Jagat Narula

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Early molecular imaging of interstitial changes in patients after myocardial infarction: comparison with delayed contrast-enhanced magnetic resonance imaging
    Johan Verjans
    Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
    J Nucl Cardiol 17:1065-72. 2010
  2. ncbi Role of molecular imaging in defining and denying death
    Jagat Narula
    University of California Irvine Medical Center, Orange 92868-4080, USA
    J Nucl Cardiol 11:349-57. 2004
  3. ncbi Heart failure in diabetes: are you exhausted, sweetheart?
    Jagat Narula
    Division of Cardiology, University of California, School of Medicine, Irvine, CA 92868 4080, USA
    Heart Fail Clin 2:xi-xii. 2006
  4. ncbi Imaging heart failure: premonition to prevention in predisposed
    Jagat Narula
    Division of Cardiology, University of California Irvine School of Medicine, Irvine, CA 92868-4080, USA
    Heart Fail Clin 2:ix-x. 2006
  5. ncbi Natriuretic peptides in heart failure: empathizing with the sobbing heart
    Jagat Narula
    Division of Cardiology, University of California School of Medicine, Irvine, CA 92868-4080, USA
    Heart Fail Clin 2:xi-xiii. 2006
  6. ncbi Vascular rejection in heart transplantation: when ignorance is not bliss
    Jagat Narula
    University of California, Irvine, CA, USA
    Heart Fail Clin 3:ix-x. 2007
  7. ncbi Arithmetic of vulnerable plaques for noninvasive imaging
    Jagat Narula
    University of California Irvine School of Medicine, Orange, CA 92868 4080, USA
    Nat Clin Pract Cardiovasc Med 5:S2-10. 2008
  8. ncbi Mechanisms of disease: apoptosis in heart failure--seeing hope in death
    Jagat Narula
    Division of Cardiology, University of California, Irvine School of Medicine, 101 The City Drive, Building 53, Mail Route 81, Orange, CA 92868, USA
    Nat Clin Pract Cardiovasc Med 3:681-8. 2006
  9. ncbi Assessment of myocardial damage in regurgitant valvular disease
    Jagat Narula
    Division of Cardiovascular Pathophysiology and The Howard Gilman Institute for Valvular Heart Diseases, Weill Medical College of Cornell University, New York, NY, USA
    Adv Cardiol 41:57-61. 2004
  10. ncbi Molecular imaging of matrix metalloproteinase expression in atherosclerotic plaques of mice deficient in apolipoprotein e or low-density-lipoprotein receptor
    Satoru Ohshima
    Division of Cardiology, University of California, Irvine School of Medicine, Irvine, California, USA
    J Nucl Med 50:612-7. 2009

Research Grants

  1. Imaging Apoptosis to Detect Unstable Atheromatous Plaque
    Jagat Narula; Fiscal Year: 2004
  2. Targeting MMPS to Image Atherosclerosis
    Jagat Narula; Fiscal Year: 2007

Detail Information

Publications111 found, 100 shown here

  1. ncbi Early molecular imaging of interstitial changes in patients after myocardial infarction: comparison with delayed contrast-enhanced magnetic resonance imaging
    Johan Verjans
    Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
    J Nucl Cardiol 17:1065-72. 2010
    ..In experimental studies, RIP has been shown to target integrins associated with collagen-producing myofibroblasts (MFB)...
  2. ncbi Role of molecular imaging in defining and denying death
    Jagat Narula
    University of California Irvine Medical Center, Orange 92868-4080, USA
    J Nucl Cardiol 11:349-57. 2004
  3. ncbi Heart failure in diabetes: are you exhausted, sweetheart?
    Jagat Narula
    Division of Cardiology, University of California, School of Medicine, Irvine, CA 92868 4080, USA
    Heart Fail Clin 2:xi-xii. 2006
  4. ncbi Imaging heart failure: premonition to prevention in predisposed
    Jagat Narula
    Division of Cardiology, University of California Irvine School of Medicine, Irvine, CA 92868-4080, USA
    Heart Fail Clin 2:ix-x. 2006
  5. ncbi Natriuretic peptides in heart failure: empathizing with the sobbing heart
    Jagat Narula
    Division of Cardiology, University of California School of Medicine, Irvine, CA 92868-4080, USA
    Heart Fail Clin 2:xi-xiii. 2006
  6. ncbi Vascular rejection in heart transplantation: when ignorance is not bliss
    Jagat Narula
    University of California, Irvine, CA, USA
    Heart Fail Clin 3:ix-x. 2007
  7. ncbi Arithmetic of vulnerable plaques for noninvasive imaging
    Jagat Narula
    University of California Irvine School of Medicine, Orange, CA 92868 4080, USA
    Nat Clin Pract Cardiovasc Med 5:S2-10. 2008
    ..Precise metrics of typical vulnerable atherosclerotic plaque dimensions will need to be defined to facilitate their identification by noninvasive imaging modalities...
  8. ncbi Mechanisms of disease: apoptosis in heart failure--seeing hope in death
    Jagat Narula
    Division of Cardiology, University of California, Irvine School of Medicine, 101 The City Drive, Building 53, Mail Route 81, Orange, CA 92868, USA
    Nat Clin Pract Cardiovasc Med 3:681-8. 2006
    ..This process of 'apoptosis interruptus' could allow development of novel strategies to reverse or attenuate heart failure...
  9. ncbi Assessment of myocardial damage in regurgitant valvular disease
    Jagat Narula
    Division of Cardiovascular Pathophysiology and The Howard Gilman Institute for Valvular Heart Diseases, Weill Medical College of Cornell University, New York, NY, USA
    Adv Cardiol 41:57-61. 2004
  10. ncbi Molecular imaging of matrix metalloproteinase expression in atherosclerotic plaques of mice deficient in apolipoprotein e or low-density-lipoprotein receptor
    Satoru Ohshima
    Division of Cardiology, University of California, Irvine School of Medicine, Irvine, California, USA
    J Nucl Med 50:612-7. 2009
    ..Matrix metalloproteinases (MMPs) are expressed in atherosclerotic plaques and play an important role in plaque instability...
  11. ncbi Molecular imaging of interstitial alterations in remodeling myocardium after myocardial infarction
    Susanne W M van den Borne
    University of California, Irvine School of Medicine, Irvine, California, USA
    J Am Coll Cardiol 52:2017-28. 2008
    ..The purpose of this study was to evaluate interstitial alterations in myocardial remodeling using a radiolabeled Cy5.5-RGD imaging peptide (CRIP) that targets myofibroblasts...
  12. ncbi Annexin A5 uptake in ischemic myocardium: demonstration of reversible phosphatidylserine externalization and feasibility of radionuclide imaging
    Heidi Kenis
    Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands
    J Nucl Med 51:259-67. 2010
    ....
  13. ncbi Dual molecular imaging for targeting metalloproteinase activity and apoptosis in atherosclerosis: molecular imaging facilitates understanding of pathogenesis
    Nezam Haider
    Department of Cardiology, Irvine School of Medicine, University of California, C116 Med Sci I, Irvine, CA 92697, USA
    J Nucl Cardiol 16:753-62. 2009
    ..Macrophage apoptosis and MMP activity contribute to vulnerability of atherosclerotic plaques to rupture. By employing molecular imaging techniques, we investigated if apoptosis and MMP release are interlinked...
  14. ncbi Molecular imaging for efficacy of pharmacologic intervention in myocardial remodeling
    Susanne W M van den Borne
    Division of Cardiology and Department of Pathology, University of California Irvine School of Medicine, Irvine, CA 92697, USA
    JACC Cardiovasc Imaging 2:187-98. 2009
    ..Using molecular imaging techniques, we examined interstitial alterations during postmyocardial infarction (MI) remodeling and assessed the efficacy of antiangiotensin and antimineralocorticoid intervention, alone and in combination...
  15. ncbi Annexin A5: an imaging biomarker of cardiovascular risk
    Edward M Laufer
    Dept of Cardiology, University of Maastricht, Maastricht, The Netherlands
    Basic Res Cardiol 103:95-104. 2008
    ..In this review we will discuss the introduction of Annexin A5 in preclinical and clinical imaging studies and provide an outlook on novel opportunities of Annexin A5 based targeting of PS...
  16. ncbi Molecular imaging of matrix metalloproteinase in atherosclerotic lesions: resolution with dietary modification and statin therapy
    Shinichiro Fujimoto
    University of California, Irvine School of Medicine, Irvine, California 92697, USA
    J Am Coll Cardiol 52:1847-57. 2008
    ....
  17. ncbi The extent of coronary atherosclerosis is associated with increasing circulating levels of high sensitive cardiac troponin T
    Eduard M Laufer
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
    Arterioscler Thromb Vasc Biol 30:1269-75. 2010
    ..This study explored the relationship between coronary atherosclerotic plaque burden and quantifiable circulating levels of troponin measured with a recently introduced high sensitive cardiac troponin T (hs-cTnT) assay...
  18. ncbi Myocardial remodeling after infarction: the role of myofibroblasts
    Susanne W M van den Borne
    Cardiovascular Research Institute Maastricht, Department of Pharmacology and Toxicology and Cardiology, Maastricht University, Maastricht, The Netherlands
    Nat Rev Cardiol 7:30-7. 2010
    ....
  19. ncbi Broad and specific caspase inhibitor-induced acute repression of apoptosis in atherosclerotic lesions evaluated by radiolabeled annexin A5 imaging
    Masayoshi Sarai
    University of California, Irvine, California
    J Am Coll Cardiol 50:2305-12. 2007
    ..The purpose of this study was to evaluate the role of caspase inhibitors on acute resolution of apoptosis in atherosclerotic lesions as evaluated by imaging with annexin A5...
  20. ncbi Imaging of patent foramen ovale with 64-section multidetector CT
    Farhood Saremi
    Department of Radiological Sciences, University of California Irvine, UCI Medical Center, Orange, CA 92868 3298, USA
    Radiology 249:483-92. 2008
    ....
  21. ncbi Right atrial cavotricuspid isthmus: anatomic characterization with multi-detector row CT
    Farhood Saremi
    Departments of Radiological Sciences and Cardiology, University of California, Irvine, University of California Medical Center, 101 The City Drive, Route 140, Orange, CA 92868 3298, USA
    Radiology 247:658-68. 2008
    ..To retrospectively evaluate the anatomic characteristics of the right atrial cavotricuspid isthmus (CTI) by using 64-section multi-detector row computed tomography (CT)...
  22. ncbi Noninvasive imaging of angiotensin receptors after myocardial infarction
    Johan W H Verjans
    Department of Cardiology, University of California at Irvine, School of Medicine, 101 The City Drive, Orange, CA 92868 4080, USA
    JACC Cardiovasc Imaging 1:354-62. 2008
    ..The purpose of this study was to evaluate the feasibility of noninvasive imaging of angiotensin II (AT) receptor upregulation in a mouse model of post-myocardial infarction (MI) heart failure (HF)...
  23. ncbi Bachmann Bundle and its arterial supply: imaging with multidetector CT--implications for interatrial conduction abnormalities and arrhythmias
    Farhood Saremi
    Department of Radiological Sciences, University of California, Irvine Medical Center, 101 The City Drive, Rte 140, Orange, CA 92868 3298, USA
    Radiology 248:447-57. 2008
    ..To retrospectively investigate anatomy of Bachmann Bundle (BB) and its vascular supply at 64-section multidetector computed tomography (CT) in healthy patients and patients with abnormalities...
  24. ncbi Noninvasive detection of programmed cell loss with 99mTc-labeled annexin A5 in heart failure
    Bas L J H Kietselaer
    Department of Cardiology, University Hospital of Maastricht, Maastricht, The Netherlands
    J Nucl Med 48:562-7. 2007
    ..The present study evaluated the role of annexin A5 imaging for detection of PCD in heart failure patients...
  25. ncbi In vitro measurement of cell death with the annexin A5 affinity assay
    Hugo van Genderen
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Maastricht, PO Box 616, 6200 MD, Maastricht, The Netherlands
    Nat Protoc 1:363-7. 2006
    ..The entire procedure takes about 30 minutes for flow cytometry and 45 minutes for confocal scanning-laser microscopy. Various precautions and considerations are discussed further in the protocol described here...
  26. ncbi Targeting of matrix metalloproteinase activation for noninvasive detection of vulnerable atherosclerotic lesions
    Dagmar Hartung
    School of Medicine, University of California, Irvine, CA 92697, USA
    Eur J Nucl Med Mol Imaging 34:S1-8. 2007
    ..They also contribute to attenuation of fibrous cap and hence susceptibility to rupture. Assessment of metalloproteinase expression and activity should provide information about plaque instability...
  27. ncbi Myeloperoxidase, subclinical atherosclerosis, and cardiovascular disease events
    Nathan D Wong
    Division of Cardiology, University of California, Irvine, California, USA
    JACC Cardiovasc Imaging 2:1093-9. 2009
    ..We evaluated whether myeloperoxidase (MPO) predicts future cardiovascular disease (CVD) events in asymptomatic adults and whether subclinical atherosclerosis may affect this relation...
  28. ncbi Extracellular annexin A5: functions of phosphatidylserine-binding and two-dimensional crystallization
    Hugo O van Genderen
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, Maastricht, The Netherlands
    Biochim Biophys Acta 1783:953-63. 2008
    ..We further highlight the recent discovery of internalization of extracellular annexin A5 by phosphatidylserine-expressing cells...
  29. ncbi Clinical feasibility of molecular imaging of plaque inflammation in atherosclerosis
    Nobuhiro Tahara
    University of California, Irvine, California, USA
    J Nucl Med 50:331-4. 2009
    ..These 2 imaging strategies have demonstrated the clinical feasibility of imaging for detection of inflammation...
  30. ncbi Effect of an antimicrobial agent on atherosclerotic plaques: assessment of metalloproteinase activity by molecular imaging
    Satoru Ohshima
    University of California Irvine School of Medicine, Irvine, California, USA
    J Am Coll Cardiol 55:1240-9. 2010
    ..Technetium-99m-labeled matrix metalloproteinase inhibitor (MPI) was used for the noninvasive assessment of matrix metalloproteinase (MMP) activity in atherosclerotic plaques after minocycline (MC) intervention...
  31. ncbi Radiolabeled Monocyte Chemotactic Protein 1 for the detection of inflammation in experimental atherosclerosis
    Dagmar Hartung
    University of California School of Medicine, Irvine, CA 92697, USA
    J Nucl Med 48:1816-21. 2007
    ....
  32. ncbi Annexin A5 inhibits engulfment through internalization of PS-expressing cell membrane patches
    Heidi Kenis
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Exp Cell Res 312:719-26. 2006
    ..Interestingly, cells with internalized annexin A5 still express PS at their surface. We conclude that other ligands within the PS-expressing membrane patch act together with PS as an "eat me" signal...
  33. ncbi Molecular imaging of interstitial alterations after myocardial infarction
    Johan Verjans
    Cardiovascular Research Institute Maastricht, University Maastricht, Maastricht, The Netherlands
    J Cardiovasc Transl Res 1:221-4. 2008
    ..Molecular imaging of interstitial changes may identify patients at risk to develop HF, before adverse remodeling has occurred. In addition, it may also serve as a surrogate endpoint for the assessment of treatment efficacy...
  34. ncbi MDCT of the S-shaped sinoatrial node artery
    Farhood Saremi
    Department of Radiological Sciences, University of California, Irvine, UCI Medical Center, 101 The City Dr, Route 140, Orange, CA 92868 3298, USA
    AJR Am J Roentgenol 190:1569-75. 2008
    ....
  35. ncbi Multidetector computed tomography shows intramyocardial fat deposition
    Aidan R Raney
    Department of Radiologic Sciences, University of California, Irvine, Orange, CA 92868 3298, USA
    J Cardiovasc Comput Tomogr 2:152-63. 2008
    ..Intramyocardial fat deposition occurs as an age-related process and in multiple pathologic processes...
  36. ncbi Coronary venous aneurysm in patients without cardiac arrhythmia as detected by MDCT: an anatomic variant or a pathologic entity
    Farhood Saremi
    Department of Radiological Sciences, University of California, Irvine, Orange, California 92868 3298, USA
    JACC Cardiovasc Imaging 3:257-65. 2010
    ..The aim of this study was to determine the prevalence of coronary venous aneurysm in patients with no history of cardiac arrhythmia using 64-slice multidetector computed tomography...
  37. ncbi Molecular imaging of macrophage cell death for the assessment of plaque vulnerability
    Eduard M Laufer
    Department of Cardiology, Maastricht University Medical Center, Maastricht, The Netherlands
    Arterioscler Thromb Vasc Biol 29:1031-8. 2009
    ..These processes offer specific biological targets that can potentially be exploited to obtain biological information on atherosclerosis development in the individual patient...
  38. ncbi Past, present, and future of annexin A5: from protein discovery to clinical applications
    Hendrikus H Boersma
    Department of Nuclear Medicine, Maastricht University Hospital, Maastricht, The Netherlands
    J Nucl Med 46:2035-50. 2005
    ..In addition, experiences with radiolabeled anxA5 open novel avenues for drug targeting with anxA5 as a biologic "cruise missile."..
  39. ncbi Prevalence of left atrial appendage pseudothrombus filling defects in patients with atrial fibrillation undergoing coronary computed tomography angiography
    Farhood Saremi
    Department of Radiological Sciences, University of California Irvine, UCI Medical Center, Orange, CA 92868 3298, USA
    J Cardiovasc Comput Tomogr 2:164-71. 2008
    ..However, blood stasis in the left atrial appendage (LAA) of patients with atrial fibrillation (AF) may be a common cause for false-positive results...
  40. ncbi Cardiac magnetic resonance imaging: infarct size is an independent predictor of mortality in patients with coronary artery disease
    David Bello
    Division of Cardiology, Orlando Regional Medical Center, Orlando, FL 32806, USA
    Magn Reson Imaging 29:50-6. 2011
    ..Prior studies using indirect methods to assess infarct size have shown that patients with larger myocardial infarctions have a worse prognosis than those with smaller myocardial infarctions...
  41. ncbi Cardiovascular imaging and diagnostic procedures in pregnancy
    David L Ain
    The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1030, New York, NY 10029, USA
    Cardiol Clin 30:331-41. 2012
    ..Additionally cardiologists must understand indications for and limitations of each diagnostic imaging test, potential harmful effects of various modalities, and precautions that must be taken to protect the fetus...
  42. ncbi Counting heads in the war against cancer: defining the role of annexin A5 imaging in cancer treatment and surveillance
    Maarten F Corsten
    Department of Cardiology, Cardiovascular Research Institute Maastricht, University Maastricht, P. Debyelaan 25, 6229 AD Maastricht, The Netherlands
    Cancer Res 66:1255-60. 2006
    ..This might be of significant value for pharmacologic therapy development as well as clinical monitoring of treatment success...
  43. ncbi Noninvasive monitoring the biology of atherosclerotic plaque development with radiolabeled annexin V and matrix metalloproteinase inhibitor in spontaneous atherosclerotic mice
    Yared Tekabe
    Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    J Nucl Cardiol 17:1073-81. 2010
    ..To compare the ability of (99m)Tc-labeled broad-based matrix metalloproteinase inhibitor (RP805) (MPI) and (99m)Tc-annexin V to identify more advanced atherosclerotic disease in apolipoprotein E-null (apoE(-/-)) mice...
  44. ncbi Concurrent upregulation of endogenous proapoptotic and antiapoptotic factors in failing human hearts
    Nezam Haider
    University of California Irvine School of Medicine, Irvine, CA, USA
    Nat Clin Pract Cardiovasc Med 6:250-61. 2009
    ..We investigated whether activation of endogenous apoptosis inhibitors plays a part when death receptor and mitochondrial apoptotic pathways have been triggered...
  45. ncbi Noninvasive imaging of atherosclerotic lesions in apolipoprotein E-deficient and low-density-lipoprotein receptor-deficient mice with annexin A5
    Satoshi Isobe
    Division of Cardiology, University of California, Irvine School of Medicine, 92697, USA
    J Nucl Med 47:1497-505. 2006
    ..CONCLUSION: This study demonstrates the feasibility of noninvasive imaging of atherosclerosis with radiolabeled annexin A5 in transgenic mouse models of human atherosclerosis...
  46. ncbi Comparison of Framingham, PROCAM, SCORE, and Diamond Forrester to predict coronary atherosclerosis and cardiovascular events
    Mathijs O Versteylen
    Department of Cardiology, Maastricht University Medical Center, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
    J Nucl Cardiol 18:904-11. 2011
    ..We studied four frequently used risk scores in their ability to predict for coronary artery disease (CAD) and major adverse cardiovascular events in patients presenting with stable chest pain at the cardiology outpatient clinic...
  47. ncbi Molecular imaging of myocardial remodeling after infarction
    Johan W H Verjans
    Division of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Methods Mol Biol 680:227-35. 2011
    ..In this chapter we describe the assessment of angiotensin II receptor and αvβ3 integrin upregulation in a mouse model after myocardial infarction using real time in vivo fluorescence imaging and nuclear imaging...
  48. ncbi Detection of phrenic nerves and their relation to cardiac anatomy using 64-slice multidetector computed tomography
    Yuji Matsumoto
    Division of Cardiology, Department of Medicine, University of California, Irvine, California, USA
    Am J Cardiol 100:133-7. 2007
    ..In the setting of electrophysiologic interventions, MDCT before a procedure may elucidate anatomic relationships and help minimize inadvertent complications...
  49. ncbi Evolving role of molecular imaging for new understanding: targeting myofibroblasts to predict remodeling
    Hans J de Haas
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Ann N Y Acad Sci 1254:33-41. 2012
    ..We define molecular targets on myofibroblasts and discuss the feasibility of molecular imaging of these cells for early detection and treatment of patients at risk for development of HF after myocardial infarction...
  50. ncbi Atherosclerosis in chronic kidney disease: lessons learned from glycation in diabetes
    Dilbahar S Mohar
    Division of Cardiology, University of California Irvine School of Medicine, Orange, CA 92868 3298, USA
    Med Clin North Am 96:57-65. 2012
    ..It is logical to extrapolate that carbamylation may result in modification of vessel wall proteins similar to glycation, and predispose to atherosclerosis...
  51. ncbi Histopathologic evaluation of basilar artery atherosclerosis
    Artak Labadzhyan
    Department of Medicine, UC Irvine, Orange, CA 92868, USA
    J Neurol Sci 307:97-9. 2011
    ..There has been limited attention to pathological features of basilar artery atherosclerosis. It has been assumed that pathology of basilar artery atherosclerosis mimics that of other vascular beds...
  52. ncbi Endomyocardial biopsy for non-transplant-related disorders
    Navneet Narula
    Division of Cardiology, Department of Pathology, University of California, Irvine Medical Center, Orange, CA 92868, USA
    Am J Clin Pathol 123:S106-18. 2005
    ..This review focuses on the growing number of diseases that can be diagnosed by EMB in adult and pediatric age groups...
  53. ncbi Risk assessment and predictive value of coronary artery disease testing
    Leslee J Shaw
    School of Medicine, Emory University, Atlanta, Georgia 30306, USA
    J Nucl Med 50:1296-306. 2009
    ..Despite a high level of evidence, comparative research is not available across modalities that could definitively drive utilization of cardiac imaging modalities...
  54. ncbi The primary vasculitides: a clinicopathologic correlation
    Navneet Narula
    Department of Pathology, University of California Medical Center, Irvine, Orange 92868, USA
    Am J Clin Pathol 124:S84-95. 2005
    ..Incorporation of antineutrophil cytoplasmic antibodies in defining the pathogenesis of vasculitis has been particularly useful in diagnosing those small vessel vasculitides that are life threatening and need immediate intervention...
  55. ncbi A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations
    Weiwei Fan
    Center for Molecular and Mitochondrial Medicine and Genetics, University of California, Irvine, CA 92697, USA
    Science 319:958-62. 2008
    ..Thus, severe mtDNA mutations appear to be selectively eliminated from the female germ line, thereby minimizing their impact on population fitness...
  56. ncbi Arterial supply to sinuatrial and atrioventricular nodes: imaging with multidetector CT
    Farhood Saremi
    Department of Radiological Sciences, University of California, Irvine, University of California Medical Center, 101 The City Drive, Route 140, Orange, CA 92868 3298, USA
    Radiology 246:99-107; discussion 108-9. 2008
    ..To retrospectively evaluate the depiction of anatomic characteristics of the arterial supply to the sinuatrial node (SAN) and the atrioventricular node (AVN) with 64-section computed tomography (CT)...
  57. ncbi Potentiation of Doxorubicin cardiotoxicity by iron loading in a rodent model
    Gurusher S Panjrath
    Division of Cardiology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    J Am Coll Cardiol 49:2457-64. 2007
    ..The role of iron toward doxorubicin (DOX) cardiotoxicity was studied using a rodent model of dietary carbonyl iron loading...
  58. ncbi Selective improvement in Seattle Heart Failure Model risk stratification using iodine-123 meta-iodobenzylguanidine imaging
    Eric S Ketchum
    Division of Cardiology, University of Washington, 1959 NE Pacific Street, PO Box 356422, Seattle, WA, USA
    J Nucl Cardiol 19:1007-16. 2012
    ..This study investigated the incremental value of MIBG cardiac imaging when added to the SHFM for prediction of all-cause mortality...
  59. ncbi Emerging trends in CV flow visualization
    Partho P Sengupta
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    JACC Cardiovasc Imaging 5:305-16. 2012
    ..Finally, we discuss the potential clinical applications and technical challenges with suggestions for further investigations...
  60. ncbi Imaging of the right ventricle
    Javier Sanz
    Zena and Michael A Wiener Cardiovascular Institute and Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, Box 1030, New York, NY 10029, USA
    Cardiol Clin 30:189-203. 2012
    ..In this article, we review the current state of RV imaging...
  61. ncbi Mister Rogers' neighborhood
    Jagat Narula
    Division of Cardiology, University of California, School of Medicine, Orange, CA 92868, USA
    Heart Fail Clin 2:ix-x. 2006
  62. ncbi Review of noninvasive imaging for hypertrophic cardiac syndromes and restrictive physiology
    Steven J Fowler
    University of California at Irvine, Orange, CA 9286, USA
    Heart Fail Clin 2:215-30. 2006
  63. ncbi Functional strain-line pattern in the human left ventricle
    Gianni Pedrizzetti
    Dipartimento Ingegneria e Architettura, Universita di Trieste, Italy
    Phys Rev Lett 109:048103. 2012
    ..The same concept can help in characterizing the relation between functional and anatomical properties of biological tissues, as well as fiber-reinforced engineered materials...
  64. ncbi Noncompaction of the left ventricle: primary cardiomyopathy with an elusive genetic etiology
    Michael V Zaragoza
    Center for Molecular and Mitochondrial Medicine and Genetics and the Department of Pediatrics, Division of Genetics and Metabolism, University of California, Irvine, California 92697 3940, USA
    Curr Opin Pediatr 19:619-27. 2007
    ..Understanding the genetics may depend on clarifying the distinctive diagnostic features and investigating the contribution of all known cardiomyopathy-causing genes with overlapping morphology...
  65. ncbi Mortals turn me on
    Sudhir Gupta
    School of Medicine, University of California-Irvine, 101 The City Drive, Irvine, CA 92868, USA
    J Nucl Med 46:906-8. 2005
  66. ncbi Minimizing radiation dose for coronary CT angiography
    Gabriel Vorobiof
    Memorial Heart and Vascular Institute, Department of Cardiology, Long Beach Memorial Medical Center, 2801 Atlantic Avenue, Long Beach, CA 90806, USA
    Cardiol Clin 30:9-17. 2012
    ..There are several main determinants of total radiation dose, and these are outlined in this review. Integration of these dose-saving techniques will go a long way in maintaining diagnostic image quality and improving patient safety...
  67. ncbi Defective intercellular adhesion complex in myocardium predisposes to infarct rupture in humans
    Susanne W M van den Borne
    Department of Pharmacology and Toxicology and Pathology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    J Am Coll Cardiol 51:2184-92. 2008
    ..Our goal was to evaluate intercellular adhesion complex proteins in myocardium in human infarct rupture...
  68. ncbi Cell surface-expressed phosphatidylserine and annexin A5 open a novel portal of cell entry
    Heidi Kenis
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    J Biol Chem 279:52623-9. 2004
    ..We demonstrated that living tumor cells can take up substances through this novel portal of cell entry. This opens new avenues for targeted drug delivery and cell entry...
  69. ncbi Beta-adrenergic blockers in heart failure: review of mechanisms of action and clinical outcomes
    Shiyam Satwani
    Division of Cardiology, Drexel University College of Medicine, Philadelphia, PA, USA
    J Cardiovasc Pharmacol Ther 9:243-55. 2004
    ..The clinical evidence from controlled trials of the efficacy of beta-blockers in treating heart failure is summarized. Finally, the concomitant use of beta-blockers and positive inotropic agents in advanced heart failure is discussed...
  70. ncbi Imaging vulnerable plaque by ultrasound
    Anthony N Demaria
    Division of Cardiology, University of California San Diego, San Diego, California, USA
    J Am Coll Cardiol 47:C32-9. 2006
    ..These advances pave the way for future clinical trials in assessing the ability of such techniques to diagnose vulnerable plaques and to assess the effects of both pharmacologic and mechanical therapies on plaque characteristics...
  71. ncbi Targeted ultrasound imaging using microbubbles
    Flordeliza S Villanueva
    Division of Cardiology, Cardiovascular Institute, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Cardiol Clin 22:283-98, vii. 2004
    ..This approach has been applied to the ultrasound imaging of pathophysiologic processes such as inflammation associated with ischemia reperfusion, heart transplant rejection, atherosclerotic plaque, thrombus, and apoptosis...
  72. ncbi Activation of apoptotic caspase cascade during the transition to pressure overload-induced heart failure
    Narain Moorjani
    Department of Cardiothoracic Surgery, Oxford Heart Centre, John Radcliffe Hospital, Oxford, England
    J Am Coll Cardiol 48:1451-8. 2006
    ..A pressure overload model was developed to simulate aortic stenosis and assess caspase activity during the transition to heart failure...
  73. ncbi Left ventricular structure and function: basic science for cardiac imaging
    Partho P Sengupta
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
    J Am Coll Cardiol 48:1988-2001. 2006
    ....
  74. ncbi Role of caspases in Ox-LDL-induced apoptotic cascade in human coronary artery endothelial cells
    Jiawei Chen
    Department of Internal Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA
    Circ Res 94:370-6. 2004
    ..This is followed by activation of apoptotic signaling pathway, involving release of cytochrome c and Smac and activation of caspase-9 and then caspase-3...
  75. ncbi A conceptual paradox of MIBG uptake in heart failure: retention with incontinence!
    Jagat Narula
    J Nucl Cardiol 10:700-4. 2003
  76. ncbi Myocardial contrast echocardiography in acute myocardial infarction
    Johan W Verjans
    Department of Cardiovascular Medicine and Surgery, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Curr Opin Cardiol 18:346-50. 2003
    ..SUMMARY: This review provides an update of the current role and future clinical applications of MCE in acute myocardial infarction...
  77. ncbi Invited commentary: P.S.* I love you: implications of phosphatidyl serine (PS) reversal in acute ischemic syndromes
    Jagat Narula
    Heart Failure/Transplant Center, Hahnemann University Hospital, Philadelphia, Pennsylvania 19102-1192, USA
    J Nucl Med 44:397-9. 2003
  78. ncbi Noninvasive detection of cell death: from tracking epitaphs to counting coffins
    Jagat Narula
    J Nucl Cardiol 9:554-60. 2002
  79. ncbi Extension of borderzone myocardium in postinfarction dilated cardiomyopathy
    Benjamin M Jackson
    Harrison Department of Surgical Research, Philadelphia, Pennsylvania 19104, USA
    J Am Coll Cardiol 40:1160-7; discussion 1168-71. 2002
    ..Preventing extension of borderzone myocardium by medical or surgical means offers the prospect of preventing late-onset heart failure following transmural expanding MIs...
  80. ncbi Pathogenetic basis of myocardial dysfunction and amenability to reversal
    Shaila Garg
    Hahnemann University Hospital, Broad and Vine Streets, Philadelphia, PA 19102-1192, USA
    Cardiol Clin 21:83-91. 2003
    ..It will be a challenge to identify the role for concomitant drug therapy and to develop weaning programs for device support. Finally, guidelines will have to be developed to monitor and manage these patients after explantation of LVAD...
  81. ncbi An ovine model of postinfarction dilated cardiomyopathy
    Sina L Moainie
    Harrison Department of Surgical Research, University of Pennsylvania School of Medicine, Philadelphia, USA
    Ann Thorac Surg 74:753-60. 2002
    ..This simple model contains only infarcted and fully perfused, hypocontractile myocardium produced by a moderate-sized, regional infarction...
  82. ncbi The popcorn plaques
    Jagat Narula
    Nat Med 13:532-4. 2007
  83. ncbi Exposing ACE up the sleeve
    Y Chandrashekhar
    University of Minnesota, Minneapolis, Minnesota, USA
    J Nucl Med 48:173-4. 2007
  84. ncbi The sequence of regional ventricular motion
    Manel Ballester-Rodes
    Department of Medicine, Faculty of Medicine, University of Lleida, Spain
    Eur J Cardiothorac Surg 29:S139-44. 2006
    ..This would explain the movements of the base of the heart and the twisting motion of the ventricles seen at magnetic resonance studies...
  85. ncbi Novel imaging strategies for predicting remodeling and evolution of heart failure: targeting the Renin-Angiotensin system
    Jamshid Shirani
    Geisinger Medical Center, Danville, PA 17822-2160, USA
    Heart Fail Clin 2:231-47. 2006
  86. ncbi Functional consequences of caspase activation in cardiac myocytes
    Catherine Communal
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 99:6252-6. 2002
    ..Induction of apoptosis in cardiac cells was associated with similar cleavage of myofilaments. Therefore, activation of apoptotic pathways may lead to contractile dysfunction before cell death...
  87. ncbi Role of noninvasive antimyosin imaging in infants and children with clinically suspected myocarditis
    María Eugenia Rioja Martin
    Department of Nuclear Medicine, Hospital Ramon y Cajal, Madrid, Spain
    J Nucl Med 45:429-37. 2004
    ..Therefore, a noninvasive test of adequate diagnostic accuracy is highly desirable. We evaluated the role of antimyosin scintigraphy in infants and children with clinically suspected myocarditis...
  88. ncbi Surgical options in heart failure
    Stephen Westaby
    Oxford Heart Centre, John Radcliffe Hospital, Headington, United Kingdom
    Surg Clin North Am 84:xv-xix. 2004
  89. ncbi ECG-edit function in multidetector-row computed tomography coronary arteriography for patients with arrhythmias
    Hideyuki Matsutani
    Department of Radiological Technology, Takase Clinic, Takasaki, Japan
    Circ J 72:1071-8. 2008
    ..ECG-gating is necessary for cardiac computed tomography, but is not suitable for arrhythmias, so the aim of this study was to evaluate the usefulness of the ECG-edit function for this purpose...
  90. ncbi The role of endomyocardial biopsy in the management of cardiovascular disease: a scientific statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology. Endorsed by the Heart Failure Society of
    Leslie T Cooper
    J Am Coll Cardiol 50:1914-31. 2007
  91. ncbi Twist and untwist mechanics of the left ventricle
    Partho P Sengupta
    Division of Cardiovascular Diseases, Mayo Clinic, Scottsdale, AZ 85259, USA
    Heart Fail Clin 4:315-24. 2008
    ..Variations in left ventricular twist encountered in different experimental and clinical situations are discussed...
  92. ncbi Imaging of unstable atherosclerotic lesions
    Jagat Narula
    Eur J Nucl Med Mol Imaging 32:1-5. 2005
  93. ncbi Risk factors for heart failure
    Satish Kenchaiah
    The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA
    Med Clin North Am 88:1145-72. 2004
    ....
  94. ncbi Challenging the neuronal MIBG uptake by pharmacological intervention: effect of a single dose of oral amitriptyline on regional cardiac MIBG uptake
    Montserrat Estorch
    Department of Nuclear Medicine, Hospital Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Eur J Nucl Med Mol Imaging 31:1575-80. 2004
    ..This study was undertaken to assess whether a single oral dose of amitriptyline could influence cardiac MIBG distribution...
  95. ncbi Culprit plaque in myocardial infarction going beyond angiography
    Aloke V Finn
    J Am Coll Cardiol 50:2204-6. 2007
  96. ncbi Molecular biology of myocardial recovery
    Jianyi Zhang
    University of Minnesota Health Science Center, Minneapolis, MN 55455, USA
    Surg Clin North Am 84:223-42. 2004
    ..If it is confirmed that LVAD unloading can contribute significantly to reverse remodeling, the role of LVADs may graduate from bridge-to-transplantation or destination therapy to bridge-to-recovery...
  97. ncbi Multislice computed tomographic characteristics of coronary lesions in acute coronary syndromes
    Sadako Motoyama
    Department of Cardiology, Fujita Health University, Toyoake, Japan
    J Am Coll Cardiol 50:319-26. 2007
    ..To evaluate the feasibility of noninvasive assessment of the characteristics of disrupted atherosclerotic plaques, the authors interrogated the culprit lesions in acute coronary syndromes (ACS) by multislice computed tomography (CT)...
  98. ncbi Reclassifying heart failure: predominantly subendocardial, subepicardial, and transmural
    Partho P Sengupta
    Mayo Clinic, Scottsdale, AZ, USA
    Heart Fail Clin 4:379-82. 2008
    ..This review proposes a new algorithm for exploring the spectrum of altered cardiac muscle mechanics in patients with heart failure...
  99. ncbi Echocardiography in heart failure: applications, utility, and new horizons
    James N Kirkpatrick
    Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Am Coll Cardiol 50:381-96. 2007
    ..In addition, we will highlight some of the limitations of echocardiography...
  100. ncbi The Annexin code: revealing endocarditis
    Bas L J H Kietselaer
    Department of Cardiology, University Hospital of Maastricht, PO Box 5800, P. Debyelaan 25, 6202 AZ Maastricht, The Netherlands
    Eur Heart J 28:948. 2007
  101. ncbi Atherosclerotic plaque characterization by 0.5-mm-slice multislice computed tomographic imaging
    Sadako Motoyama
    Department of Cardiology, Fujita Health University, Toyoake, Japan
    Circ J 71:363-6. 2007
    ..The present study was performed to compare the 0.5-mm-slice MSCT density of plaques with intravascular ultrasound (IVUS) findings...

Research Grants6

  1. Imaging Apoptosis to Detect Unstable Atheromatous Plaque
    Jagat Narula; Fiscal Year: 2004
    ..The impending surgical intervention will allow histopathological evaluation of the endarterectomy specimens to define potential utility of annexin imaging. ..
  2. Targeting MMPS to Image Atherosclerosis
    Jagat Narula; Fiscal Year: 2007
    ..The extent of inflammation and MMP expression in the plaques will be ascertained histopathologically. (End of Abstract) ..