Nicholas R Natale

Summary

Affiliation: University of Idaho
Country: USA

Publications

  1. ncbi request reprint Can selective ligands for glutamate binding proteins be rationally designed?
    Nicholas R Natale
    301 Renfrew Hall, Department of Chemistry, University of Idaho, Moscow, ID 83844 2343 USA
    Curr Top Med Chem 6:823-47. 2006
  2. ncbi request reprint Catalytic asymmetric synthesis of glutamate analogues
    David J Burkhart
    Department of Chemistry, University of Idaho, 301 Renfrew Hall, Moscow, ID 83844 2343, USA
    Org Lett 6:1285-8. 2004
  3. pmc Fluorescent probes of the isoxazole-dihydropyridine scaffold: MDR-1 binding and homology model
    Monika I Szabon-Watola
    Department of Chemistry, University of Idaho, Moscow, ID 83843, United States
    Bioorg Med Chem Lett 24:117-21. 2014
  4. pmc Design, synthesis and biological evaluation of a novel class of anticancer agents: anthracenylisoxazole lexitropsin conjugates
    Xiaochun Han
    Department of Chemistry, University of Idaho, Moscow, ID 83844, United States
    Bioorg Med Chem 17:1671-80. 2009
  5. ncbi request reprint Unique structure-activity relationship for 4-isoxazolyl-1,4-dihydropyridines
    Gerald W Zamponi
    Department of Pharmacology and Therapeutics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    J Med Chem 46:87-96. 2003

Research Grants

Collaborators

  • Kathy Ruth Magnusson
  • Chun Li
  • Ronald Crawford
  • Monika I Szabon-Watola
  • Xiaochun Han
  • David J Burkhart
  • Jared K Nelson
  • Gerald W Zamponi
  • Scott A Steiger
  • Sarah V Ulatowski
  • Kathleen M George
  • Christina D Hayes
  • Andrzej Paszczynski
  • Peiwen Zhou
  • William Fusco
  • Kevin C Rider
  • Michael D Mosher
  • Andrew R McKenzie
  • Xue Zhao
  • Katherine I Myers
  • Alex Blumenfeld
  • Stephanie C Stotz
  • Richard J Staples
  • Victoria Hulubei
  • Tina M Andro

Detail Information

Publications5

  1. ncbi request reprint Can selective ligands for glutamate binding proteins be rationally designed?
    Nicholas R Natale
    301 Renfrew Hall, Department of Chemistry, University of Idaho, Moscow, ID 83844 2343 USA
    Curr Top Med Chem 6:823-47. 2006
    ..The prospects for unraveling cross-reactivity will be weighed in light of a critical comparison of the glutamate binding protein targets...
  2. ncbi request reprint Catalytic asymmetric synthesis of glutamate analogues
    David J Burkhart
    Department of Chemistry, University of Idaho, 301 Renfrew Hall, Moscow, ID 83844 2343, USA
    Org Lett 6:1285-8. 2004
    ..Chiral centers alpha or beta at the C-5 position do not detract from diastereoselectivity of the Jacobsen-Strecker reaction. [reaction: see text]..
  3. pmc Fluorescent probes of the isoxazole-dihydropyridine scaffold: MDR-1 binding and homology model
    Monika I Szabon-Watola
    Department of Chemistry, University of Idaho, Moscow, ID 83843, United States
    Bioorg Med Chem Lett 24:117-21. 2014
    ..A homology model for IDHP binding at MDR-1 is presented which represents our current working hypothesis. ..
  4. pmc Design, synthesis and biological evaluation of a novel class of anticancer agents: anthracenylisoxazole lexitropsin conjugates
    Xiaochun Han
    Department of Chemistry, University of Idaho, Moscow, ID 83844, United States
    Bioorg Med Chem 17:1671-80. 2009
    ..Evidence consistent with a mechanism of action via the interaction of these compounds with G-quadruplex (G4) DNA and a structural based rational for the observed selectivity of the AIMs for G4 over B-DNA is presented...
  5. ncbi request reprint Unique structure-activity relationship for 4-isoxazolyl-1,4-dihydropyridines
    Gerald W Zamponi
    Department of Pharmacology and Therapeutics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    J Med Chem 46:87-96. 2003
    ..A variable-temperature NMR study confirmed the computation. With Striessnig's computational sequence homologation procedure, a working hypothesis was derived from the data that explains the unique SAR for IDs...

Research Grants1

  1. Ligands to study the glutamate receptor and transporters
    NICHOLAS NATALE; Fiscal Year: 2006
    ..And also relevant to the special considerations for the AREA program, our research group has had a significant positive impact on the participation of University of Idaho students in research. ..