Saleh Naser

Summary

Affiliation: University of Central Florida
Country: USA

Publications

  1. pmc Role of ATG16L, NOD2 and IL23R in Crohn's disease pathogenesis
    Saleh A Naser
    Department of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA
    World J Gastroenterol 18:412-24. 2012
  2. pmc Cellular infiltration and cytokine expression correlate with fistulizing state in Crohn's disease
    Saleh A Naser
    Department of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA
    Clin Vaccine Immunol 18:1416-9. 2011
  3. ncbi request reprint Occurrence of the IS900 gene in Mycobacterium avium complex derived from HIV patients
    S A Naser
    Department of Molecular Biology and Microbiology and Center for Discovery of Drugs and Diagnostics, University of Central Florida, Orlando, Florida 32816, USA
    Mol Cell Probes 13:367-72. 1999
  4. ncbi request reprint Culture of Mycobacterium avium subspecies paratuberculosis from the blood of patients with Crohn's disease
    Saleh A Naser
    Department of Molecular Biology and Microbiology and Biomolecular Science Center, Burnett College of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USA
    Lancet 364:1039-44. 2004
  5. ncbi request reprint In situ identification of mycobacteria in Crohn's disease patient tissue using confocal scanning laser microscopy
    S A Naser
    Department of Molecular Biology and Microbiology, University of Central Florida, Orlando 32816, USA
    Mol Cell Probes 16:41-8. 2002
  6. ncbi request reprint Evaluation of surgical tissue from patients with Crohn's disease for the presence of Mycobacterium avium subspecies paratuberculosis DNA by in situ hybridization and nested polymerase chain reaction
    Claudia Romero
    Department of Molecular Biology and Microbiology and Biomolecular Science Center, The Burnett College of Biomedical Sciences, University of Central Florida, Orlando, Florida 32816, USA
    Inflamm Bowel Dis 11:116-25. 2005
  7. ncbi request reprint Inhibition of phagosome maturation and survival of Mycobacterium avium subspecies paratuberculosis in polymorphonuclear leukocytes from Crohn's disease patients
    John Rumsey
    Department of Molecular Biology and Microbiology and Biomolecular Science Center, Burnett College of Biomedical Sciences University of Central Florida, Orlando, FL 32816, USA
    Med Sci Monit 12:BR130-9. 2006
  8. ncbi request reprint Seroreactivities against Saccharomyces cerevisiae and Mycobacterium avium subsp. paratuberculosis p35 and p36 antigens in Crohn's disease patients
    Ira Shafran
    Department of Molecular Biology and Microbiology, University of Central Florida, Orlando, USA
    Dig Dis Sci 47:2079-81. 2002
  9. pmc Correlation between rpoB gene mutation in Mycobacterium avium subspecies paratuberculosis and clinical rifabutin and rifampicin resistance for treatment of Crohn's disease
    Daniel R Beckler
    Department of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Florida, FL 32816, United States
    World J Gastroenterol 14:2723-30. 2008
  10. ncbi request reprint Synthesis and biological evaluation of new citrate-based siderophores as potential probes for the mechanism of iron uptake in mycobacteria
    Hongyan Guo
    Center for Discovery of Drugs and Diagnostics, Department of Chemistry, University of Central Florida, Orlando, FL 32816 2366, USA
    J Med Chem 45:2056-63. 2002

Research Grants

Collaborators

Detail Information

Publications19

  1. pmc Role of ATG16L, NOD2 and IL23R in Crohn's disease pathogenesis
    Saleh A Naser
    Department of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA
    World J Gastroenterol 18:412-24. 2012
    ..The purpose of this review is to examine all genetic aspects and theories of CD, including up to date multiple population studies performed worldwide...
  2. pmc Cellular infiltration and cytokine expression correlate with fistulizing state in Crohn's disease
    Saleh A Naser
    Department of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA
    Clin Vaccine Immunol 18:1416-9. 2011
    ..Differentiation of cell subpopulations may be important for establishing a direct relationship with each state of CD (inflammatory, stricturing, and fistulizing states)...
  3. ncbi request reprint Occurrence of the IS900 gene in Mycobacterium avium complex derived from HIV patients
    S A Naser
    Department of Molecular Biology and Microbiology and Center for Discovery of Drugs and Diagnostics, University of Central Florida, Orlando, Florida 32816, USA
    Mol Cell Probes 13:367-72. 1999
    ..avium subsp. avium especially those isolated from HIV patients. Ultimately the IS900 PCR-based assay may provide a useful tool for diagnostic and epidemiological studies related to MAC infections in HIV patients...
  4. ncbi request reprint Culture of Mycobacterium avium subspecies paratuberculosis from the blood of patients with Crohn's disease
    Saleh A Naser
    Department of Molecular Biology and Microbiology and Biomolecular Science Center, Burnett College of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USA
    Lancet 364:1039-44. 2004
    ..Crohn's disease, a form of inflammatory bowel disease, resembles some aspects of tuberculosis, leprosy, and paratuberculosis. The role of Mycobacterium avium subspecies paratuberculosis (MAP) in Crohn's disease is controversial...
  5. ncbi request reprint In situ identification of mycobacteria in Crohn's disease patient tissue using confocal scanning laser microscopy
    S A Naser
    Department of Molecular Biology and Microbiology, University of Central Florida, Orlando 32816, USA
    Mol Cell Probes 16:41-8. 2002
    ..This technique adds an additional approach to investigate MAP role in CD etiology especially when the culture approach is long and inconsistent...
  6. ncbi request reprint Evaluation of surgical tissue from patients with Crohn's disease for the presence of Mycobacterium avium subspecies paratuberculosis DNA by in situ hybridization and nested polymerase chain reaction
    Claudia Romero
    Department of Molecular Biology and Microbiology and Biomolecular Science Center, The Burnett College of Biomedical Sciences, University of Central Florida, Orlando, Florida 32816, USA
    Inflamm Bowel Dis 11:116-25. 2005
    ..The data add more evidence toward a possible association of MAP in the pathogenesis of CD...
  7. ncbi request reprint Inhibition of phagosome maturation and survival of Mycobacterium avium subspecies paratuberculosis in polymorphonuclear leukocytes from Crohn's disease patients
    John Rumsey
    Department of Molecular Biology and Microbiology and Biomolecular Science Center, Burnett College of Biomedical Sciences University of Central Florida, Orlando, FL 32816, USA
    Med Sci Monit 12:BR130-9. 2006
    ..Mycobacterium avium subspecies paratuberculosis (MAP) is an intracellular pathogen that is known to parasitize macrophages. MAP is the known etiological agent of Johne's disease and implicated in the etiology of Crohn's disease...
  8. ncbi request reprint Seroreactivities against Saccharomyces cerevisiae and Mycobacterium avium subsp. paratuberculosis p35 and p36 antigens in Crohn's disease patients
    Ira Shafran
    Department of Molecular Biology and Microbiology, University of Central Florida, Orlando, USA
    Dig Dis Sci 47:2079-81. 2002
    ..Larger studies are needed to investigate the combined use of these serologic markers for the diagnosis of CD...
  9. pmc Correlation between rpoB gene mutation in Mycobacterium avium subspecies paratuberculosis and clinical rifabutin and rifampicin resistance for treatment of Crohn's disease
    Daniel R Beckler
    Department of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Florida, FL 32816, United States
    World J Gastroenterol 14:2723-30. 2008
    ..To investigate overlapping regions of the rpoB gene previously involved with rifamycin resistance in M. tuberculosis and seek correlation between rpoB mutations in clinical MAP strains with susceptibility to RIF and RFB...
  10. ncbi request reprint Synthesis and biological evaluation of new citrate-based siderophores as potential probes for the mechanism of iron uptake in mycobacteria
    Hongyan Guo
    Center for Discovery of Drugs and Diagnostics, Department of Chemistry, University of Central Florida, Orlando, FL 32816 2366, USA
    J Med Chem 45:2056-63. 2002
    ..In this regard, new structural elements were identified (e.g., an imide motif or 2-octenoyl side chain), whose presence stimulated mycobacterial growth...
  11. ncbi request reprint Synthesis and biological evaluation of new acinetoferrin homologues for use as iron transport probes in mycobacteria
    Richard A Gardner
    Department of Chemistry and Department of Molecular Biology and Microbiology, University of Central Florida, Orlando, Florida 32816 2366, USA
    J Med Chem 47:4933-40. 2004
    ..Last, a siderophore from Streptomyces pilosus, deferrioxamine B, was shown to cross-feed M. avium subsp. paratuberculosis with the same efficiency as the more costly, native chelator, mycobactin J...
  12. ncbi request reprint One-step, nanoparticle-mediated bacterial detection with magnetic relaxation
    Charalambos Kaittanis
    NanoScience Technology Center, University of Central Florida, 12424 Research Parkway, Suite 400, Orlando, Florida 32826, USA
    Nano Lett 7:380-3. 2007
    ..The use of the described magnetic nanosensors in the identification and quantification of bacteria in clinical and environmental samples is anticipated...
  13. ncbi request reprint Successful treatment of a Crohn's disease patient infected with bacteremic Mycobacterium paratuberculosis
    William Chamberlin
    Am J Gastroenterol 102:689-91. 2007
  14. pmc Molecular epidemiology of Mycobacterium avium subsp. paratuberculosis: evidence for limited strain diversity, strain sharing, and identification of unique targets for diagnosis
    Alifiya S Motiwala
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, 44691, USA
    J Clin Microbiol 41:2015-26. 2003
    ..Further, the results of our analyses reveal a relatively higher degree of genetic heterogeneity among M. avium subsp. paratuberculosis isolates recovered from human and ovine sources...
  15. pmc Mycobacterium avium subsp. paratuberculosis strains isolated from Crohn's disease patients and animal species exhibit similar polymorphic locus patterns
    Alifiya H Ghadiali
    Food Animal Health Research Program, Ohio Agricultural Research Development Center, The Ohio State University, Wooster, Ohio 44691, USA
    J Clin Microbiol 42:5345-8. 2004
    ..Identification of a limited number of genotypes among human strains implies the existence of human disease-associated genotypes and strain sharing with animals...
  16. doi request reprint Blood cultures of 19 Crohn's disease patients
    William Chamberlin
    Am J Gastroenterol 103:802-3. 2008
  17. ncbi request reprint Integrating theories of the etiology of Crohn's disease. On the etiology of Crohn's disease: questioning the hypotheses
    William M Chamberlin
    Department of Medicine, Texas Tech Medical Center, El Paso, TX 79905, USA
    Med Sci Monit 12:RA27-33. 2006
    ..Critics claim that MAP is merely a secondary invader. The three theories differ primarily by emphasizing different aspects of the same overall process...
  18. ncbi request reprint Debate on the lack of evidence of Mycobacterium avium subsp. paratuberculosis in Crohn's disease
    Saleh A Naser
    Inflamm Bowel Dis 11:1123. 2005
  19. ncbi request reprint Mycobacterium in Crohn's disease is hard to digest
    Saleh A Naser
    Gastroenterology 129:1359-60; author reply 1360-1. 2005

Research Grants4

  1. Mycobacterium avium subspecies in Crohn's Disease
    Saleh Naser; Fiscal Year: 2005
    ..Ultimately, the outcome of this study will go a long way toward clearing up the MAP debate. ..