Satya Narayan

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint SN2 DNA-alkylating agent-induced phosphorylation of p53 and activation of p21 gene expression
    Aruna S Jaiswal
    Department of Anatomy and Cell Biology, UF Shands Cancer Center, College of Medicine, University of Florida, P O Box 100232, Gainesville, FL 32610, USA
    Mutat Res 500:17-30. 2002
  2. ncbi request reprint Transforming growth factor -beta receptor signaling in cancer
    Satya Narayan
    Department of Anatomy and Cell Biology and UF Shands Cancer Center, University of Florida, Gainesville, FL 32610, USA
    Front Biosci 10:1135-45. 2005
  3. ncbi request reprint Tumor suppressor APC blocks DNA polymerase beta-dependent strand displacement synthesis during long patch but not short patch base excision repair and increases sensitivity to methylmethane sulfonate
    Satya Narayan
    Department of Anatomy and Cell Biology and Shands Cancer Center, University of Florida, Gainesville, Florida 32610, USA
    J Biol Chem 280:6942-9. 2005
  4. pmc Role of APC and DNA mismatch repair genes in the development of colorectal cancers
    Satya Narayan
    Department of Anatomy and Cell Biology and UF Shands Cancer Center, College of Medicine, Academic Research Building, Room R4 216, 1600 SW Archer Road, University of Florida, Gainesville, FL 32610, USA
    Mol Cancer 2:41. 2003
  5. ncbi request reprint Cigarette smoke condensate-induced transformation of normal human breast epithelial cells in vitro
    Satya Narayan
    Department of Anatomy and Cell Biology, UF Shands Cancer Center, Academic Research Building, Room R4 216, PO Box 100232, University of Florida, Gainesville, FL 32610, USA
    Oncogene 23:5880-9. 2004
  6. ncbi request reprint Zinc stabilizes adenomatous polyposis coli (APC) protein levels and induces cell cycle arrest in colon cancer cells
    Aruna S Jaiswal
    Department of Anatomy and Cell Biology and UF Shands Cancer Center, College of Medicine, University of Florida, Gainesville, Florida 32610, USA
    J Cell Biochem 93:345-57. 2004
  7. pmc Adenomatous polyposis coli-mediated accumulation of abasic DNA lesions lead to cigarette smoke condensate-induced neoplastic transformation of normal breast epithelial cells
    Aruna S Jaiswal
    Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL, USA
    Neoplasia 15:454-60. 2013
  8. pmc 9-bromonoscapine-induced mitotic arrest of cigarette smoke condensate-transformed breast epithelial cells
    Aruna S Jaiswal
    Department of Anatomy and Cell Biology and UF Shands Cancer Center, University of Florida, Gainesville, Florida 32610, USA
    J Cell Biochem 106:1146-56. 2009
  9. pmc DNA polymerase β as a novel target for chemotherapeutic intervention of colorectal cancer
    Aruna S Jaiswal
    Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 6:e16691. 2011
  10. pmc Adenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and function
    Aruna S Jaiswal
    Division of Hematology and Oncology, Department of Medicine, University of Florida, Gainesville, FL 32610, USA
    Neoplasia 14:495-508. 2012

Detail Information

Publications26

  1. ncbi request reprint SN2 DNA-alkylating agent-induced phosphorylation of p53 and activation of p21 gene expression
    Aruna S Jaiswal
    Department of Anatomy and Cell Biology, UF Shands Cancer Center, College of Medicine, University of Florida, P O Box 100232, Gainesville, FL 32610, USA
    Mutat Res 500:17-30. 2002
    ....
  2. ncbi request reprint Transforming growth factor -beta receptor signaling in cancer
    Satya Narayan
    Department of Anatomy and Cell Biology and UF Shands Cancer Center, University of Florida, Gainesville, FL 32610, USA
    Front Biosci 10:1135-45. 2005
    ..This review discusses the TGF-beta ligands and receptors, its positive and negative regulators in signaling, as well as its important roles with respect to tumor suppression and progression...
  3. ncbi request reprint Tumor suppressor APC blocks DNA polymerase beta-dependent strand displacement synthesis during long patch but not short patch base excision repair and increases sensitivity to methylmethane sulfonate
    Satya Narayan
    Department of Anatomy and Cell Biology and Shands Cancer Center, University of Florida, Gainesville, Florida 32610, USA
    J Biol Chem 280:6942-9. 2005
    ..Thus, APC may play a critical role in determining utilization of long versus short patch BER pathways and affect the susceptibility of colon cancer cells to carcinogenic and chemotherapeutic agents...
  4. pmc Role of APC and DNA mismatch repair genes in the development of colorectal cancers
    Satya Narayan
    Department of Anatomy and Cell Biology and UF Shands Cancer Center, College of Medicine, Academic Research Building, Room R4 216, 1600 SW Archer Road, University of Florida, Gainesville, FL 32610, USA
    Mol Cancer 2:41. 2003
    ..The focus of this review is to summarize the functions of APC and MMR gene products in the development of colorectal cancers...
  5. ncbi request reprint Cigarette smoke condensate-induced transformation of normal human breast epithelial cells in vitro
    Satya Narayan
    Department of Anatomy and Cell Biology, UF Shands Cancer Center, Academic Research Building, Room R4 216, PO Box 100232, University of Florida, Gainesville, FL 32610, USA
    Oncogene 23:5880-9. 2004
    ..In summary, our results suggest that CSC is capable of transforming the MCF10A cells in vitro, supporting the role of cigarette smoking and increased risk for breast cancer...
  6. ncbi request reprint Zinc stabilizes adenomatous polyposis coli (APC) protein levels and induces cell cycle arrest in colon cancer cells
    Aruna S Jaiswal
    Department of Anatomy and Cell Biology and UF Shands Cancer Center, College of Medicine, University of Florida, Gainesville, Florida 32610, USA
    J Cell Biochem 93:345-57. 2004
    ..On the other hand, ZnCl2 inhibits the proliferation of colon cancer cells (which carry the mutant APC gene) by disrupting cellular attachment and microtubule stability...
  7. pmc Adenomatous polyposis coli-mediated accumulation of abasic DNA lesions lead to cigarette smoke condensate-induced neoplastic transformation of normal breast epithelial cells
    Aruna S Jaiswal
    Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL, USA
    Neoplasia 15:454-60. 2013
    ....
  8. pmc 9-bromonoscapine-induced mitotic arrest of cigarette smoke condensate-transformed breast epithelial cells
    Aruna S Jaiswal
    Department of Anatomy and Cell Biology and UF Shands Cancer Center, University of Florida, Gainesville, Florida 32610, USA
    J Cell Biochem 106:1146-56. 2009
    ....
  9. pmc DNA polymerase β as a novel target for chemotherapeutic intervention of colorectal cancer
    Aruna S Jaiswal
    Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 6:e16691. 2011
    ..Our findings suggest a potential novel strategy for the development of highly specific structure-based inhibitor for the prevention of colonic tumor progression...
  10. pmc Adenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and function
    Aruna S Jaiswal
    Division of Hematology and Oncology, Department of Medicine, University of Florida, Gainesville, FL 32610, USA
    Neoplasia 14:495-508. 2012
    ....
  11. ncbi request reprint Structure/function analysis of the interaction of adenomatous polyposis coli with DNA polymerase beta and its implications for base excision repair
    Ramesh Balusu
    Department of Anatomy and Cell Biology, UF Shands Cancer Center, University of Florida, Gainesville, Florida 32610, USA
    Biochemistry 46:13961-74. 2007
    ..Collectively, our findings indicate that APC blocked both Pol-beta-directed SN- and LP-BER pathways and increased sensitivity of cells to alkylation induced DNA damage...
  12. pmc A novel inhibitor of DNA polymerase beta enhances the ability of temozolomide to impair the growth of colon cancer cells
    Aruna S Jaiswal
    Department of Anatomy and Cell Biology and University of Florida Shands Cancer Center, University of Florida, Gainesville, FL 32610, USA
    Mol Cancer Res 7:1973-83. 2009
    ..Our findings provide the "proof-of-concept" for the development of highly specific and thus safer structure-based inhibitors for the prevention of tumor progression and/or treatment of colorectal cancer...
  13. ncbi request reprint Adenomatous polyposis coli-mediated hypersensitivity of mouse embryonic fibroblast cell lines to methylmethane sulfonate treatment: implication of base excision repair pathways
    Chanakya N Kundu
    Department of Anatomy and Cell Biology and UF Shands Cancer Center, University of Florida, Gainesville, FL 32610, USA
    Carcinogenesis 28:2089-95. 2007
    ..These results suggest that an increased level of Apc can increase the efficacy of DNA-alkylating drugs used as a curative therapy...
  14. pmc Mechanism of adenomatous polyposis coli (APC)-mediated blockage of long-patch base excision repair
    Aruna S Jaiswal
    Department of Anatomy and Cell Biology and UF Shands Cancer Center, University of Florida, Gainesville, Florida 32610, USA
    Biochemistry 45:15903-14. 2006
    ..Third, APC can block LP-BER by blocking hit-and-run synthesis. These studies will have important implications for APC in DNA damage-induced carcinogenesis and chemoprevention...
  15. pmc N-methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA
    Aruna S Jaiswal
    UF Shands Cancer Center and Anatomy and Cell Biology, College of Medicine, Academic Research Building, Room R4 216, PO Box 100232, University of Florida, Gainesville, FL 32610, USA
    Mol Cancer 3:3. 2004
    ..In the present study we report that the DNA-damaging agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) is able to induce senescence in the HCT-116 colon cancer cell line...
  16. ncbi request reprint Long-patch base excision repair of apurinic/apyrimidinic site DNA is decreased in mouse embryonic fibroblast cell lines treated with plumbagin: involvement of cyclin-dependent kinase inhibitor p21Waf-1/Cip-1
    Aruna S Jaiswal
    Department of Anatomy and Cell Biology, College of Medicine, The University of Florida, Gainesville 32610, USA
    Oncogene 21:5912-22. 2002
    ..These findings suggest that plumbagin induced p21 levels play a regulatory role in cell cycle arrest, apoptosis, and polbeta-dependent and -independent LP-BER pathways in MEF cells...
  17. pmc Amino acid Asp181 of 5'-flap endonuclease 1 is a useful target for chemotherapeutic development
    Harekrushna Panda
    Department of Anatomy and Cell Biology and UF Shands Cancer Center, University of Florida, Gainesville, Florida 32610, USA
    Biochemistry 48:9952-8. 2009
    ....
  18. ncbi request reprint Reduced levels of the adenomatous polyposis coli (APC) protein are associated with ceramide-induced apoptosis of colon cancer cells
    Aruna S Jaiswal
    Department of Anatomy and Cell Biology, Academic Research Building, College of Medicine, University of Florida, Gainesville, 32610, USA
    J Cancer Res Clin Oncol 130:695-703. 2004
    ....
  19. pmc A novel function of adenomatous polyposis coli (APC) in regulating DNA repair
    Aruna S Jaiswal
    Department of Anatomy and Cell Biology and UF Shands Cancer Center, College of Medicine, University of Florida, Room 255, 1376 Mowry Road, Gainesville, FL 32610, United States
    Cancer Lett 271:272-80. 2008
    ....
  20. ncbi request reprint 7,12-Dimethylbenzanthracene-dependent transcriptional regulation of adenomatous polyposis coli (APC) gene expression in normal breast epithelial cells is mediated by GC-box binding protein Sp3
    Aruna S Jaiswal
    Department of Anatomy and Cell Biology and UF Shands Cancer Center, University of Florida, Gainesville, FL 32610, USA
    Carcinogenesis 27:252-61. 2006
    ..From these results we conclude that the increased pAPCP promoter activity in the MCF10A cell line in response to DMBA treatment is mediated by Sp3...
  21. ncbi request reprint Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells
    Aruna S Jaiswal
    Department of Anatomy and Cell Biology, College of Medicine, The University of Florida, Gainesville, Florida, FL 32610, USA
    Oncogene 21:8414-27. 2002
    ..Our results suggest that curcumin treatment impairs both Wnt signaling and cell-cell adhesion pathways, resulting in G(2)/M phase arrest and apoptosis in HCT-116 cells...
  22. pmc Assembly of the base excision repair complex on abasic DNA and role of adenomatous polyposis coli on its functional activity
    Aruna S Jaiswal
    Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida 32610, United States
    Biochemistry 50:1901-9. 2011
    ..Wild-type APC in the BER complex reduces the repair activity, probably because of interaction with multiple components of the system...
  23. ncbi request reprint Curcumin, a multi-functional chemopreventive agent, blocks growth of colon cancer cells by targeting beta-catenin-mediated transactivation and cell-cell adhesion pathways
    Satya Narayan
    Department of Anatomy and Cell Biology and UF Shands Cancer Center, College of Medicine, The University of Florida, Gainesville, FL 32610, USA
    J Mol Histol 35:301-7. 2004
    ..Curcumin (diferuloylmethane), a natural plant product, possesses such chemopreventive activity that targets multiple signalling pathways in the prevention of colon cancer development...
  24. ncbi request reprint Involvement of adenomatous polyposis coli in colorectal tumorigenesis
    Aruna S Jaiswal
    Department of Anatomy and Cell Biology and UF Shands Cancer Center, University of Florida, Gainesville, FL 32610 0232, USA
    Front Biosci 10:1118-34. 2005
    ..The role of APC is also implicated in cell migration, cell-cell adhesion, cell cycle control, and apoptosis. This article summarizes the structure-function studies and the role of APC mutations in colon cancer development...
  25. pmc Discovery of a novel class of AKT pleckstrin homology domain inhibitors
    Daruka Mahadevan
    College of Medicine, Arizona Cancer Center, University of Arizona, Tucson, AZ 85721 0038, USA
    Mol Cancer Ther 7:2621-32. 2008
    ..These results show that these compounds are the first small molecules selectively targeting the PH domain of AKT...
  26. ncbi request reprint Estrogen-induced generation of reactive oxygen and nitrogen species, gene damage, and estrogen-dependent cancers
    Deodutta Roy
    Department of Environmental and Occupational Health, Florida International University, Miami, Florida 33199, USA
    J Toxicol Environ Health B Crit Rev 10:235-57. 2007
    ....