Jagat Narula

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Heart failure in diabetes: are you exhausted, sweetheart?
    Jagat Narula
    Division of Cardiology, University of California, School of Medicine, Irvine, CA 92868 4080, USA
    Heart Fail Clin 2:xi-xii. 2006
  2. pmc Early molecular imaging of interstitial changes in patients after myocardial infarction: comparison with delayed contrast-enhanced magnetic resonance imaging
    Johan Verjans
    Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
    J Nucl Cardiol 17:1065-72. 2010
  3. ncbi request reprint Mechanisms of disease: apoptosis in heart failure--seeing hope in death
    Jagat Narula
    Division of Cardiology, University of California, Irvine School of Medicine, 101 The City Drive, Building 53, Mail Route 81, Orange, CA 92868, USA
    Nat Clin Pract Cardiovasc Med 3:681-8. 2006
  4. ncbi request reprint Assessment of myocardial damage in regurgitant valvular disease
    Jagat Narula
    Division of Cardiovascular Pathophysiology and The Howard Gilman Institute for Valvular Heart Diseases, Weill Medical College of Cornell University, New York, NY, USA
    Adv Cardiol 41:57-61. 2004
  5. ncbi request reprint Role of molecular imaging in defining and denying death
    Jagat Narula
    University of California Irvine Medical Center, Orange 92868 4080, USA
    J Nucl Cardiol 11:349-57. 2004
  6. ncbi request reprint Imaging heart failure: premonition to prevention in predisposed
    Jagat Narula
    Division of Cardiology, University of California Irvine School of Medicine, Irvine, CA 92868 4080, USA
    Heart Fail Clin 2:ix-x. 2006
  7. doi request reprint Arithmetic of vulnerable plaques for noninvasive imaging
    Jagat Narula
    University of California Irvine School of Medicine, Orange, CA 92868 4080, USA
    Nat Clin Pract Cardiovasc Med 5:S2-10. 2008
  8. ncbi request reprint Natriuretic peptides in heart failure: empathizing with the sobbing heart
    Jagat Narula
    Division of Cardiology, University of California School of Medicine, Irvine, CA 92868 4080, USA
    Heart Fail Clin 2:xi-xiii. 2006
  9. ncbi request reprint Vascular rejection in heart transplantation: when ignorance is not bliss
    Jagat Narula
    University of California, Irvine, CA, USA
    Heart Fail Clin 3:ix-x. 2007
  10. doi request reprint Molecular imaging for efficacy of pharmacologic intervention in myocardial remodeling
    Susanne W M van den Borne
    Division of Cardiology and Department of Pathology, University of California Irvine School of Medicine, Irvine, CA 92697, USA
    JACC Cardiovasc Imaging 2:187-98. 2009

Research Grants

Detail Information

Publications123 found, 100 shown here

  1. ncbi request reprint Heart failure in diabetes: are you exhausted, sweetheart?
    Jagat Narula
    Division of Cardiology, University of California, School of Medicine, Irvine, CA 92868 4080, USA
    Heart Fail Clin 2:xi-xii. 2006
  2. pmc Early molecular imaging of interstitial changes in patients after myocardial infarction: comparison with delayed contrast-enhanced magnetic resonance imaging
    Johan Verjans
    Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
    J Nucl Cardiol 17:1065-72. 2010
    ..In experimental studies, RIP has been shown to target integrins associated with collagen-producing myofibroblasts (MFB)...
  3. ncbi request reprint Mechanisms of disease: apoptosis in heart failure--seeing hope in death
    Jagat Narula
    Division of Cardiology, University of California, Irvine School of Medicine, 101 The City Drive, Building 53, Mail Route 81, Orange, CA 92868, USA
    Nat Clin Pract Cardiovasc Med 3:681-8. 2006
    ..This process of 'apoptosis interruptus' could allow development of novel strategies to reverse or attenuate heart failure...
  4. ncbi request reprint Assessment of myocardial damage in regurgitant valvular disease
    Jagat Narula
    Division of Cardiovascular Pathophysiology and The Howard Gilman Institute for Valvular Heart Diseases, Weill Medical College of Cornell University, New York, NY, USA
    Adv Cardiol 41:57-61. 2004
  5. ncbi request reprint Role of molecular imaging in defining and denying death
    Jagat Narula
    University of California Irvine Medical Center, Orange 92868 4080, USA
    J Nucl Cardiol 11:349-57. 2004
  6. ncbi request reprint Imaging heart failure: premonition to prevention in predisposed
    Jagat Narula
    Division of Cardiology, University of California Irvine School of Medicine, Irvine, CA 92868 4080, USA
    Heart Fail Clin 2:ix-x. 2006
  7. doi request reprint Arithmetic of vulnerable plaques for noninvasive imaging
    Jagat Narula
    University of California Irvine School of Medicine, Orange, CA 92868 4080, USA
    Nat Clin Pract Cardiovasc Med 5:S2-10. 2008
    ..Precise metrics of typical vulnerable atherosclerotic plaque dimensions will need to be defined to facilitate their identification by noninvasive imaging modalities...
  8. ncbi request reprint Natriuretic peptides in heart failure: empathizing with the sobbing heart
    Jagat Narula
    Division of Cardiology, University of California School of Medicine, Irvine, CA 92868 4080, USA
    Heart Fail Clin 2:xi-xiii. 2006
  9. ncbi request reprint Vascular rejection in heart transplantation: when ignorance is not bliss
    Jagat Narula
    University of California, Irvine, CA, USA
    Heart Fail Clin 3:ix-x. 2007
  10. doi request reprint Molecular imaging for efficacy of pharmacologic intervention in myocardial remodeling
    Susanne W M van den Borne
    Division of Cardiology and Department of Pathology, University of California Irvine School of Medicine, Irvine, CA 92697, USA
    JACC Cardiovasc Imaging 2:187-98. 2009
    ..Using molecular imaging techniques, we examined interstitial alterations during postmyocardial infarction (MI) remodeling and assessed the efficacy of antiangiotensin and antimineralocorticoid intervention, alone and in combination...
  11. ncbi request reprint Molecular imaging of interstitial alterations in remodeling myocardium after myocardial infarction
    Susanne W M van den Borne
    University of California, Irvine School of Medicine, Irvine, California, USA
    J Am Coll Cardiol 52:2017-28. 2008
    ..The purpose of this study was to evaluate interstitial alterations in myocardial remodeling using a radiolabeled Cy5.5-RGD imaging peptide (CRIP) that targets myofibroblasts...
  12. doi request reprint Molecular imaging of matrix metalloproteinase expression in atherosclerotic plaques of mice deficient in apolipoprotein e or low-density-lipoprotein receptor
    Satoru Ohshima
    Division of Cardiology, University of California, Irvine School of Medicine, Irvine, California, USA
    J Nucl Med 50:612-7. 2009
    ..Matrix metalloproteinases (MMPs) are expressed in atherosclerotic plaques and play an important role in plaque instability...
  13. pmc Dual molecular imaging for targeting metalloproteinase activity and apoptosis in atherosclerosis: molecular imaging facilitates understanding of pathogenesis
    Nezam Haider
    Department of Cardiology, Irvine School of Medicine, University of California, C116 Med Sci I, Irvine, CA 92697, USA
    J Nucl Cardiol 16:753-62. 2009
    ..Macrophage apoptosis and MMP activity contribute to vulnerability of atherosclerotic plaques to rupture. By employing molecular imaging techniques, we investigated if apoptosis and MMP release are interlinked...
  14. doi request reprint Annexin A5 uptake in ischemic myocardium: demonstration of reversible phosphatidylserine externalization and feasibility of radionuclide imaging
    Heidi Kenis
    Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands
    J Nucl Med 51:259-67. 2010
    ....
  15. pmc Noninvasive imaging of angiotensin receptors after myocardial infarction
    Johan W H Verjans
    Department of Cardiology, University of California at Irvine, School of Medicine, 101 The City Drive, Orange, CA 92868 4080, USA
    JACC Cardiovasc Imaging 1:354-62. 2008
    ..The purpose of this study was to evaluate the feasibility of noninvasive imaging of angiotensin II (AT) receptor upregulation in a mouse model of post-myocardial infarction (MI) heart failure (HF)...
  16. ncbi request reprint Broad and specific caspase inhibitor-induced acute repression of apoptosis in atherosclerotic lesions evaluated by radiolabeled annexin A5 imaging
    Masayoshi Sarai
    University of California, Irvine, California
    J Am Coll Cardiol 50:2305-12. 2007
    ..The purpose of this study was to evaluate the role of caspase inhibitors on acute resolution of apoptosis in atherosclerotic lesions as evaluated by imaging with annexin A5...
  17. doi request reprint Annexin A5: an imaging biomarker of cardiovascular risk
    Edward M Laufer
    Dept of Cardiology, University of Maastricht, Maastricht, The Netherlands
    Basic Res Cardiol 103:95-104. 2008
    ..In this review we will discuss the introduction of Annexin A5 in preclinical and clinical imaging studies and provide an outlook on novel opportunities of Annexin A5 based targeting of PS...
  18. doi request reprint Molecular imaging of matrix metalloproteinase in atherosclerotic lesions: resolution with dietary modification and statin therapy
    Shinichiro Fujimoto
    University of California, Irvine School of Medicine, Irvine, California 92697, USA
    J Am Coll Cardiol 52:1847-57. 2008
    ....
  19. doi request reprint Right atrial cavotricuspid isthmus: anatomic characterization with multi-detector row CT
    Farhood Saremi
    Departments of Radiological Sciences and Cardiology, University of California, Irvine, University of California Medical Center, 101 The City Drive, Route 140, Orange, CA 92868 3298, USA
    Radiology 247:658-68. 2008
    ..To retrospectively evaluate the anatomic characteristics of the right atrial cavotricuspid isthmus (CTI) by using 64-section multi-detector row computed tomography (CT)...
  20. pmc Histopathologic characteristics of atherosclerotic coronary disease and implications of the findings for the invasive and noninvasive detection of vulnerable plaques
    Jagat Narula
    Mount Sinai School of Medicine, New York, New York 10029, USA
    J Am Coll Cardiol 61:1041-51. 2013
    ..The goal of this study was to identify histomorphologic characteristics of atherosclerotic plaques and to determine the amenability of some of these components to be used as markers for invasive and noninvasive imaging...
  21. doi request reprint Myeloperoxidase, subclinical atherosclerosis, and cardiovascular disease events
    Nathan D Wong
    Division of Cardiology, University of California, Irvine, California, USA
    JACC Cardiovasc Imaging 2:1093-9. 2009
    ..We evaluated whether myeloperoxidase (MPO) predicts future cardiovascular disease (CVD) events in asymptomatic adults and whether subclinical atherosclerosis may affect this relation...
  22. doi request reprint Myocardial remodeling after infarction: the role of myofibroblasts
    Susanne W M van den Borne
    Cardiovascular Research Institute Maastricht, Department of Pharmacology and Toxicology and Cardiology, Maastricht University, Maastricht, The Netherlands
    Nat Rev Cardiol 7:30-7. 2010
    ....
  23. ncbi request reprint The extent of coronary atherosclerosis is associated with increasing circulating levels of high sensitive cardiac troponin T
    Eduard M Laufer
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
    Arterioscler Thromb Vasc Biol 30:1269-75. 2010
    ..This study explored the relationship between coronary atherosclerotic plaque burden and quantifiable circulating levels of troponin measured with a recently introduced high sensitive cardiac troponin T (hs-cTnT) assay...
  24. ncbi request reprint Imaging of patent foramen ovale with 64-section multidetector CT
    Farhood Saremi
    Department of Radiological Sciences, University of California Irvine, UCI Medical Center, Orange, CA 92868 3298, USA
    Radiology 249:483-92. 2008
    ....
  25. doi request reprint Combined use of exercise electrocardiography, coronary calcium score and cardiac CT angiography for the prediction of major cardiovascular events in patients presenting with stable chest pain
    Mathijs O Versteylen
    Department of Cardiology, Maastricht University Medic al Center, Maastricht, The Netherlands
    Int J Cardiol 167:121-5. 2013
    ..Recently cardiac computed tomographic angiography (CCTA) has been employed. We evaluated the prognostic value of the combined use of exercise-ECG and CCTA for the development of cardiovascular endpoints...
  26. ncbi request reprint Bachmann Bundle and its arterial supply: imaging with multidetector CT--implications for interatrial conduction abnormalities and arrhythmias
    Farhood Saremi
    Department of Radiological Sciences, University of California, Irvine Medical Center, 101 The City Drive, Rte 140, Orange, CA 92868 3298, USA
    Radiology 248:447-57. 2008
    ..To retrospectively investigate anatomy of Bachmann Bundle (BB) and its vascular supply at 64-section multidetector computed tomography (CT) in healthy patients and patients with abnormalities...
  27. doi request reprint Second-hand tobacco smoke in never smokers is a significant risk factor for coronary artery calcification
    David F Yankelevitz
    Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
    JACC Cardiovasc Imaging 6:651-7. 2013
    ....
  28. ncbi request reprint Radiolabeled Monocyte Chemotactic Protein 1 for the detection of inflammation in experimental atherosclerosis
    Dagmar Hartung
    University of California School of Medicine, Irvine, CA 92697, USA
    J Nucl Med 48:1816-21. 2007
    ....
  29. ncbi request reprint Noninvasive detection of programmed cell loss with 99mTc-labeled annexin A5 in heart failure
    Bas L J H Kietselaer
    Department of Cardiology, University Hospital of Maastricht, Maastricht, The Netherlands
    J Nucl Med 48:562-7. 2007
    ..The present study evaluated the role of annexin A5 imaging for detection of PCD in heart failure patients...
  30. ncbi request reprint In vitro measurement of cell death with the annexin A5 affinity assay
    Hugo van Genderen
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Maastricht, PO Box 616, 6200 MD, Maastricht, The Netherlands
    Nat Protoc 1:363-7. 2006
    ..The entire procedure takes about 30 minutes for flow cytometry and 45 minutes for confocal scanning-laser microscopy. Various precautions and considerations are discussed further in the protocol described here...
  31. ncbi request reprint Targeting of matrix metalloproteinase activation for noninvasive detection of vulnerable atherosclerotic lesions
    Dagmar Hartung
    School of Medicine, University of California, Irvine, CA 92697, USA
    Eur J Nucl Med Mol Imaging 34:S1-8. 2007
    ..They also contribute to attenuation of fibrous cap and hence susceptibility to rupture. Assessment of metalloproteinase expression and activity should provide information about plaque instability...
  32. doi request reprint Extracellular annexin A5: functions of phosphatidylserine-binding and two-dimensional crystallization
    Hugo O van Genderen
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, Maastricht, The Netherlands
    Biochim Biophys Acta 1783:953-63. 2008
    ..We further highlight the recent discovery of internalization of extracellular annexin A5 by phosphatidylserine-expressing cells...
  33. doi request reprint Effect of an antimicrobial agent on atherosclerotic plaques: assessment of metalloproteinase activity by molecular imaging
    Satoru Ohshima
    University of California Irvine School of Medicine, Irvine, California, USA
    J Am Coll Cardiol 55:1240-9. 2010
    ..Technetium-99m-labeled matrix metalloproteinase inhibitor (MPI) was used for the noninvasive assessment of matrix metalloproteinase (MMP) activity in atherosclerotic plaques after minocycline (MC) intervention...
  34. ncbi request reprint Clinical feasibility of molecular imaging of plaque inflammation in atherosclerosis
    Nobuhiro Tahara
    University of California, Irvine, California, USA
    J Nucl Med 50:331-4. 2009
    ..These 2 imaging strategies have demonstrated the clinical feasibility of imaging for detection of inflammation...
  35. pmc The impact of pressure overload on coronary vascular changes following myocardial infarction in rats
    Jiqiu Chen
    Cardiovascular Research Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Physiol Heart Circ Physiol 304:H719-28. 2013
    ..Pressure overload could increase vascular tolerance to I/R injury, but also trigger severe global ventricular fibrosis and results in atrial thrombus and pulmonary edema...
  36. doi request reprint Molecular imaging of interstitial alterations after myocardial infarction
    Johan Verjans
    Cardiovascular Research Institute Maastricht, University Maastricht, Maastricht, The Netherlands
    J Cardiovasc Transl Res 1:221-4. 2008
    ..Molecular imaging of interstitial changes may identify patients at risk to develop HF, before adverse remodeling has occurred. In addition, it may also serve as a surrogate endpoint for the assessment of treatment efficacy...
  37. ncbi request reprint Annexin A5 inhibits engulfment through internalization of PS-expressing cell membrane patches
    Heidi Kenis
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Exp Cell Res 312:719-26. 2006
    ..Interestingly, cells with internalized annexin A5 still express PS at their surface. We conclude that other ligands within the PS-expressing membrane patch act together with PS as an "eat me" signal...
  38. doi request reprint Coronary venous aneurysm in patients without cardiac arrhythmia as detected by MDCT: an anatomic variant or a pathologic entity
    Farhood Saremi
    Department of Radiological Sciences, University of California, Irvine, Orange, California 92868 3298, USA
    JACC Cardiovasc Imaging 3:257-65. 2010
    ..The aim of this study was to determine the prevalence of coronary venous aneurysm in patients with no history of cardiac arrhythmia using 64-slice multidetector computed tomography...
  39. doi request reprint MDCT of the S-shaped sinoatrial node artery
    Farhood Saremi
    Department of Radiological Sciences, University of California, Irvine, UCI Medical Center, 101 The City Dr, Route 140, Orange, CA 92868 3298, USA
    AJR Am J Roentgenol 190:1569-75. 2008
    ....
  40. ncbi request reprint Multidetector computed tomography shows intramyocardial fat deposition
    Aidan R Raney
    Department of Radiologic Sciences, University of California, Irvine, Orange, CA 92868 3298, USA
    J Cardiovasc Comput Tomogr 2:152-63. 2008
    ..Intramyocardial fat deposition occurs as an age-related process and in multiple pathologic processes...
  41. pmc Vitamin K-antagonists accelerate atherosclerotic calcification and induce a vulnerable plaque phenotype
    Leon J Schurgers
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 7:e43229. 2012
    ....
  42. ncbi request reprint Past, present, and future of annexin A5: from protein discovery to clinical applications
    Hendrikus H Boersma
    Department of Nuclear Medicine, Maastricht University Hospital, Maastricht, The Netherlands
    J Nucl Med 46:2035-50. 2005
    ..In addition, experiences with radiolabeled anxA5 open novel avenues for drug targeting with anxA5 as a biologic "cruise missile."..
  43. doi request reprint Molecular imaging of macrophage cell death for the assessment of plaque vulnerability
    Eduard M Laufer
    Department of Cardiology, Maastricht University Medical Center, Maastricht, The Netherlands
    Arterioscler Thromb Vasc Biol 29:1031-8. 2009
    ..These processes offer specific biological targets that can potentially be exploited to obtain biological information on atherosclerosis development in the individual patient...
  44. doi request reprint Cardiac magnetic resonance imaging: infarct size is an independent predictor of mortality in patients with coronary artery disease
    David Bello
    Division of Cardiology, Orlando Regional Medical Center, Orlando, FL 32806, USA
    Magn Reson Imaging 29:50-6. 2011
    ..Prior studies using indirect methods to assess infarct size have shown that patients with larger myocardial infarctions have a worse prognosis than those with smaller myocardial infarctions...
  45. ncbi request reprint Prevalence of left atrial appendage pseudothrombus filling defects in patients with atrial fibrillation undergoing coronary computed tomography angiography
    Farhood Saremi
    Department of Radiological Sciences, University of California Irvine, UCI Medical Center, Orange, CA 92868 3298, USA
    J Cardiovasc Comput Tomogr 2:164-71. 2008
    ..However, blood stasis in the left atrial appendage (LAA) of patients with atrial fibrillation (AF) may be a common cause for false-positive results...
  46. doi request reprint CRT improves LV filling dynamics: insights from echocardiographic particle imaging velocimetry
    Georg Goliasch
    Zena and Michael A Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
    JACC Cardiovasc Imaging 6:704-13. 2013
    ..These data suggest that CRT plays an important role in optimization of left ventricular diastolic filling...
  47. doi request reprint Cardiovascular imaging and diagnostic procedures in pregnancy
    David L Ain
    The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1030, New York, NY 10029, USA
    Cardiol Clin 30:331-41. 2012
    ..Additionally cardiologists must understand indications for and limitations of each diagnostic imaging test, potential harmful effects of various modalities, and precautions that must be taken to protect the fetus...
  48. ncbi request reprint Counting heads in the war against cancer: defining the role of annexin A5 imaging in cancer treatment and surveillance
    Maarten F Corsten
    Department of Cardiology, Cardiovascular Research Institute Maastricht, University Maastricht, P Debyelaan 25, 6229 AD Maastricht, The Netherlands
    Cancer Res 66:1255-60. 2006
    ..This might be of significant value for pharmacologic therapy development as well as clinical monitoring of treatment success...
  49. ncbi request reprint Noninvasive monitoring the biology of atherosclerotic plaque development with radiolabeled annexin V and matrix metalloproteinase inhibitor in spontaneous atherosclerotic mice
    Yared Tekabe
    Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    J Nucl Cardiol 17:1073-81. 2010
    ..To compare the ability of (99m)Tc-labeled broad-based matrix metalloproteinase inhibitor (RP805) (MPI) and (99m)Tc-annexin V to identify more advanced atherosclerotic disease in apolipoprotein E-null (apoE(-/-)) mice...
  50. ncbi request reprint Concurrent upregulation of endogenous proapoptotic and antiapoptotic factors in failing human hearts
    Nezam Haider
    University of California Irvine School of Medicine, Irvine, CA, USA
    Nat Clin Pract Cardiovasc Med 6:250-61. 2009
    ..We investigated whether activation of endogenous apoptosis inhibitors plays a part when death receptor and mitochondrial apoptotic pathways have been triggered...
  51. ncbi request reprint Advances in the understanding of plaque composition and treatment options: year in review
    Matthew I Tomey
    Zena and Michael A Wiener Cardiovascular Institute and Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, New York
    J Am Coll Cardiol 63:1604-16. 2014
    ..Here, we review the dynamic and exciting progress that has occurred over the last 12 months in this arena, while acknowledging future work that remains to be done to refine and validate new imaging modalities and therapies...
  52. doi request reprint Coronary artery calcium scanning in asymptomatic patients with diabetes mellitus: a paradigm shift
    Harvey S Hecht
    Mount Sinai School of Medicine, New York, New York, USA
    J Diabetes 4:342-50. 2012
    ....
  53. ncbi request reprint Endomyocardial biopsy for non-transplant-related disorders
    Navneet Narula
    Division of Cardiology, Department of Pathology, University of California, Irvine Medical Center, Orange, CA 92868, USA
    Am J Clin Pathol 123:S106-18. 2005
    ..This review focuses on the growing number of diseases that can be diagnosed by EMB in adult and pediatric age groups...
  54. doi request reprint Evolving role of molecular imaging for new understanding: targeting myofibroblasts to predict remodeling
    Hans J de Haas
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Ann N Y Acad Sci 1254:33-41. 2012
    ..We define molecular targets on myofibroblasts and discuss the feasibility of molecular imaging of these cells for early detection and treatment of patients at risk for development of HF after myocardial infarction...
  55. pmc Comparison of Framingham, PROCAM, SCORE, and Diamond Forrester to predict coronary atherosclerosis and cardiovascular events
    Mathijs O Versteylen
    Department of Cardiology, Maastricht University Medical Center, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
    J Nucl Cardiol 18:904-11. 2011
    ..We studied four frequently used risk scores in their ability to predict for coronary artery disease (CAD) and major adverse cardiovascular events in patients presenting with stable chest pain at the cardiology outpatient clinic...
  56. doi request reprint Molecular imaging of myocardial remodeling after infarction
    Johan W H Verjans
    Division of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Methods Mol Biol 680:227-35. 2011
    ..In this chapter we describe the assessment of angiotensin II receptor and αvβ3 integrin upregulation in a mouse model after myocardial infarction using real time in vivo fluorescence imaging and nuclear imaging...
  57. ncbi request reprint Detection of phrenic nerves and their relation to cardiac anatomy using 64-slice multidetector computed tomography
    Yuji Matsumoto
    Division of Cardiology, Department of Medicine, University of California, Irvine, California, USA
    Am J Cardiol 100:133-7. 2007
    ..In the setting of electrophysiologic interventions, MDCT before a procedure may elucidate anatomic relationships and help minimize inadvertent complications...
  58. ncbi request reprint Noncompaction of the left ventricle: primary cardiomyopathy with an elusive genetic etiology
    Michael V Zaragoza
    Center for Molecular and Mitochondrial Medicine and Genetics and the Department of Pediatrics, Division of Genetics and Metabolism, University of California, Irvine, California 92697 3940, USA
    Curr Opin Pediatr 19:619-27. 2007
    ..Understanding the genetics may depend on clarifying the distinctive diagnostic features and investigating the contribution of all known cardiomyopathy-causing genes with overlapping morphology...
  59. doi request reprint Impact of an automated multimodality point-of-order decision support tool on rates of appropriate testing and clinical decision making for individuals with suspected coronary artery disease: a prospective multicenter study
    Fay Y Lin
    Department of Medicine, Weill Cornell Medical College, New York, NY, USA
    J Am Coll Cardiol 62:308-16. 2013
    ..This study sought to evaluate the impact of a multimodality-appropriate use criteria decision support tool (AUC-DST) on rates of appropriate testing and clinical decision making...
  60. doi request reprint Atherosclerosis in chronic kidney disease: lessons learned from glycation in diabetes
    Dilbahar S Mohar
    Division of Cardiology, University of California Irvine School of Medicine, Orange, CA 92868 3298, USA
    Med Clin North Am 96:57-65. 2012
    ..It is logical to extrapolate that carbamylation may result in modification of vessel wall proteins similar to glycation, and predispose to atherosclerosis...
  61. pmc Histopathologic evaluation of basilar artery atherosclerosis
    Artak Labadzhyan
    Department of Medicine, UC Irvine, Orange, CA 92868, USA
    J Neurol Sci 307:97-9. 2011
    ..There has been limited attention to pathological features of basilar artery atherosclerosis. It has been assumed that pathology of basilar artery atherosclerosis mimics that of other vascular beds...
  62. ncbi request reprint Risk assessment and predictive value of coronary artery disease testing
    Leslee J Shaw
    School of Medicine, Emory University, Atlanta, Georgia 30306, USA
    J Nucl Med 50:1296-306. 2009
    ..Despite a high level of evidence, comparative research is not available across modalities that could definitively drive utilization of cardiac imaging modalities...
  63. ncbi request reprint The primary vasculitides: a clinicopathologic correlation
    Navneet Narula
    Department of Pathology, University of California Medical Center, Irvine, Orange 92868, USA
    Am J Clin Pathol 124:S84-95. 2005
    ..Incorporation of antineutrophil cytoplasmic antibodies in defining the pathogenesis of vasculitis has been particularly useful in diagnosing those small vessel vasculitides that are life threatening and need immediate intervention...
  64. pmc A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations
    Weiwei Fan
    Center for Molecular and Mitochondrial Medicine and Genetics, University of California, Irvine, CA 92697, USA
    Science 319:958-62. 2008
    ..Thus, severe mtDNA mutations appear to be selectively eliminated from the female germ line, thereby minimizing their impact on population fitness...
  65. ncbi request reprint Potentiation of Doxorubicin cardiotoxicity by iron loading in a rodent model
    Gurusher S Panjrath
    Division of Cardiology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    J Am Coll Cardiol 49:2457-64. 2007
    ..The role of iron toward doxorubicin (DOX) cardiotoxicity was studied using a rodent model of dietary carbonyl iron loading...
  66. ncbi request reprint Arterial supply to sinuatrial and atrioventricular nodes: imaging with multidetector CT
    Farhood Saremi
    Department of Radiological Sciences, University of California, Irvine, University of California Medical Center, 101 The City Drive, Route 140, Orange, CA 92868 3298, USA
    Radiology 246:99-107; discussion 108-9. 2008
    ..To retrospectively evaluate the depiction of anatomic characteristics of the arterial supply to the sinuatrial node (SAN) and the atrioventricular node (AVN) with 64-section computed tomography (CT)...
  67. pmc Preclinical evaluation of MR attenuation correction versus CT attenuation correction on a sequential whole-body MR/PET scanner
    Jason Bini
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Invest Radiol 48:313-22. 2013
    ..The objective of the current study was to evaluate the MRAC implemented on the combined MR/PET scanner versus the CTAC with the same PET data in an animal model...
  68. doi request reprint Selective improvement in Seattle Heart Failure Model risk stratification using iodine-123 meta-iodobenzylguanidine imaging
    Eric S Ketchum
    Division of Cardiology, University of Washington, 1959 NE Pacific Street, PO Box 356422, Seattle, WA, USA
    J Nucl Cardiol 19:1007-16. 2012
    ..This study investigated the incremental value of MIBG cardiac imaging when added to the SHFM for prediction of all-cause mortality...
  69. doi request reprint Emerging trends in CV flow visualization
    Partho P Sengupta
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    JACC Cardiovasc Imaging 5:305-16. 2012
    ..Finally, we discuss the potential clinical applications and technical challenges with suggestions for further investigations...
  70. doi request reprint Imaging of the right ventricle
    Javier Sanz
    Zena and Michael A Wiener Cardiovascular Institute and Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, Box 1030, New York, NY 10029, USA
    Cardiol Clin 30:189-203. 2012
    ..In this article, we review the current state of RV imaging...
  71. ncbi request reprint Review of noninvasive imaging for hypertrophic cardiac syndromes and restrictive physiology
    Steven J Fowler
    University of California at Irvine, Orange, CA 9286, USA
    Heart Fail Clin 2:215-30. 2006
  72. ncbi request reprint Mister Rogers' neighborhood
    Jagat Narula
    Division of Cardiology, University of California, School of Medicine, Orange, CA 92868, USA
    Heart Fail Clin 2:ix-x. 2006
  73. ncbi request reprint Novel imaging strategies for assessment of cerebrovascular involvement
    Cheuk Ying Tang
    Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 79:674-82. 2012
    ..This article reviews a few of these novel imaging techniques...
  74. ncbi request reprint Increased thin-cap neoatheroma and periprocedural myocardial infarction in drug-eluting stent restenosis: multimodality intravascular imaging of drug-eluting and bare-metal stents
    Ziad A Ali
    Division of Cardiology, Mount Sinai School of Medicine, New York, NY
    Circ Cardiovasc Interv 6:507-17. 2013
    ..Re-endothelialization is delayed after drug-eluting stent (DES) implantation. In this setting, neointima is more prone to become lipid laden and develop neoatherosclerosis (NA), potentially increasing plaque vulnerability...
  75. ncbi request reprint Noninvasive imaging of atherosclerotic lesions in apolipoprotein E-deficient and low-density-lipoprotein receptor-deficient mice with annexin A5
    Satoshi Isobe
    Division of Cardiology, University of California, Irvine School of Medicine, 92697, USA
    J Nucl Med 47:1497-505. 2006
    ..We evaluated the feasibility of annexin A5 imaging in transgenic apoE(-/-) and LDLR(-/-) mice with or without a cholesterol diet...
  76. ncbi request reprint Functional strain-line pattern in the human left ventricle
    Gianni Pedrizzetti
    Dipartimento Ingegneria e Architettura, Universita di Trieste, Italy
    Phys Rev Lett 109:048103. 2012
    ..The same concept can help in characterizing the relation between functional and anatomical properties of biological tissues, as well as fiber-reinforced engineered materials...
  77. ncbi request reprint Mortals turn me on
    Sudhir Gupta
    School of Medicine, University of California Irvine, 101 The City Drive, Irvine, CA 92868, USA
    J Nucl Med 46:906-8. 2005
  78. doi request reprint Minimizing radiation dose for coronary CT angiography
    Gabriel Vorobiof
    Memorial Heart and Vascular Institute, Department of Cardiology, Long Beach Memorial Medical Center, 2801 Atlantic Avenue, Long Beach, CA 90806, USA
    Cardiol Clin 30:9-17. 2012
    ..There are several main determinants of total radiation dose, and these are outlined in this review. Integration of these dose-saving techniques will go a long way in maintaining diagnostic image quality and improving patient safety...
  79. ncbi request reprint Cell surface-expressed phosphatidylserine and annexin A5 open a novel portal of cell entry
    Heidi Kenis
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    J Biol Chem 279:52623-9. 2004
    ..We demonstrated that living tumor cells can take up substances through this novel portal of cell entry. This opens new avenues for targeted drug delivery and cell entry...
  80. doi request reprint Defective intercellular adhesion complex in myocardium predisposes to infarct rupture in humans
    Susanne W M van den Borne
    Department of Pharmacology and Toxicology and Pathology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    J Am Coll Cardiol 51:2184-92. 2008
    ..Our goal was to evaluate intercellular adhesion complex proteins in myocardium in human infarct rupture...
  81. ncbi request reprint Beta-adrenergic blockers in heart failure: review of mechanisms of action and clinical outcomes
    Shiyam Satwani
    Division of Cardiology, Drexel University College of Medicine, Philadelphia, PA, USA
    J Cardiovasc Pharmacol Ther 9:243-55. 2004
    ..The clinical evidence from controlled trials of the efficacy of beta-blockers in treating heart failure is summarized. Finally, the concomitant use of beta-blockers and positive inotropic agents in advanced heart failure is discussed...
  82. ncbi request reprint Imaging vulnerable plaque by ultrasound
    Anthony N Demaria
    Division of Cardiology, University of California San Diego, San Diego, California, USA
    J Am Coll Cardiol 47:C32-9. 2006
    ..These advances pave the way for future clinical trials in assessing the ability of such techniques to diagnose vulnerable plaques and to assess the effects of both pharmacologic and mechanical therapies on plaque characteristics...
  83. ncbi request reprint Targeted ultrasound imaging using microbubbles
    Flordeliza S Villanueva
    Division of Cardiology, Cardiovascular Institute, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Cardiol Clin 22:283-98, vii. 2004
    ..This approach has been applied to the ultrasound imaging of pathophysiologic processes such as inflammation associated with ischemia reperfusion, heart transplant rejection, atherosclerotic plaque, thrombus, and apoptosis...
  84. ncbi request reprint Role of noninvasive antimyosin imaging in infants and children with clinically suspected myocarditis
    María Eugenia Rioja Martin
    Department of Nuclear Medicine, Hospital Ramon y Cajal, Madrid, Spain
    J Nucl Med 45:429-37. 2004
    ..Therefore, a noninvasive test of adequate diagnostic accuracy is highly desirable. We evaluated the role of antimyosin scintigraphy in infants and children with clinically suspected myocarditis...
  85. ncbi request reprint Surgical options in heart failure
    Stephen Westaby
    Oxford Heart Centre, John Radcliffe Hospital, Headington, United Kingdom
    Surg Clin North Am 84:xv-xix. 2004
  86. ncbi request reprint Molecular biology of myocardial recovery
    Jianyi Zhang
    University of Minnesota Health Science Center, Minneapolis, MN 55455, USA
    Surg Clin North Am 84:223-42. 2004
    ..If it is confirmed that LVAD unloading can contribute significantly to reverse remodeling, the role of LVADs may graduate from bridge-to-transplantation or destination therapy to bridge-to-recovery...
  87. ncbi request reprint Role of caspases in Ox-LDL-induced apoptotic cascade in human coronary artery endothelial cells
    Jiawei Chen
    Department of Internal Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA
    Circ Res 94:370-6. 2004
    ..This is followed by activation of apoptotic signaling pathway, involving release of cytochrome c and Smac and activation of caspase-9 and then caspase-3...
  88. ncbi request reprint Challenging the neuronal MIBG uptake by pharmacological intervention: effect of a single dose of oral amitriptyline on regional cardiac MIBG uptake
    Montserrat Estorch
    Department of Nuclear Medicine, Hospital Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Eur J Nucl Med Mol Imaging 31:1575-80. 2004
    ..This study was undertaken to assess whether a single oral dose of amitriptyline could influence cardiac MIBG distribution...
  89. ncbi request reprint A conceptual paradox of MIBG uptake in heart failure: retention with incontinence!
    Jagat Narula
    J Nucl Cardiol 10:700-4. 2003
  90. ncbi request reprint Myocardial contrast echocardiography in acute myocardial infarction
    Johan W Verjans
    Department of Cardiovascular Medicine and Surgery, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Curr Opin Cardiol 18:346-50. 2003
    ..Myocardial contrast echocardiography (MCE) has evolved into an important clinical tool for imaging coronary microcirculation. It can be used to delineate the spectrum of perfusion derangements that characterize acute myocardial infarction...
  91. ncbi request reprint Pathogenetic basis of myocardial dysfunction and amenability to reversal
    Shaila Garg
    Hahnemann University Hospital, Broad and Vine Streets, Philadelphia, PA 19102 1192, USA
    Cardiol Clin 21:83-91. 2003
    ..It will be a challenge to identify the role for concomitant drug therapy and to develop weaning programs for device support. Finally, guidelines will have to be developed to monitor and manage these patients after explantation of LVAD...
  92. ncbi request reprint Invited commentary: P.S.* I love you: implications of phosphatidyl serine (PS) reversal in acute ischemic syndromes
    Jagat Narula
    Heart Failure Transplant Center, Hahnemann University Hospital, Philadelphia, Pennsylvania 19102 1192, USA
    J Nucl Med 44:397-9. 2003
  93. ncbi request reprint Noninvasive detection of cell death: from tracking epitaphs to counting coffins
    Jagat Narula
    J Nucl Cardiol 9:554-60. 2002
  94. ncbi request reprint Extension of borderzone myocardium in postinfarction dilated cardiomyopathy
    Benjamin M Jackson
    Harrison Department of Surgical Research, Philadelphia, Pennsylvania 19104, USA
    J Am Coll Cardiol 40:1160-7; discussion 1168-71. 2002
    ..Preventing extension of borderzone myocardium by medical or surgical means offers the prospect of preventing late-onset heart failure following transmural expanding MIs...
  95. ncbi request reprint An ovine model of postinfarction dilated cardiomyopathy
    Sina L Moainie
    Harrison Department of Surgical Research, University of Pennsylvania School of Medicine, Philadelphia, USA
    Ann Thorac Surg 74:753-60. 2002
    ..This article describes an ovine model that develops after an anterobasal infarction...
  96. pmc Functional consequences of caspase activation in cardiac myocytes
    Catherine Communal
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 99:6252-6. 2002
    ..Induction of apoptosis in cardiac cells was associated with similar cleavage of myofilaments. Therefore, activation of apoptotic pathways may lead to contractile dysfunction before cell death...
  97. ncbi request reprint Risk factors for heart failure
    Satish Kenchaiah
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Med Clin North Am 88:1145-72. 2004
    ....
  98. ncbi request reprint Echocardiography in heart failure: applications, utility, and new horizons
    James N Kirkpatrick
    Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Am Coll Cardiol 50:381-96. 2007
    ..In addition, we will highlight some of the limitations of echocardiography...
  99. doi request reprint Reclassifying heart failure: predominantly subendocardial, subepicardial, and transmural
    Partho P Sengupta
    Mayo Clinic, Scottsdale, AZ, USA
    Heart Fail Clin 4:379-82. 2008
    ..This review proposes a new algorithm for exploring the spectrum of altered cardiac muscle mechanics in patients with heart failure...
  100. ncbi request reprint ECG-edit function in multidetector-row computed tomography coronary arteriography for patients with arrhythmias
    Hideyuki Matsutani
    Department of Radiological Technology, Takase Clinic, Takasaki, Japan
    Circ J 72:1071-8. 2008
    ..ECG-gating is necessary for cardiac computed tomography, but is not suitable for arrhythmias, so the aim of this study was to evaluate the usefulness of the ECG-edit function for this purpose...
  101. ncbi request reprint The popcorn plaques
    Jagat Narula
    Nat Med 13:532-4. 2007

Research Grants6

  1. Imaging Apoptosis to Detect Unstable Atheromatous Plaque
    Jagat Narula; Fiscal Year: 2002
    ..The impending surgical intervention will allow histopathological evaluation of the endarterectomy specimens to define potential utility of annexin imaging. ..
  2. Imaging Apoptosis to Detect Unstable Atheromatous Plaque
    Jagat Narula; Fiscal Year: 2003
    ..The impending surgical intervention will allow histopathological evaluation of the endarterectomy specimens to define potential utility of annexin imaging. ..
  3. Targeting MMPS to Image Atherosclerosis
    Jagat Narula; Fiscal Year: 2005
    ..The extent of inflammation and MMP expression in the plaques will be ascertained histopathologically. (End of Abstract) ..
  4. Targeting MMPS to Image Atherosclerosis
    Jagat Narula; Fiscal Year: 2006
    ..The extent of inflammation and MMP expression in the plaques will be ascertained histopathologically. (End of Abstract) ..
  5. Targeting MMPS to Image Atherosclerosis
    Jagat Narula; Fiscal Year: 2007
    ..The extent of inflammation and MMP expression in the plaques will be ascertained histopathologically. (End of Abstract) ..
  6. Imaging Apoptosis to Detect Unstable Atheromatous Plaque
    Jagat Narula; Fiscal Year: 2004
    ..The impending surgical intervention will allow histopathological evaluation of the endarterectomy specimens to define potential utility of annexin imaging. ..