Research Topics
| J P NataroSummaryAffiliation: University of Maryland Country: USA Publications
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Detail Information
Publications
Diarrheagenic Escherichia coliJ P Nataro
Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
Clin Microbiol Rev 11:142-201. 1998..coli strains and describes how their pathogenic schemes underlie the clinical manifestations, diagnostic approach, and epidemiologic investigation of these important pathogens...- Safety, immunogenicity, and transmissibility in humans of CVD 1203, a live oral Shigella flexneri 2a vaccine candidate attenuated by deletions in aroA and virGK L Kotloff
Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, USA
Infect Immun 64:4542-8. 1996..We conclude that engineered deletions in virG and aroA markedly attenuate wild-type S. flexneri but preserve immunogenicity; however, less reactogenic vaccines are needed... - Safety of live oral Salmonella typhi vaccine strains with deletions in htrA and aroC aroD and immune response in humansC O Tacket
Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
Infect Immun 65:452-6. 1997..typhi flagellar and particulate antigens after the higher doses. These studies demonstrate the potential of CVD 908-htrA as a live vector for the delivery of heterologous genes, and a clinical trial of such a construct is planned... - Phase 2 clinical trial of attenuated Salmonella enterica serovar typhi oral live vector vaccine CVD 908-htrA in U.S. volunteersC O Tacket
Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
Infect Immun 68:1196-201. 2000..This phase 2 study supports the further development of CVD 908-htrA as a single-dose vaccine against typhoid fever and as a possible live vector for oral delivery of other vaccine antigens... - Effect of prior experimental human enteropathogenic Escherichia coli infection on illness following homologous and heterologous rechallengeM S Donnenberg
Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
Infect Immun 66:52-8. 1998..These studies indicate that prior EPEC infection can reduce disease severity upon homologous challenge. Further studies may require the development of new model systems... - Safety and immunogenicity in humans of an attenuated Salmonella typhi vaccine vector strain expressing plasmid-encoded hepatitis B antigens stabilized by the Asd-balanced lethal vector systemC O Tacket
Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
Infect Immun 65:3381-5. 1997.... - Investigation of the roles of toxin-coregulated pili and mannose-sensitive hemagglutinin pili in the pathogenesis of Vibrio cholerae O139 infectionC O Tacket
Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
Infect Immun 66:692-5. 1998..01). We conclude that TCP are an important colonization factor of V. cholerae O139 and probably of El Tor V. cholerae O1. In contrast, MSHA does not appear to promote intestinal colonization in humans... - Shigella flexneri 2a strain CVD 1207, with specific deletions in virG, sen, set, and guaBA, is highly attenuated in humansK L Kotloff
Division of Infectious Diseases, Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Infect Immun 68:1034-9. 2000..flexneri 2a by rational use of recombinant DNA technology that achieves a remarkable degree of attenuation compared with earlier recombinant strains, even when administered at high dosage... - T84 cells in culture as a model for enteroaggregative Escherichia coli pathogenesisJ P Nataro
Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201, USA
Infect Immun 64:4761-8. 1996..Although the factor(s) required for this effect remains to be elucidated, T84 cells may serve as a valuable model in EAEC pathogenesis studies... - Identification and cloning of a novel plasmid-encoded enterotoxin of enteroinvasive Escherichia coli and Shigella strainsJ P Nataro
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, USA
Infect Immun 63:4721-8. 1995..We believe that the sen gene product may constitute all or part of a novel enterotoxin in EIEC and Shigella spp... - Cytoskeletal effects induced by pet, the serine protease enterotoxin of enteroaggregative Escherichia coliF Navarro-Garcia
Center for Vaccine Development, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Infect Immun 67:2184-92. 1999..These data suggest that Pet is a cytoskeleton-altering toxin and that its protease activity is involved in each of the observed phenotypes... 
Molecular switches--the ON and OFF of bacterial phase variationI R Henderson
Center for Vaccine Development, Department of Pediatrics, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201, USA
Mol Microbiol 33:919-32. 1999..Phase variation events are usually random, but may be modulated by environmental conditions. The mechanisms of phase variation events and their significance within the microbial community are discussed here...- Characterization of pic, a secreted protease of Shigella flexneri and enteroaggregative Escherichia coliI R Henderson
Center for Vaccine Development, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Infect Immun 67:5587-96. 1999..Functional analysis of the Pic protein implicates this factor in mucinase activity, serum resistance, and hemagglutination. Our data suggest that Pic may be a multifunctional protein involved in enteric pathogenesis... - In vitro effects of a high-molecular-weight heat-labile enterotoxin from enteroaggregative Escherichia coliF Navarro-Garcia
Department of Public Health, Faculty of Medicine, UNAM, 04510 Mexico DF, Mexico
Infect Immun 66:3149-54. 1998..Our data suggest that some EAggEC strains produce a ca. 108-kDa enterotoxin/cytotoxin which is encoded on the large virulence plasmid... - Role of EspB in experimental human enteropathogenic Escherichia coli infectionC O Tacket
Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Infect Immun 68:3689-95. 2000..These results demonstrate that EspB is a critical virulence determinant of EPEC infections and suggest that EspB contributes to an immune response... - Roles for Fis and YafK in biofilm formation by enteroaggregative Escherichia coliJ Sheikh
Center for Vaccine Development, Department of Pediatrics, University of Maryland School of Medicine, 685 W Baltimore St, Baltimore, MD 21201, USA
Mol Microbiol 41:983-97. 2001..Our data do not suggest a role for type 1 fimbriae or motility in biofilm formation. EAEC appears to form a novel biofilm, which may be mediated solely by AAF and may reflect its interactions with the intestinal mucosa... - Identification of sat, an autotransporter toxin produced by uropathogenic Escherichia coliD M Guyer
Department of Microbiology and Immunology, and Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Mol Microbiol 38:53-66. 2000..Based upon its association with pathogenic isolates, its cytopathic phenotype and its ability to elicit a strong antibody response after infection, we postulate that Sat represents a novel virulence determinant of uropathogenic E. coli... - Enteroaggregative Escherichia coliJ P Nataro
University of Maryland School of Medicine, Baltimore 21201, USA
Emerg Infect Dis 4:251-61. 1998..EAEC's ability to stimulate the release of inflammatory mediators may also play a role in intestinal illness... - The great escape: structure and function of the autotransporter proteinsI R Henderson
Dept of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
Trends Microbiol 6:370-8. 1998..Members of this family have been implicated as important or putative virulence factors in many Gram-negative pathogens... - The sigA gene which is borne on the she pathogenicity island of Shigella flexneri 2a encodes an exported cytopathic protease involved in intestinal fluid accumulationK Al-Hasani
Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia
Infect Immun 68:2457-63. 2000..SigA was at least partly responsible for the ability of S. flexneri to stimulate fluid accumulation in ligated rabbit ileal loops... - A plasmid-encoded type IV fimbrial gene of enteropathogenic Escherichia coli associated with localized adherenceM S Donnenberg
Department of Veterans Affairs Medical Center, Baltimore, Maryland 21201
Mol Microbiol 6:3427-37. 1992..These studies describe an EPEC plasmid-encoded fimbrial gene, a candidate for the elusive EPEC adherence factor responsible for localized adherence... - Measuring cell surface elasticity on enteroaggregative Escherichia coli wild type and dispersin mutant by AFMM A Beckmann
UT-ORNL Graduate School of Genome Science and Technology, The University of Tennessee, Knoxville, 37996-0840, USA
Ultramicroscopy 106:695-702. 2006..This work represents an initial step in efforts to understand the pathogenic role of the dispersin protein in the wild-type bacteria...