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Genomes and Genes | Maiken NedergaardSummaryAffiliation: University of Rochester Country: USA Publications
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Publications
Artifact versus reality--how astrocytes contribute to synaptic eventsMaiken Nedergaard
Division of Glia Disease and Therapeutics, Department of Neurosurgery, Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, NY 14580, USA
Glia 60:1013-23. 2012....
Glial calcium and diseases of the nervous systemMaiken Nedergaard
Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
Cell Calcium 47:140-9. 2010..In this review we summarise the role of glial calcium signalling in various forms of pathological processes including neurological and psychiatric disorders and neurodegeneration...- Astrocytes modulate neural network activity by Ca²+-dependent uptake of extracellular K+Fushun Wang
Division of Glia Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical School, Rochester, NY 14640, USA
Sci Signal 5:ra26. 2012..Active control of the extracellular K+ concentration thus provides astrocytes with a simple yet powerful mechanism to rapidly modulate network activity... - Loss of astrocytic domain organization in the epileptic brainNancy Ann Oberheim
Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA
J Neurosci 28:3264-76. 2008..Reorganization of astrocytes may, in concert with dendritic sprouting and new synapse formation, form the structural basis for recurrent excitation in the epileptic brain... - Extracellular Ca²⁺ acts as a mediator of communication from neurons to gliaArnulfo Torres
Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, NY 14642, USA
Sci Signal 5:ra8. 2012..Thus, astrocytic ATP release evoked by an activity-associated decrease in [Ca(2+)](e) may provide a negative feedback mechanism that potentiates inhibitory transmission in response to local hyperexcitability... 
Astrocytic Ca2+ signaling evoked by sensory stimulation in vivoXiaohai Wang
Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
Nat Neurosci 9:816-23. 2006..These findings indicate that astrocytes respond to synaptic input, by means of spillover or ectopic release of glutamate, and that increases in astrocytic Ca(2+) occur independently of postsynaptic excitatory activity...- Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activityDitte Lovatt
Center for Translational Neuromedicine, Departments of Neurosurgery and Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 109:6265-70. 2012..This study shows that adenosine-mediated synaptic depression is not a consequence of astrocytic ATP release, but is instead an autonomic feedback mechanism that suppresses excitatory transmission during prolonged activity... - Glutamate-dependent neuroglial calcium signaling differs between young and adult brainWei Sun
Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA
Science 339:197-200. 2013..Neuroglial signaling in the adult brain may therefore occur in a manner fundamentally distinct from that exhibited during development... - Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injuryMichael J Chen
Department of Neurosurgery, Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York, USA
Glia 60:1660-70. 2012..Since Cx43/Cx30 is expressed by astrocytes, these findings also support an important role of astrocytes in the development of chronic pain... - Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injuryWeiguo Peng
Department of Neurosurgery, Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 106:12489-93. 2009..1), which crosses the blood-brain barrier. Systemic administration of BBG may thus comprise a readily feasible approach by which to treat traumatic SCI in humans... - Adenosine is crucial for deep brain stimulation-mediated attenuation of tremorLane Bekar
Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester, Rochester, New York 14642, USA
Nat Med 14:75-80. 2008.... - Cortical spreading depression causes and coincides with tissue hypoxiaTakahiro Takano
Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Box 645, Rochester, New York 14642, USA
Nat Neurosci 10:754-62. 2007..Increasing O2 availability shortens the duration of CSD and improves local redox state. Our results indicate that tissue hypoxia associated with CSD is caused by a transient increase in O2 demand exceeding vascular O2 supply... - Bergmann glia modulate cerebellar Purkinje cell bistability via Ca2+-dependent K+ uptakeFushun Wang
Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 109:7911-6. 2012..Thus, Bergmann glia play a previously unappreciated role in controlling the membrane potential and thereby the activity of adjacent Purkinje cells... - Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regionsKarl A Kasischke
Department of Neurology, Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, New York 14642, USA
J Cereb Blood Flow Metab 31:68-81. 2011..Thus, two-photon NADH imaging can be applied to expose vascular supply regions and to localize functionally relevant microregional cortical hypoxia with micrometer spatial resolution... - Receptor-mediated glutamate release from volume sensitive channels in astrocytesTakahiro Takano
Center for Aging and Developmental Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 102:16466-71. 2005..Our observations indicate that volume-sensitive channel may constitute a previously uncharacterized target for modulation of astrocyte-neuronal interactions... - Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edemaAlexander S Thrane
Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 108:846-51. 2011.... - Cultured astrocytes do not release adenosine during hypoxic conditionsTakumi Fujita
Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York, USA
J Cereb Blood Flow Metab 32:e1-7. 2012..These results show that cultured astrocytes do not release adenosine during mild hypoxia, an observation consistent with their high resistance to hypoxia... - Critical role of connexin 43 in secondary expansion of traumatic spinal cord injuryChunlan Huang
Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, New York 14642, USA
J Neurosci 32:3333-8. 2012..Connexins may thereby constitute a new therapeutic target in spinal cord injury... - Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cordNeeta S Roy
Department of Neurology and Neuroscience, Cornell University Medical Center, New York, New York 10021, USA
Nat Biotechnol 22:297-305. 2004..The cells have survived >168 doublings in vitro, with karyotypic normalcy and without replicative senescence. hTERT overexpression thus permits the generation of progenitor lines able to give rise to phenotypically restricted neurons... - Heterogeneity of astrocytic form and functionNancy Ann Oberheim
Center for Translational Neuromedicine, Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA
Methods Mol Biol 814:23-45. 2012.... - Imaging of cortical astrocytes using 2-photon laser scanning microscopy in the intact mouse brainGuo Feng Tian
Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
Adv Drug Deliv Rev 58:773-87. 2006.... - Astrocyte-mediated control of cerebral blood flowTakahiro Takano
Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, New York 14642, USA
Nat Neurosci 9:260-7. 2006..These observations implicate astrocytes in the control of local microcirculation and suggest that one of their physiological roles is to mediate vasodilation in response to increased neural activity... - The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortexDitte Lovatt
Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA
J Neurosci 27:12255-66. 2007.... - Adenosine A1 receptors mediate local anti-nociceptive effects of acupunctureNanna Goldman
Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York, USA
Nat Neurosci 13:883-8. 2010..These observations indicate that adenosine mediates the effects of acupuncture and that interfering with adenosine metabolism may prolong the clinical benefit of acupuncture... - Locus coeruleus alpha-adrenergic-mediated activation of cortical astrocytes in vivoLane K Bekar
Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester, Rochester, NY 14642, USA
Cereb Cortex 18:2789-95. 2008..Future investigations of LC function must therefore consider the possibility that LC neuromodulatory effects are in part derived from activation of astrocytes... - Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult miceXiaoning Han
Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Cell Stem Cell 12:342-53. 2013..Mice allografted with murine GPCs showed no enhancement of either LTP or learning. These findings indicate that human glia differentially enhance both activity-dependent plasticity and learning in mice... - Cognitive deficits and delayed neuronal loss in a mouse model of multiple microinfarctsMinghuan Wang
Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA
J Neurosci 32:17948-60. 2012..The long-lasting gliosis, delayed neuronal loss, and demyelination suggest that the therapeutic window for microinfarcts may be much wider (perhaps days to weeks) than for larger strokes... - The locus coeruleus-norepinephrine network optimizes coupling of cerebral blood volume with oxygen demandLane K Bekar
Division of Glia Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York, USA
J Cereb Blood Flow Metab 32:2135-45. 2012..As LC neuron loss is prominent in Alzheimer and Parkinson diseases, the diminished ability to couple blood volume to oxygen demand may contribute to their pathogenesis... - An astrocytic basis of epilepsyGuo-Feng Tian
Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
Nat Med 11:973-81. 2005..Our results show an unanticipated key role for astrocytes in seizure activity. As such, these findings identify astrocytes as a proximal target for the treatment of epileptic disorders... - Astrocytes and ischemic injuryTakahiro Takano
Divison of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Stroke 40:S8-12. 2009..Neuroprotective efforts targeting the functional integrity of astrocytes may constitute a superior strategy for future neuroprotection... - Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's diseaseTakahiro Takano
Department of Neurosurgery, Center for Aging and Developmental Biology, University of Rochester Medical Center, 601 Elmwood Ave, Box 645, Rochester, NY 14642, USA
Ann N Y Acad Sci 1097:40-50. 2007.... - Resolving vesicle fusion from lysis to monitor calcium-triggered lysosomal exocytosis in astrocytesJyoti K Jaiswal
The Rockefeller University, 1230 York Avenue, Box 304, New York, NY 10065, USA
Proc Natl Acad Sci U S A 104:14151-6. 2007..We have used this approach to demonstrate that lysosomes undergo calcium-triggered exocytosis in astrocytes... - Uniquely hominid features of adult human astrocytesNancy Ann Oberheim
Center for Translational Neuromedicine, Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
J Neurosci 29:3276-87. 2009..On this basis, we posit that this astrocytic complexity has permitted the increased functional competence of the adult human brain... - General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortexAlexander Stanley Thrane
Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 109:18974-9. 2012..We propose that these glial effects may constitute a nonneuronal mechanism for sedative action of anesthetic drugs... - P2X7 receptor inhibition improves recovery after spinal cord injuryXiaohai Wang
Department of Neurosurgery, Center for Aging and Developmental Biology, University of Rochester Medical Center, Rochester, New York 14642, USA
Nat Med 10:821-7. 2004..P2X7R antagonists inhibit this process, reducing both the histological extent and functional sequelae of acute SCI... - Glial progenitor cell-based treatment and modeling of neurological diseaseSteven A Goldman
Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Science 338:491-5. 2012.... - Glial regulation of the cerebral microvasculatureCostantino Iadecola
Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, New York 10021, USA
Nat Neurosci 10:1369-76. 2007..The involvement of astrocytes in neurovascular coupling has broad implications for the interpretation of functional imaging signals and for the understanding of brain diseases that are associated with neurovascular dysfunction... - Astrocytic calcium signaling: mechanism and implications for functional brain imagingXiaohai Wang
Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY, USA
Methods Mol Biol 489:93-109. 2009.... - Two-photon in vivo imaging of cellsDaniel J Christensen
The Institute of Optics, University of Rochester, Rochester, NY, USA
Pediatr Nephrol 26:1483-9. 2011..This review focuses on providing the reader with a short history of, and impetus behind, two-photon imaging, its working mechanics, and emerging technologies related to biological multiphoton imaging... - A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid βJeffrey J Iliff
Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
Sci Transl Med 4:147ra111. 2012..Clearance through paravenous flow may also regulate extracellular levels of proteins involved with neurodegenerative conditions, its impairment perhaps contributing to the mis-accumulation of soluble proteins... - Traditional acupuncture triggers a local increase in adenosine in human subjectsTakahiro Takano
Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, NY, USA
J Pain 13:1215-23. 2012.... - Deciphering migraineTakahiro Takano
Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, New York 14642, USA
J Clin Invest 119:16-9. 2009.... - Purine receptor mediated actin cytoskeleton remodeling of human fibroblastsNanna Goldman
Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, United States
Cell Calcium 53:297-301. 2013..These observations indicate that purine signaling induces transient changes in fibroblast cytoarchitecture that could be related to the beneficial effects of acupuncture... - Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouseMartha S Windrem
Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
Cell Stem Cell 2:553-65. 2008..These data demonstrate that the neonatal transplantation of human glial progenitor cells can effectively treat disorders of congenital and perinatal hypomyelination... - Astrocytic complexity distinguishes the human brainNancy Ann Oberheim
Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Trends Neurosci 29:547-53. 2006..We propose that human cortical evolution has been accompanied by increasing complexity in the form and function of astrocytes, which reflects an expansion of their functional roles in synaptic modulation and cortical circuitry... - Brain connexins in demyelinating diseases: therapeutic potential of glial targetsMaria Luisa Cotrina
Division of Glia Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, NY 14640, USA
Brain Res 1487:61-8. 2012..This article is part of a Special Issue entitled Electrical Synapses... - Signaling at the gliovascular interfaceMarie Simard
Department of Neurosurgery, New York Medical College, Valhalla, New York 10590, USA
J Neurosci 23:9254-62. 2003..It is speculated that calcium signaling may play a role in astrocytic functions related to the blood-brain barrier, including blood flow regulation, metabolic trafficking, and water homeostasis... - Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brainMarta C Nunes
Department of Neurology and Neuroscience, Cornell University Medical College, New York, New York, USA
Nat Med 9:439-47. 2003..These experiments indicate that an abundant pool of mitotically competent neurogenic progenitor cells resides in the adult human white matter... - Role of glial cells in cerebral ischemiaMaiken Nedergaard
Department of Neurosurgery, Center for Aging and Developmental Biology, University of Rochester Medical Center, Rochester, New York, USA
Glia 50:281-6. 2005..By emphasizing open issues in this field, we hope to stimulate further research into this relatively unexplored aspect of brain pathophysiology... - Physiological and pathological functions of P2X7 receptor in the spinal cordMaria Luisa Cotrina
Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY, 14642, USA
Purinergic Signal 5:223-32. 2009..We will discuss the mechanisms for P2X7R actions and the potential that manipulating the P2X7R signaling pathway may have for therapeutic intervention in pathological events, specifically in the spinal cord... - Astrocyte-mediated control of cerebral microcirculationChristopher M Anderson
Department of Neurology, University of California-San Francisco, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Trends Neurosci 26:340-4; author reply 344-5. 2003..This finding represents a breakthrough in our knowledge both of astrocyte function and of the mechanism of activity-dependent cerebral blood flow regulation... - Astrocytes in the aging brainMaria Luisa Cotrina
Department of Anatomy and Cell Biology, New York Medical College, Valhalla, NY 10595, USA
J Neurosci Res 67:1-10. 2002 - A central role of connexin 43 in hypoxic preconditioningJane H C Lin
Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
J Neurosci 28:681-95. 2008..Thus, adaptive modulation of Cx43 can offset environmental stress by adenosine-mediated elevation of cellular resistance... - Astrocyte-mediated activation of neuronal kainate receptorsQing Song Liu
Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
Proc Natl Acad Sci U S A 101:3172-7. 2004..By modulating the activity of interneurons, astrocytes may play a critical role in circuit function of hippocampus... - New roles for astrocytes: redefining the functional architecture of the brainMaiken Nedergaard
Department of Cell Biology, New York Medical College, Valhalla, NY 10595, USA
Trends Neurosci 26:523-30. 2003..By these means, astrocytes might establish the functional as well as the structural architecture of the adult brain... - Astrocytic glutamate release-induced transient depolarization and epileptiform discharges in hippocampal CA1 pyramidal neuronsNing Kang
Department. of Cell Biology and Anatomy, New York Medical College, Valhalla, 10595, USA
J Neurophysiol 94:4121-30. 2005..Our study provides a novel mechanism, astrocytic release of glutamate, for seizure initiation... - DM-nitrophen provides physiologically significant increases of intracellular [Ca2+] in the presence of Mg2+Takahiro Takano
Cell Calcium 41:503-4. 2007 - Development of tight junction molecules in blood vessels of germinal matrix, cerebral cortex, and white matterPraveen Ballabh
Department of Pediatrics, Westchester Medicak Center New York Medical College, Valhalla, 10595, USA
Pediatr Res 58:791-8. 2005.... - Intercellular calcium signaling mediated by point-source burst release of ATPGregory Arcuino
Department of Cell Biology, Anatomy, and Pathology, New York Medical College, Valhalla, NY 10595, USA
Proc Natl Acad Sci U S A 99:9840-5. 2002.... - Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cellsJane H C Lin
Departments of Pathology and Anatomy and Cell Biology, New York Medical College, Valhalla, New York 10595, USA
J Neurosci 22:4302-11. 2002.... - Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cellsNeeta Singh Roy
Department of Neurology, Cornell University Medical College, NYC, NY 10021, USA
Exp Neurol 196:224-34. 2005..These results suggest the utility of promoter/enhancer-based FACS for the isolation of specific phenotypes from hES cell populations as a means of purifying clinically appropriate vectors for cell therapy... - Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neuronsChristopher M Anderson
Department of Pharmacology and Therapeutics, University of Manitoba and Division of Neurodegenerative Disorders, St Boniface Hospital Research Center, Winnipeg, Canada R2H 2A6
Trends Neurosci 29:257-62. 2006.... - Astrocyte end-feet in germinal matrix, cerebral cortex, and white matter in developing infantsNadine El-Khoury
Department of Pediatrics, Westchester Medical Center, New York Medical College, Valhalla, New York 10595, USA
Pediatr Res 59:673-9. 2006.... - Beyond the role of glutamate as a neurotransmitterMaiken Nedergaard
Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
Nat Rev Neurosci 3:748-55. 2002..Here, we review the current knowledge on glutamatergic signalling in non-neuronal cells, with a special emphasis on astrocytes... - Maturational changes in laminin, fibronectin, collagen IV, and perlecan in germinal matrix, cortex, and white matter and effect of betamethasoneHongmin Xu
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
J Neurosci Res 86:1482-500. 2008..Because fibronectin provides structural stability to the blood vessels, its reduced expression in the germinal matrix may contribute to the fragility of germinal matrix vasculature and the propensity to hemorrhage in premature neonates... - Connexin 43 hemichannels are permeable to ATPJian Kang
Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
J Neurosci 28:4702-11. 2008..Furthermore, a putative Cx43 hemichannel with characteristics identical to the Cx43 hemichannel in C6 cells was identified in the membrane of hippocampal astrocytes in acutely prepared slices... - Paucity of pericytes in germinal matrix vasculature of premature infantsAlex Braun
Department of Pathology, New York Medical College, Westchester Medical Center, Valhalla, New York 10595, USA
J Neurosci 27:12012-24. 2007..Hence, a paucity of pericytes in the GM vasculature may contribute to its propensity to hemorrhage, and a lower expression of TGF-beta1 could be a basis of reduced pericyte density in its vasculature... - Activity-dependent long-term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neuronsJun Xu
Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
J Neurosci 25:1750-60. 2005..This new form of hippocampal neuronal plasticity could be a cellular correlate of learning and memory besides synaptic LTP... - Purinergic signaling regulates neural progenitor cell expansion and neurogenesisJane H C Lin
Department of Cell Biology, New York Medical College, Valhalla, NY, USA
Dev Biol 302:356-66. 2007..As a result, progenitor cell-derived neurogenesis is thus associated with regions of both active purinergic signaling and modulation thereof... - Anatomic analysis of blood vessels in germinal matrix, cerebral cortex, and white matter in developing infantsPraveen Ballabh
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
Pediatr Res 56:117-24. 2004..of the GM compared with gray and white matter may play a role in GM hemorrhage, whereas a relatively low vascularity of white matter may increase the propensity for the occurrence of periventricular leukomalacia in premature infants.. - Presynaptic inactivation of action potentials and postsynaptic inhibition of GABAA currents contribute to KA-induced disinhibition in CA1 pyramidal neuronsNing Kang
Dept. of Cell Biology and Anatomy, New York Medical College, Basic Science Bldg, Rm. 220, Valhalla, NY 10595, USA
J Neurophysiol 92:873-82. 2004..Thus the postsynaptic KAR-mediated inhibition of GABA(A) currents may contribute to the KAR agonist-induced decrease in the potency of uIPSCs and KA-induced disinhibition... - New roles for astrocytes (stars at last)Bruce Ransom
Department of Neurology, University of Washington, 1959 NE Pacific, Room RR650, Box 356465, Seattle, WA 98195, USA
Trends Neurosci 26:520-2. 2003..But now, at last, astrocytes have our attention... - Connexin mediates gap junction-independent resistance to cellular injuryJane H C Lin
Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
J Neurosci 23:430-41. 2003..Moreover, cells expressing nonfunctional mutant connexins also acquired a high resistance to injury. These observations identify Cx proteins as active players in cell survival... - Erythropoietin strikes a new cordSteven A Goldman
Nat Med 8:785-7. 2002
Research Grants
- Calcium Signalling Among Non-Neuronal Brain CellsMaiken Nedergaard; Fiscal Year: 2004..The long-distance multicellular calcium signaling pathway that we propose, and its attendant hormonal regulation, suggests immediately testable strategies for its abrogation. ..
- CONTROL OF ASTROCYTIC SIGNALINGMaiken Nedergaard; Fiscal Year: 2006..abstract_text> ..
- The Role of Astrocytes in Ischemic StrokeMaiken Nedergaard; Fiscal Year: 2007..Our hope is that these studies ultimately will result in new treatment options for patients with acute ischemic stroke. ..
- Mediators of Functional Hyperemia and Its Dysregulation in Post-Traumatic BrainMaiken Nedergaard; Fiscal Year: 2007....
- Mediators of Functional Hyperemia and Its Dysregulation in Post-Traumatic BrainMaiken Nedergaard; Fiscal Year: 2009....
- Mediators of Functional Hyperemia and Its Dysregulation in Post-Traumatic BrainMaiken Nedergaard; Fiscal Year: 2010....
- Astrocyte Dysfunction in EpilepsyMaiken Nedergaard; Fiscal Year: 2010..By more specifically targeting the glial cause of neuronal excitability, we might be able to achieve more specific, less variable and less toxic treatment options for patients with epilepsy. ..
- Astrocyte Dysfunction in EpilepsyMaiken Nedergaard; Fiscal Year: 2009..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
- Antiapoptotic Actions of ConnexinMaiken Nedergaard; Fiscal Year: 2004..Defining the pathways, by which connexin proteins increase cellular resistance to injury, may provide a potential new therapeutic target for preventing cell death in acute pathologies as stroke and head trauma. ..
- ASTROCYTE MEDIATED PROPAGATION OF ISCHEMIC BRAIN DAMAGEMaiken Nedergaard; Fiscal Year: 2000..Is focal ischemia associated with a decrease in gap junctional function intake live rat brain? 4. Will manipulations of junctional conductance affect the outcome of ischemia? ..
- MULTI-PHOTON CONFOCAL MICROSCOPE SYSTEMMaiken Nedergaard; Fiscal Year: 2001..The multi-photon confocal microscope system will become a core facility at New York Medical College, serving the entire medical science community. ..
- CONTROL OF ASTROCYTIC SIGNALINGMaiken Nedergaard; Fiscal Year: 2002..abstract_text> ..
- CONTROL OF ASTROCYTIC SIGNALINGMaiken Nedergaard; Fiscal Year: 2003..abstract_text> ..
- Astrocyte Dysfunction in EpilepsyMaiken Nedergaard; Fiscal Year: 2010..By more specifically targeting the glial cause of neuronal excitability, we might be able to achieve more specific, less variable and less toxic treatment options for patients with epilepsy. ..