendant hormonal regulation, suggests immediately testable strategies for its abrogation. ..
  24. CONTROL OF ASTROCYTIC SIGNALING
    Maiken Nedergaard; Fiscal Year: 2002
    ..abstract_text> ..
  25. Calcium Signalling Among Non-Neuronal Brain Cells
    Maiken Nedergaard; Fiscal Year: 2002
    ..The long-distance multicellular calcium signaling pathway that we propose, and its attendant hormonal regulation, suggests immediately testable strategies for its abrogation. ..
  26. Antiapoptotic Actions of Connexin
    Maiken Nedergaard; Fiscal Year: 2002
    ..Defining the pathways, by which connexin proteins increase cellular resistance to injury, may provide a potential new therapeutic target for preventing cell death in acute pathologies as stroke and head trauma. ..
  27. CONTROL OF ASTROCYTIC SIGNALING
    Maiken Nedergaard; Fiscal Year: 2003
    ..abstract_text> ..
  28. Antiapoptotic Actions of Connexin
    Maiken Nedergaard; Fiscal Year: 2003
    ..Defining the pathways, by which connexin proteins increase cellular resistance to injury, may provide a potential new therapeutic target for preventing cell death in acute pathologies as stroke and head trauma. ..
  29. Calcium Signalling Among Non-Neuronal Brain Cells
    Maiken Nedergaard; Fiscal Year: 2003
    ..The long-distance multicellular calcium signaling pathway that we propose, and its attendant hormonal regulation, suggests immediately testable strategies for its abrogation. ..
  30. Astrocyte Dysfunction in Epilepsy
    Maiken Nedergaard; Fiscal Year: 2010
    ..By more specifically targeting the glial cause of neuronal excitability, we might be able to achieve more specific, less variable and less toxic treatment options for patients with epilepsy. ..