Dean T Nardelli

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. doi request reprint Human Lyme disease vaccines: past and future concerns
    Dean T Nardelli
    University of Wisconsin, Department of Medical Microbiology and Immunology, Wisconsin State Laboratory of Hygiene, 465 Henry Mall, Madison, WI 53706, USA
    Future Microbiol 4:457-69. 2009
  2. doi request reprint Role of IL-17, transforming growth factor-beta, and IL-6 in the development of arthritis and production of anti-outer surface protein A borreliacidal antibodies in Borrelia-vaccinated and -challenged mice
    Dean T Nardelli
    Wisconsin State Laboratory of Hygiene, University of Wisconsin, Madison, WI 53706, USA
    FEMS Immunol Med Microbiol 53:265-74. 2008
  3. pmc Interleukin-23 is required for development of arthritis in mice vaccinated and challenged with Borrelia species
    Nicholas J Kotloski
    University of Wisconsin, Wisconsin State Laboratory of Hygiene, 465 Henry Mall, Madison, WI 53706, USA
    Clin Vaccine Immunol 15:1199-207. 2008
  4. pmc Anti-p19 antibody treatment exacerbates lyme arthritis and enhances borreliacidal activity
    Sara Heil Peterson
    University of Wisconsin, Wisconsin State Laboratory of Hygiene, Department of Bacteriology, and Department of Pathology, Veterans Administration Hospital, Madison, WI 53706, USA
    Clin Vaccine Immunol 14:510-7. 2007
  5. pmc CD4(+) CD25(+) T cells prevent arthritis associated with Borrelia vaccination and infection
    Dean T Nardelli
    University of Wisconsin, Wisconsin State Laboratory of Hygiene, 465 Henry Mall, Madison, WI 53706, USA
    Clin Diagn Lab Immunol 12:786-92. 2005
  6. pmc Anti-interleukin-15 prevents arthritis in Borrelia-vaccinated and -infected mice
    Corey A Amlong
    University of Wisconsin, Wisconsin State Laboratory of Hygiene, Department of Bacteriology, 465 Henry Mall, Madison, WI 53706, USA
    Clin Vaccine Immunol 13:289-96. 2006
  7. pmc Anti-CD25 antibody treatment of mice vaccinated and challenged with Borrelia spp. does not exacerbate arthritis but inhibits borreliacidal antibody production
    Dean T Nardelli
    University of Wisconsin, Wisconsin State Laboratory of Hygiene, 465 Henry Mall, Madison, WI 53706, USA
    Clin Vaccine Immunol 13:884-91. 2006
  8. pmc Association of CD4+ CD25+ T cells with prevention of severe destructive arthritis in Borrelia burgdorferi-vaccinated and challenged gamma interferon-deficient mice treated with anti-interleukin-17 antibody
    Dean T Nardelli
    Wisconsin State Laboratory of Hygiene, University of Wisconsin, 465 Henry Mall, Madison, WI 53706, USA
    Clin Diagn Lab Immunol 11:1075-84. 2004
  9. pmc Interleukin-6 promotes anti-OspA borreliacidal antibody production in vitro
    Erik L Munson
    University of Wisconsin, Wisconsin State Laboratory of Hygiene, 465 Henry Mall, Madison, WI 53706, USA
    Clin Vaccine Immunol 13:19-25. 2006
  10. pmc Interleukin-35 enhances Lyme arthritis in Borrelia-vaccinated and -infected mice
    Joseph Kuo
    Wisconsin State Laboratory of Hygiene, 465 Henry Mall, Madison, WI 53706, USA
    Clin Vaccine Immunol 18:1125-32. 2011

Collaborators

  • Ronald F Schell
  • Steven M Callister
  • Thomas F Warner
  • Sara Heil Peterson
  • Erik L Munson
  • Joseph Kuo
  • David J DeCoster
  • Nicholas J Kotloski
  • Jose R Torrealba
  • Corey A Amlong
  • Douglas M England
  • Matthew A Burchill
  • K H Kevin Luk
  • Monica C Remington
  • Scott M Kirk
  • John A Christopherson

Detail Information

Publications14

  1. doi request reprint Human Lyme disease vaccines: past and future concerns
    Dean T Nardelli
    University of Wisconsin, Department of Medical Microbiology and Immunology, Wisconsin State Laboratory of Hygiene, 465 Henry Mall, Madison, WI 53706, USA
    Future Microbiol 4:457-69. 2009
    ..Importantly, many of the drawbacks of the Lyme disease vaccine were apparent or foreseeable prior to its approval. These pitfalls must be confronted before the construction of a new, effective and safe human Lyme disease vaccine...
  2. doi request reprint Role of IL-17, transforming growth factor-beta, and IL-6 in the development of arthritis and production of anti-outer surface protein A borreliacidal antibodies in Borrelia-vaccinated and -challenged mice
    Dean T Nardelli
    Wisconsin State Laboratory of Hygiene, University of Wisconsin, Madison, WI 53706, USA
    FEMS Immunol Med Microbiol 53:265-74. 2008
    ..These findings demonstrate a role for the combined effects of IL-17, IL-6, and TGF-beta in the adaptive immune events leading to the development of Borrelia-induced arthritis...
  3. pmc Interleukin-23 is required for development of arthritis in mice vaccinated and challenged with Borrelia species
    Nicholas J Kotloski
    University of Wisconsin, Wisconsin State Laboratory of Hygiene, 465 Henry Mall, Madison, WI 53706, USA
    Clin Vaccine Immunol 15:1199-207. 2008
    ..These findings provide insight into previously overlooked immune mechanisms responsible for the development of Lyme arthritis...
  4. pmc Anti-p19 antibody treatment exacerbates lyme arthritis and enhances borreliacidal activity
    Sara Heil Peterson
    University of Wisconsin, Wisconsin State Laboratory of Hygiene, Department of Bacteriology, and Department of Pathology, Veterans Administration Hospital, Madison, WI 53706, USA
    Clin Vaccine Immunol 14:510-7. 2007
    ..The novel activities of anti-p19 antibody show that p19 may be an important therapeutic site for the treatment of Lyme arthritis...
  5. pmc CD4(+) CD25(+) T cells prevent arthritis associated with Borrelia vaccination and infection
    Dean T Nardelli
    University of Wisconsin, Wisconsin State Laboratory of Hygiene, 465 Henry Mall, Madison, WI 53706, USA
    Clin Diagn Lab Immunol 12:786-92. 2005
    ..These findings establish a major role for CD4(+) CD25(+) T cells in the prevention of arthritis in Borrelia-vaccinated and challenged animals...
  6. pmc Anti-interleukin-15 prevents arthritis in Borrelia-vaccinated and -infected mice
    Corey A Amlong
    University of Wisconsin, Wisconsin State Laboratory of Hygiene, Department of Bacteriology, 465 Henry Mall, Madison, WI 53706, USA
    Clin Vaccine Immunol 13:289-96. 2006
    ..These results suggest that IL-15 plays a major role in orchestrating IL-17 induction of arthritis associated with Borrelia-vaccinated and -infected mice...
  7. pmc Anti-CD25 antibody treatment of mice vaccinated and challenged with Borrelia spp. does not exacerbate arthritis but inhibits borreliacidal antibody production
    Dean T Nardelli
    University of Wisconsin, Wisconsin State Laboratory of Hygiene, 465 Henry Mall, Madison, WI 53706, USA
    Clin Vaccine Immunol 13:884-91. 2006
    ..These findings suggest that additional mechanisms besides CD4(+) CD25(+) T cells are involved in the regulation of the immune response to Borrelia infection following vaccination...
  8. pmc Association of CD4+ CD25+ T cells with prevention of severe destructive arthritis in Borrelia burgdorferi-vaccinated and challenged gamma interferon-deficient mice treated with anti-interleukin-17 antibody
    Dean T Nardelli
    Wisconsin State Laboratory of Hygiene, University of Wisconsin, 465 Henry Mall, Madison, WI 53706, USA
    Clin Diagn Lab Immunol 11:1075-84. 2004
    ..These results suggest that CD4+ CD25+ T cells are involved in regulation of a severe destructive arthritis induced with an experimental model of vaccination and challenge with B. burgdorferi...
  9. pmc Interleukin-6 promotes anti-OspA borreliacidal antibody production in vitro
    Erik L Munson
    University of Wisconsin, Wisconsin State Laboratory of Hygiene, 465 Henry Mall, Madison, WI 53706, USA
    Clin Vaccine Immunol 13:19-25. 2006
    ..Treatment with anti-IL-6 also inhibited enhanced borreliacidal antibody production induced by anti-gamma interferon. These data suggest that IL-6 plays a significant role in the production of anti-OspA borreliacidal antibodies...
  10. pmc Interleukin-35 enhances Lyme arthritis in Borrelia-vaccinated and -infected mice
    Joseph Kuo
    Wisconsin State Laboratory of Hygiene, 465 Henry Mall, Madison, WI 53706, USA
    Clin Vaccine Immunol 18:1125-32. 2011
    ..Our data do not support a role for IL-35 as a potential therapeutic agent to reduce inflammation in Lyme arthritis...
  11. pmc Neutralization of gamma interferon augments borreliacidal antibody production and severe destructive Lyme arthritis in C3H/HeJ mice
    Erik L Munson
    Wisconsin State Laboratory of Hygiene, University of Wisconsin, Madison, Wisconsin 53706, USA
    Clin Diagn Lab Immunol 11:35-41. 2004
    ..These studies are needed to ensure an effective and safe vaccine against infection with B. burgdorferi...
  12. pmc Lyme arthritis: current concepts and a change in paradigm
    Dean T Nardelli
    Wisconsin State Laboratory of Hygiene, University of Wisconsin, 465 Henry Mall, Madison, WI 53706, USA
    Clin Vaccine Immunol 15:21-34. 2008
  13. doi request reprint Mycobacterium tuberculosis susceptibility testing by flow cytometry
    Ronald F Schell
    University of Wisconsin, Madison, Wisconsin, USA
    Curr Protoc Cytom . 2004
    ..The use of flow cytometry both improves the quality of susceptibility testing and advances public health measures for the prevention and control of this ancient scourge...
  14. pmc Inhibition of interleukin-17 prevents the development of arthritis in vaccinated mice challenged with Borrelia burgdorferi
    Matthew A Burchill
    Wisconsin State Laboratory of Hygiene, University of Wisconsin, Madison 53706, USA
    Infect Immun 71:3437-42. 2003
    ..Therapeutic intervention may be a realistic approach to prevent arthritis, especially if IL-17 is involved in the perpetuation of chronic or intermittent arthritis...