Research Topics
| Yuri N NaumovSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
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Detail Information
Publications
Quantitative measurement of pathogen-specific human memory T cell repertoire diversity using a CDR3 beta-specific microarrayXujing Wang
The Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, The Medical College of Wisconsin and The Children s Hospital Research Institute of Children s Hospital of Wisconsin, Milwaukee, WI 53226, USA
BMC Genomics 8:329. 2007..We have used the memory T cell repertoire to an influenza-derived peptide as a test case for developing such a method...- Multiple glycines in TCR alpha-chains determine clonally diverse nature of human T cell memory to influenza A virusYuri N Naumov
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 181:7407-19. 2008.... 
Selective T cell expansion during aging of CD8 memory repertoires to influenza revealed by modelingYuri N Naumov
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 186:6617-24. 2011..We propose that responses to periodic virus exposure may drive such expansion, ensuring that the remaining clonotypes are optimized for continued protection...
Complex T cell memory repertoires participate in recall responses at extremes of antigenic loadYuri N Naumov
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 177:2006-14. 2006....- CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infectionsMarkus Cornberg
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 184:2825-38. 2010..Defining such cross-reactive networks between commonly encountered human pathogens may facilitate the design of vaccines... - Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopesShalyn C Clute
Department of Pathology and Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 185:6753-64. 2010..We suggest that dissimilar cross-reactive epitopes might generate a broad, rather than a narrow, T cell repertoire if there is a lack of dominant high-affinity clones; this hypothesis is supported by computer simulation... - A fractal clonotype distribution in the CD8+ memory T cell repertoire could optimize potential for immune responsesYuri N Naumov
Department of Pathology, University of Massachusetts Medical School, Worchester, MA 01655, USA
J Immunol 170:3994-4001. 2003..Self similarity, power laws, and recursive mapping algorithms are associated with fractal systems. Thus, Ag-specific memory CD8 T cell repertoires can be considered as fractal, which could indicate optimized flexibility and robustness... - Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosisShalyn C Clute
Department of Pathology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
J Clin Invest 115:3602-12. 2005..Our results support the concept that cross-reactive memory CD8+ T cells activated by EBV contribute to the characteristic lymphoproliferation of IM... - Memory of mice and men: CD8+ T-cell cross-reactivity and heterologous immunityLiisa K Selin
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Immunol Rev 211:164-81. 2006.... - CD1d-restricted T cells regulate dendritic cell function and antitumor immunity in a granulocyte-macrophage colony-stimulating factor-dependent fashionSilke Gillessen
Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 100:8874-9. 2003..DCs from immunized CD1d-deficient mice showed compromised maturation and function. Together, these results delineate a role for CD1d-restricted T cell-DC cross talk in the shaping of antitumor immunity...