James P Nataro

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Genomic characterization of enteroaggregative Escherichia coli from children in Mali
    Nadia Boisen
    Department of Microbiological Surveillance and Research, Statens Serum Institut, Copenhagen, Denmark
    J Infect Dis 205:431-44. 2012
  2. ncbi request reprint Diarrhea among children in developing countries
    James P Nataro
    Department of Pediatrics, University of Virginia School of Medicine, University of Virginia Children s Hospital, Charlottesville, USA
    Adv Exp Med Biol 764:73-80. 2013
  3. ncbi request reprint Safety and immunogenicity of CVD 1208S, a live, oral DeltaguaBA Deltasen Deltaset Shigella flexneri 2a vaccine grown on animal-free media
    Karen L Kotloff
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Hum Vaccin 3:268-75. 2007
  4. pmc Enteroaggregative Escherichia coli strain in a novel weaned mouse model: exacerbation by malnutrition, biofilm as a virulence factor and treatment by nitazoxanide
    David T Bolick
    Center for Global Health, Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Med Microbiol 62:896-905. 2013
  5. pmc Nitazoxanide inhibits biofilm production and hemagglutination by enteroaggregative Escherichia coli strains by blocking assembly of AafA fimbriae
    Eliah R Shamir
    Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia 22908, USA
    Antimicrob Agents Chemother 54:1526-33. 2010
  6. pmc Short report: high prevalence of serine protease autotransporter cytotoxins among strains of enteroaggregative Escherichia coli
    Nadia Boisen
    Department of Bacteriology, Mycology and Parasitology, Statens Serum Institut, Copenhagen, Denmark
    Am J Trop Med Hyg 80:294-301. 2009
  7. pmc The fimbriae of enteroaggregative Escherichia coli induce epithelial inflammation in vitro and in a human intestinal xenograft model
    Erik J Boll
    Department of Microbiological Surveillance and Research, Statens Serum Institut, Denmark
    J Infect Dis 206:714-22. 2012
  8. pmc Role of class 1 serine protease autotransporter in the pathogenesis of Citrobacter rodentium colitis
    Vidhya Vijayakumar
    Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Infect Immun 82:2626-36. 2014
  9. pmc The major pilin subunit of the AAF/II fimbriae from enteroaggregative Escherichia coli mediates binding to extracellular matrix proteins
    Mauricio J Farfan
    Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Infect Immun 76:4378-84. 2008
  10. pmc New adhesin of enteroaggregative Escherichia coli related to the Afa/Dr/AAF family
    Nadia Boisen
    Statens Serum Institut, Department of Bacteriology, Mycology and Parasitology, Copenhagen, Denmark
    Infect Immun 76:3281-92. 2008

Collaborators

Detail Information

Publications21

  1. pmc Genomic characterization of enteroaggregative Escherichia coli from children in Mali
    Nadia Boisen
    Department of Microbiological Surveillance and Research, Statens Serum Institut, Copenhagen, Denmark
    J Infect Dis 205:431-44. 2012
    ..Enteroaggregative Escherichia coli (EAEC) is a cause of epidemic and sporadic diarrhea, yet its role as an enteric pathogen is not fully understood...
  2. ncbi request reprint Diarrhea among children in developing countries
    James P Nataro
    Department of Pediatrics, University of Virginia School of Medicine, University of Virginia Children s Hospital, Charlottesville, USA
    Adv Exp Med Biol 764:73-80. 2013
    ..Results of the studies will inform diarrhea prevention and management efforts worldwide...
  3. ncbi request reprint Safety and immunogenicity of CVD 1208S, a live, oral DeltaguaBA Deltasen Deltaset Shigella flexneri 2a vaccine grown on animal-free media
    Karen L Kotloff
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Hum Vaccin 3:268-75. 2007
    ....
  4. pmc Enteroaggregative Escherichia coli strain in a novel weaned mouse model: exacerbation by malnutrition, biofilm as a virulence factor and treatment by nitazoxanide
    David T Bolick
    Center for Global Health, Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Med Microbiol 62:896-905. 2013
    ....
  5. pmc Nitazoxanide inhibits biofilm production and hemagglutination by enteroaggregative Escherichia coli strains by blocking assembly of AafA fimbriae
    Eliah R Shamir
    Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia 22908, USA
    Antimicrob Agents Chemother 54:1526-33. 2010
    ..Antimicrobial agents that inhibit the assembly or function of fimbrial filaments should be good candidates for the prevention of infection...
  6. pmc Short report: high prevalence of serine protease autotransporter cytotoxins among strains of enteroaggregative Escherichia coli
    Nadia Boisen
    Department of Bacteriology, Mycology and Parasitology, Statens Serum Institut, Copenhagen, Denmark
    Am J Trop Med Hyg 80:294-301. 2009
    ..coli pathotypes rarely harbored a cytotoxic SPATE gene. SPATEs may be relevant to the pathogenesis of both EAEC and Shigella spp...
  7. pmc The fimbriae of enteroaggregative Escherichia coli induce epithelial inflammation in vitro and in a human intestinal xenograft model
    Erik J Boll
    Department of Microbiological Surveillance and Research, Statens Serum Institut, Denmark
    J Infect Dis 206:714-22. 2012
    ..Although previous studies report on the inflammatory aspects of EAEC pathogenesis, the mechanisms by which EAEC trigger these events are not well understood...
  8. pmc Role of class 1 serine protease autotransporter in the pathogenesis of Citrobacter rodentium colitis
    Vidhya Vijayakumar
    Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Infect Immun 82:2626-36. 2014
    ..Our data suggest a previously unsuspected role for class 1 SPATEs in enteric infection. ..
  9. pmc The major pilin subunit of the AAF/II fimbriae from enteroaggregative Escherichia coli mediates binding to extracellular matrix proteins
    Mauricio J Farfan
    Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Infect Immun 76:4378-84. 2008
    ..Finally, increased bacterial adherence was observed when apical secretion of fibronectin was induced by adenosine in polarized T84 cells. Binding to fibronectin may contribute to colonization of the gastrointestinal tract by EAEC...
  10. pmc New adhesin of enteroaggregative Escherichia coli related to the Afa/Dr/AAF family
    Nadia Boisen
    Statens Serum Institut, Department of Bacteriology, Mycology and Parasitology, Copenhagen, Denmark
    Infect Immun 76:3281-92. 2008
    ..Four related adhesins have now been found to confer AA in typical EAEC strains; our data suggest that, together, these variants may account for AA in the large majority of strains...
  11. ncbi request reprint Pathogenesis of enteroaggregative Escherichia coli infection
    Susan M Harrington
    Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA
    FEMS Microbiol Lett 254:12-8. 2006
    ..This article reviews these virulence elements and presents on-going areas of research in EAEC pathogenesis...
  12. pmc The Global Enteric Multicenter Study (GEMS) of diarrheal disease in infants and young children in developing countries: epidemiologic and clinical methods of the case/control study
    Karen L Kotloff
    Department of Pediatrics, University of Maryland School of Medicine, Center for Vaccine Development, 685 W Baltimore St, HSF 480, Baltimore, MD 21201, USA
    Clin Infect Dis 55:S232-45. 2012
    ....
  13. pmc Atypical enteropathogenic Escherichia coli: typical pathogens?
    James P Nataro
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Emerg Infect Dis 12:696. 2006
  14. doi request reprint Development of a multiplex polymerase chain reaction assay for diarrheagenic Escherichia coli and Shigella spp. and its evaluation on colonies, culture broths, and stool
    Mami Taniuchi
    Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA
    Diagn Microbiol Infect Dis 73:121-8. 2012
    ..Stool DNA yielded higher sensitivity than colony pools compared with broth DNA as the standard. We propose using this assay to screen for DEC directly in stool or stool broths...
  15. pmc Characterization of systemic and pneumonic murine models of plague infection using a conditionally virulent strain
    Gabriela Mellado-Sanchez
    Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore St, Room 480, Baltimore, MD 21201, USA
    Comp Immunol Microbiol Infect Dis 36:113-28. 2013
    ..The models of infection described could serve as safe and practical tools for identifying promising vaccine candidates that warrant further potency evaluation using fully virulent strains in BSL-3 settings...
  16. ncbi request reprint Solution structure of the novel dispersin protein of enteroaggregative Escherichia coli
    Jorge J Velarde
    Center for Vaccine Development, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Mol Microbiol 66:1123-35. 2007
    ..We also show that the AAF organelles contribute positive charge to the bacterial surface, suggesting that dispersin's role in fimbrial function is to overcome electrostatic attraction between AAF and the bacterial surface...
  17. ncbi request reprint Deletion in the Shigella enterotoxin genes further attenuates Shigella flexneri 2a bearing guanine auxotrophy in a phase 1 trial of CVD 1204 and CVD 1208
    Karen L Kotloff
    Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Infect Dis 190:1745-54. 2004
    ....
  18. pmc Bacterial serine proteases secreted by the autotransporter pathway: classification, specificity, and role in virulence
    Fernando Ruiz-Perez
    Department of Pediatrics, School of Medicine, University of Virginia, P O Box 800326, MR4 Room 4012C, 409 Lane Road, Charlottesville, VA, 22908, USA
    Cell Mol Life Sci 71:745-70. 2014
    ..Here, we discuss their classification, substrate specificity, and potential roles in pathogenesis. ..
  19. pmc A large family of antivirulence regulators modulates the effects of transcriptional activators in Gram-negative pathogenic bacteria
    Araceli E Santiago
    Department of Pediatrics, University of Virginia School of Medicine and University of Virginia Children s Hospital, Charlottesville, Virginia, United States of America
    PLoS Pathog 10:e1004153. 2014
    ..We propose the name ANR (AraC Negative Regulators) for this family. ..
  20. ncbi request reprint Diarrheagenic Escherichia coli infection in Baltimore, Maryland, and New Haven, Connecticut
    James P Nataro
    Center for Vaccine Development, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Clin Infect Dis 43:402-7. 2006
    ..Diarrhea remains a common complaint among US patients who seek medical attention...
  21. pmc Intracellular expression of the plasmid-encoded toxin from enteroaggregative Escherichia coli
    Bao Quan Sui
    Center for Vaccine Development, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 71:5364-70. 2003
    ..These studies corroborate an intracellular site of action for the Pet toxin, further implicate a role for spectrin in Pet intoxication, and provide a powerful tool for Pet structure and function analyses...