Research Topics
Species | R D NebesSummaryAffiliation: University of Pittsburgh Country: USA Publications
Research Grants
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Detail Information
Publications
The greater sensitivity of elderly APOE ε4 carriers to anticholinergic medications is independent of cerebrovascular disease riskRobert D Nebes
Department of Psychiatry, University of Pittsburgh Medical School, Pennsylvania, USA
Am J Geriatr Pharmacother 10:185-92. 2012..Recent studies found use of anticholinergic medications to be associated with greater performance decrements in older persons who carry an ε4 allele of the apolipoprotein E (APOE) gene than in those carrying only ε2 or ε3 alleles...- Cognitive slowing associated with elevated serum anticholinergic activity in older individuals is decreased by caffeine useRobert D Nebes
Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 19:169-75. 2011.... - Self-reported sleep quality predicts poor cognitive performance in healthy older adultsRobert D Nebes
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
J Gerontol B Psychol Sci Soc Sci 64:180-7. 2009..Sleep problems may contribute to performance variability between elderly individuals but only in certain cognitive domains... 
Serum anticholinergic activity and motor performance in elderly personsRobert D Nebes
Department of Psychiatry, University of Pittsburgh Medical Center, Pennsylvania, USA
J Gerontol A Biol Sci Med Sci 62:83-5. 2007..Medications prescribed to elderly persons often have an anticholinergic effect, as do many commonly used over-the-counter drugs. Anticholinergic medications are known to produce psychomotor slowing, especially in older persons...- The relation of white matter hyperintensities to cognitive performance in the normal old: education mattersRobert D Nebes
University of Pittsburgh Medical Center, Pennsylvania, USA
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 13:326-40. 2006..This is consistent with recent concepts of cognitive reserve, but does raise a question as to the underlying source of the cognitive decrement found in the sort of well-educated elders typically used in cognitive-aging studies... - Serum anticholinergic activity, white matter hyperintensities, and cognitive performanceR D Nebes
Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Neurology 65:1487-9. 2005.... - Relationship of deep white matter hyperintensities and apolipoprotein E genotype to depressive symptoms in older adults without clinical depressionR D Nebes
Western Psychiatric Institute and Clinic, Thomas Detre Hall, 3811 O Hara St, Pittsburgh, PA 15213, USA
Am J Psychiatry 158:878-84. 2001.... - Cognitive and motor slowing in Alzheimer's disease and geriatric depressionR D Nebes
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
J Int Neuropsychol Soc 4:426-34. 1998..Thus, this study suggests that AD produces a slowing in both cognitive and motor processes, whereas depression results solely in a motor retardation... - Complementary category learning systems identified using event-related functional MRIH J Aizenstein
University of Pittsburgh Medical School, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Cogn Neurosci 12:977-87. 2000..Moreover, in both the implicit and explicit conditions a similar pattern of decreased activation was found in parietal regions. This commonality suggests that these dissociable systems also operate in parallel... - Hypothyroidism and cognition: preliminary evidence for a specific defect in memoryL A Burmeister
Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania, USA
Thyroid 11:1177-85. 2001.... - The nature and determinants of neuropsychological functioning in late-life depressionMeryl A Butters
Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
Arch Gen Psychiatry 61:587-95. 2004..Further studies of neuropsychological functioning in remitted LLD patients are needed to parse episode-related and persistent factors and to relate them to underlying neural dysfunction... - Instantiation of semantic categories in sentence comprehension by Alzheimer patientsR D Nebes
Department of Psychiatry, University of Pittsburgh School of Medicine, USA
J Int Neuropsychol Soc 5:685-91. 1999..Results showed that Alzheimer patients were highly accurate at instantiating even objects they could not name. This is consistent with a relative preservation of semantic knowledge about concrete objects in Alzheimer patients... - The relation of White Matter Hyperintensities to implicit learning in healthy older adultsH J Aizenstein
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Int J Geriatr Psychiatry 17:664-9. 2002.... - Dual-task performance in depressed geriatric patientsR D Nebes
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Psychiatry Res 102:139-51. 2001.... - Protecting sleep, promoting health in later life: a randomized clinical trialCharles F Reynolds
Sleep and Chronobiology Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Psychosom Med 72:178-86. 2010..5 years; and 2) if maintenance or enhancement of sleep continuity and depth promotes the maintenance or enhancement of health-related quality of life... - Sleeping well, aging well: a descriptive and cross-sectional study of sleep in "successful agers" 75 and olderHenry C Driscoll
Sleep and Chronobiology Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Am J Geriatr Psychiatry 16:74-82. 2008.... - Longitudinal increase in the volume of white matter hyperintensities in late-onset depressionRobert D Nebes
Department of Psychiatry, WPIC, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Int J Geriatr Psychiatry 17:526-30. 2002..However, at present there is little evidence that a longitudinal increase in WMH burden within an individual is associated with the onset of a late-life depression... - Executive functioning, illness course, and relapse/recurrence in continuation and maintenance treatment of late-life depression: is there a relationship?Meryl A Butters
Intervention Research Center for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh Medical Center, USA
Am J Geriatr Psychiatry 12:387-94. 2004..The authors tested the hypothesis that impaired executive functioning leads to high rates of relapse and recurrence in late-life depression... - Persistence of cognitive impairment in geriatric patients following antidepressant treatment: a randomized, double-blind clinical trial with nortriptyline and paroxetineRobert D Nebes
Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
J Psychiatr Res 37:99-108. 2003..The present results suggest that cognitive dysfunction persists in older depressed patients even after their mood disorder has responded to antidepressant medications... - Detecting age differences in resistance to perceptual and motor interferenceJ Richard Jennings
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Exp Aging Res 37:179-97. 2011..The two scores were uncorrelated in the young but significantly correlated in the older group. Overall, the MAPIT appeared to yield reliable measures of two aspects of inhibition that demonstrate a differential impact of age... 
Inhibitory processes relate differently to balance/reaction time dual tasks in young and older adultsDavid N Mendelson
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 17:1-18. 2010..In the young, neither perceptual nor motor inhibition was associated with sensory switch cost. Inhibitory skills appear particularly important in the elderly for processing events from multiple sensory channels while maintaining balance...- Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserveAnn D Cohen
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Neurosci 29:14770-8. 2009.... - Perceptual inhibition is associated with sensory integration in standing postural control among older adultsMark S Redfern
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Gerontol B Psychol Sci Soc Sci 64:569-76. 2009..68, p < .001). Motor inhibition was not correlated with sway on either group. Perceptual inhibition may be a component of the sensory integration process important for maintaining balance in older adults... - Frequent amyloid deposition without significant cognitive impairment among the elderlyHoward Jay Aizenstein
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Arch Neurol 65:1509-17. 2008.... - Regional brain activation during concurrent implicit and explicit sequence learningHoward J Aizenstein
University of Pittsburgh Medical School, Department of Psychiatry, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Cereb Cortex 14:199-208. 2004..Our results suggest a relative dissociation of the brain regions engaged during ESL and ISL, whereby ESL and ISL can be viewed as partially distinct but overlapping parallel processes... - Prefrontal and striatal activation in elderly subjects during concurrent implicit and explicit sequence learningHoward J Aizenstein
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Department of Psychiatry, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Neurobiol Aging 27:741-51. 2006..Moreover, these changes are observed during an implicit task, and thus do not seem to be mediated by awareness...
Research Grants
- Effect of anticholinergic drugs & white matter hyperintensities on balance & gaitRobert Nebes; Fiscal Year: 2009..If the proposed studies show that anticholinergic medications are associated with balance and gait problems, then reducing usage of these medications could lessen the mobility limitations present in many older persons ..
- Anticholinergic Drugs, Cognitive Deficits & Normal AgingRobert Nebes; Fiscal Year: 2006..We will also examine whether the decrements that anticholinergic drugs produce in higher-level cognitive abilities are mediated through decreases in working memory, processing speed or inhibitory efficiency. ..
- AGING, WHITE MATTER HYPERINTENSITIES & COGNITIVE DECLINERobert Nebes; Fiscal Year: 2001....
- Effect of anticholinergic drugs & white matter hyperintensities on balance & gaitRobert D Nebes; Fiscal Year: 2010..If the proposed studies show that anticholinergic medications are associated with balance and gait problems, then reducing usage of these medications could lessen the mobility limitations present in many older persons ..