R D Nebes

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Cognitive aging in persons with minimal amyloid-β and white matter hyperintensities
    Robert D Nebes
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Electronic address
    Neuropsychologia 51:2202-9. 2013
  2. pmc The greater sensitivity of elderly APOE ε4 carriers to anticholinergic medications is independent of cerebrovascular disease risk
    Robert D Nebes
    Department of Psychiatry, University of Pittsburgh Medical School, Pennsylvania, USA
    Am J Geriatr Pharmacother 10:185-92. 2012
  3. pmc Cognitive slowing associated with elevated serum anticholinergic activity in older individuals is decreased by caffeine use
    Robert D Nebes
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 19:169-75. 2011
  4. pmc Self-reported sleep quality predicts poor cognitive performance in healthy older adults
    Robert D Nebes
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    J Gerontol B Psychol Sci Soc Sci 64:180-7. 2009
  5. ncbi request reprint Serum anticholinergic activity and motor performance in elderly persons
    Robert D Nebes
    Department of Psychiatry, University of Pittsburgh Medical Center, Pennsylvania, USA
    J Gerontol A Biol Sci Med Sci 62:83-5. 2007
  6. ncbi request reprint The relation of white matter hyperintensities to cognitive performance in the normal old: education matters
    Robert D Nebes
    University of Pittsburgh Medical Center, Pennsylvania, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 13:326-40. 2006
  7. ncbi request reprint Serum anticholinergic activity, white matter hyperintensities, and cognitive performance
    R D Nebes
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Neurology 65:1487-9. 2005
  8. ncbi request reprint Relationship of deep white matter hyperintensities and apolipoprotein E genotype to depressive symptoms in older adults without clinical depression
    R D Nebes
    Western Psychiatric Institute and Clinic, Thomas Detre Hall, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 158:878-84. 2001
  9. ncbi request reprint Cognitive and motor slowing in Alzheimer's disease and geriatric depression
    R D Nebes
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    J Int Neuropsychol Soc 4:426-34. 1998
  10. ncbi request reprint Complementary category learning systems identified using event-related functional MRI
    H J Aizenstein
    University of Pittsburgh Medical School, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Cogn Neurosci 12:977-87. 2000

Detail Information

Publications27

  1. pmc Cognitive aging in persons with minimal amyloid-β and white matter hyperintensities
    Robert D Nebes
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Electronic address
    Neuropsychologia 51:2202-9. 2013
    ....
  2. pmc The greater sensitivity of elderly APOE ε4 carriers to anticholinergic medications is independent of cerebrovascular disease risk
    Robert D Nebes
    Department of Psychiatry, University of Pittsburgh Medical School, Pennsylvania, USA
    Am J Geriatr Pharmacother 10:185-92. 2012
    ..Recent studies found use of anticholinergic medications to be associated with greater performance decrements in older persons who carry an ε4 allele of the apolipoprotein E (APOE) gene than in those carrying only ε2 or ε3 alleles...
  3. pmc Cognitive slowing associated with elevated serum anticholinergic activity in older individuals is decreased by caffeine use
    Robert D Nebes
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 19:169-75. 2011
    ....
  4. pmc Self-reported sleep quality predicts poor cognitive performance in healthy older adults
    Robert D Nebes
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    J Gerontol B Psychol Sci Soc Sci 64:180-7. 2009
    ..Sleep problems may contribute to performance variability between elderly individuals but only in certain cognitive domains...
  5. ncbi request reprint Serum anticholinergic activity and motor performance in elderly persons
    Robert D Nebes
    Department of Psychiatry, University of Pittsburgh Medical Center, Pennsylvania, USA
    J Gerontol A Biol Sci Med Sci 62:83-5. 2007
    ..Medications prescribed to elderly persons often have an anticholinergic effect, as do many commonly used over-the-counter drugs. Anticholinergic medications are known to produce psychomotor slowing, especially in older persons...
  6. ncbi request reprint The relation of white matter hyperintensities to cognitive performance in the normal old: education matters
    Robert D Nebes
    University of Pittsburgh Medical Center, Pennsylvania, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 13:326-40. 2006
    ..This is consistent with recent concepts of cognitive reserve, but does raise a question as to the underlying source of the cognitive decrement found in the sort of well-educated elders typically used in cognitive-aging studies...
  7. ncbi request reprint Serum anticholinergic activity, white matter hyperintensities, and cognitive performance
    R D Nebes
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Neurology 65:1487-9. 2005
    ....
  8. ncbi request reprint Relationship of deep white matter hyperintensities and apolipoprotein E genotype to depressive symptoms in older adults without clinical depression
    R D Nebes
    Western Psychiatric Institute and Clinic, Thomas Detre Hall, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 158:878-84. 2001
    ....
  9. ncbi request reprint Cognitive and motor slowing in Alzheimer's disease and geriatric depression
    R D Nebes
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    J Int Neuropsychol Soc 4:426-34. 1998
    ..Thus, this study suggests that AD produces a slowing in both cognitive and motor processes, whereas depression results solely in a motor retardation...
  10. ncbi request reprint Complementary category learning systems identified using event-related functional MRI
    H J Aizenstein
    University of Pittsburgh Medical School, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Cogn Neurosci 12:977-87. 2000
    ..Moreover, in both the implicit and explicit conditions a similar pattern of decreased activation was found in parietal regions. This commonality suggests that these dissociable systems also operate in parallel...
  11. ncbi request reprint Hypothyroidism and cognition: preliminary evidence for a specific defect in memory
    L A Burmeister
    Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Thyroid 11:1177-85. 2001
    ....
  12. ncbi request reprint The nature and determinants of neuropsychological functioning in late-life depression
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Gen Psychiatry 61:587-95. 2004
    ..Cognitive impairment in late-life depression (LLD) is highly prevalent, disabling, poorly understood, and likely related to long-term outcome...
  13. ncbi request reprint Instantiation of semantic categories in sentence comprehension by Alzheimer patients
    R D Nebes
    Department of Psychiatry, University of Pittsburgh School of Medicine, USA
    J Int Neuropsychol Soc 5:685-91. 1999
    ..Results showed that Alzheimer patients were highly accurate at instantiating even objects they could not name. This is consistent with a relative preservation of semantic knowledge about concrete objects in Alzheimer patients...
  14. ncbi request reprint The relation of White Matter Hyperintensities to implicit learning in healthy older adults
    H J Aizenstein
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 17:664-9. 2002
    ....
  15. ncbi request reprint Dual-task performance in depressed geriatric patients
    R D Nebes
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Psychiatry Res 102:139-51. 2001
    ....
  16. ncbi request reprint Executive functioning, illness course, and relapse/recurrence in continuation and maintenance treatment of late-life depression: is there a relationship?
    Meryl A Butters
    Intervention Research Center for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh Medical Center, USA
    Am J Geriatr Psychiatry 12:387-94. 2004
    ..The authors tested the hypothesis that impaired executive functioning leads to high rates of relapse and recurrence in late-life depression...
  17. ncbi request reprint Persistence of cognitive impairment in geriatric patients following antidepressant treatment: a randomized, double-blind clinical trial with nortriptyline and paroxetine
    Robert D Nebes
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Psychiatr Res 37:99-108. 2003
    ..The present results suggest that cognitive dysfunction persists in older depressed patients even after their mood disorder has responded to antidepressant medications...
  18. pmc Sleeping well, aging well: a descriptive and cross-sectional study of sleep in "successful agers" 75 and older
    Henry C Driscoll
    Sleep and Chronobiology Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 16:74-82. 2008
    ....
  19. ncbi request reprint Longitudinal increase in the volume of white matter hyperintensities in late-onset depression
    Robert D Nebes
    Department of Psychiatry, WPIC, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 17:526-30. 2002
    ..However, at present there is little evidence that a longitudinal increase in WMH burden within an individual is associated with the onset of a late-life depression...
  20. pmc Protecting sleep, promoting health in later life: a randomized clinical trial
    Charles F Reynolds
    Sleep and Chronobiology Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Psychosom Med 72:178-86. 2010
    ..5 years; and 2) if maintenance or enhancement of sleep continuity and depth promotes the maintenance or enhancement of health-related quality of life...
  21. pmc Detecting age differences in resistance to perceptual and motor interference
    J Richard Jennings
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Exp Aging Res 37:179-97. 2011
    ..The two scores were uncorrelated in the young but significantly correlated in the older group. Overall, the MAPIT appeared to yield reliable measures of two aspects of inhibition that demonstrate a differential impact of age...
  22. doi request reprint Inhibitory processes relate differently to balance/reaction time dual tasks in young and older adults
    David N Mendelson
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 17:1-18. 2010
    ..In the young, neither perceptual nor motor inhibition was associated with sensory switch cost. Inhibitory skills appear particularly important in the elderly for processing events from multiple sensory channels while maintaining balance...
  23. pmc Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserve
    Ann D Cohen
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 29:14770-8. 2009
    ....
  24. pmc Perceptual inhibition is associated with sensory integration in standing postural control among older adults
    Mark S Redfern
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Gerontol B Psychol Sci Soc Sci 64:569-76. 2009
    ..68, p < .001). Motor inhibition was not correlated with sway on either group. Perceptual inhibition may be a component of the sensory integration process important for maintaining balance in older adults...
  25. pmc Frequent amyloid deposition without significant cognitive impairment among the elderly
    Howard Jay Aizenstein
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 65:1509-17. 2008
    ....
  26. ncbi request reprint Regional brain activation during concurrent implicit and explicit sequence learning
    Howard J Aizenstein
    University of Pittsburgh Medical School, Department of Psychiatry, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Cereb Cortex 14:199-208. 2004
    ..Our results suggest a relative dissociation of the brain regions engaged during ESL and ISL, whereby ESL and ISL can be viewed as partially distinct but overlapping parallel processes...
  27. ncbi request reprint Prefrontal and striatal activation in elderly subjects during concurrent implicit and explicit sequence learning
    Howard J Aizenstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Department of Psychiatry, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Neurobiol Aging 27:741-51. 2006
    ..Moreover, these changes are observed during an implicit task, and thus do not seem to be mediated by awareness...

Research Grants12

  1. Effect of anticholinergic drugs & white matter hyperintensities on balance & gait
    Robert Nebes; Fiscal Year: 2009
    ..If the proposed studies show that anticholinergic medications are associated with balance and gait problems, then reducing usage of these medications could lessen the mobility limitations present in many older persons ..
  2. Anticholinergic Drugs, Cognitive Deficits & Normal Aging
    Robert Nebes; Fiscal Year: 2006
    ..We will also examine whether the decrements that anticholinergic drugs produce in higher-level cognitive abilities are mediated through decreases in working memory, processing speed or inhibitory efficiency. ..
  3. Anticholinergic Drugs, Cognitive Deficits & Normal Aging
    Robert Nebes; Fiscal Year: 2005
    ..We will also examine whether the decrements that anticholinergic drugs produce in higher-level cognitive abilities are mediated through decreases in working memory, processing speed or inhibitory efficiency. ..
  4. Anticholinergic Drugs, Cognitive Deficits & Normal Aging
    Robert Nebes; Fiscal Year: 2004
    ..We will also examine whether the decrements that anticholinergic drugs produce in higher-level cognitive abilities are mediated through decreases in working memory, processing speed or inhibitory efficiency. ..
  5. Anticholinergic Drugs, Cognitive Deficits & Normal Aging
    Robert Nebes; Fiscal Year: 2003
    ..We will also examine whether the decrements that anticholinergic drugs produce in higher-level cognitive abilities are mediated through decreases in working memory, processing speed or inhibitory efficiency. ..
  6. Anticholinergic Drugs, Cognitive Deficits & Normal Aging
    Robert Nebes; Fiscal Year: 2002
    ..We will also examine whether the decrements that anticholinergic drugs produce in higher-level cognitive abilities are mediated through decreases in working memory, processing speed or inhibitory efficiency. ..
  7. AGING, WHITE MATTER HYPERINTENSITIES & COGNITIVE DECLINE
    Robert Nebes; Fiscal Year: 2001
    ....
  8. AGING, WHITE MATTER HYPERINTENSITIES & COGNITIVE DECLINE
    Robert Nebes; Fiscal Year: 2000
    ....
  9. AGING, WHITE MATTER HYPERINTENSITIES & COGNITIVE DECLINE
    Robert Nebes; Fiscal Year: 1999
    ....
  10. Effect of anticholinergic drugs & white matter hyperintensities on balance & gait
    Robert D Nebes; Fiscal Year: 2010
    ..If the proposed studies show that anticholinergic medications are associated with balance and gait problems, then reducing usage of these medications could lessen the mobility limitations present in many older persons ..