D W Nebert


Affiliation: University of Cincinnati
Country: USA


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    Nebert D, Vesell E. Can personalized drug therapy be achieved? A closer look at pharmaco-metabonomics. Trends Pharmacol Sci. 2006;27:580-6 pubmed
    ..However, recent advances in metabonomics are exciting and show promise. In the future, and perhaps in combination with proteomics, metabonomics might complement genomics in achieving personalized drug therapy. ..
  2. Chen J, Galvez Peralta M, Zhang X, Deng J, Liu Z, Nebert D. In utero gene expression in the Slc39a8(neo/neo) knockdown mouse. Sci Rep. 2018;8:10703 pubmed publisher
    ..g. GATA proteins) and other TFs interacting with GATA proteins (e.g. TAL1), predominantly in yolk sac. These data strongly support the phenotype of dysmorphogenesis and anemia seen in Slc39a8(neo/neo) mice in utero. ..
  3. Nebert D, Wikvall K, Miller W. Human cytochromes P450 in health and disease. Philos Trans R Soc Lond B Biol Sci. 2013;368:20120431 pubmed publisher
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    Nebert D. Drug-metabolizing enzymes, polymorphisms and interindividual response to environmental toxicants. Clin Chem Lab Med. 2000;38:857-61 pubmed
    ..The end result can be large interindividual differences in risk of environmentally caused toxicity or cancer. ..
  5. Nebert D, Vasiliou V. Analysis of the glutathione S-transferase (GST) gene family. Hum Genomics. 2004;1:460-4 pubmed
    ..It is concluded that the complete GST gene family comprises 16 genes in six subfamilies--alpha (GSTA), mu (GSTM), omega (GSTO), pi (GSTP), theta (GSTT) and zeta (GSTZ). ..
  6. Schneider S, Liu Z, Wang B, Miller M, Afton S, Soleimani M, et al. Oral cadmium in mice carrying 5 versus 2 copies of the Slc39a8 gene: comparison of uptake, distribution, metal content, and toxicity. Int J Toxicol. 2014;33:14-20 pubmed publisher
  7. Monte A, Brocker C, Nebert D, Gonzalez F, Thompson D, Vasiliou V. Improved drug therapy: triangulating phenomics with genomics and metabolomics. Hum Genomics. 2014;8:16 pubmed publisher
    ..This systems biology approach has the potential, in specific subsets of patients, to avoid drug therapy that will be either ineffective or unsafe. ..
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    Nebert D, Dalton T. The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis. Nat Rev Cancer. 2006;6:947-60 pubmed
    ..We suggest a two-tiered system to predict an overall inter-individual risk of tumorigenesis based on DNA variants in certain 'early defence' CYP genes, combined with polymorphisms in various downstream target genes. ..
  9. Jorge Nebert L, Jiang Z, Chakraborty R, Watson J, Jin L, McGarvey S, et al. Analysis of human CYP1A1 and CYP1A2 genes and their shared bidirectional promoter in eight world populations. Hum Mutat. 2010;31:27-40 pubmed publisher

More Information


  1. Nebert D, Galvez Peralta M, Hay E, Li H, Johansson E, Yin C, et al. ZIP14 and ZIP8 zinc/bicarbonate symporters in Xenopus oocytes: characterization of metal uptake and inhibition. Metallomics. 2012;4:1218-25 pubmed publisher
  2. Galvez Peralta M, Wang Z, Bao S, Knoell D, Nebert D. Tissue-Specific Induction of Mouse ZIP8 and ZIP14 Divalent Cation/Bicarbonate Symporters by, and Cytokine Response to, Inflammatory Signals. Int J Toxicol. 2014;33:246-258 pubmed
    ..In the context of cadmium-mediated toxicity, our data suggest that tissues other than liver, kidney, and lung should also be considered. ..
  3. Nebert D. Aryl hydrocarbon receptor (AHR): "pioneer member" of the basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family of "sensors" of foreign and endogenous signals. Prog Lipid Res. 2017;67:38-57 pubmed publisher
  4. Jorge Nebert L, Gálvez Peralta M, Landero Figueroa J, Somarathna M, Hojyo S, Fukada T, et al. Comparing gene expression during cadmium uptake and distribution: untreated versus oral Cd-treated wild-type and ZIP14 knockout mice. Toxicol Sci. 2015;143:26-35 pubmed publisher
    ..These data underscore the complex interplay between the gastrointestinal tract and renal proteins that might be relevant to Cd uptake and distribution in animals exposed to oral Cd. ..
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    Nebert D, Roe A, Dieter M, Solis W, Yang Y, Dalton T. Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis. Biochem Pharmacol. 2000;59:65-85 pubmed
    ..These proposed endogenous functions of the AHR and [Ah] enzymes are, of course, in addition to the frequently described functions of "metabolic potentiation" and "detoxification" of various foreign chemicals. ..
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    Nebert D, Dalton T, Okey A, Gonzalez F. Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. J Biol Chem. 2004;279:23847-50 pubmed
  7. Nebert D, Shi Z, Galvez Peralta M, Uno S, Dragin N. Oral benzo[a]pyrene: understanding pharmacokinetics, detoxication, and consequences--Cyp1 knockout mouse lines as a paradigm. Mol Pharmacol. 2013;84:304-13 pubmed publisher
  8. Jorge Nebert L, Zhang G, Wilson K, Jiang Z, Butler R, Gluckman J, et al. Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype. Hum Genomics. 2016;10:39 pubmed
    ..Considering the cohort size, we therefore conclude that the variant alleles chosen for these four genes, alone or in combinations, are not statistically significantly associated with risk of cigarette-smoking-induced HNSCC. ..
  9. Zhang G, Nebert D. Personalized medicine: Genetic risk prediction of drug response. Pharmacol Ther. 2017;175:75-90 pubmed publisher