Laura A Napolitano

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Increased circulating interleukin-7 levels in HIV-1-infected women
    Laura A Napolitano
    Gladstone Institute of Virology and Immunology, University of California at San Francisco, 94158, USA
    J Acquir Immune Defic Syndr 40:581-4. 2005
  2. ncbi Growth hormone enhances thymic function in HIV-1-infected adults
    Laura A Napolitano
    Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA
    J Clin Invest 118:1085-98. 2008
  3. ncbi Increased thymic mass and circulating naive CD4 T cells in HIV-1-infected adults treated with growth hormone
    Laura A Napolitano
    Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, CA 94141, USA
    AIDS 16:1103-11. 2002
  4. ncbi Effects of IL-7 on early human thymocyte progenitor cells in vitro and in SCID-hu Thy/Liv mice
    Laura A Napolitano
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94141, USA
    J Immunol 171:645-54. 2003
  5. ncbi Growth hormone-induced stimulation of multilineage human hematopoiesis
    Mary B Hanley
    Gladstone Institute of Virology and Immunology, 1650 Owens Street, San Francisco, California 94158-2261, USA
    Stem Cells 23:1170-9. 2005
  6. ncbi Approaches to immune reconstitution in HIV infection
    Laura A Napolitano
    University of California-San Francisco, San Francisco, CA, USA
    Top HIV Med 11:160-3. 2003
  7. ncbi Associations of insulin-like growth factor (IGF)-I and IGF-binding protein-3 with HIV disease progression in women
    Howard D Strickler
    Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 197:319-27. 2008
  8. ncbi Accumulation of DC-SIGN+CD40+ dendritic cells with reduced CD80 and CD86 expression in lymphoid tissue during acute HIV-1 infection
    Karin Lore
    Division of Clinical Virology, Department of Microbiology, Pathology and Immunology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    AIDS 16:683-92. 2002

Research Grants

  1. REGULATION OF THYMOPOIESIS IN HIV1 DISEASE
    Laura Napolitano; Fiscal Year: 2003
  2. Growth Hormone/Insulin-Like Growth Factor-1/T-Cell
    Laura Napolitano; Fiscal Year: 2005
  3. Positron Emission Tomography to Evaluate Thymic Function
    Laura Napolitano; Fiscal Year: 2006
  4. Effects of Growth Hormone and Insulin-like Growth Factor-1 on Thymopoiesis
    Laura Napolitano; Fiscal Year: 2007

Detail Information

Publications8

  1. ncbi Increased circulating interleukin-7 levels in HIV-1-infected women
    Laura A Napolitano
    Gladstone Institute of Virology and Immunology, University of California at San Francisco, 94158, USA
    J Acquir Immune Defic Syndr 40:581-4. 2005
    ..0032) after controlling for CD4 count, age, and race. Given the important role of IL-7 in T-cell development and homeostasis, these findings suggest that higher IL-7 levels may contribute to higher CD4 counts in women...
  2. ncbi Growth hormone enhances thymic function in HIV-1-infected adults
    Laura A Napolitano
    Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA
    J Clin Invest 118:1085-98. 2008
    ..Further, these randomized, prospective data have shown that thymic involution can be pharmacologically reversed in humans, suggesting that immune-based therapies could be used to enhance thymopoiesis in immunodeficient individuals...
  3. ncbi Increased thymic mass and circulating naive CD4 T cells in HIV-1-infected adults treated with growth hormone
    Laura A Napolitano
    Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, CA 94141, USA
    AIDS 16:1103-11. 2002
    ..CONCLUSION: GH has significant effects on the human immune system, including the reversal of thymic atrophy in HIV-1-infected adults. De-novo T cell production may thus be inducible in immunodeficient adults...
  4. ncbi Effects of IL-7 on early human thymocyte progenitor cells in vitro and in SCID-hu Thy/Liv mice
    Laura A Napolitano
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94141, USA
    J Immunol 171:645-54. 2003
    ..Given the growing interest in the use of IL-7 for the treatment of human immunodeficiency, these findings support additional investigation into its in vivo effects on thymopoiesis and HIV infection...
  5. ncbi Growth hormone-induced stimulation of multilineage human hematopoiesis
    Mary B Hanley
    Gladstone Institute of Virology and Immunology, 1650 Owens Street, San Francisco, California 94158-2261, USA
    Stem Cells 23:1170-9. 2005
    ..These findings identify specific targets of GH and IGF-I within human FBM, and demonstrate direct and indirect effects that may contribute to GH-mediated enhancement of human hemato-lymphopoiesis...
  6. ncbi Approaches to immune reconstitution in HIV infection
    Laura A Napolitano
    University of California-San Francisco, San Francisco, CA, USA
    Top HIV Med 11:160-3. 2003
  7. ncbi Associations of insulin-like growth factor (IGF)-I and IGF-binding protein-3 with HIV disease progression in women
    Howard D Strickler
    Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 197:319-27. 2008
    ....
  8. ncbi Accumulation of DC-SIGN+CD40+ dendritic cells with reduced CD80 and CD86 expression in lymphoid tissue during acute HIV-1 infection
    Karin Lore
    Division of Clinical Virology, Department of Microbiology, Pathology and Immunology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    AIDS 16:683-92. 2002
    ..Dendritic cells (DC) are target cells for HIV-1 and play a key role in antigen presentation and activation of T cells...

Research Grants4

  1. REGULATION OF THYMOPOIESIS IN HIV1 DISEASE
    Laura Napolitano; Fiscal Year: 2003
    ....
  2. Growth Hormone/Insulin-Like Growth Factor-1/T-Cell
    Laura Napolitano; Fiscal Year: 2005
    ..We will perform longitudinal analysis of HIV and CMV-specific immune responses in the context of a randomized prospective clinical study examining the effects of GH on the immune system of HIV-infected adults. ..
  3. Positron Emission Tomography to Evaluate Thymic Function
    Laura Napolitano; Fiscal Year: 2006
    ..abstract_text> ..
  4. Effects of Growth Hormone and Insulin-like Growth Factor-1 on Thymopoiesis
    Laura Napolitano; Fiscal Year: 2007
    ..If successful, this information would be directly applicable to the future development of targeted therapies to enhance T cell production in immunodeficient individuals. ..