Rajesh Narendran

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi request reprint Positron emission tomography imaging of amphetamine-induced dopamine release in the human cortex: a comparative evaluation of the high affinity dopamine D2/3 radiotracers [11C]FLB 457 and [11C]fallypride
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 63:447-61. 2009
  2. pmc Cocaine Abuse in Humans Is Not Associated with Increased Microglial Activation: An 18-kDa Translocator Protein Positron Emission Tomography Imaging Study with [11C]PBR28
    Rajesh Narendran
    Departments of Radiology, Psychiatry, and
    J Neurosci 34:9945-50. 2014
  3. pmc Improved working memory but no effect on striatal vesicular monoamine transporter type 2 after omega-3 polyunsaturated fatty acid supplementation
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e46832. 2012
  4. pmc In vivo evidence for low striatal vesicular monoamine transporter 2 (VMAT2) availability in cocaine abusers
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, USA
    Am J Psychiatry 169:55-63. 2012
  5. pmc A comparative evaluation of the dopamine D(2/3) agonist radiotracer [11C](-)-N-propyl-norapomorphine and antagonist [11C]raclopride to measure amphetamine-induced dopamine release in the human striatum
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh Medical Center Presbyterian, PET Facility, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Pharmacol Exp Ther 333:533-9. 2010
  6. pmc Positron emission tomography imaging of D(2/3) agonist binding in healthy human subjects with the radiotracer [(11)C]-N-propyl-norapomorphine: preliminary evaluation and reproducibility studies
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 63:574-84. 2009
  7. doi request reprint Cocaine abuse and sensitization of striatal dopamine transmission: a critical review of the preclinical and clinical imaging literature
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15232, USA
    Synapse 62:851-69. 2008
  8. pmc Evaluation of dopamine D₂/₃ specific binding in the cerebellum for the positron emission tomography radiotracer [¹¹C]FLB 457: implications for measuring cortical dopamine release
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 65:991-7. 2011
  9. pmc Imaging of dopamine D2/3 agonist binding in cocaine dependence: a [11C]NPA positron emission tomography study
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 65:1344-9. 2011
  10. ncbi request reprint Amphetamine-induced dopamine release: duration of action as assessed with the D2/3 receptor agonist radiotracer (-)-N-[(11)C]propyl-norapomorphine ([11C]NPA) in an anesthetized nonhuman primate
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Synapse 61:106-9. 2007

Detail Information

Publications32

  1. doi request reprint Positron emission tomography imaging of amphetamine-induced dopamine release in the human cortex: a comparative evaluation of the high affinity dopamine D2/3 radiotracers [11C]FLB 457 and [11C]fallypride
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 63:447-61. 2009
    ..These findings suggest that [(11)C]FLB 457 is superior to [(11)C]fallypride for measurement of changes in cortical synaptic dopamine...
  2. pmc Cocaine Abuse in Humans Is Not Associated with Increased Microglial Activation: An 18-kDa Translocator Protein Positron Emission Tomography Imaging Study with [11C]PBR28
    Rajesh Narendran
    Departments of Radiology, Psychiatry, and
    J Neurosci 34:9945-50. 2014
    ..Further research with more direct markers of microglial activation is necessary to conclusively rule out neuroinflammation in cocaine dependence. ..
  3. pmc Improved working memory but no effect on striatal vesicular monoamine transporter type 2 after omega-3 polyunsaturated fatty acid supplementation
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e46832. 2012
    ..However, the lack of change in [(11)C]DBTZ BP(ND) indicates that striatal VMAT2 regulation is not the mechanism of action by which n-3 PUFA improves cognitive performance...
  4. pmc In vivo evidence for low striatal vesicular monoamine transporter 2 (VMAT2) availability in cocaine abusers
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, USA
    Am J Psychiatry 169:55-63. 2012
    ....
  5. pmc A comparative evaluation of the dopamine D(2/3) agonist radiotracer [11C](-)-N-propyl-norapomorphine and antagonist [11C]raclopride to measure amphetamine-induced dopamine release in the human striatum
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh Medical Center Presbyterian, PET Facility, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Pharmacol Exp Ther 333:533-9. 2010
    ..Nevertheless, these data add to the growing literature that suggests D(2/3) agonist radiotracers are more vulnerable to endogenous competition by dopamine than existing D(2/3) antagonist radiotracers...
  6. pmc Positron emission tomography imaging of D(2/3) agonist binding in healthy human subjects with the radiotracer [(11)C]-N-propyl-norapomorphine: preliminary evaluation and reproducibility studies
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 63:574-84. 2009
    ..The aim of the present study was to define the optimal analytic method to derive accurate and reliable D(2/3) receptor parameters with [(11)C]NPA...
  7. doi request reprint Cocaine abuse and sensitization of striatal dopamine transmission: a critical review of the preclinical and clinical imaging literature
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15232, USA
    Synapse 62:851-69. 2008
    ..This article reviews the methodological differences between the preclinical and clinical PET studies that have investigated DA sensitization in order to address the discrepancy between the human and animal literature...
  8. pmc Evaluation of dopamine D₂/₃ specific binding in the cerebellum for the positron emission tomography radiotracer [¹¹C]FLB 457: implications for measuring cortical dopamine release
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 65:991-7. 2011
    ..Nevertheless, caution is advised when using reference tissue methods that rely solely on the cerebellum signal as an input function to quantify [¹¹C]FLB 457 BP(ND)...
  9. pmc Imaging of dopamine D2/3 agonist binding in cocaine dependence: a [11C]NPA positron emission tomography study
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 65:1344-9. 2011
    ....
  10. ncbi request reprint Amphetamine-induced dopamine release: duration of action as assessed with the D2/3 receptor agonist radiotracer (-)-N-[(11)C]propyl-norapomorphine ([11C]NPA) in an anesthetized nonhuman primate
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Synapse 61:106-9. 2007
  11. ncbi request reprint Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]-(+)-PHNO is a D3 receptor preferring agonist in vivo
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York 10032, USA
    Synapse 60:485-95. 2006
    ..This property might contribute to its higher vulnerability to endogenous DA compared to [11C]raclopride and [11C]NPA...
  12. pmc Positron emission tomography imaging of dopamine D₂/₃ receptors in the human cortex with [¹¹C]FLB 457: reproducibility studies
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 65:35-40. 2011
    ..These data support the further validation of [¹¹C]FLB 457 as a tool to measure amphetamine-induced dopamine release in the human cortex...
  13. ncbi request reprint In vivo vulnerability to competition by endogenous dopamine: comparison of the D2 receptor agonist radiotracer (-)-N-[11C]propyl-norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer [11C]-raclopride
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    Synapse 52:188-208. 2004
    ..In conclusion, [11C]NPA might provide a superior radiotracer to probe presynaptic DA function with PET in health and disease...
  14. pmc Dopamine D1 receptors in cocaine dependence measured with PET and the choice to self-administer cocaine
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neuropsychopharmacology 34:1774-82. 2009
    ....
  15. doi request reprint No effect of dopamine depletion on the binding of the high-affinity D 2/3 radiotracer [11C]FLB 457 in the human cortex
    W Gordon Frankle
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 64:879-85. 2010
    ..In contrast to the measurement of DA release, the combination of low D(2) receptor density and low basal DA levels in the cortex greatly reduce the power to detect alterations in [(11)C]FLB 457 binding secondary to DA depletion...
  16. ncbi request reprint Measurement of the proportion of D2 receptors configured in state of high affinity for agonists in vivo: a positron emission tomography study using [11C]N-propyl-norapomorphine and [11C]raclopride in baboons
    Rajesh Narendran
    New York State Psychiatric Institute, 1051 Riverside Dr, Box 31, New York, NY 10032, USA
    J Pharmacol Exp Ther 315:80-90. 2005
    ....
  17. ncbi request reprint Altered prefrontal dopaminergic function in chronic recreational ketamine users
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Am J Psychiatry 162:2352-9. 2005
    ..In this study, dopamine D1 receptor availability was assessed by using positron emission tomography and the selective D1 receptor radioligand [11C]NNC 112 in a group of 14 recreational chronic ketamine users and matched healthy subjects...
  18. pmc Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)/D(3) receptors following acute dopamine depletion
    Diana Martinez
    Department of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Psychiatry 166:1170-7. 2009
    ..The purpose of this study was to measure D(2)/D(3) receptors following acute dopamine depletion in cocaine-dependent volunteers relative to healthy comparison subjects...
  19. ncbi request reprint Modulation of amphetamine-induced dopamine release by group II metabotropic glutamate receptor agonist LY354740 in non-human primates studied with positron emission tomography
    Bart N M van Berckel
    Department of Psychiatry, Columbia University, New York, NY, USA
    Neuropsychopharmacology 31:967-77. 2006
    ....
  20. pmc Dopamine type 2/3 receptor availability in the striatum and social status in human volunteers
    Diana Martinez
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 67:275-8. 2010
    ..The goal of the present study was to examine this phenomena in human subjects using PET and the radiotracer [(11)C]raclopride...
  21. ncbi request reprint Estimation of serotonin transporter parameters with 11C-DASB in healthy humans: reproducibility and comparison of methods
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, NY 10032, USA
    J Nucl Med 47:815-26. 2006
    ..The aim of the present study was to define the optimal analytic method to derive accurate and reliable serotonin transporter (SERT) receptor parameters with (11)C-3-amino-4-(2-[(dimethylamino)methyl]phenylthio)benzonitrile ((11)C-DASB)...
  22. pmc Human biodistribution and dosimetry of the D2/3 agonist 11C-N-propylnorapomorphine (11C-NPA) determined from PET
    Charles M Laymon
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Nucl Med 50:814-7. 2009
    ..We measured the whole-body distribution of intravenously injected (11)C-N-propylnorapomorphine ((11)C-NPA), a dopamine agonist PET tracer, in human subjects and determined the resulting absorbed radiation doses...
  23. ncbi request reprint Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Psychiatry 164:622-9. 2007
    ..Furthermore, the relationship between this dopamine response and the choice to self-administer cocaine in a laboratory model of relapse was investigated...
  24. pmc [11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levels
    W Gordon Frankle
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e32443. 2012
    ..67, p = 0.05) measured via EEG during a cognitive control task. These data provide a replication of our previous study demonstrating the ability to measure in vivo, with PET, acute shifts in extracellular GABA...
  25. pmc Reproducibility of post-amphetamine [11C]FLB 457 binding to cortical D2/3 receptors
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e76905. 2013
    ..These data further support the use [(11)C]FLB 457 and amphetamine to characterize cortical dopamine transmission in neuropsychiatric disorders...
  26. doi request reprint Human biodistribution and dosimetry of the PET radioligand [¹¹C]flumazenil (FMZ)
    Charles M Laymon
    Department of Radiology, UPMC Presbyterian Hospital, University of Pittsburgh, Room B 938, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Mol Imaging Biol 14:115-22. 2012
    ..We measure the whole-body distribution of IV injected [¹¹C]Flumazenil (FMZ) as a function of time in adult subjects and determine the absorbed radiation doses...
  27. ncbi request reprint Mechanism of action of antipsychotic drugs: from dopamine D(2) receptor antagonism to glutamate NMDA facilitation
    Marc Laruelle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Clin Ther 27:S16-24. 2005
    ..The fundamental pathologic processes associated with schizophrenia remain uncertain...
  28. doi request reprint Synthesis and characterization of two PET radioligands for the metabotropic glutamate 1 (mGlu1) receptor
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Synapse 66:1002-14. 2012
    ..Radioligands with higher affinity and/or lower lipophilicity are needed to successfully image the mGlu1 receptor in humans...
  29. pmc Tiagabine increases [11C]flumazenil binding in cortical brain regions in healthy control subjects
    W Gordon Frankle
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 34:624-33. 2009
    ....
  30. ncbi request reprint Serotonin transporter availability in patients with schizophrenia: a positron emission tomography imaging study with [11C]DASB
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York 10032, USA
    Biol Psychiatry 57:1510-6. 2005
    ..The aim of this study was to compare SERT availability in vivo in patients with schizophrenia and matched control subjects...
  31. ncbi request reprint Quantitative analysis of (-)-N-(11)C-propyl-norapomorphine in vivo binding in nonhuman primates
    Dah Ren Hwang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Nucl Med 45:338-46. 2004
    ..The goal of this study was to develop and evaluate analytic strategies to derive in vivo (11)C-NPA binding parameters...
  32. doi request reprint Imaging neurotransmitter release by drugs of abuse
    Diana Martinez
    NYS Psychiatric Institute, New York, NY 10032, USA
    Curr Top Behav Neurosci 3:219-45. 2010
    ..The results of these studies suggest that cocaine and alcohol addiction are associated with a loss of dopamine transmission, and a number of studies show that this loss correlates with severity of disease...

Research Grants7

  1. Imaging dopamine-2 (D2) receptor sites in schizophrenia
    Rajesh Narendran; Fiscal Year: 2007
    ..abstract_text> ..
  2. Imaging Cortical Dopamine Transmission in Alcohol Dependence
    Rajesh Narendran; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE In this application, we propose to use PET and fMRI to evaluate the functional significance of DA transmission abnormalities in the cortex of alcoholics. ..
  3. PET Imaging of Cortical Dopamine Transmission in Cocaine Addiction
    Rajesh Narendran; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: In this application we propose to further validate the use of [11C]FLB 457 to measure amphetamine- induced dopamine (DA) transmission in the human cortex. ..
  4. Imaging Cortical Dopamine Transmission in Alcohol Dependence
    Rajesh Narendran; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE In this application, we propose to use PET and fMRI to evaluate the functional significance of DA transmission abnormalities in the cortex of alcoholics. ..
  5. PET Imaging of Cortical Dopamine Transmission in Cocaine Addiction
    Rajesh Narendran; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: In this application we propose to further validate the use of [11C]FLB 457 to measure amphetamine- induced dopamine (DA) transmission in the human cortex. ..
  6. In vivo measurement of dopamine transmission in schizophrenia
    Rajesh Narendran; Fiscal Year: 2011
    ..In this proposal we seek to better understand the neurobiology underlying the cognitive abnormalities in schizophrenia;with the hope that, in turn, this will advance the development of novel treatments for these cognitive impairments. ..