DEBI NAYAK

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Influenza virus morphogenesis and budding
    Debi P Nayak
    Department of Microbiology, Immunology and Molecular Genetics, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Virus Res 143:147-61. 2009
  2. ncbi request reprint Assembly and budding of influenza virus
    Debi P Nayak
    Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Virus Res 106:147-65. 2004
  3. ncbi request reprint D-4F, an apolipoprotein A-I mimetic peptide, inhibits the inflammatory response induced by influenza A infection of human type II pneumocytes
    Brian J Van Lenten
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 1679, USA
    Circulation 110:3252-8. 2004
  4. ncbi request reprint Influenza infection promotes macrophage traffic into arteries of mice that is prevented by D-4F, an apolipoprotein A-I mimetic peptide
    Brian J Van Lenten
    Department of Medicine, UCLA School of Medicine, University of California at Los Angeles, 90095 1679, USA
    Circulation 106:1127-32. 2002
  5. pmc Basic residues of the helix six domain of influenza virus M1 involved in nuclear translocation of M1 can be replaced by PTAP and YPDL late assembly domain motifs
    Eric Ka Wai Hui
    Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, UCLA School of Medicine, Los Angeles, California 90095 1747, USA
    J Virol 77:7078-92. 2003
  6. pmc Mutations in influenza virus M1 CCHH, the putative zinc finger motif, cause attenuation in mice and protect mice against lethal influenza virus infection
    Eric Ka Wai Hui
    Department of Microbiology, Immunology, and Molecular Genetics, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 1747, USA
    J Virol 80:5697-707. 2006
  7. ncbi request reprint Inhibition of influenza virus matrix (M1) protein expression and virus replication by U6 promoter-driven and lentivirus-mediated delivery of siRNA
    Eric Ka Wai Hui
    Department of Microbiology, Molecular Biology Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    J Gen Virol 85:1877-84. 2004
  8. ncbi request reprint Influenza A virus hemagglutinin containing basolateral localization signal does not alter the apical budding of a recombinant influenza A virus in polarized MDCK cells
    Subrata Barman
    Department of Microbiology, Immunology, and Molecular Genetics, Molecular Biology Institute, UCLA School of Medicine, Los Angeles, California 90095 1747, USA
    Virology 305:138-52. 2003
  9. ncbi request reprint Conserved cysteine and histidine residues in the putative zinc finger motif of the influenza A virus M1 protein are not critical for influenza virus replication
    Eric Ka Wai Hui
    Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Gen Virol 84:3105-13. 2003
  10. ncbi request reprint Role of lipid rafts in virus assembly and budding
    Debi P Nayak
    Department of Microbiology, Immunology and Molecular Genetics, UCLA School of Medicine, Molecular Biology Institute, Los Angeles, California 90095 1747, USA
    Adv Virus Res 58:1-28. 2002

Research Grants

Collaborators

Detail Information

Publications14

  1. pmc Influenza virus morphogenesis and budding
    Debi P Nayak
    Department of Microbiology, Immunology and Molecular Genetics, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Virus Res 143:147-61. 2009
    ..We provide our current understanding of these important processes leading to the production of infectious influenza virus particles...
  2. ncbi request reprint Assembly and budding of influenza virus
    Debi P Nayak
    Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Virus Res 106:147-65. 2004
    ..Elucidation of both viral and host factors involved in viral morphogenesis and budding may lead to the development of drugs interfering with the steps of viral morphogenesis and in disease progression...
  3. ncbi request reprint D-4F, an apolipoprotein A-I mimetic peptide, inhibits the inflammatory response induced by influenza A infection of human type II pneumocytes
    Brian J Van Lenten
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 1679, USA
    Circulation 110:3252-8. 2004
    ..We previously reported that an apoA-I mimetic peptide, D-4F, reduced inflammatory responses to influenza virus in mice. To further define the antiinflammatory activity of D-4F, a human alveolar type II cell line, A549, was used...
  4. ncbi request reprint Influenza infection promotes macrophage traffic into arteries of mice that is prevented by D-4F, an apolipoprotein A-I mimetic peptide
    Brian J Van Lenten
    Department of Medicine, UCLA School of Medicine, University of California at Los Angeles, 90095 1679, USA
    Circulation 106:1127-32. 2002
    ..The present study tested this hypothesis...
  5. pmc Basic residues of the helix six domain of influenza virus M1 involved in nuclear translocation of M1 can be replaced by PTAP and YPDL late assembly domain motifs
    Eric Ka Wai Hui
    Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, UCLA School of Medicine, Los Angeles, California 90095 1747, USA
    J Virol 77:7078-92. 2003
    ..Furthermore, these sequences of H6 domain can be replaced by late (L) domain motifs and therefore may provide a function similar to that of the L domains of other negative-strand RNA and retroviruses...
  6. pmc Mutations in influenza virus M1 CCHH, the putative zinc finger motif, cause attenuation in mice and protect mice against lethal influenza virus infection
    Eric Ka Wai Hui
    Department of Microbiology, Immunology, and Molecular Genetics, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 1747, USA
    J Virol 80:5697-707. 2006
    ....
  7. ncbi request reprint Inhibition of influenza virus matrix (M1) protein expression and virus replication by U6 promoter-driven and lentivirus-mediated delivery of siRNA
    Eric Ka Wai Hui
    Department of Microbiology, Molecular Biology Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    J Gen Virol 85:1877-84. 2004
    ..Therefore, lentivirus-mediated delivery of siRNA and gene silencing can be used in studying the specific functions of virus genes in replication and may have a potential therapeutic application...
  8. ncbi request reprint Influenza A virus hemagglutinin containing basolateral localization signal does not alter the apical budding of a recombinant influenza A virus in polarized MDCK cells
    Subrata Barman
    Department of Microbiology, Immunology, and Molecular Genetics, Molecular Biology Institute, UCLA School of Medicine, Los Angeles, California 90095 1747, USA
    Virology 305:138-52. 2003
    ..Therefore HA, the major glycoprotein alone, does not determine the budding site, and other factor(s), possibly both viral and host, is responsible for selecting the budding site of influenza virus...
  9. ncbi request reprint Conserved cysteine and histidine residues in the putative zinc finger motif of the influenza A virus M1 protein are not critical for influenza virus replication
    Eric Ka Wai Hui
    Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Gen Virol 84:3105-13. 2003
    ..However, the lethal phenotype of the Ala(155) mutation shows that the H9 region of M1 provides some other critical function(s) in virus replication...
  10. ncbi request reprint Role of lipid rafts in virus assembly and budding
    Debi P Nayak
    Department of Microbiology, Immunology and Molecular Genetics, UCLA School of Medicine, Molecular Biology Institute, Los Angeles, California 90095 1747, USA
    Adv Virus Res 58:1-28. 2002
  11. ncbi request reprint Role of G protein and protein kinase signalling in influenza virus budding in MDCK cells
    Eric Ka Wai Hui
    Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center JCCC, UCLA School of Medicine, Los Angeles, CA 90095 1747, USA
    J Gen Virol 83:3055-66. 2002
    ..Also, in digitonin-permeabilized MDCK cells, the introduction of CK2 substrate peptides caused a down-regulation of virus budding. These results suggest that CK2 activity also regulates influenza virus budding...
  12. pmc YRKL sequence of influenza virus M1 functions as the L domain motif and interacts with VPS28 and Cdc42
    Eric Ka Wai Hui
    Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, David Geffen School of Medicine, UCLA, Los Angeles, 90095, USA
    J Virol 80:2291-308. 2006
    ..These results indicated that VPS28, a component of ESCRT-I, and Cdc42, a small G protein, are associated with the M1 protein and involved in the influenza virus life cycle...
  13. pmc Lipid raft disruption by cholesterol depletion enhances influenza A virus budding from MDCK cells
    Subrata Barman
    Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1747, USA
    J Virol 81:12169-78. 2007
    ..These data show that disruption of lipid rafts by cholesterol depletion caused an enhancement of virus particle release from infected cells and a decrease in the infectivity of virus particles...
  14. pmc Role of transmembrane domain and cytoplasmic tail amino acid sequences of influenza a virus neuraminidase in raft association and virus budding
    Subrata Barman
    Department of Microbiology, Immunology, and Molecular Genetics, Molecular Biology Institute, University of California Los Angeles School of Medicine, Los Angeles, CA 90095 1747, USA
    J Virol 78:5258-69. 2004
    ..In addition, aberrant morphogenesis including elongated particle formation of some mutant viruses indicates the involvement of NA in virus morphogenesis and budding...

Research Grants33

  1. INTERFERENCE BY DEFECTIVE INFLUENZA VIRUSES
    DEBI NAYAK; Fiscal Year: 2001
    ..what are the functions of nucleocapsid protein (NP) in modulating the polymerase activity, and 5. what are the requirements of type (A, B, and C) specificity for viral polymerases? ..
  2. CLONING AND EXPRESSION OF INFLUENZA VIRAL RNA SEGMENTS
    DEBI NAYAK; Fiscal Year: 2005
    ..A detailed understanding of these processes will facilitate the rational development of antiviral agents which could interfere with one or more steps in virus assembly. ..
  3. CLONING OF INFLUENZA VIRAL RNA SEGMENTS
    DEBI NAYAK; Fiscal Year: 1980
    ..Finally using E. coli promotor, we hope to synthesize major viral antigens (hemagglutinin and neuraminidase) which may provide a better immunogen(s) against influenza...
  4. CLONING AND EXPRESSION OF INFLUENZA VIRAL RNA SEGMENTS
    DEBI NAYAK; Fiscal Year: 1992
    ..In addition, we are expressing influenza viral HA and NA in yeast (Saccharomyces cerevisiae), which may be of potential use in the development of an improved subunit vaccine...
  5. INTERFERENCE BY DEFECTIVE INFLUENZA VIRUSES
    DEBI NAYAK; Fiscal Year: 2007
    ..abstract_text> ..