Research Topics
| Sonia NapravnikSummaryAffiliation: University of North Carolina Country: USA Publications
Research Grants
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Detail Information
Publications
Enrollment, retention, and visit attendance in the University of North Carolina Center for AIDS Research HIV clinical cohort, 2001-2007Chanelle J Howe
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
AIDS Res Hum Retroviruses 26:875-81. 2010..The UNC CFAR clinical cohort has ample enrollment with retention and visit attendance modestly influenced by factors such as disease severity...- Outcomes of second combination antiretroviral therapy regimens among HIV-infected persons in clinical care: a multicenter cohort studySonia Napravnik
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7215, USA
AIDS Res Hum Retroviruses 29:574-80. 2013..The effectiveness of second cART regimens improved over calendar time and was independent of the anchor agent in the regimen... - Quantifying the treatment efficacy of reverse transcriptase inhibitors: new analyses of clinical data based on within-host modelingRomulus Breban
Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA
BMC Public Health 9:S11. 2009..Current measures of the clinical efficacy of antiretroviral therapy (ART) in the treatment of HIV include the change in HIV RNA in the plasma and the gain in CD4 cells... - CD4 count at presentation for HIV care in the United States and Canada: are those over 50 years more likely to have a delayed presentation?Keri N Althoff
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA
AIDS Res Ther 7:45. 2010..10%, respectively). Due to the increasing proportion, consistently lower CD4 counts, and more advanced HIV disease in adults ≥50-year-old at first presentation for HIV care, renewed HIV testing efforts are needed... 
HIV-1 drug resistance evolution among patients on potent combination antiretroviral therapy with detectable viremiaSonia Napravnik
School of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, 27599, USA
J Acquir Immune Defic Syndr 40:34-40. 2005....- Triple-class antiretroviral drug resistance: risk and predictors among HIV-1-infected patientsSonia Napravnik
Division of Infectious Diseases, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
AIDS 21:825-34. 2007..HIV-1 triple-class antiretroviral drug resistance (TC-DR) may substantially limit therapeutic options and compromise clinical outcomes... - Factors associated with fewer visits for HIV primary care at a tertiary care center in the Southeastern U.SSonia Napravnik
Division of Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7215, USA
AIDS Care 18:S45-50. 2006..Interventions including more intensive counseling and active outreach for newly HIV diagnosed individuals and support with obtaining health insurance and transportation may lead to improved outcomes... 
Quantification of CD4 responses to combined antiretroviral therapy over 5 years among HIV-infected children in Kinshasa, Democratic Republic of CongoAndrew Edmonds
Department of Epidemiology, The University of North Carolina at Chapel Hill, McGavran Greenberg Hall, CB 7435, Chapel Hill, NC 27599 7435, USA
J Acquir Immune Defic Syndr 61:90-8. 2012..We sought to describe this relationship...- Viremia copy-years predicts mortality among treatment-naive HIV-infected patients initiating antiretroviral therapyMichael J Mugavero
Department of Medicine, Division of Infectious Diseases, University of Alabama, Birmingham, AL, USA
Clin Infect Dis 53:927-35. 2011..We evaluated the cumulative effect of exposure to HIV replication on mortality following initiation of combination antiretroviral therapy (ART)... - The effect of highly active antiretroviral therapy on the survival of HIV-infected children in a resource-deprived setting: a cohort studyAndrew Edmonds
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
PLoS Med 8:e1001044. 2011..Because most pediatric HIV occurs in low- and middle-income countries, our objective was to provide a first estimate of this effect among children living in a resource-deprived setting... - Immunosuppression, hepatitis C infection, and acute renal failure in HIV-infected patientsNora Franceschini
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27514, USA
J Acquir Immune Defic Syndr 42:368-72. 2006..Low CD4 cell counts predict HIV-related morbidity and mortality and may be associated with acute renal failure (ARF)... - HIV-1 viral load and phenotypic antiretroviral drug resistance assays based on reverse transcriptase activity in comparison to amplification based HIV-1 RNA and genotypic assaysSonia Napravnik
Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
J Clin Virol 47:18-22. 2010..Amplification based HIV-1 viral load and genotypic resistance assays are expensive, technologically complex and may be difficult to implement in resource limited settings. Inexpensive, simpler assays are urgently needed... - Advanced immunosuppression at entry to HIV care in the southeastern United States and associated risk factorsCynthia L Gay
The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
AIDS 20:775-8. 2006..Male sex was an independent predictor in multivariable analysis. These results indicate an urgent need to increase HIV testing for earlier diagnosis in the southeastern USA... - Prevalence of transmitted antiretroviral drug resistance differs between acutely and chronically HIV-infected patientsElizabeth L Yanik
Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA
J Acquir Immune Defic Syndr 61:258-62. 2012..AHI was associated with 1.9 times the prevalence of TDR (95% confidence intervals: 1.0 to 3.6) in multivariable analysis. AHI patients may represent a vanguard group that portends increasing TDR in the future... - Anti-retroviral therapy reduces incident tuberculosis in HIV-infected childrenAndrew Edmonds
The University of North Carolina at Chapel Hill, Department of Epidemiology, Chapel Hill, NC, USA
Int J Epidemiol 38:1612-21. 2009..We aimed to estimate the effect of anti-retroviral therapy (ART) on incident tuberculosis (TB) in a cohort of HIV-infected children... - Performance characteristics of the Cavidi ExaVir viral load assay and the ultra-sensitive P24 assay relative to the Roche Monitor HIV-1 RNA assayPaul Stewart
The University of North Carolina at Chapel Hill, Department of Biostatistics, Chapel Hill, NC 27599 7420, USA paul
J Clin Virol 49:198-204. 2010.... - Phylogenetic insights into regional HIV transmissionAnn M Dennis
Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina 27599 7030, USA
AIDS 26:1813-22. 2012..We integrated phylogenetic analyses with clinical data to reveal trends in local HIV transmission... - Late entry to HIV care among Latinos compared with non-Latinos in a southeastern US cohortAnn M Dennis
Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7030, USA
Clin Infect Dis 53:480-7. 2011..The southeastern United States is a rapidly growing Latino settlement area where ethnic disparities may contribute to late presentation to care... - Copy-years viremia as a measure of cumulative human immunodeficiency virus viral burdenStephen R Cole
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
Am J Epidemiol 171:198-205. 2010..Copy-years viremia, a novel measure of cumulative viral burden, may provide prognostic information beyond traditional single measures of viremia... - Risk factors for tuberculosis after highly active antiretroviral therapy initiation in the United States and Canada: implications for tuberculosis screeningTimothy R Sterling
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
J Infect Dis 204:893-901. 2011..Identifying factors associated with developing tuberculosis after HAART initiation could focus screening efforts... - Incidence and etiology of acute renal failure among ambulatory HIV-infected patientsNora Franceschini
Division of Nephrology and Hypertension, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Kidney Int 67:1526-31. 2005..Its incidence and causes have not been studied since the introduction of highly active antiretroviral therapy (HAART) in HIV ambulatory patients... - Ezetimibe alone reduces low-density lipoprotein cholesterol in HIV-infected patients receiving combination antiretroviral therapyDavid A Wohl
University of North Carolina, Chapel Hill, NC 27599, USA
Clin Infect Dis 47:1105-8. 2008..5% (+4 mg/dL) with ezetimibe treatment and placebo, respectively (P = .04). Ezetimibe was safe and effective in reducing low-density lipoprotein cholesterol and is an option for patients who cannot tolerate treatment with a statin... - Effect of hepatitis C coinfection on discontinuation and modification of initial HAART in primary HIV careDina Hooshyar
Division of Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599-7215, USA
AIDS 20:575-83. 2006..95-2.03; P = 0.09). CONCLUSION: HCV coinfection was only marginally associated with a shorter duration of an initial HAART regimen, suggesting optimization of a first HAART regimen may not appreciably depend on HCV serostatus... - HIV and parasitic infection and the effect of treatment among adult outpatients in MalawiMina C Hosseinipour
University of North Carolina Project, Lilongwe, Malawi
J Infect Dis 195:1278-82. 2007..Successful treatment of parasitic infections had no effect on HIV RNA levels. Although common, parasitic infections did not impact HIV RNA levels... - Comparative effectiveness of initial antiretroviral therapy regimens: ACTG 5095 and 5142 clinical trials relative to ART-CC cohort studyMichael J Mugavero
Division of Infectious Disease, Department of Medicine, University of Alabama, Birmingham, AL, USA
J Acquir Immune Defic Syndr 58:253-60. 2011.... - Self-report of current and prior antiretroviral drug use in comparison to the medical record among HIV-infected patients receiving primary HIV careEmily Suzanne Brouwer
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
Pharmacoepidemiol Drug Saf 20:432-9. 2011..In this study we assessed the ability of HIV-infected patients receiving care in a university infectious diseases clinic to accurately recall current and past ARVs... - Randomized study of the safety and efficacy of fish oil (omega-3 fatty acid) supplementation with dietary and exercise counseling for the treatment of antiretroviral therapy-associated hypertriglyceridemiaDavid A Wohl
Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA
Clin Infect Dis 41:1498-504. 2005..Whether omega-3 fatty acid supplementation can reduce hypertriglyceridemia associated with antiretroviral therapy is not known... - Gender difference in HIV RNA levels: a meta-analysis of published studiesSonia Napravnik
School of Public Health, Department of Epidemiology, Division of Infectious Diseases, University of North Carolina at Chapel Hill, 27599, USA
J Acquir Immune Defic Syndr 31:11-9. 2002.... - Frequency of HIV-related medication errors and associated risk factors in hospitalized patientsSonak D Pastakia
Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Purdue University, Indianapolis, IN 46202, USA
Ann Pharmacother 42:491-7. 2008..Retrospective studies of hospitalized HIV-infected patients have noted a high occurrence of drug-related errors, ranging from 5% to 30%... - Substance abuse and symptoms of mental illness among HIV-positive persons in the SoutheastKathryn Whetten
Department of Public Policy, Duke University, Durham, NC, USA
South Med J 98:9-14. 2005..Antiretroviral therapies will not reach their potential for slowing the HIV/AIDS epidemic and prolonging survival if comorbidities that influence patient behavior are not addressed...
Research Grants
- Comparative safety of antiretrovirals among HIV-infected patients: minimizing corSonia Napravnik; Fiscal Year: 2010....