Michael R Narkewicz

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. ncbi Folate cofactors regulate serine metabolism in fetal ovine hepatocytes
    Michael R Narkewicz
    Department of Pediatrics, Section of Pediatric Gastroenterology, University of Colorado School of Medicine and The Children s Hospital, Denver, Colorado 80218, USA
    Pediatr Res 52:589-94. 2002
  2. ncbi Hepatic dysfunction following the Fontan procedure
    Michael R Narkewicz
    Department of Pediatrics, University of Colorado School of Medicine and The Children s Hospital, Denver, 80218, USA
    J Pediatr Gastroenterol Nutr 36:352-7. 2003
  3. pmc Ophthalmologic complications in children with chronic hepatitis C treated with pegylated interferon
    Michael R Narkewicz
    Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Colorado Denver School of Medicine and The Children s Hospital, Aurora, CO 80045, USA
    J Pediatr Gastroenterol Nutr 51:183-6. 2010
  4. ncbi Connective tissue growth factor expression is increased in biliary epithelial cells in biliary atresia
    Michael R Narkewicz
    Department of Pediatrics, The Pediatric Liver Center, The Children s Hospital, University of Colorado School of Medicine, Denver, CO 80218, USA
    J Pediatr Surg 40:1721-5. 2005
  5. ncbi Biliary atresia: an update on our understanding of the disorder
    M R Narkewicz
    Pediatric Liver Disease Section, Pediatric Gastroenterology, Hepatology and Nutrition, Pediatric Liver Center, University of Colorado School of Medicine, Children s Hospital, Denver, Colorado 80218, USA
    Curr Opin Pediatr 13:435-40. 2001
  6. ncbi Serine and glycine transport in fetal ovine hepatocytes
    M R Narkewicz
    Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine and The Children s Hospital, Denver, CO 80218, USA
    Biochim Biophys Acta 1474:41-6. 2000
  7. ncbi Correction of hypozincemia following liver transplantation in children is associated with reduced urinary zinc loss
    M R Narkewicz
    Department of Pediatrics, The Pediatric Liver Center, University of Colorado School of Medicine and The Children s Hospital, Denver, CO 80218, USA
    Hepatology 29:830-3. 1999
  8. pmc Autoantibodies and autoimmune disease during treatment of children with chronic hepatitis C
    Jean P Molleston
    Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Indiana University School of Medicine, Indianapolis, IN, USA
    J Pediatr Gastroenterol Nutr 56:304-10. 2013
  9. pmc Pegylated interferon for chronic hepatitis C in children affects growth and body composition: results from the pediatric study of hepatitis C (PEDS-C) trial
    Maureen M Jonas
    Division of Gastroenterology, Hepatology and Nutrition, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Hepatology 56:523-31. 2012
  10. pmc Evaluation of the liver injury unit scoring system to predict survival in a multinational study of pediatric acute liver failure
    Brandy R Lu
    Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA
    J Pediatr 162:1010-6.e1-4. 2013

Detail Information

Publications45

  1. ncbi Folate cofactors regulate serine metabolism in fetal ovine hepatocytes
    Michael R Narkewicz
    Department of Pediatrics, Section of Pediatric Gastroenterology, University of Colorado School of Medicine and The Children s Hospital, Denver, Colorado 80218, USA
    Pediatr Res 52:589-94. 2002
    ..Both folate cofactor availability and hormone concentrations regulate serine metabolism in the fetal liver. We speculate that serine metabolism may be a marker of fetal hepatic folate cofactor supply...
  2. ncbi Hepatic dysfunction following the Fontan procedure
    Michael R Narkewicz
    Department of Pediatrics, University of Colorado School of Medicine and The Children s Hospital, Denver, 80218, USA
    J Pediatr Gastroenterol Nutr 36:352-7. 2003
    ..The objective of this study was to characterize hepatic function and its relationship to cardiac function in children who had undergone the Fontan procedure...
  3. pmc Ophthalmologic complications in children with chronic hepatitis C treated with pegylated interferon
    Michael R Narkewicz
    Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Colorado Denver School of Medicine and The Children s Hospital, Aurora, CO 80045, USA
    J Pediatr Gastroenterol Nutr 51:183-6. 2010
    ..Our purpose is to describe the ophthalmologic complications of pegylated interferon-alpha2a with either placebo or ribavirin in children with chronic HCV (the PEDS-C trial)...
  4. ncbi Connective tissue growth factor expression is increased in biliary epithelial cells in biliary atresia
    Michael R Narkewicz
    Department of Pediatrics, The Pediatric Liver Center, The Children s Hospital, University of Colorado School of Medicine, Denver, CO 80218, USA
    J Pediatr Surg 40:1721-5. 2005
    ..The objective of this study was to evaluate hepatic CTGF messenger RNA (mRNA) expression and its relationship to hepatic histology in children with BA...
  5. ncbi Biliary atresia: an update on our understanding of the disorder
    M R Narkewicz
    Pediatric Liver Disease Section, Pediatric Gastroenterology, Hepatology and Nutrition, Pediatric Liver Center, University of Colorado School of Medicine, Children s Hospital, Denver, Colorado 80218, USA
    Curr Opin Pediatr 13:435-40. 2001
    ..It is also the leading indication for liver transplantation in children. This review focuses on recent advances in the etiology, diagnosis, and management of biliary atresia...
  6. ncbi Serine and glycine transport in fetal ovine hepatocytes
    M R Narkewicz
    Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine and The Children s Hospital, Denver, CO 80218, USA
    Biochim Biophys Acta 1474:41-6. 2000
    ....
  7. ncbi Correction of hypozincemia following liver transplantation in children is associated with reduced urinary zinc loss
    M R Narkewicz
    Department of Pediatrics, The Pediatric Liver Center, University of Colorado School of Medicine and The Children s Hospital, Denver, CO 80218, USA
    Hepatology 29:830-3. 1999
    ....
  8. pmc Autoantibodies and autoimmune disease during treatment of children with chronic hepatitis C
    Jean P Molleston
    Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Indiana University School of Medicine, Indianapolis, IN, USA
    J Pediatr Gastroenterol Nutr 56:304-10. 2013
    ..Autoantibodies were studied in a well-characterized cohort of children with chronic hepatitis C during treatment with pegylated interferon and ribavirin to assess the relation with treatment and development of autoimmune disease...
  9. pmc Pegylated interferon for chronic hepatitis C in children affects growth and body composition: results from the pediatric study of hepatitis C (PEDS-C) trial
    Maureen M Jonas
    Division of Gastroenterology, Hepatology and Nutrition, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Hepatology 56:523-31. 2012
    ..Percent body fat, fat-free mass z scores, and triceps skinfold z scores decreased with therapy. Dietary energy intake and levels of physical activity did not change during treatment...
  10. pmc Evaluation of the liver injury unit scoring system to predict survival in a multinational study of pediatric acute liver failure
    Brandy R Lu
    Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA
    J Pediatr 162:1010-6.e1-4. 2013
    ....
  11. pmc The combination of ribavirin and peginterferon is superior to peginterferon and placebo for children and adolescents with chronic hepatitis C
    Kathleen B Schwarz
    Department of Pediatrics, Division of Gastroenterology and Nutrition, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Gastroenterology 140:450-458.e1. 2011
    ..We conducted a randomized controlled trial of PEG and ribavirin, compared with PEG and placebo, in children 5 to 17 years old with chronic hepatitis C...
  12. pmc Pulmonary vascular complications in asymptomatic children with portal hypertension
    John R Whitworth
    Pediatric Gastroenterology, Hepatology and Nutrition, USA
    J Pediatr Gastroenterol Nutr 49:607-12. 2009
    ....
  13. pmc Evaluation of a scoring system for assessing prognosis in pediatric acute liver failure
    Brandy R Lu
    Department of Pediatrics, The Children s Hospital, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    Clin Gastroenterol Hepatol 6:1140-5. 2008
    ..The aims of this study were to test the predictive value of the LIU score in a subsequent validation set of patients and to derive a hospital admission LIU (aLIU) score predictive of outcome...
  14. doi NASPGHAN practice guidelines: Diagnosis and management of hepatitis C infection in infants, children, and adolescents
    Cara L Mack
    Digestive Health Institute, Pediatric Liver Center, University of Colorado School of Medicine and Children s Hospital Colorado, Aurora, CO 80045, USA
    J Pediatr Gastroenterol Nutr 54:838-55. 2012
    ..The guideline details the epidemiology and natural history of HCV infection in children, the diagnostic workup, monitoring and treatment of disease, and provides an update on future treatment options and areas of research...
  15. ncbi Characterization of acute liver failure and development of a continuous risk of death staging system in children
    Edwin Liu
    Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Children s Hospital and University of Colorado Health Sciences Center, 1056 East 19th Avenue, Box B290, Denver, CO 80218 1088, USA
    J Hepatol 44:134-41. 2006
    ..There is currently no system for staging severity of ALF in children. The aim of this study was to characterize pediatric ALF in a tertiary hospital and to derive a scoring system to stratify severity of ALF based on predicted mortality...
  16. pmc Immunophenotype predicts outcome in pediatric acute liver failure
    John Bucuvalas
    Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital, Cincinnati, OH 45229, USA
    J Pediatr Gastroenterol Nutr 56:311-5. 2013
    ....
  17. doi Pulmonary function in individuals who underwent liver transplantation: from the US cystic fibrosis foundation registry
    Melissa R Miller
    Colorado School of Public Health at University of Colorado Denver, Aurora, CO, USA
    Liver Transpl 18:585-93. 2012
    ..LT is neither beneficial nor detrimental to pulmonary function in CF but returns FEV(1) decline to the same trajectory found for matched non-LT individuals with CF...
  18. doi Recommendations for screening, monitoring, and referral of pediatric chronic hepatitis B
    Barbara A Haber
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 124:e1007-13. 2009
    ....
  19. ncbi Acute hepatitis and liver failure associated with influenza A infection in children
    John R Whitworth
    Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Pediatric Liver Center, Denver, CO, USA
    J Pediatr Gastroenterol Nutr 43:536-8. 2006
  20. ncbi Interferon treatment for chronic hepatitis B: enhanced response in children 5 years old or younger
    Gregory E Kobak
    Pediatric Liver Center and Section of Pediatric Gastroenterology, University of Colorado Health Sciences Center, Denver, CO, USA
    J Pediatr 145:340-5. 2004
    ..To test the hypothesis that there is an improved response to interferon in children with chronic hepatitis B (HBV) who are < or =5 years of age...
  21. doi Incidence and clinical significance of elevated liver function tests in cystic fibrosis clinical trials
    Nicole Mayer-Hamblett
    Department of Pediatrics, University of Washington, Seattle, WA 98101 9300, USA
    Contemp Clin Trials 34:232-8. 2013
    ..The objectives of this study were to characterize emergence rates of elevated LFTs in CF trials and their association with clinical outcomes...
  22. pmc Characterization and outcomes of young infants with acute liver failure
    Shikha S Sundaram
    Department of Pediatrics, Section of Gastroenterology, Hepatology and Nutrition, The Children s Hospital, University of Colorado School of Medicine, Aurora, CO, USA
    J Pediatr 159:813-818.e1. 2011
    ..To characterize infants aged ≤ 90 days enrolled in an international, multicenter, prospective registry of children aged < 18 years with acute liver failure (ALF)...
  23. doi Hepatic veno-occlusive disease and human herpes virus 7 infection in primary agammaglobulinemia
    Jason S Soden
    Pediatric Liver Center and Liver Transplantation Program, Department of Pediatrics, University of Colorado Denver School of Medicine, and The Children s Hospital, Aurora, CO 80045, USA
    J Pediatr 154:299-302. 2009
    ..We report a case of end-stage liver disease in a patient with x-linked agammaglobulinemia who was found to have VOD and evidence of human herpes virus 7 infection in the explanted liver after transplantation...
  24. ncbi Autoantibodies in mothers of children with neonatal liver disease
    Joanna M Burch
    Department of Dermatology, University of Colorado School of Medicine, CO, USA
    J Pediatr Gastroenterol Nutr 37:262-7. 2003
    ..This study was performed to determine whether idiopathic neonatal cholestasis (INC) represents NLE without its cardiac or cutaneous findings...
  25. pmc Innate immune function in placenta and cord blood of hepatitis C--seropositive mother-infant dyads
    Christine Waasdorp Hurtado
    Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics Digestive Health Institute, University of Colorado School of Medicine, The Children s Hospital, Aurora, Colorado, United States of America
    PLoS ONE 5:e12232. 2010
    ....
  26. ncbi Safety, efficacy and pharmacokinetics of peginterferon alpha2a (40 kd) in children with chronic hepatitis C
    Kathleen B Schwarz
    Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Pediatr Gastroenterol Nutr 43:499-505. 2006
    ..In conclusion, our findings provide a basis for larger studies evaluating the efficacy and safety of pegINF-alpha2a as monotherapy as well as in combination with ribavirin in pediatric patients with chronic hepatitis C...
  27. ncbi Comparison of indices of vitamin A status in children with chronic liver disease
    Andrew P Feranchak
    Pediatric Liver Center and Liver Transplantation Program, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, The Children s Hospital, Denver, CO, USA
    Hepatology 42:782-92. 2005
    ..Our data suggest that serum retinol level as an initial screen followed by confirmation with a modified oral RDR test is the most effective means of identifying vitamin A deficiency in these subjects...
  28. ncbi The "C" of viral hepatitis in children
    Michael R Narkewicz
    Pediatric Liver Center, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Colorado School of Medicine and The Children s Hospital, Denver, Colorado, USA
    Semin Liver Dis 27:295-311. 2007
    ..Herein, we describe the virus and its life cycle and summarize our current understanding of the epidemiology and natural history of perinatally acquired infection and review current and future therapy of HCV infection in children...
  29. ncbi Fetal hepatic and umbilical uptakes of glucogenic substrates during a glucagon-somatostatin infusion
    Cecilia Teng
    Departments of Pediatrics and Physiology, University of Colorado School of Medicine, Aurora, Colorado, 80045 0508, USA
    Am J Physiol Endocrinol Metab 282:E542-50. 2002
    ....
  30. doi Choledochoduodenostomy in pediatric liver transplantation
    Jeffrey Campsen
    Department of Surgery, Division of Transplant Surgery, University of Colorado Denver School of Medicine, Aurora, CO, USA
    Pediatr Transplant 15:237-9. 2011
    ..We provide preliminary evidence that CDD is an alternative technique for biliary reconstruction when CC is not possible in pediatric liver transplant recipients that have a hostile abdomen or to preserve bowel length...
  31. ncbi Niemann-pick disease type C in neonatal cholestasis at a North American Center
    Baruch Yerushalmi
    Pediatric Liver Center and Liver Transplantation Program, Department of Pediatrics, University of Colorado School of Medicine and The Children s Hospital, Denver, Colorado 80218, USA
    J Pediatr Gastroenterol Nutr 35:44-50. 2002
    ..To determine the frequency of Niemann-Pick disease type C (NPC) among children being evaluated for neonatal cholestasis during a 2-year period...
  32. ncbi Plasma markers of platelet activation in cystic fibrosis liver and lung disease
    Kathleen B Schwarz
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Pediatr Gastroenterol Nutr 37:187-91. 2003
    ....
  33. doi Pattern of diagnostic evaluation for the causes of pediatric acute liver failure: an opportunity for quality improvement
    Michael R Narkewicz
    Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado Denver School of Medicine and the Pediatric Liver Center, The Children s Hospital, Aurora, CO, USA
    J Pediatr 155:801-806.e1. 2009
    ..To describe the frequency of diagnostic testing for the 4 most common causes of pediatric acute liver failure (PALF) (drugs, metabolic disease, autoimmune process, and infections) in indeterminate PALF within the PALF Study Group Database...
  34. pmc Portopulmonary hypertension in pediatric patients
    Adria A Condino
    Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pathology, The Children s Hospital, University of Colorado Health Sciences Center, Denver, CO, USA
    J Pediatr 147:20-6. 2005
    ..To investigate the clinical presentation, manifestations, and response to therapy of portopulmonary hypertension (PPHTN) in pediatric patients...
  35. ncbi Response of elevated Epstein-Barr virus DNA levels to therapeutic changes in pediatric liver transplant patients: 56-month follow up and outcome
    Ronald D Holmes
    Pediatric Gastroenterology, Department of Pediatrics, University of Michigan, 1500 E Medical Center Dr, Ann Arbor 48109, USA
    Transplantation 74:367-72. 2002
    ..The aim of this study is to report the results of EBV DNA PCR screening in a transplant population and to examine the risk factors for developing elevated EBV DNA PCR and the effect of interventions for reducing EBV DNA levels...
  36. ncbi Pathogenesis and outcome of biliary atresia: current concepts
    Ronald J Sokol
    Pediatric Liver Center and Liver Transplantation Program, Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado, U S A
    J Pediatr Gastroenterol Nutr 37:4-21. 2003
  37. ncbi Ontogeny of hepatic enzymes involved in serine- and folate-dependent one-carbon metabolism in rabbits
    H R Thompson
    Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Colorado School of Medicine, Denver, CO 80218, USA
    Am J Physiol Gastrointest Liver Physiol 280:G873-8. 2001
    ..Throughout development, there are multiple potential sources for production of 5,10-MTHF, but early in gestation high MTHFR activity and low MTHFS activity could reduce 5,10-MTHF availability...
  38. doi Preoperative imaging does not predict intrahepatic involvement in choledochal cysts
    Shannon N Acker
    Department of Surgery, Division of Pediatric Surgery, University of Colorado School of Medicine and Children s Hospital Colorado, Aurora, CO 80045, USA Electronic address
    J Pediatr Surg 48:2378-82. 2013
    ..We hypothesize that preoperative intrahepatic ductal dilation is not predictive of postoperative intrahepatic involvement...
  39. pmc Acute hepatitis in three patients with systemic juvenile idiopathic arthritis taking interleukin-1 receptor antagonist
    Scott Canna
    Division of Rheumatology, The Children s Hospital, 13123 E 16th Ave, Aurora, CO 80045, USA
    Pediatr Rheumatol Online J 7:21. 2009
    ..We investigated the etiology of acute hepatitis in three children with systemic Juvenile Idiopathic Arthritis (sJIA) taking Interleukin-1 receptor antagonist (IL1RA)...
  40. ncbi Spontaneous perforation of the bile duct in a toddler: the role of endoscopic retrograde cholangiopancreatography in diagnosis and therapy
    Barrett H Barnes
    Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine, and Pediatric Liver Center, The Children s Hospital, Denver, Colorado 80218 1088, USA
    J Pediatr Gastroenterol Nutr 43:695-7. 2006
  41. ncbi Survival after first esophageal variceal hemorrhage in patients with biliary atresia
    D Miga
    Pediatric Liver Center and Liver Transplantation Program, Section of Pediatric Gastroenterology, Hepatology and Nutrition, The Department of Pediatrics, University of Colorado School of Medicine and The Children's Hospital, Denver, Colorado 80218, USA
    J Pediatr 139:291-6. 2001
    ..6 (0.1, 3.1) times the risk of a same-aged child who did not have EVH. CONCLUSIONS: Children with biliary atresia and first EVH episode have a variable prognosis related to total serum bilirubin concentration at the time of the episode...
  42. ncbi Effect of ursodeoxycholic acid therapy on hepatic function in children with intrahepatic cholestatic liver disease
    M R Narkewicz
    Department of Pediatrics, University of Colorado School of Medicine, Denver, USA
    J Pediatr Gastroenterol Nutr 26:49-55. 1998
    ..However, the effect of UDCA on quantitative tests of hepatic function in children is uncertain...
  43. ncbi Research agenda for pediatric gastroenterology, hepatology and nutrition: hepatobiliary disorders. Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition for the Children's Digestive Health and Nutrition Foundation
    Benjamin Shneider
    Children s Digestive Health and Nutrition Foundation, PO Box 6, Flourtown, PA 19031, USA
    J Pediatr Gastroenterol Nutr 35:S268-74. 2002
  44. ncbi Development of the liver and bile ducts
    Frederick Suchy
    Mt Sinai Medical Center, New York, New York, USA
    J Pediatr Gastroenterol Nutr 35:S4-6. 2002
  45. pmc Pathology of chronic hepatitis C in children: liver biopsy findings in the Peds-C Trial
    Zachary D Goodman
    Armed Forces Institute of Pathology and Veterans Administration Special Reference Laboratory for Pathology, Washington, DC, USA
    Hepatology 47:836-43. 2008
    ....