Kent L Nastiuk

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc In vivo MRI volumetric measurement of prostate regression and growth in mice
    Kent L Nastiuk
    Department of Pathology and Laboratory Medicine, University of California, Irvine, CA, USA
    BMC Urol 7:12. 2007
  2. doi request reprint FLICE-like inhibitory protein blocks transforming growth factor beta 1-induced caspase activation and apoptosis in prostate epithelial cells
    Kent L Nastiuk
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California Irvine, Medical Sciences I D450, Irvine, CA 92697 4800, USA
    Mol Cancer Res 6:231-42. 2008
  3. ncbi request reprint FLIP-ping out: death receptor signaling in the prostate
    Kent L Nastiuk
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Irvine, California 92697 4800, USA
    Cancer Biol Ther 7:1171-9. 2008
  4. doi request reprint Transforming growth factor beta1 induces apoptosis by suppressing FLICE-like inhibitory protein in DU145 prostate epithelial cells
    Kiwon S Yoo
    Department of Pathology and Laboratory Medicine, Medical Sciences I D450, University of California, Irvine, Irvine, CA 92697 4800, USA
    Int J Cancer 124:834-42. 2009
  5. pmc TNF is necessary for castration-induced prostate regression, whereas TRAIL and FasL are dispensable
    Jennifer S Davis
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Irvine, California 92697 4800, USA
    Mol Endocrinol 25:611-20. 2011
  6. pmc Sequential proteolytic processing of an interferon-alpha receptor subunit by TNF-alpha converting enzyme and presenilins
    Peter D Pioli
    Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA 92697, USA
    J Interferon Cytokine Res 32:312-25. 2012
  7. ncbi request reprint Androgen regulation of FLICE-like inhibitory protein gene expression in the rat prostate
    Kent L Nastiuk
    Department of Pathology, College of Medicine, University of California, Irvine, USA
    J Cell Physiol 196:386-93. 2003
  8. pmc Nuclear transit of the intracellular domain of the interferon receptor subunit IFNaR2 requires Stat2 and Irf9
    Ashraf El Fiky
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Irvine, Irvine, CA 92679, United States
    Cell Signal 20:1400-8. 2008

Collaborators

  • Hui Liu
  • David Danielpour
  • John J Krolewski
  • Ashraf El Fiky
  • Peter D Pioli
  • Jennifer S Davis
  • Kiwon S Yoo
  • Abu M Z Saleh
  • Arif Azam
  • Pete Pioli
  • Kiwon Yoo

Detail Information

Publications8

  1. pmc In vivo MRI volumetric measurement of prostate regression and growth in mice
    Kent L Nastiuk
    Department of Pathology and Laboratory Medicine, University of California, Irvine, CA, USA
    BMC Urol 7:12. 2007
    ..Temporal monitoring of mouse prostate regression requires multiple animals and examination of histological sections...
  2. doi request reprint FLICE-like inhibitory protein blocks transforming growth factor beta 1-induced caspase activation and apoptosis in prostate epithelial cells
    Kent L Nastiuk
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California Irvine, Medical Sciences I D450, Irvine, CA 92697 4800, USA
    Mol Cancer Res 6:231-42. 2008
    ....
  3. ncbi request reprint FLIP-ping out: death receptor signaling in the prostate
    Kent L Nastiuk
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Irvine, California 92697 4800, USA
    Cancer Biol Ther 7:1171-9. 2008
    ..However, it is not yet known which of the death receptor pathways is required for prostate apoptosis in vivo, and this remains an active topic of research...
  4. doi request reprint Transforming growth factor beta1 induces apoptosis by suppressing FLICE-like inhibitory protein in DU145 prostate epithelial cells
    Kiwon S Yoo
    Department of Pathology and Laboratory Medicine, Medical Sciences I D450, University of California, Irvine, Irvine, CA 92697 4800, USA
    Int J Cancer 124:834-42. 2009
    ..Furthermore, inhibition of caspase-8 by siRNA knockdown partially rescued the apoptotic effects of TGFbeta1, suggesting a role for death receptor signaling components in TGFbeta-mediated death of prostate epithelial cells...
  5. pmc TNF is necessary for castration-induced prostate regression, whereas TRAIL and FasL are dispensable
    Jennifer S Davis
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Irvine, California 92697 4800, USA
    Mol Endocrinol 25:611-20. 2011
    ..These findings support a physiologic role for TNF in prostate regression after androgen withdrawal. Understanding this role may lead to novel therapies for prostate cancer...
  6. pmc Sequential proteolytic processing of an interferon-alpha receptor subunit by TNF-alpha converting enzyme and presenilins
    Peter D Pioli
    Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA 92697, USA
    J Interferon Cytokine Res 32:312-25. 2012
    ..In conclusion, IFNaR2 is cleaved by TACE and Presenilin 1/2, suggesting that interferons signal by both kinase and RIP-mediated pathways...
  7. ncbi request reprint Androgen regulation of FLICE-like inhibitory protein gene expression in the rat prostate
    Kent L Nastiuk
    Department of Pathology, College of Medicine, University of California, Irvine, USA
    J Cell Physiol 196:386-93. 2003
    ..By acting as an inhibitor of caspase-8, FLIP may protect prostatic epithelium from apoptosis. Androgen withdrawal, by reducing FLIP mRNA levels, might leave the cells vulnerable to as yet unidentified cell death signals...
  8. pmc Nuclear transit of the intracellular domain of the interferon receptor subunit IFNaR2 requires Stat2 and Irf9
    Ashraf El Fiky
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Irvine, Irvine, CA 92679, United States
    Cell Signal 20:1400-8. 2008
    ..Overall, the data suggest that liberation of the IFNaR2-ICD by regulated proteolysis could trigger a novel mechanism for moving the transcription factor Stat2 to the nucleus...