Rajesh Narendran


Affiliation: University of Pittsburgh
Country: USA


  1. Narendran R, Frankle W, Mason N, Rabiner E, Gunn R, Searle G, et al. Positron emission tomography imaging of amphetamine-induced dopamine release in the human cortex: a comparative evaluation of the high affinity dopamine D2/3 radiotracers [11C]FLB 457 and [11C]fallypride. Synapse. 2009;63:447-61 pubmed publisher
    ..These findings suggest that [(11)C]FLB 457 is superior to [(11)C]fallypride for measurement of changes in cortical synaptic dopamine. ..
  2. Narendran R, Tollefson S, Fasenmyer K, Paris J, Himes M, Lopresti B, et al. Decreased Nociceptin Receptors Are Related to Resilience and Recovery in College Women Who Have Experienced Sexual Violence: Therapeutic Implications for Posttraumatic Stress Disorder. Biol Psychiatry. 2019;: pubmed publisher
    ..Decreased midbrain and cerebellum nociceptin receptors are associated with less severe PTSD symptoms. Medications that target nociceptin should be explored to prevent and treat PTSD. ..
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    Narendran R, Slifstein M, Guillin O, Hwang Y, Hwang D, Scher E, et al. Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]-(+)-PHNO is a D3 receptor preferring agonist in vivo. Synapse. 2006;60:485-95 pubmed
    ..This property might contribute to its higher vulnerability to endogenous DA compared to [11C]raclopride and [11C]NPA. ..
  4. Narendran R, Frankle W, Mason N, Laymon C, Lopresti B, Price J, et al. Positron emission tomography imaging of D(2/3) agonist binding in healthy human subjects with the radiotracer [(11)C]-N-propyl-norapomorphine: preliminary evaluation and reproducibility studies. Synapse. 2009;63:574-84 pubmed publisher
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    Narendran R, Slifstein M, Hwang D, Hwang Y, Scher E, Reeder S, et al. Amphetamine-induced dopamine release: duration of action as assessed with the D2/3 receptor agonist radiotracer (-)-N-[(11)C]propyl-norapomorphine ([11C]NPA) in an anesthetized nonhuman primate. Synapse. 2007;61:106-9 pubmed
  6. Narendran R, Martinez D. Cocaine abuse and sensitization of striatal dopamine transmission: a critical review of the preclinical and clinical imaging literature. Synapse. 2008;62:851-69 pubmed publisher
    ..This article reviews the methodological differences between the preclinical and clinical PET studies that have investigated DA sensitization in order to address the discrepancy between the human and animal literature. ..
  7. Narendran R, Mason N, Laymon C, Lopresti B, Velasquez N, May M, et al. A comparative evaluation of the dopamine D(2/3) agonist radiotracer [11C](-)-N-propyl-norapomorphine and antagonist [11C]raclopride to measure amphetamine-induced dopamine release in the human striatum. J Pharmacol Exp Ther. 2010;333:533-9 pubmed publisher
    ..Nevertheless, these data add to the growing literature that suggests D(2/3) agonist radiotracers are more vulnerable to endogenous competition by dopamine than existing D(2/3) antagonist radiotracers. ..
  8. Narendran R, Mason N, May M, Chen C, Kendro S, Ridler K, et al. Positron emission tomography imaging of dopamine D?/? receptors in the human cortex with [¹¹C]FLB 457: reproducibility studies. Synapse. 2011;65:35-40 pubmed publisher
    ..These data support the further validation of [¹¹C]FLB 457 as a tool to measure amphetamine-induced dopamine release in the human cortex...
  9. Narendran R, Mason N, Chen C, Himes M, Keating P, May M, et al. Evaluation of dopamine D?/? specific binding in the cerebellum for the positron emission tomography radiotracer [¹¹C]FLB 457: implications for measuring cortical dopamine release. Synapse. 2011;65:991-7 pubmed publisher
    ..Nevertheless, caution is advised when using reference tissue methods that rely solely on the cerebellum signal as an input function to quantify [¹¹C]FLB 457 BP(ND)...

More Information


  1. Narendran R, Lopresti B, Martinez D, Mason N, Himes M, May M, et al. In vivo evidence for low striatal vesicular monoamine transporter 2 (VMAT2) availability in cocaine abusers. Am J Psychiatry. 2012;169:55-63 pubmed publisher
    ..Further research is necessary to understand the clinical relevance of this observation to relapse and outcome in abstinent cocaine abusers. ..
  2. Narendran R, FRANKLE W, MASON N, Muldoon M, Moghaddam B. Improved working memory but no effect on striatal vesicular monoamine transporter type 2 after omega-3 polyunsaturated fatty acid supplementation. PLoS ONE. 2012;7:e46832 pubmed publisher
    ..However, the lack of change in [(11)C]DBTZ BP(ND) indicates that striatal VMAT2 regulation is not the mechanism of action by which n-3 PUFA improves cognitive performance. ..
  3. Narendran R, Jedema H, Lopresti B, Mason N, Himes M, Bradberry C. Decreased vesicular monoamine transporter type 2 availability in the striatum following chronic cocaine self-administration in nonhuman primates. Biol Psychiatry. 2015;77:488-92 pubmed publisher
    ..Future studies should attempt to clarify the clinical significance of lower VMAT2 in cocaine abusers, for example, its relationship to relapse and vulnerability to mood disorders. ..
  4. Narendran R, Ciccocioppo R, Lopresti B, Paris J, Himes M, Mason N. Nociceptin Receptors in Alcohol Use Disorders: A Positron Emission Tomography Study Using [11C]NOP-1A. Biol Psychiatry. 2018;84:708-714 pubmed publisher
    ..The results of this study do not support alterations in the binding to NOP receptors in alcohol dependence. However, this finding does not necessarily rule out alterations in nociceptin transmission in alcohol dependence. ..