M Navab

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Mechanisms of disease: proatherogenic HDL--an evolving field
    Mohamad Navab
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1679, USA
    Nat Clin Pract Endocrinol Metab 2:504-11. 2006
  2. pmc High-density lipoprotein and 4F peptide reduce systemic inflammation by modulating intestinal oxidized lipid metabolism: novel hypotheses and review of literature
    Mohamad Navab
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Room A2 237 CHS, Los Angeles, CA 90095 1679, USA
    Arterioscler Thromb Vasc Biol 32:2553-60. 2012
  3. pmc D-4F-mediated reduction in metabolites of arachidonic and linoleic acids in the small intestine is associated with decreased inflammation in low-density lipoprotein receptor-null mice
    Mohamad Navab
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Lipid Res 53:437-45. 2012
  4. pmc Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis
    Jennifer M P Woo
    Department of Medicine Rheumatology, David Geffen School of Medicine, University of California, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
    Arthritis Res Ther 12:R93. 2010
  5. ncbi request reprint Human apolipoprotein A-I and A-I mimetic peptides: potential for atherosclerosis reversal
    Mohamad Navab
    David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Curr Opin Lipidol 15:645-9. 2004
  6. ncbi request reprint Oxidized lipids as mediators of coronary heart disease
    Mohamad Navab
    Department of Medicine, Cardiology, University of California Los Angeles, 90095 1679, USA
    Curr Opin Lipidol 13:363-72. 2002
  7. doi request reprint HDL and cardiovascular disease: atherogenic and atheroprotective mechanisms
    Mohamad Navab
    Department of Medicine, David Geffen School of Medicine, UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1679, USA
    Nat Rev Cardiol 8:222-32. 2011
  8. ncbi request reprint Apo A-1 mimetic peptides as atheroprotective agents in murine models
    Mohamad Navab
    Department of Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, California 90095 1679, USA
    Curr Drug Targets 9:204-9. 2008
  9. pmc A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids
    Mohamad Navab
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1679, USA
    J Lipid Res 50:1538-47. 2009
  10. ncbi request reprint D-4F and statins synergize to render HDL antiinflammatory in mice and monkeys and cause lesion regression in old apolipoprotein E-null mice
    Mohamad Navab
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 1679, USA
    Arterioscler Thromb Vasc Biol 25:1426-32. 2005

Detail Information

Publications105 found, 100 shown here

  1. ncbi request reprint Mechanisms of disease: proatherogenic HDL--an evolving field
    Mohamad Navab
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1679, USA
    Nat Clin Pract Endocrinol Metab 2:504-11. 2006
    ..The quality and function of HDL are also attractive targets for emerging therapies...
  2. pmc High-density lipoprotein and 4F peptide reduce systemic inflammation by modulating intestinal oxidized lipid metabolism: novel hypotheses and review of literature
    Mohamad Navab
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Room A2 237 CHS, Los Angeles, CA 90095 1679, USA
    Arterioscler Thromb Vasc Biol 32:2553-60. 2012
    ..Studies with apolipoprotein A-I mimetic peptides suggest that the small intestine is a major tissue regulating systemic inflammation in mouse models of atherosclerosis and may be important for determining the functionality of HDL...
  3. pmc D-4F-mediated reduction in metabolites of arachidonic and linoleic acids in the small intestine is associated with decreased inflammation in low-density lipoprotein receptor-null mice
    Mohamad Navab
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Lipid Res 53:437-45. 2012
    ..05). We conclude that D-4F administration reduces levels of free metabolites of arachidonic and linoleic acids in the small intestine and this is associated with decreased inflammation in LDL receptor deficient mice...
  4. pmc Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis
    Jennifer M P Woo
    Department of Medicine Rheumatology, David Geffen School of Medicine, University of California, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
    Arthritis Res Ther 12:R93. 2010
    ....
  5. ncbi request reprint Human apolipoprotein A-I and A-I mimetic peptides: potential for atherosclerosis reversal
    Mohamad Navab
    David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Curr Opin Lipidol 15:645-9. 2004
    ..Recent publications related to the potential use of apolipoprotein (apo)A-I and apoA-I mimetic peptides in the treatment of atherosclerosis are reviewed...
  6. ncbi request reprint Oxidized lipids as mediators of coronary heart disease
    Mohamad Navab
    Department of Medicine, Cardiology, University of California Los Angeles, 90095 1679, USA
    Curr Opin Lipidol 13:363-72. 2002
    ..This generates a series of biologically active, oxidized phospholipids that mediate the cellular events seen in the developing fatty streak...
  7. doi request reprint HDL and cardiovascular disease: atherogenic and atheroprotective mechanisms
    Mohamad Navab
    Department of Medicine, David Geffen School of Medicine, UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1679, USA
    Nat Rev Cardiol 8:222-32. 2011
    ..Robust assays to evaluate the function of HDL are needed to supplement the measurement of HDL-cholesterol levels in the clinic...
  8. ncbi request reprint Apo A-1 mimetic peptides as atheroprotective agents in murine models
    Mohamad Navab
    Department of Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, California 90095 1679, USA
    Curr Drug Targets 9:204-9. 2008
    ....
  9. pmc A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids
    Mohamad Navab
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1679, USA
    J Lipid Res 50:1538-47. 2009
    ..Niclosamide itself did not inhibit trypsin activity. The combination of niclosamide with apolipoprotein mimetic peptides appears to be a promising method for oral delivery of these peptides...
  10. ncbi request reprint D-4F and statins synergize to render HDL antiinflammatory in mice and monkeys and cause lesion regression in old apolipoprotein E-null mice
    Mohamad Navab
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 1679, USA
    Arterioscler Thromb Vasc Biol 25:1426-32. 2005
    ..We tested for synergy between pravastatin and D-4F by administering oral doses of each in combination that were predetermined to be ineffective when given as single agents...
  11. ncbi request reprint Oral synthetic phospholipid (DMPC) raises high-density lipoprotein cholesterol levels, improves high-density lipoprotein function, and markedly reduces atherosclerosis in apolipoprotein E-null mice
    Mohamad Navab
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Room 47 123 CHS, 10833 Le Conte Ave, Los Angeles, Calif 90095 1679, USA
    Circulation 108:1735-9. 2003
    ..1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a phospholipid that does not exist in nature and has been used in vitro to study lipid binding. We tested DMPC in vivo in apolipoprotein (apo) E-null mice...
  12. ncbi request reprint Human apolipoprotein AI mimetic peptides for the treatment of atherosclerosis
    Mohamad Navab
    Department of Medicine, David Geffen School of Medicine, 10833 Le Conte Avenue, University of California, Los Angeles, Los Angeles, CA 90095 1679, USA
    Curr Opin Investig Drugs 4:1100-4. 2003
    ....
  13. doi request reprint Inflammation and metabolic disorders
    Mohamad Navab
    Division of Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    Curr Opin Clin Nutr Metab Care 11:459-64. 2008
    ..Study of the effects of life style including healthy nutrition will help further elucidate the mechanisms involved in the adverse effects of poor nutrition...
  14. ncbi request reprint Apolipoprotein A-I mimetic peptides
    Mohamad Navab
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 1679, USA
    Arterioscler Thromb Vasc Biol 25:1325-31. 2005
    ..However, understanding these physical-chemical properties provides an explanation for the mechanism of action of the active peptides...
  15. ncbi request reprint Potential clinical utility of high-density lipoprotein-mimetic peptides
    Mohamad Navab
    David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Curr Opin Lipidol 17:440-4. 2006
    ..To determine the potential clinical utility of high-density lipoprotein-mimetic peptides...
  16. pmc The role of dysfunctional HDL in atherosclerosis
    Mohamad Navab
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1679, USA
    J Lipid Res 50:S145-9. 2009
    ..In animal models and perhaps in humans, dysfunctional HDL can be improved by apoA-I mimetic peptides that bind oxidized lipids with high affinity...
  17. ncbi request reprint Oral D-4F causes formation of pre-beta high-density lipoprotein and improves high-density lipoprotein-mediated cholesterol efflux and reverse cholesterol transport from macrophages in apolipoprotein E-null mice
    Mohamad Navab
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90095 1679, USA
    Circulation 109:3215-20. 2004
    ..These studies were designed to determine the mechanism of action of an oral apolipoprotein (apo) A-I mimetic peptide, D-4F, which previously was shown to dramatically reduce atherosclerosis in mice...
  18. ncbi request reprint Oral small peptides render HDL antiinflammatory in mice and monkeys and reduce atherosclerosis in ApoE null mice
    Mohamad Navab
    David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 1679, USA
    Circ Res 97:524-32. 2005
    ....
  19. ncbi request reprint The double jeopardy of HDL
    Mohamad Navab
    Atherosclerosis Research Unit, Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1679, USA
    Ann Med 37:173-8. 2005
    ..Thus, HDL structure and function may be more important than HDL-cholesterol levels in predicting risk for cardiovascular disease...
  20. pmc Structure and function of HDL mimetics
    Mohamad Navab
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1679, USA
    Arterioscler Thromb Vasc Biol 30:164-8. 2010
    ..Many of these peptides have been shown to have antiinflammatory properties. Based on studies in a number of animal models and in early human clinical trials, HDL mimetics appear to have promise as diagnostic and therapeutic agents...
  21. ncbi request reprint An oral apoJ peptide renders HDL antiinflammatory in mice and monkeys and dramatically reduces atherosclerosis in apolipoprotein E-null mice
    Mohamad Navab
    David Geffen School of Medicine, UCLA, Los Angeles, California 90095 1679, USA
    Arterioscler Thromb Vasc Biol 25:1932-7. 2005
    ..To determine the properties of a peptide synthesized from D-amino acids corresponding to residues 113 to 122 in apolipoprotein (apo) J...
  22. pmc Intestine may be a major site of action for the apoA-I mimetic peptide 4F whether administered subcutaneously or orally
    Mohamad Navab
    Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    J Lipid Res 52:1200-10. 2011
    ..We conclude: i) the dose of 4F administered and not the plasma level achieved determines efficacy; ii) the intestine may be a major site of action for the peptide regardless of the route of administration...
  23. ncbi request reprint Apolipoprotein A-I mimetic peptides and their role in atherosclerosis prevention
    Mohamad Navab
    Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Nat Clin Pract Cardiovasc Med 3:540-7. 2006
    ..Vasoreactivity and endothelial sloughing were also improved in other rodent studies. Early human clinical trials are now being carried out on 4F. Here, we review the studies on apoA-I mimetic peptides that have been carried out so far...
  24. ncbi request reprint The role of high-density lipoprotein in inflammation
    Mohamad Navab
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California in Los Angeles, Room 47 123 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095 1679, USA
    Trends Cardiovasc Med 15:158-61. 2005
    ..Understanding the role of HDL in inflammation may lead to new diagnostic and therapeutic approaches to atherosclerosis and other inflammatory conditions...
  25. ncbi request reprint The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL
    Mohamad Navab
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Lipid Res 45:993-1007. 2004
    ..Apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides may both promote a reduction in oxidized lipids and enhance reverse cholesterol transport and therefore may have therapeutic potential...
  26. ncbi request reprint A cell-free assay for detecting HDL that is dysfunctional in preventing the formation of or inactivating oxidized phospholipids
    M Navab
    Atherosclerosis Research Unit, Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Lipid Res 42:1308-17. 2001
    ....
  27. ncbi request reprint High-density lipoprotein: antioxidant and anti-inflammatory properties
    Mohamad Navab
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1679, USA
    Curr Atheroscler Rep 9:244-8. 2007
    ..Therefore, HDL composition, structure, and function appear to be more crucial than HDL cholesterol concentrations in determining risk for cardiovascular disorders...
  28. ncbi request reprint Oral administration of an Apo A-I mimetic Peptide synthesized from D-amino acids dramatically reduces atherosclerosis in mice independent of plasma cholesterol
    Mohamad Navab
    Department of Medicine, University of California Los Angeles, California, USA
    Circulation 105:290-2. 2002
    ..When added to the drinking water of apoE-null mice, D-4F decreased lesions by approximately 75% at the lowest dose tested (0.05 mg/mL). The marked reduction in lesions occurred independent of changes in total plasma or HDL-cholesterol...
  29. doi request reprint The effect of apolipoprotein mimetic peptides in inflammatory disorders other than atherosclerosis
    Mohamad Navab
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1679, USA
    Trends Cardiovasc Med 18:61-6. 2008
    ..Published studies of apolipoprotein mimetic peptides in models of inflammatory disorders other than atherosclerosis suggest that they may have efficacy in a wide range of inflammatory conditions...
  30. ncbi request reprint High-density lipoprotein loses its anti-inflammatory properties during acute influenza a infection
    B J Van Lenten
    Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA
    Circulation 103:2283-8. 2001
    ..Viruses have been identified as one of a variety of potential agents that are implicated in atherogenesis...
  31. pmc Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio
    M Navab
    Department of Medicine, School of Medicine, College of Letters and Sciences, University of California, Los Angeles 90095, USA
    J Clin Invest 99:2005-19. 1997
    ..We conclude that: (a) mildly oxidized LDL can induce an increased apoJ/PON ratio, and (b) the apoJ/PON ratio may prove to be a better predictor of atherosclerosis than the total cholesterol/HDL cholesterol ratio...
  32. pmc Overexpression of apolipoprotein AII in transgenic mice converts high density lipoproteins to proinflammatory particles
    L W Castellani
    Department of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Clin Invest 100:464-74. 1997
    ..We conclude that overexpression of apoAII converts HDL from an anti- to a proinflammatory particle and that paraoxonase plays a role in this transformation...
  33. ncbi request reprint Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis
    D M Shih
    Division of Cardiology, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095, USA
    Nature 394:284-7. 1998
    ..When fed on a high-fat, high-cholesterol diet, PON1-null mice were more susceptible to atherosclerosis than their wild-type littermates...
  34. ncbi request reprint Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids
    S T Reddy
    Atherosclerosis Research Unit, Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Arterioscler Thromb Vasc Biol 21:542-7. 2001
    ..Furthermore, PON3 expression is not regulated in HepG2 cells by oxidized phospholipids and is not regulated in the livers of mice fed a high-fat atherogenic diet...
  35. ncbi request reprint Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein
    C J Ng
    Atherosclerosis Research Unit, University of California, Los Angeles, California 90095 1679, USA
    J Biol Chem 276:44444-9. 2001
    ..However, in contrast to PON1 and PON3, PON2 may exert its antioxidant functions at the cellular level, joining the host of intracellular antioxidant enzymes that protect cells from oxidative stress...
  36. ncbi request reprint Mitogen-activated protein kinase phosphatase 1 activity is necessary for oxidized phospholipids to induce monocyte chemotactic activity in human aortic endothelial cells
    S Reddy
    Atherosclerosis Research Unit, Department of Medicine, University of California, Los Angeles, California 90095 1679, USA
    J Biol Chem 276:17030-5. 2001
    ..Our results implicate a direct role for MKP-1 in ox-PAPC-induced signaling pathways that result in the production of MCP-1 protein by ox-PAPC-treated HAEC...
  37. ncbi request reprint HDL and the inflammatory response induced by LDL-derived oxidized phospholipids
    M Navab
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095-1736, USA
    Arterioscler Thromb Vasc Biol 21:481-8. 2001
    ..It is proposed that LDL-derived oxidized phospholipids and HDL may be part of a system of nonspecific innate immunity and that the detection of proinflammatory HDL may be a useful marker of susceptibility to atherosclerosis...
  38. ncbi request reprint Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo
    A D Watson
    Department of Medicine, Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095 1679, USA
    J Biol Chem 272:13597-607. 1997
    ..Overall, these studies suggest that specific oxidized derivatives of arachidonic acid-containing phospholipids may be important initiators of atherogenesis...
  39. pmc Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress
    Jesus A Araujo
    Department of Medicine, David Geffen School of Medicine, 10833 Le Conte Ave, CHS 52 175, Box 951680, Los Angeles, CA 90095, USA
    Circ Res 102:589-96. 2008
    ..We conclude that ultrafine particles concentrate the proatherogenic effects of ambient PM and may constitute a significant cardiovascular risk factor...
  40. ncbi request reprint Structural identification of a novel pro-inflammatory epoxyisoprostane phospholipid in mildly oxidized low density lipoprotein
    A D Watson
    Department of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 274:24787-98. 1999
    ..The identification of this molecule adds epoxyisoprostanes to the growing list of biologically active isoprostanes...
  41. ncbi request reprint Role of group II secretory phospholipase A2 in atherosclerosis: 1. Increased atherogenesis and altered lipoproteins in transgenic mice expressing group IIa phospholipase A2
    B Ivandic
    Department of Microbiology and Molecular Genetics and Molecular Biology Institute, Division of Cardiology, University of California, Los Angeles 90095, USA
    Arterioscler Thromb Vasc Biol 19:1284-90. 1999
    ..These data also provide a possible mechanism for the observation that there is an increased incidence of coronary artery disease in many chronic inflammatory diseases...
  42. ncbi request reprint Oxidized phospholipids induce changes in hepatic paraoxonase and ApoJ but not monocyte chemoattractant protein-1 via interleukin-6
    B J Van Lenten
    Division of Cardiology, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095 1679, USA
    J Biol Chem 276:1923-9. 2001
    ..We conclude that IL-6 is critical to short term but not long term regulation of PON and that IL-6 is not required for OXPL regulation of MCP-1...
  43. ncbi request reprint Proatherogenic high-density lipoprotein, vascular inflammation, and mimetic peptides
    Roger Yu
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Curr Atheroscler Rep 10:171-6. 2008
    ..Published studies of apolipoprotein mimetic peptides in models of inflammatory disorders other than atherosclerosis suggest that they have efficacy in a wide range of inflammatory conditions...
  44. ncbi request reprint Adenovirus-mediated expression of human paraoxonase 3 protects against the progression of atherosclerosis in apolipoprotein E-deficient mice
    Carey J Ng
    Atherosclerosis Research Unit, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095, USA
    Arterioscler Thromb Vasc Biol 27:1368-74. 2007
    ..The objective of the present study was to determine whether elevated levels of human PON3 in mice could protect against the progression of atherosclerosis in vivo...
  45. pmc Genetic-dietary regulation of serum paraoxonase expression and its role in atherogenesis in a mouse model
    D M Shih
    Department of Medicine, School of Medicine, University of California Los Angeles, 90095, USA
    J Clin Invest 97:1630-9. 1996
    ..In a set of recombinant inbred strains derived from the B6 and C3H parental strains, low paraoxonase mRNA levels segregated with aortic lesion development, supporting a role for paraoxonase in atherogenesis...
  46. ncbi request reprint Inflammatory/antiinflammatory properties of high-density lipoprotein distinguish patients from control subjects better than high-density lipoprotein cholesterol levels and are favorably affected by simvastatin treatment
    Benjamin J Ansell
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 1679, USA
    Circulation 108:2751-6. 2003
    ..The inflammatory/antiinflammatory properties of HDL were compared with HDL cholesterol in 2 groups of patients and in age- and sex-matched control subjects...
  47. pmc Hemoglobin and its scavenger protein haptoglobin associate with apoA-1-containing particles and influence the inflammatory properties and function of high density lipoprotein
    Junji Watanabe
    Atherosclerosis Research Unit, Department of Medicine Cardiology, University of California, Los Angeles, California 90095, USA
    J Biol Chem 284:18292-301. 2009
    ..Our data strongly suggest that HDL can become proinflammatory via the Hb x Hp pathway in mice and humans, and dissociation of Hb x Hp x Hx complexes from apoA-1-containing particles of HDL may be a novel target for the treatment of CHD...
  48. ncbi request reprint Aromatic residue position on the nonpolar face of class a amphipathic helical peptides determines biological activity
    Geeta Datta
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 279:26509-17. 2004
    ....
  49. pmc L-4F differentially alters plasma levels of oxidized fatty acids resulting in more anti-inflammatory HDL in mice
    Satoshi Imaizumi
    Department of Medicine, and David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1679, USA
    Drug Metab Lett 4:139-48. 2010
    ..i) L-4F differentially alters plasma levels of oxidized fatty acids in vivo. ii) The resistance of the C3H/HeJ strain to atherosclerosis may in part be mediated by a reduced reaction of this strain to these potent lipid oxidants...
  50. ncbi request reprint Adenovirus mediated expression of human paraoxonase 2 protects against the development of atherosclerosis in apolipoprotein E-deficient mice
    Carey J Ng
    Atherosclerosis Research Unit, Division of Cardiology, Department of Medicine, 47 123 CHS, Los Angeles, CA 90095, USA
    Mol Genet Metab 89:368-73. 2006
    ....
  51. ncbi request reprint Genetic control of HDL levels and composition in an interspecific mouse cross (CAST/Ei x C57BL/6J)
    M Mehrabian
    Department of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 41:1936-46. 2000
    ..Our results suggest that novel genes are likely to be important in the control of HDL metabolism, and they provide evidence of genetic factors influencing the interaction of LCAT with HDL...
  52. ncbi request reprint The role of high-density lipoproteins in oxidation and inflammation
    B J Van Lenten
    Department of Medicine, University of California, Los Angeles, California, USA
    Trends Cardiovasc Med 11:155-61. 2001
    ..This "chameleon-like" nature of HDL is considered to be due to the complex composition of HDL. The data reviewed here demonstrate the key role of HDL in modulating inflammation and its implications for atherogenesis...
  53. ncbi request reprint A complex flow pattern of low shear stress and flow reversal promotes monocyte binding to endothelial cells
    H M Honda
    Department of Medicine, University of California, Los Angeles, CA 90095 1679, USA
    Atherosclerosis 158:385-90. 2001
    ..These findings suggest a mechanism by which areas of low shear stress and flow reversal are predisposed to the development of atherosclerotic lesions...
  54. pmc In vitro stimulation of HDL anti-inflammatory activity and inhibition of LDL pro-inflammatory activity in the plasma of patients with end-stage renal disease by an apoA-1 mimetic peptide
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, Orange, California, USA
    Kidney Int 76:437-44. 2009
    ..Whether 4F or other apolipoproteinA-1 mimetic peptides will have any therapeutic benefit in end-stage renal disease will have to be examined directly in clinical studies...
  55. ncbi request reprint High-density lipoprotein increases intracellular calcium levels by releasing calcium from internal stores in human endothelial cells
    H M Honda
    Department of Medicine, University of California, Los Angeles 90095 1679, USA
    Atherosclerosis 143:299-306. 1999
    ..These findings suggest that HDL, like LDL, can modulate EC Ca(i) and that this occurs via a pertussis toxin-sensitive G protein-mediated pathway which involves phospholipase C...
  56. ncbi request reprint Pulsatile flow regulates monocyte adhesion to oxidized lipid-induced endothelial cells
    T K Hsiai
    Division of Cardiology, Department of Medicine, UCLA School of Medicine, UCLA School of Engineering and Applied Sciences, Los Angeles, California, USA
    Arterioscler Thromb Vasc Biol 21:1770-6. 2001
    ..These results suggest that shear stress slew rates regulate monocyte binding by modulating the expression of a potent monocyte chemoattractant...
  57. ncbi request reprint Structural requirements for antioxidative and anti-inflammatory properties of apolipoprotein A-I mimetic peptides
    G M Anantharamaiah
    Department of Medicine, Biochemistry, and Molecular Genetics and Atherosclerosis Research Unit, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Lipid Res 48:1915-23. 2007
    ..Understanding the structure and function of apoA-I and HDL through studies of the amphipathic helix motif may lead to peptide-based therapies for inhibiting atherosclerosis and other related inflammatory lipid disorders...
  58. pmc Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy
    Daniel Cruz
    Division of Cardiology, Molecular Biology Institute, Department of Microbiology, Immunology, and Molecular Genetics, UCLA David Geffen School of Medicine, Howard Hughes Medical Institute, Los Angeles, California 90095, USA
    J Clin Invest 118:2917-28. 2008
    ....
  59. ncbi request reprint HDL-inflammatory index correlates with poor outcome in hemodialysis patients
    K Kalantar-Zadeh
    Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
    Kidney Int 72:1149-56. 2007
    ..Our findings suggest an important role of inflammatory HDL in patients with CKD leading to poor outcome...
  60. ncbi request reprint D-4F reduces EO6 immunoreactivity, SREBP-1c mRNA levels, and renal inflammation in LDL receptor-null mice fed a Western diet
    Georgette M Buga
    Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095 1679, USA
    J Lipid Res 49:192-205. 2008
    ..We conclude that D-4F reduced renal oxidized phospholipids, resulting in lower expression of SREBP-1c, which, in turn, resulted in lower triglyceride content and reduced renal inflammation...
  61. doi request reprint Treatment with an apolipoprotein A-1 mimetic peptide in combination with pravastatin inhibits collagen-induced arthritis
    Christina Charles-Schoeman
    Division of Rheumatology, at the UCLA David Geffen School of Medicine, 1000 Veteran Avenue, Room 32 59, Los Angeles, CA, USA
    Clin Immunol 127:234-44. 2008
    ..Combination D-4F/pravastatin significantly reduced clinical disease activity in CIA, and may have dual therapeutic potential in other autoimmune diseases with increased cardiovascular morbidity and mortality...
  62. pmc HIV-1 infected patients with suppressed plasma viremia on treatment have pro-inflammatory HDL
    Theodoros Kelesidis
    Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Lipids Health Dis 10:35. 2011
    ..We hypothesized that HIV-1-infected persons on antiretroviral therapy would have pro-inflammatory high density lipoprotein (HDL), and that an apoA-1 mimetic peptide might reverse the inflammatory properties of HDL in these persons...
  63. pmc L-5F, an apolipoprotein A-I mimetic, inhibits tumor angiogenesis by suppressing VEGF/basic FGF signaling pathways
    Feng Gao
    David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 5347, USA
    Integr Biol (Camb) 3:479-89. 2011
    ..In conclusion, our data that L-5F inhibits angiogenesis suggests that apoA-I mimetic peptides may serve as novel anti-angiogenesis agents for the treatment of angiogenesis-associated diseases, including cancer...
  64. pmc Apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides inhibit tumor development in a mouse model of ovarian cancer
    Feng Su
    Department of Obstetrics and Gynecology, University of California, Los Angeles, CA 90095 5347, USA
    Proc Natl Acad Sci U S A 107:19997-20002. 2010
    ....
  65. pmc Apolipoprotein A-I mimetic peptides prevent atherosclerosis development and reduce plaque inflammation in a murine model of diabetes
    Cecilia Morgantini
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Diabetes 59:3223-8. 2010
    ..To determine the effect of the apolipoprotein A-I (ApoA-I) mimetic peptide, D-4F, on atherosclerosis development in a pre-existing diabetic condition...
  66. pmc Oxpholipin 11D: an anti-inflammatory peptide that binds cholesterol and oxidized phospholipids
    Piotr Ruchala
    Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e10181. 2010
    ..This domain is usually flanked N-terminally by arginine and C-terminally by valine. We used this 14-residue sequence as a template to create a small library of peptides that bind cholesterol and other lipids...
  67. pmc Anti-inflammatory apoA-I-mimetic peptides bind oxidized lipids with much higher affinity than human apoA-I
    Brian J Van Lenten
    Department of Medicine David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1679, USA
    J Lipid Res 49:2302-11. 2008
    ..The extraordinary ability of 4F to bind pro-inflammatory oxidized lipids probably accounts for its remarkable anti-inflammatory properties...
  68. pmc Multiple indications for anti-inflammatory apolipoprotein mimetic peptides
    Brian J Van Lenten
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1679, USA
    Curr Opin Investig Drugs 9:1157-62. 2008
    ....
  69. pmc Apolipoprotein A-I mimetic peptides
    Brian J Van Lenten
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Curr Atheroscler Rep 11:52-7. 2009
    ....
  70. pmc L-4F alters hyperlipidemic (but not healthy) mouse plasma to reduce platelet aggregation
    Georgette M Buga
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 1679, USA
    Arterioscler Thromb Vasc Biol 30:283-9. 2010
    ..Background and Purpose- Hyperlipidemia is associated with platelet hyperreactivity. We hypothesized that L-4F, an apolipoprotein A-I mimetic peptide, would inhibit platelet aggregation in hyperlipidemic mice...
  71. ncbi request reprint Chronic inflammatory disorders and accelerated atherosclerosis: chronic kidney disease
    Kaveh D Navab
    David Geffen School of Medicine, 10833 Le Conte Ave, University of California Los Angeles, CA 90095, USA
    Curr Pharm Des 17:17-20. 2011
    ..Whether HDL mimetic peptides will have therapeutic benefit in patients with renal failure will have to be determined in clinical studies...
  72. ncbi request reprint Lipoprotein inflammatory properties and serum amyloid A levels but not cholesterol levels predict lesion area in cholesterol-fed rabbits
    Brian J Van Lenten
    Department of Medicine, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA 90095 1679, USA
    J Lipid Res 48:2344-53. 2007
    ..HII correlated closely with SAA levels (r = 0.6616; r(2) = 0.4377, P < 0.0001). Thus, HII, LII, and SAA are better predictors of lesion area than are total plasma or HDL-cholesterol levels in cholesterol-fed rabbits...
  73. ncbi request reprint The paraoxonase gene family and atherosclerosis
    Carey J Ng
    Atherosclerosis Research Unit, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Free Radic Biol Med 38:153-63. 2005
    ....
  74. ncbi request reprint D-4F, an apolipoprotein A-I mimetic peptide, inhibits the inflammatory response induced by influenza A infection of human type II pneumocytes
    Brian J Van Lenten
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 1679, USA
    Circulation 110:3252-8. 2004
    ..We previously reported that an apoA-I mimetic peptide, D-4F, reduced inflammatory responses to influenza virus in mice. To further define the antiinflammatory activity of D-4F, a human alveolar type II cell line, A549, was used...
  75. ncbi request reprint Anti-inflammatory properties of HDL
    Benjamin J Ansell
    Atherosclerosis Research Unit, Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Rev Endocr Metab Disord 5:351-8. 2004
  76. ncbi request reprint Potential role for mitogen-activated protein kinase phosphatase-1 in the development of atherosclerotic lesions in mouse models
    Srinivasa T Reddy
    Atherosclerosis Research Unit, Division of Cardiology, Department of Medicine, University of California Los Angeles, 650 Charles E Young Drive South, A8 131, CHS, Los Angeles, CA 90095, USA
    Arterioscler Thromb Vasc Biol 24:1676-81. 2004
    ..We previously reported that MKP-1 activity is required for Ox-PAPC-mediated endothelial/monocyte interactions; however, an in vivo role of MKP-1 in atherogenesis has not been investigated...
  77. ncbi request reprint Micro sensors: linking real-time oscillatory shear stress with vascular inflammatory responses
    Tzung K Hsiai
    Department of Biomedical Engineering, Division of Cardiovascular Medicine, USC School of Engineering and School of Medicine, Los Angeles, CA 90089 1451, USA
    Ann Biomed Eng 32:189-201. 2004
    ..6 dyn/cm2 and Reynolds number between 0 and 22.2 in the presence of activated adhesion molecule and chemokine mRNA expression...
  78. ncbi request reprint Pulsatile versus oscillatory shear stress regulates NADPH oxidase subunit expression: implication for native LDL oxidation
    Juliana Hwang
    Department of Biomedical Engineering and Division of Cardiovascular Medicine, University of Southern California, Los Angeles, Calif, USA
    Circ Res 93:1225-32. 2003
    ..The formation of modified LDL via O2-* production may also affect the regulation of monocyte chemoattractant protein-1 expression and monocyte/BAEC binding...
  79. ncbi request reprint Identification of genes induced by oxidized phospholipids in human aortic endothelial cells
    Srinivasa T Reddy
    Atherosclerosis Research Unit, Department of Medicine, Department of Molecular and Medical Pharmacology, University of California Los Angeles, 650 Charles E Young Drive South, A8 131 CHS, Los Angeles, CA 90095, USA
    Vascul Pharmacol 38:211-8. 2002
    ..The observed pattern of gene induction suggests that Ox-PAPC may play multiple roles in angiogenesis, atherosclerosis, and inflammation and wound healing...
  80. ncbi request reprint ATP-binding cassette transporter 1 participates in LDL oxidation by artery wall cells
    Srinivasa T Reddy
    Atherosclerosis Research Unit, Division of Cardiology, Department of Medicine, University of California, Los Angeles 90095, USA
    Arterioscler Thromb Vasc Biol 22:1877-83. 2002
    ..Therefore, we evaluated whether ABCA1 participates in LDL oxidation...
  81. ncbi request reprint Influenza infection promotes macrophage traffic into arteries of mice that is prevented by D-4F, an apolipoprotein A-I mimetic peptide
    Brian J Van Lenten
    Department of Medicine, UCLA School of Medicine, University of California at Los Angeles, 90095 1679, USA
    Circulation 106:1127-32. 2002
    ..The present study tested this hypothesis...
  82. ncbi request reprint Modifying the anti-inflammatory effects of high-density lipoprotein
    Benjamin J Ansell
    Department of Medicine, David Geffen School of Medicine at UCLA, 100 UCLA Medical Plaza, Suite 525, Los Angeles, CA 90095, USA
    Curr Atheroscler Rep 9:57-63. 2007
    ..Treatment with statins and/or apolipoprotein A1 mimetic peptides improves HDL's anti-inflammatory functions, and these as well as other medications may represent a novel pathway through which to target atherosclerosis...
  83. ncbi request reprint Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2
    Carey J Ng
    Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 281:29491-500. 2006
    ..These results demonstrate that PON2 plays a protective role in atherosclerosis...
  84. ncbi request reprint D-4F decreases brain arteriole inflammation and improves cognitive performance in LDL receptor-null mice on a Western diet
    Georgette M Buga
    Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095 1679, USA
    J Lipid Res 47:2148-60. 2006
    ..05). We conclude that a WD induces brain arteriole inflammation and cognitive impairment that is ameliorated by oral D-4F without altering plasma lipids, blood pressure, or arteriole lumen size...
  85. ncbi request reprint Differential association of hemoglobin with proinflammatory high density lipoproteins in atherogenic/hyperlipidemic mice. A novel biomarker of atherosclerosis
    Junji Watanabe
    Atherosclerosis Research Unit, Department of Medicine Cardiology, University of California, Los Angeles, California 90095, USA
    J Biol Chem 282:23698-707. 2007
    ..Our data suggest that Hb contributes to the proinflammatory nature of HDL in mouse and human models of atherosclerosis and may serve as a novel biomarker for atherosclerosis...
  86. ncbi request reprint Proinflammatory high-density lipoprotein as a biomarker for atherosclerosis in patients with systemic lupus erythematosus and rheumatoid arthritis
    Maureen McMahon
    University of California at Los Angeles David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Arthritis Rheum 54:2541-9. 2006
    ..This study was undertaken to determine whether patients with SLE, who have chronic inflammation that causes oxidative damage, have more proinflammatory HDL and higher levels of ox-LDL, thus predisposing them to atherosclerosis...
  87. ncbi request reprint Oral amphipathic peptides as therapeutic agents
    Srinivasa T Reddy
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095 1679, USA
    Expert Opin Investig Drugs 15:13-21. 2006
    ..In addition, the peptide D-4F stimulates the formation and cycling of pre-beta HDL. These amphipathic peptides appear to have therapeutic potential as oral agents...
  88. doi request reprint The effect of HDL mimetic peptide 4F on PON1
    Ladan Vakili
    David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Adv Exp Med Biol 660:167-72. 2010
    ..Following is a brief description of some of the HDL mimetic peptides that can improve HDL and the effect of the peptide on PON1 activity...
  89. ncbi request reprint An apolipoprotein A-I mimetic works best in the presence of apolipoprotein A-I
    Mohamad Navab
    Circ Res 97:1085-6. 2005
  90. ncbi request reprint Increased low-density lipoprotein oxidation and impaired high-density lipoprotein antioxidant defense are associated with increased macrophage homing and atherosclerosis in dyslipidemic obese mice: LCAT gene transfer decreases atherosclerosis
    Ann Mertens
    Cardiovascular Research Unit at the Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit Leuven, Campus Gasthuisberg, O and N, Herestraat 49, B 3000 Leuven, Belgium
    Circulation 107:1640-6. 2003
    ..We investigated the association between oxidation of apolipoprotein B-containing lipoproteins, high-density lipoprotein (HDL) antioxidant defense, and atherosclerosis in these mice...
  91. ncbi request reprint Increased atherosclerosis in mice lacking apolipoprotein A-I attributable to both impaired reverse cholesterol transport and increased inflammation
    Ryan E Moore
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Circ Res 97:763-71. 2005
    ....
  92. pmc A novel anti-atherogenic role for COX-2--potential mechanism for the cardiovascular side effects of COX-2 inhibitors
    Ajay Narasimha
    Department of Molecular and Medical Pharmacology, University of California Los Angeles, CA, United States
    Prostaglandins Other Lipid Mediat 84:24-33. 2007
    ..Our results suggest, for the first time, that COX-2 deficiency contributes to the pro-atherogenic properties of HDL in mice...
  93. ncbi request reprint Coronary artery disease is associated with the ratio of apolipoprotein A-I/B and serum concentration of apolipoprotein B, but not with paraoxonase enzyme activity in Iranian subjects
    Maziar Rahmani
    Endocrine Research Center, P O Box 4763, Shaheed Beheshti University of Medical Sciences, 19395, Tehran, Iran
    Atherosclerosis 162:381-9. 2002
    ....
  94. ncbi request reprint Monocyte recruitment to endothelial cells in response to oscillatory shear stress
    Tzung K Hsiai
    Department of Biomedical Engineering and Division of Cardiovascular Medicine, USC School of Engineering and Keck School of Medicine, Los Angeles 90089 1451, USA
    FASEB J 17:1648-57. 2003
    ..Oscillatory flow induces up-regulation of adhesion molecules and cytokines to mediate monocyte/EC interactions over a dynamic range of shear stress +/- 2.6 dyn/cm2 (P=0.50, n=10)...
  95. pmc Safety, pharmacokinetics, and pharmacodynamics of oral apoA-I mimetic peptide D-4F in high-risk cardiovascular patients
    LeAnne T Bloedon
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    J Lipid Res 49:1344-52. 2008
    ..We conclude that unformulated D-4F has low bioavailability that is improved under fasting conditions, and that a single dose of D-4F is safe and well tolerated and may improve the HDL anti-inflammatory index...
  96. ncbi request reprint Apparent paradox of low-fat "healthy" diets increasing plasma levels of oxidized low-density lipoprotein and lipoprotein(a)
    Mohamad Navab
    Arterioscler Thromb Vasc Biol 24:392-3. 2004
  97. ncbi request reprint PLTP deficiency improves the anti-inflammatory properties of HDL and reduces the ability of LDL to induce monocyte chemotactic activity
    Daoguang Yan
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 10032, USA
    J Lipid Res 45:1852-8. 2004
    ..We conclude that PLTP deficiency improves the anti-inflammatory properties of HDL in mice and reduces the ability of LDL to induce monocyte chemotactic activity...
  98. ncbi request reprint Antiinflammatory properties of HDL
    Philip J Barter
    The Heart Research Institute, 145 Missenden Rd, Camperdown, Sydney 2050, Australia
    Circ Res 95:764-72. 2004
    ..These antioxidant and antiinflammatory properties of HDL may be as important as its cholesterol efflux function in terms of protecting against the development of atherosclerosis...
  99. ncbi request reprint Understanding changes in high density lipoproteins during the acute phase response
    Brian J Van Lenten
    Arterioscler Thromb Vasc Biol 26:1687-8. 2006
  100. ncbi request reprint High-density lipoprotein function recent advances
    Benjamin J Ansell
    Atherosclerosis Research Unit, Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Am Coll Cardiol 46:1792-8. 2005
    ..Functional characterization of HDL is a promising method for enhanced assessment of cardiovascular risk and effectiveness of risk reduction...