D W Nebert

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. pmc Generation of a 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahrd mouse line harboring the poor-affinity aryl hydrocarbon receptor
    Zhanquan Shi
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, PO Box 670056, Cincinnati, OH 45267 0056, USA
    Biochem Biophys Res Commun 376:775-80. 2008
  2. doi request reprint Oral cadmium in mice carrying 5 versus 2 copies of the slc39a8 gene: comparison of uptake, distribution, metal content, and toxicity
    Scott N Schneider
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH, USA Email
    Int J Toxicol 33:14-20. 2014
  3. pmc Update of the human and mouse SERPIN gene superfamily
    Claire Heit
    Department of Pharmaceutical Sciences, Molecular Toxicology and Environmental Health Sciences Program, University of Colorado Anschutz Medical Center, Aurora, CO 80045, USA
    Hum Genomics 7:22. 2013
  4. pmc Oral benzo[a]pyrene: understanding pharmacokinetics, detoxication, and consequences--Cyp1 knockout mouse lines as a paradigm
    Daniel W Nebert
    Department of Environmental Health, and the Center for Environmental Genetics, University of Cincinnati Medical Center, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Mol Pharmacol 84:304-13. 2013
  5. pmc Update of human and mouse matrix metalloproteinase families
    Brian C Jackson
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    Hum Genomics 4:194-201. 2010
  6. pmc Evolutionary divergence and functions of the human acyl-CoA thioesterase gene ( ACOT ) family
    Chad Brocker
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    Hum Genomics 4:411-20. 2010
  7. pmc Analysis and update of the human solute carrier (SLC) gene superfamily
    Lei He
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA 02114, USA
    Hum Genomics 3:195-206. 2009
  8. pmc Update on genome completion and annotations: Protein Information Resource
    Cathy Wu
    Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC, USA
    Hum Genomics 1:229-33. 2004
  9. pmc Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily
    Brian C Jackson
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Center, Aurora, CO 80045, USA
    Hum Genomics 5:691-702. 2011
  10. pmc Update on the olfactory receptor (OR) gene superfamily
    Tsviya Olender
    The Crown Human Genome Center, Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    Hum Genomics 3:87-97. 2008

Research Grants

  1. Molecular Genetics of Cadmium Toxicity
    Daniel Nebert; Fiscal Year: 2007
  2. Molecular Genetics of Cadmium Toxicity
    Daniel W Nebert; Fiscal Year: 2010
  3. CYPIAI GENE AND ENVIRONMENTAL Toxicity
    Daniel Nebert; Fiscal Year: 2003
  4. GENOTOXICITY IN CYP1A2-DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 1993
  5. MOLECULAR GENETICS OF CD TOXICITY
    Daniel Nebert; Fiscal Year: 2004
  6. CYP1A1 GENE AND ENVIRONMENTAL TOXICITY
    Daniel Nebert; Fiscal Year: 2005
  7. Human HNSCC: CYP1B1/1A1/1A2 and AHR Gene Polymorphisms
    Daniel Nebert; Fiscal Year: 2007
  8. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
  9. GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 2002
  10. CYP1A1 GENE AND ENVIRONMENTAL TOXICITY
    Daniel Nebert; Fiscal Year: 1999

Collaborators

Detail Information

Publications128 found, 100 shown here

  1. pmc Generation of a 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahrd mouse line harboring the poor-affinity aryl hydrocarbon receptor
    Zhanquan Shi
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, PO Box 670056, Cincinnati, OH 45267 0056, USA
    Biochem Biophys Res Commun 376:775-80. 2008
    ..This new mouse line is perhaps more relevant than the former to human risk assessment vis-à-vis human CYP1A1 and CYP1A2 substrates, because poor-affinity rather than high-affinity AHR occurs in the vast majority of the human population...
  2. doi request reprint Oral cadmium in mice carrying 5 versus 2 copies of the slc39a8 gene: comparison of uptake, distribution, metal content, and toxicity
    Scott N Schneider
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH, USA Email
    Int J Toxicol 33:14-20. 2014
    ....
  3. pmc Update of the human and mouse SERPIN gene superfamily
    Claire Heit
    Department of Pharmaceutical Sciences, Molecular Toxicology and Environmental Health Sciences Program, University of Colorado Anschutz Medical Center, Aurora, CO 80045, USA
    Hum Genomics 7:22. 2013
    ..Further characterization of these proteins will likely reveal potential biomarkers and therapeutic targets for disease. ..
  4. pmc Oral benzo[a]pyrene: understanding pharmacokinetics, detoxication, and consequences--Cyp1 knockout mouse lines as a paradigm
    Daniel W Nebert
    Department of Environmental Health, and the Center for Environmental Genetics, University of Cincinnati Medical Center, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Mol Pharmacol 84:304-13. 2013
    ....
  5. pmc Update of human and mouse matrix metalloproteinase families
    Brian C Jackson
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    Hum Genomics 4:194-201. 2010
    ..Although there has been much clinical interest in MMP inhibitors (MMPIs), few trials have been successful - often due to the broad nature of inhibition and the complex role of different MMPs in a given disease state...
  6. pmc Evolutionary divergence and functions of the human acyl-CoA thioesterase gene ( ACOT ) family
    Chad Brocker
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    Hum Genomics 4:411-20. 2010
    ....
  7. pmc Analysis and update of the human solute carrier (SLC) gene superfamily
    Lei He
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA 02114, USA
    Hum Genomics 3:195-206. 2009
    ..Understanding and characterising the functions of these transporters is relevant to medicine, genetics, developmental biology, pharmacology and cancer chemotherapy...
  8. pmc Update on genome completion and annotations: Protein Information Resource
    Cathy Wu
    Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC, USA
    Hum Genomics 1:229-33. 2004
    ..The PIR system allows consistent, rich and accurate protein annotation for all investigators...
  9. pmc Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily
    Brian C Jackson
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Center, Aurora, CO 80045, USA
    Hum Genomics 5:691-702. 2011
    ..Such information is predicted to reveal valuable novel drug targets for the treatment of inflammation, as well as designing biomarkers that might identify tissue damage or cancer...
  10. pmc Update on the olfactory receptor (OR) gene superfamily
    Tsviya Olender
    The Crown Human Genome Center, Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    Hum Genomics 3:87-97. 2008
    ..The nomenclature system (based on evolutionary divergence of genes into families and subfamilies of the OR gene superfamily) has been designed similarly to that originally used for the CYP gene superfamily...
  11. pmc The truth about mouse, human, worms and yeast
    David R Nelson
    Department of Molecular Sciences and The UT Center of Excellence in Genomics and Bioinformatics, University of Tennessee, Memphis, Tennessee 38163, USA
    Hum Genomics 1:146-9. 2004
    ..Current large disparities between human Unigene predictions (127,835 genes) and gene-scanning methods (45,000 genes) still need to be resolved. This will be the challenge during the next few years...
  12. pmc Cyclophilin nomenclature problems, or, 'a visit from the sequence police'
    Daniel W Nebert
    Department of Environmental Health and Center for Environmental Genetics CEG, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA dan nerbert uc edu
    Hum Genomics 1:381-8. 2004
    ....
  13. pmc Evolutionary divergence and functions of the human interleukin (IL) gene family
    Chad Brocker
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    Hum Genomics 5:30-55. 2010
    ..This suggests that the gene family organisation may be subject to further change in the near future...
  14. pmc Evolutionary divergence and functions of the ADAM and ADAMTS gene families
    Chad N Brocker
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    Hum Genomics 4:43-55. 2009
    ....
  15. pmc Human ATP-binding cassette (ABC) transporter family
    Vasilis Vasiliou
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    Hum Genomics 3:281-90. 2009
    ....
  16. pmc Update of human and mouse forkhead box (FOX) gene families
    Brian C Jackson
    Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, 80045, USA
    Hum Genomics 4:345-52. 2010
    ....
  17. pmc Human cytochromes P450 in health and disease
    Daniel W Nebert
    Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Philos Trans R Soc Lond B Biol Sci 368:20120431. 2013
    ....
  18. doi request reprint Genetic risk prediction: individualized variability in susceptibility to toxicants
    Daniel W Nebert
    Division of Human Genetics, Department of Pediatrics and Molecular Developmental Biology, University of Cincinnati Medical Center, Cincinnati, Ohio 45229, USA
    Annu Rev Pharmacol Toxicol 53:355-75. 2013
    ..Individualized risk assessment for toxicants that cause environmental diseases, although a lofty goal, remains to be achieved...
  19. doi request reprint ZIP14 and ZIP8 zinc/bicarbonate symporters in Xenopus oocytes: characterization of metal uptake and inhibition
    Daniel W Nebert
    Department of Environmental Health and Center for Environmental Genetics CEG, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Metallomics 4:1218-25. 2012
    ....
  20. pmc From human genetics and genomics to pharmacogenetics and pharmacogenomics: past lessons, future directions
    Daniel W Nebert
    Division of Human Genetics, Department of Pediatrics and Molecular Developmental Biology, Cincinnati, Ohio 45267 0056, USA
    Drug Metab Rev 40:187-224. 2008
    ..It remains unclear whether personalized medicine or individualized drug therapy will ever be achievable by means of DNA testing alone...
  21. ncbi request reprint Advances in pharmacogenomics and individualized drug therapy: exciting challenges that lie ahead
    Daniel W Nebert
    Division of Human Genetics, Department of Pediatrics and Molecular Developmental Biology, University of Cincinnati Medical Center, P O Box 670056, Cincinnati OH 45267 0056, USA
    Eur J Pharmacol 500:267-80. 2004
    ..Finally, we suggest that metabonomics, perhaps in combination with proteomics, might complement genomics in eventually helping us to achieve individualized drug therapy...
  22. ncbi request reprint Extreme discordant phenotype methodology: an intuitive approach to clinical pharmacogenetics
    D W Nebert
    Center for Environmental Genetics, Department of Environmental Health, University of Cincinnati Medical Center, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Eur J Pharmacol 410:107-120. 2000
    ..EDP methodology is mathematically intuitive and, in essence, has been used in a number of previous clinical pharmacogenetic studies. This EDP approach should be applicable to virtually any pharmaceutical agent in patient populations...
  23. ncbi request reprint Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer
    Daniel W Nebert
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    J Biol Chem 279:23847-50. 2004
    ..In the future, use of "humanized" mouse lines, containing a human AHR or CYP1 allele in place of the orthologous mouse gene, is one likely approach to show that the AHR and the CYP1 enzymes in human behave similarly to that in mouse...
  24. ncbi request reprint Drug-metabolizing enzymes, polymorphisms and interindividual response to environmental toxicants
    D W Nebert
    Department of Pediatrics, University of Cincinnati Medical Center, Ohio 45267 0056, USA
    Clin Chem Lab Med 38:857-61. 2000
    ..The end result can be large interindividual differences in risk of environmentally caused toxicity or cancer...
  25. ncbi request reprint Transcription factors and cancer: an overview
    Daniel W Nebert
    Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati Medical Center, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Toxicology 181:131-41. 2002
    ..Cancer is thus a multiplex phenotype: a crescendo of defects in hundreds if not thousands of genes, as a function of time, leading to an invasive and lethal disease...
  26. ncbi request reprint The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis
    Daniel W Nebert
    Department of Environmental Health, and Center for Environmental Genetics, University of Cincinnati Medical Center, P O Box 670056, Cincinnati, Ohio 45267 0056, USA
    Nat Rev Cancer 6:947-60. 2006
    ..We suggest a two-tiered system to predict an overall inter-individual risk of tumorigenesis based on DNA variants in certain 'early defence' CYP genes, combined with polymorphisms in various downstream target genes...
  27. ncbi request reprint Can personalized drug therapy be achieved? A closer look at pharmaco-metabonomics
    Daniel W Nebert
    Division of Human Genetics, Department of Pediatrics and Molecular Developmental Biology, Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Trends Pharmacol Sci 27:580-6. 2006
    ..However, recent advances in metabonomics are exciting and show promise. In the future, and perhaps in combination with proteomics, metabonomics might complement genomics in achieving personalized drug therapy...
  28. ncbi request reprint Inter-individual susceptibility to environmental toxicants--a current assessment
    Daniel W Nebert
    Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati Medical Center, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Toxicol Appl Pharmacol 207:34-42. 2005
    ....
  29. ncbi request reprint Proposal for an allele nomenclature system based on the evolutionary divergence of haplotypes
    Daniel W Nebert
    Center for Environmental Genetics, Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    Hum Mutat 20:463-72. 2002
    ..g., complex diseases including cancer, and/or toxicity of pharmaceutical agents or environmental pollutants)...
  30. ncbi request reprint Role of host susceptibility to toxicity and cancer caused by pesticides: cytochromes P450
    Daniel W Nebert
    Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    J Biochem Mol Toxicol 19:184-6. 2005
  31. ncbi request reprint Clinical importance of the cytochromes P450
    Daniel W Nebert
    Center for Environmental Genetics and Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Lancet 360:1155-62. 2002
    ..Mutations in many CYP genes cause inborn errors of metabolism and contribute to many clinically relevant diseases...
  32. pmc Analysis of the glutathione S-transferase (GST) gene family
    Daniel W Nebert
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Hum Genomics 1:460-4. 2004
    ..It is concluded that the complete GST gene family comprises 16 genes in six subfamilies--alpha (GSTA), mu (GSTM), omega (GSTO), pi (GSTP), theta (GSTT) and zeta (GSTZ)...
  33. pmc Update on human genome completion and annotations: gene nomenclature
    Daniel W Nebert
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Hum Genomics 1:66-71. 2003
    ....
  34. ncbi request reprint Suggestions for the nomenclature of human alleles: relevance to ecogenetics, pharmacogenetics and molecular epidemiology
    D W Nebert
    Center for Environmental Genetics and Department of Environmental Health, University of Cincinnati Medical Center, Ohio 45267 0056, USA
    Pharmacogenetics 10:279-90. 2000
    ....
  35. ncbi request reprint How knockout mouse lines will be used to study the role of drug-metabolizing enzymes and their receptors during reproduction and development, and in environmental toxicity, cancer, and oxidative stress
    D W Nebert
    Department of Environmental Health, University of Cincinnati Medical Center, OH 45267, U S A
    Biochem Pharmacol 53:249-54. 1997
    ....
  36. ncbi request reprint Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis
    D W Nebert
    Department of Environmental Health and the Center for Environmental Genetics, University of Cincinnati Medical Center, OH 45267 0056, USA
    Biochem Pharmacol 59:65-85. 2000
    ..These proposed endogenous functions of the AHR and [Ah] enzymes are, of course, in addition to the frequently described functions of "metabolic potentiation" and "detoxification" of various foreign chemicals...
  37. ncbi request reprint "Gene-swap knock-in" cassette in mice to study allelic differences in human genes
    D W Nebert
    Center for Environmental Genetics and Department of Environmental Health, University of Cincinnati Medical Center, Ohio 45267 0056, USA
    Ann N Y Acad Sci 919:148-70. 2000
    ..It is anticipated that mouse lines carrying numerous human alleles will become commonplace early in the next millennium...
  38. ncbi request reprint Pharmacogenetics and pharmacogenomics: why is this relevant to the clinical geneticist?
    D W Nebert
    Center for Environmental Genetics, Department of Environmental Health, University of Cincinnati Medical Center, OH 45267 0056, USA
    Clin Genet 56:247-58. 1999
    ....
  39. ncbi request reprint Genetic epidemiology of environmental toxicity and cancer susceptibility: human allelic polymorphisms in drug-metabolizing enzyme genes, their functional importance, and nomenclature issues
    D W Nebert
    Center for Environmental Genetics, University of Cincinnati Medical Center, Ohio 45267 0056, USA
    Drug Metab Rev 31:467-87. 1999
    ....
  40. pmc Analysis of human CYP1A1 and CYP1A2 genes and their shared bidirectional promoter in eight world populations
    Lucia F Jorge-Nebert
    Department of Environmental Health, University of Cincinnati Medical Center, PO Box 670056, Cincinnati, OH 45267 0056, USA
    Hum Mutat 31:27-40. 2010
    ....
  41. ncbi request reprint Regulation of [Ah] gene battery enzymes and glutathione levels by 5,10-dihydroindeno[1,2-b]indole in mouse hepatoma cell lines
    R M Liu
    Department of Environmental Health, University of Cincinnati Medical Center, OH 45267 0056
    Carcinogenesis 15:2347-52. 1994
    ..Furthermore, metabolism, possibly via CYP1A1, appears to be required for DHII to enhance intracellular levels of cysteine and GCS activity that result in higher GSH levels...
  42. ncbi request reprint Mouse cytosolic class 3 aldehyde dehydrogenase (Aldh3a1): gene structure and regulation of constitutive and dioxin-inducible expression
    V Vasiliou
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Ohio, USA
    Pharmacogenetics 9:569-80. 1999
    ..The dioxin-mediated upregulation of Aldh3a1 expression in mouse hepatoma Hepa-1c1c7 cell cultures was shown to depend exclusively on the aromatic hydrocarbon receptor...
  43. ncbi request reprint Extrahepatic expression of NAD(P)H:menadione oxidoreductase, UDP glucuronosyltransferase-1A6, microsomal aldehyde dehydrogenase, and hepatic nuclear factor-1 alpha mRNAs in ch/ch and 14CoS/14CoS mice
    V Vasiliou
    Center for Environmental Genetics, University of Cincinnati Medical Center, Ohio 45267 0056, USA
    Biochem Biophys Res Commun 233:631-6. 1997
    ..Our results show a wide variation in extrahepatic tissue-specific expression of all four transcripts and indicate that numerous differences exist in the extrahepatic expression of these genes between 14CoS/14CoS and ch/ch mice...
  44. ncbi request reprint Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery
    T P Dalton
    Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio, 45267 0056, USA
    Biochem Biophys Res Commun 267:184-9. 2000
    ..We postulate that CYP1A1 and CYP1A2 might have overlapping substrate specificity for metabolism of the EL, such that basal CYP1A2 in the liver can compensate for the loss of CYP1A1...
  45. ncbi request reprint Mitochondrial reactive oxygen production is dependent on the aromatic hydrocarbon receptor
    Albert P Senft
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, OH 45267, USA
    Free Radic Biol Med 33:1268-78. 2002
    ..These results suggest that both constitutive and dioxin-induced mitochondrial reactive oxygen production is associated with a function of the AHR, and these effects are independent of either CYP1A1 or CYP1A2...
  46. ncbi request reprint The Y-box motif mediates redox-dependent transcriptional activation in mouse cells
    J L Duh
    Department of Environmental Health, University of Cincinnati Medical Center, Ohio 45267 0056, USA
    J Biol Chem 270:30499-507. 1995
    ..These results suggest that the Y-box proteins may be an integral component of a eukaryotic redox signaling pathway...
  47. ncbi request reprint Mouse microsomal Class 3 aldehyde dehydrogenase: AHD3 cDNA sequence, inducibility by dioxin and clofibrate, and genetic mapping
    V Vasiliou
    Department of Environmental Health, University of Cincinnati Medical Center, Ohio 45267 0056, USA
    DNA Cell Biol 15:235-45. 1996
    ..These data indicate that, although inducible by dioxin, the Ahd3 gene does not qualify as a member of the aromatic hydrocarbon [Ah] gene battery...
  48. ncbi request reprint Dioxin causes a sustained oxidative stress response in the mouse
    H G Shertzer
    Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati Medical Center, Ohio 45267 0056, USA
    Biochem Biophys Res Commun 253:44-8. 1998
    ..These results demonstrate that dioxin exposure does produce a sustained oxidative stress response in the mouse...
  49. ncbi request reprint Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous
    T P Dalton
    Center for Environmental Genetics and the, University of Cincinnati Medical Center, Cincinnati, Ohio, 45267 0056, USA
    Biochem Biophys Res Commun 279:324-9. 2000
    ..These data show a reciprocal action between falling GSH concentrations and rising ascorbate levels. Therefore, the Gclc(+/-) mouse may be a useful genetic model for mild endogenous oxidative stress...
  50. ncbi request reprint Interaction between the Ah receptor and proteins binding to the AP-1-like electrophile response element (EpRE) during murine phase II [Ah] battery gene expression
    V Vasiliou
    Department of Environmental Health, University of Cincinnati Medical Center, OH 45267 0056, USA
    Biochem Pharmacol 50:2057-68. 1995
    ..To our knowledge, this is among the first reports of the same transcription factor operating at two different response elements upstream of a single gene...
  51. pmc Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism
    H C Liang
    Department of Environmental Health, University of Cincinnati Medical Center, OH 45267 0056, USA
    Proc Natl Acad Sci U S A 93:1671-6. 1996
    ..Availability of a viable and fertile CYP1A2-deficient mouse line will provide a valuable tool for researchers wishing to define the precise role of CYP1A2 in numerous metabolic and pharmacokinetic processes...
  52. ncbi request reprint Mouse dioxin-inducible cytosolic aldehyde dehydrogenase-3: AHD4 cDNA sequence, genetic mapping, and differences in mRNA levels
    V Vasiliou
    Department of Environmental Health, University of Cincinnati Medical Center, OH 45267 0056
    Pharmacogenetics 3:281-90. 1993
    ....
  53. ncbi request reprint Markedly increased constitutive CYP1A1 mRNA levels in the fertilized ovum of the mouse
    A Dey
    Center for Environmental Genetics and the Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio, 45267 0056, USA
    Biochem Biophys Res Commun 251:657-61. 1998
    ....
  54. ncbi request reprint Mouse dioxin-inducible NAD(P)H: menadione oxidoreductase: NMO1 cDNA sequence and genetic differences in mRNA levels
    V Vasiliou
    Department of Environmental Health, University of Cincinnati Medical Center, OH 45267 0056
    Pharmacogenetics 4:341-8. 1994
    ....
  55. ncbi request reprint Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones
    H G Shertzer
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, OH 45267 0056, USA
    Chem Biol Interact 123:31-49. 1999
    ..Isoflavone-mediated inhibition of CYP1A1 activity may contribute to the mechanism by which these soybean isoflavones protect against carcinogenesis...
  56. ncbi request reprint Sensitivity of CYP1A1 mRNA inducibility by dioxin is the same in Cyp1a2(+/+) wild-type and Cyp1a2(-/-) null mutant mice
    H C Liang
    Center for Environmental Genetics and Department of Environmental Health, University of Cincinnati Medical Center, OH 45267 0056, USA
    Biochem Pharmacol 54:1127-31. 1997
    ..These data indicate that the complete absence of the microsomal CYP1A2 enzyme has no measurable effect on hepatic expression of the Cyp1a1, gene, the only other known member of the mammalian CYP1A cytochrome P450 subfamily...
  57. ncbi request reprint Refining the mouse chromosomal location of Cdm, the major gene associated with susceptibility to cadmium-induced testicular necrosis
    T P Dalton
    Department of Environmental Health, University of Cincinnati Medical Center, Ohio 45267 0056, USA
    Pharmacogenetics 10:141-51. 2000
    ....
  58. ncbi request reprint Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response
    Yi Yang
    Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    J Biol Chem 277:49446-52. 2002
    ....
  59. ncbi request reprint For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential
    Nadine Dragin
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    J Biol Chem 281:18591-600. 2006
    ..In contrast, neither CYP1A1 nor CYP1B1 appears to play a role in dioxin-mediated teratogenesis...
  60. ncbi request reprint Activation of transcription factors in zebrafish cell cultures by environmental pollutants
    M J Carvan
    Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    Arch Biochem Biophys 376:320-7. 2000
    ....
  61. ncbi request reprint Comparison of oxidative stress response parameters in newborn mouse liver versus simian virus 40 (SV40)-transformed hepatocyte cell lines
    V Vasiliou
    Department of Environmental Health and Center for Ecogenetics and Environmental Health, University of Cincinnati Medical Center, OH 45267 0056, USA
    Biochem Pharmacol 59:703-12. 2000
    ..It is therefore likely that differences in the oxidative stress responses between the 14CoS/14CoS newborn liver and the immortalized hepatocyte cell line might be explained by the presence of large T antigen in the established cell line...
  62. ncbi request reprint Comparison of mouse hepatic mitochondrial versus microsomal cytochromes P450 following TCDD treatment
    Mary Beth Genter
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Biochem Biophys Res Commun 342:1375-81. 2006
    ..We speculate that such mitochondrial CYPs may be involved in the generation, or mitigation, of the well-known TCDD-inducible oxidative stress response...
  63. ncbi request reprint Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus
    Zhengwen Jiang
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    Hum Mutat 25:196-206. 2005
    ....
  64. ncbi request reprint Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels
    S Uno
    Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, Ohio 45267-0056, USA
    Biochem Biophys Res Commun 289:1049-56. 2001
    ....
  65. pmc Phenotype of the Cyp1a1/1a2/1b1-/- triple-knockout mouse
    Nadine Dragin
    Department of Environmental Health, University of Cincinnati Medical Center, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Mol Pharmacol 73:1844-56. 2008
    ....
  66. pmc Basal and inducible CYP1 mRNA quantitation and protein localization throughout the mouse gastrointestinal tract
    Shigeyuki Uno
    Department of Environmental Health, and The Center for Environmental Genetics CEG, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Free Radic Biol Med 44:570-83. 2008
    ..These GI tract data suggest that the inducible CYP1A1 enzyme, both in concentration and in location, might act as a "shield" in detoxifying oral BaP and, hence, protecting the animal...
  67. pmc Generation of 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-) mouse line
    Nadine Dragin
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, PO Box 670056, Cincinnati, OH 45267 0056, USA
    Biochem Biophys Res Commun 359:635-42. 2007
    ..8% C57BL/6J genetic background-having both human genes replacing the mouse orthologs. This line will be valuable for human risk assessment studies involving any environmental toxicant or drug that is a substrate for CYP1A1 or CYP1A2...
  68. ncbi request reprint Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype
    Zhengwen Jiang
    Department of Environmental Health and Center for Environmental Genetics CEG, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    Pharmacogenet Genomics 16:359-67. 2006
    ..We conclude that no SNP or haplotype in the CYP1A2 gene has yet been identified that can unequivocally be used to predict the metabolic phenotype in any individual patient...
  69. ncbi request reprint Differential regulation of mouse Ah receptor gene expression in cell lines of different tissue origins
    C T Fitzgerald
    Department of Environmental Health, University of Cincinnati Medical Center, Ohio 45267 0056, USA
    Arch Biochem Biophys 333:170-8. 1996
    ..These results indicate that both up- and down-regulation of the Ahr gene occur and exhibit tissue-and cell-type specificity...
  70. ncbi request reprint Glutamate-cysteine ligase modifier subunit: mouse Gclm gene structure and regulation by agents that cause oxidative stress
    Willy A Solis
    Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Biochem Pharmacol 63:1739-54. 2002
    ..7-kb region studied...
  71. ncbi request reprint Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl
    Christine P Curran
    Department of Environmental Health, University of Cincinnati Medical Center, P O Box 670056, Cincinnati OH 45267 0056, USA
    Toxicol Sci 89:454-64. 2006
    ..Although dioxin in utero is well known to cause AHR-dependent cleft palate and hydronephrosis, cHBB did not; thus, chronic activation of the AHR appears to be necessary but not sufficient for AHR-mediated teratogenicity...
  72. ncbi request reprint Balancer-Cre transgenic mouse germ cells direct the incomplete resolution of a tri-loxP-targeted Cyp1a1 allele, producing a conditional knockout allele
    Shigeyuki Uno
    Department of Environmental Health and Center for Environmental Genetics CEG, University of Cincinnati Medical Center, Cincinnati, OH, USA
    Biochem Biophys Res Commun 312:494-9. 2003
    ..Removal of the marker gene resulted in a conditional Cyp1a1 allele whose expression was indistinguishable from that of the wild-type allele...
  73. ncbi request reprint Dioxin increases reactive oxygen production in mouse liver mitochondria
    Albert P Senft
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    Toxicol Appl Pharmacol 178:15-21. 2002
    ..To our knowledge, this is the first report to show that dioxin increases mitochondrial respiration-dependent reactive oxygen production, which may play an important role in dioxin-induced toxicity and disease...
  74. ncbi request reprint Theophylline pharmacokinetics: comparison of Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice
    Sandrine Derkenne
    Department of Environmental Health and Center for Environmental Genetics CEG, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Pharmacogenet Genomics 15:503-11. 2005
    ..Pharmacokinetics of theophylline was investigated in Cyp1(+/+) wild-type mice, Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice, and humanized hCYP1A1_1A2 mice lacking either the mouse Cyp1a1 or Cyp1a2 gene...
  75. ncbi request reprint Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate
    Shigeyuki Uno
    Department of Environmental Health, University of Cincinnati Medical Center, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Mol Pharmacol 69:1103-14. 2006
    ..Thus, a balance between tissue-specific expression of the CYP1A1 and CYP1B1 enzymes governs sensitivity of benzo[a]pyrene toxicity and, possibly, carcinogenicity...
  76. ncbi request reprint Glutathione redox state regulates mitochondrial reactive oxygen production
    Dongxiao Shen
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, P O Box 670056, Cincinnati, Ohio 45267 0056, USA
    J Biol Chem 280:25305-12. 2005
    ..These results suggest that TCDD produces an AHR-dependent oxidative stress in mitochondria, with concomitant mitochondrial DNA damage mediated, at least in part, by an increase in the mitochondrial thiol reduction state...
  77. ncbi request reprint Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping
    V Vasiliou
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Centre, Denver, USA
    Pharmacogenetics 9:421-34. 1999
    ..uchsc.edu/sp./sp./alcdbase/a ldhcov.html) and will serve as a medium for interaction amongst colleagues in this field...
  78. ncbi request reprint P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature
    D R Nelson
    Department of Biochemistry, University of Tennessee, Memphis 38163, USA
    Pharmacogenetics 6:1-42. 1996
    ..The cDNAs, mRNAs and enzymes in all species (including mouse) should include all capital letters, and without italics or hyphens. This nomenclature system is similar to that proposed in our previous updates...
  79. ncbi request reprint Human Ah receptor (AHR) gene: localization to 7p15 and suggestive correlation of polymorphism with CYP1A1 inducibility
    J Micka
    Physician Scientist Training Program, CHRF, Cincinnati, OH 45229, USA
    Pharmacogenetics 7:95-101. 1997
    ..These data indicate that the "high' and "low' CYP1A1 inducibility trait, in the population studied, cannot be explained by a difference among these 31 amino acids in exon 9 of the AHR gene...
  80. ncbi request reprint Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice
    C Chang
    Department of Environmental Health, University of Cincinnati Medical Center, OH 45267 0056
    Pharmacogenetics 3:312-21. 1993
    ....
  81. ncbi request reprint 4-aminobiphenyl-induced liver and urinary bladder DNA adduct formation in Cyp1a2(-/-) and Cyp1a2(+/+) mice
    Yutaka Tsuneoka
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    J Natl Cancer Inst 95:1227-37. 2003
    ..We used Cyp1a2(-/-) knockout mice to examine the role of CYP1A2 in ABP-DNA adduct formation in the liver and the bladder...
  82. ncbi request reprint CYP2D1 polymorphism in methamphetamine-treated rats: genetic differences in neonatal mortality and effects on spatial learning and acoustic startle
    C V Vorhees
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229 3039, USA
    Neurotoxicol Teratol 20:265-73. 1998
    ....
  83. ncbi request reprint Cyp1a1(-/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria
    Shigeyuki Uno
    Department of Environmental Health and Center for Environmental Genetics CEG, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Toxicol Appl Pharmacol 196:410-21. 2004
    ..Our data demonstrate that CYP1A1 contributes to high-dose TCDD-induced toxicity, uroporphyria, and lethality...
  84. ncbi request reprint Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation
    Shigeyuki Uno
    Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati Medical Center, OH 45267 0056, USA
    Mol Pharmacol 65:1225-37. 2004
    ....
  85. ncbi request reprint Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure
    Ying Chen
    Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, and Center for Immunology and Inflammatory Disease, Massachusetts General Hospital, Boston, USA
    Hepatology 45:1118-28. 2007
    ..CONCLUSION: GSH is essential for hepatic function and loss of hepatocyte GSH synthesis leads to steatosis with mitochondrial injury and hepatic failure...
  86. ncbi request reprint Statistical power of association using the extreme discordant phenotype design
    Ge Zhang
    Department of Environmental Health and Center for Environmental Genetics CEG, University of Cincinnati Medical Center, Cincinnati, OH, USA
    Pharmacogenet Genomics 16:401-13. 2006
    ..The advantage of EDP design is intuitive and it has been successfully used in a number of studies...
  87. ncbi request reprint Pharmacological rescue of the 14CoS/14CoS mouse: hepatocyte apoptosis is likely caused by endogenous oxidative stress
    Matthew Z Dieter
    Department of Environmental Health and Center for Environmental Genetics CEG, University of Cincinnati Medical Center, Cincinnati, OH, USA
    Free Radic Biol Med 35:351-67. 2003
    ..The mouse data in the present study are consistent with the possibility that endogenous oxidative stress-induced apoptosis may be the underlying cause of liver pathology seen in NTBC-treated HT1 patients...
  88. ncbi request reprint The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature
    D W Nebert
    Department of Environmental Health, University of Cincinnati Medical Center, OH 45267 0056
    DNA Cell Biol 10:1-14. 1991
    ..This system is consistent with our earlier proposed nomenclature for P450 of all eukaryotes and prokaryotes, except that we are discouraging the future use of cumbersome Roman numerals...
  89. ncbi request reprint Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse
    M B Genter
    Department of Molecular and Cellular Physiology, University of Cincinnati, OH 45267 0576, USA
    Biochem Pharmacol 55:1819-26. 1998
    ..These studies provide strong evidence that, in addition to CYP2E1, CYP2A5 and 2G1 are important in AP bioactivation in the mouse olfactory mucosa and that CYP1A2 appears to be of minor importance for AP olfactory toxicity...
  90. pmc Olfactory receptor gene polymorphisms and nonallergic vasomotor rhinitis
    Jonathan A Bernstein
    University of Cincinnati College of Medicine, Department of Internal Medicine, Division of Immunology Allergy Section, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0053, USA
    J Asthma 45:287-92. 2008
    ..5 to 5 kb per tag SNP--or studies incorporating microarray analyses of the entire "OR genome" in well-characterized nVMR patients are required...
  91. pmc Early onset senescence occurs when fibroblasts lack the glutamate-cysteine ligase modifier subunit
    Ying Chen
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Free Radic Biol Med 47:410-8. 2009
    ..These results suggest that the control of GCLM, which in turn controls aspects of the cellular redox environment via GSH, is important in determining the replicative capacity of the cell...
  92. ncbi request reprint Genetically altered mice to evaluate glutathione homeostasis in health and disease
    Timothy P Dalton
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, 123 East Shields Street, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Free Radic Biol Med 37:1511-26. 2004
    ..This review focuses on the regulation of GSH homeostasis and, specifically, the new GSH-deficient mouse models that have been developed. These models will improve our understanding of the role of GSH in animal and human diseases...
  93. pmc Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype
    Zhanquan Shi
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Int J Cancer 127:2334-50. 2010
    ..This oral BaP mouse paradigm represents an example of "gene-environment interactions" in which the same exposure of carcinogen results in altered target organ and tumor type, as a function of just 1 or 2 globally absent genes...
  94. ncbi request reprint 7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes
    Howard G Shertzer
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Carcinogenesis 28:1371-8. 2007
    ..e. skin, gastric, i.p.), low hepatic expression of CYP1A2 and CYP1A1, together with high expression levels of lung CYP1B1 and CYP1A1, may define a phenotype for high susceptibility to carcinogens such as DBC...
  95. pmc TCDD decreases ATP levels and increases reactive oxygen production through changes in mitochondrial F(0)F(1)-ATP synthase and ubiquinone
    Howard G Shertzer
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, P O Box 670056 Cincinnati, OH 45267 0056, USA
    Toxicol Appl Pharmacol 217:363-74. 2006
    ..This acts in concert with glutathione to increase membrane potential and reactive oxygen production. The proposed defect in ATP synthase explains both the greater respiratory rates and the lower tissue ATP levels...
  96. ncbi request reprint Decrease in 4-aminobiphenyl-induced methemoglobinemia in Cyp1a2(-/-) knockout mice
    Howard G Shertzer
    Department of Environmental Health, Center for Environment Genetics, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    Toxicol Appl Pharmacol 181:32-7. 2002
    ..Because liver CYP1A2 levels are known to vary more than 60-fold between humans, our findings may be relevant to patients who are exposed to arylamines in the workplace...
  97. ncbi request reprint Preservation of the negative image of tooth enamel with dental impression material enhances morphometric measurements of gingival overgrowth
    Marian L Miller
    Department of Environmental Health, University of Cincinnati Medical Center, Ohio 45267 0056, USA
    Microsc Res Tech 60:528-36. 2003
    ..In conclusion, this new application for impression materials allows gingival coverage of tooth crown, as well as numerous other parameters to be measured for comparison with clinical data...
  98. ncbi request reprint Cyp1a2 protects against reactive oxygen production in mouse liver microsomes
    Howard G Shertzer
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    Free Radic Biol Med 36:605-17. 2004
    ..Our results suggest that possibly acting as an "electron sink," CYP1A2 might decrease CYP2E1-and CYP1A1-mediated H(2)O(2) production and oxidative stress. In this regard, CYP1A2 may be considered an antioxidant enzyme...
  99. ncbi request reprint Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels
    Ying Chen
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    J Biol Chem 280:33766-74. 2005
    ..On the other hand, our results from kidney suggest that gamma-GC synthesis may be controlled post-translationally...
  100. ncbi request reprint Pharmacogenomics and "individualized drug therapy": high expectations and disappointing achievements
    Daniel W Nebert
    Department of Environmental Health and Center for Environmental Genetics CEG, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    Am J Pharmacogenomics 3:361-70. 2003
    ....
  101. ncbi request reprint Naphthalene toxicity in mice and aryl hydrocarbon receptor-mediated CYPs
    Mary Beth Genter
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati, Cincinnati, OH 45267 0056, USA
    Biochem Biophys Res Commun 348:120-3. 2006
    ..In contrast, CYP1A1- and CYP1A2-null mice pretreated with 5-phenyl-1-pentyne exhibited no NP olfactory toxicity. These results suggest that AHR-mediated enzymes do not contribute significantly to NP bioactivation in the intact animal...

Research Grants39

  1. Molecular Genetics of Cadmium Toxicity
    Daniel Nebert; Fiscal Year: 2007
    ....
  2. Molecular Genetics of Cadmium Toxicity
    Daniel W Nebert; Fiscal Year: 2010
    ....
  3. CYPIAI GENE AND ENVIRONMENTAL Toxicity
    Daniel Nebert; Fiscal Year: 2003
    ..Our original aim to generate the mt1A1 and mc1A1 mice and then study BaP vs dioxin toxicity in these lines remains unchanged. ..
  4. GENOTOXICITY IN CYP1A2-DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 1993
    ..This is particularly important, since recent studies have demonstrated a trimodal distribution and >60-fold interindividual variation in the constitutive expression of CYP1A2 in human liver...
  5. MOLECULAR GENETICS OF CD TOXICITY
    Daniel Nebert; Fiscal Year: 2004
    ..These studies will enhance our understanding of heavy metal toxicity by identifying and characterizing, for the first time, a major gene responsible for susceptibility to cadmium-induced toxicity. ..
  6. CYP1A1 GENE AND ENVIRONMENTAL TOXICITY
    Daniel Nebert; Fiscal Year: 2005
    ..abstract_text> ..
  7. Human HNSCC: CYP1B1/1A1/1A2 and AHR Gene Polymorphisms
    Daniel Nebert; Fiscal Year: 2007
    ..Establishing important phenotype-genotype associations between HNSCC and these four genes would provide the first unequivocal data that humans are similar to laboratory animals regarding cancer and one or more of these genes. ..
  8. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    ..dissemination of ingested BaP and will be informative in clinical studies in which we would determine which haplotypes of these three human genes might be associated with resistance vs. sensitivity to PAH-induced toxicity and cancer. ..
  9. GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 2002
    ..S. population. ..
  10. CYP1A1 GENE AND ENVIRONMENTAL TOXICITY
    Daniel Nebert; Fiscal Year: 1999
    ....
  11. Molecular Genetics of Cadmium Toxicity
    Daniel Nebert; Fiscal Year: 2009
    ....
  12. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    ..dissemination of ingested BaP and will be informative in clinical studies in which we would determine which haplotypes of these three human genes might be associated with resistance vs. sensitivity to PAH-induced toxicity and cancer. ..