Amin A Nanji

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Animal models of nonalcoholic fatty liver disease and steatohepatitis
    Amin A Nanji
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Clin Liver Dis 8:559-74, ix. 2004
  2. ncbi request reprint Role of different dietary fatty acids in the pathogenesis of experimental alcoholic liver disease
    Amin A Nanji
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 3400 Spruce Street, Founders 7 103, Philadelphia, PA 19104, USA
    Alcohol 34:21-5. 2004
  3. ncbi request reprint Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genes
    Amin A Nanji
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 4283, USA
    Am J Physiol Gastrointest Liver Physiol 284:G321-7. 2003
  4. ncbi request reprint Alcoholic liver injury in the rat is associated with reduced expression of peroxisome proliferator-alpha (PPARalpha)-regulated genes and is ameliorated by PPARalpha activation
    Amin A Nanji
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 4283, USA
    J Pharmacol Exp Ther 310:417-24. 2004
  5. ncbi request reprint Increased severity of alcoholic liver injury in female verses male rats: a microarray analysis
    Meena R Sharma
    Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Mol Pathol 84:46-58. 2008
  6. ncbi request reprint Transcriptional networks in a rat model for nonalcoholic fatty liver disease: a microarray analysis
    Meena R Sharma
    Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, A 414 VA Medical Center, Woodland Avenue, Philadelphia, PA 19104, USA
    Exp Mol Pathol 81:202-10. 2006
  7. ncbi request reprint Animal models of alcoholic liver disease--focus on the intragastric feeding model
    Amin A Nanji
    Department of Pathology, University of Pennsylvania, Philadelphia, USA
    Alcohol Res Health 27:325-30. 2003
  8. doi request reprint A voluntary oral ethanol-feeding rat model associated with necroinflammatory liver injury
    George L Tipoe
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China
    Alcohol Clin Exp Res 32:669-82. 2008
  9. ncbi request reprint Expression of hepatocyte growth factor and its receptor c-met, correlates with severity of pathological injury in experimental alcoholic liver disease
    El Nasir Lalani
    Department of Histopathology, Imperial College School of Medicine, Hammersmith Campus, London, UK
    Int J Mol Med 15:811-7. 2005
  10. doi request reprint A voluntary oral-feeding rat model for pathological alcoholic liver injury
    George L Tipoe
    Department of Anatomy, The University of Hong Kong, Hong Kong, SAR China
    Methods Mol Biol 447:11-31. 2008

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Animal models of nonalcoholic fatty liver disease and steatohepatitis
    Amin A Nanji
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Clin Liver Dis 8:559-74, ix. 2004
    ..The purpose of this article is to update information regarding animal models in the pathogenesis of NAFLD...
  2. ncbi request reprint Role of different dietary fatty acids in the pathogenesis of experimental alcoholic liver disease
    Amin A Nanji
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 3400 Spruce Street, Founders 7 103, Philadelphia, PA 19104, USA
    Alcohol 34:21-5. 2004
    ..The mechanisms through which the fatty acids promote alcoholic liver disease include enhanced oxidative stress, production of endotoxin, and increased expression of proinflammatory cytokines...
  3. ncbi request reprint Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genes
    Amin A Nanji
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 4283, USA
    Am J Physiol Gastrointest Liver Physiol 284:G321-7. 2003
    ..Thus curcumin prevents experimental ALD, in part by suppressing induction of NF-kappaB-dependent genes...
  4. ncbi request reprint Alcoholic liver injury in the rat is associated with reduced expression of peroxisome proliferator-alpha (PPARalpha)-regulated genes and is ameliorated by PPARalpha activation
    Amin A Nanji
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 4283, USA
    J Pharmacol Exp Ther 310:417-24. 2004
    ....
  5. ncbi request reprint Increased severity of alcoholic liver injury in female verses male rats: a microarray analysis
    Meena R Sharma
    Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Mol Pathol 84:46-58. 2008
    ....
  6. ncbi request reprint Transcriptional networks in a rat model for nonalcoholic fatty liver disease: a microarray analysis
    Meena R Sharma
    Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, A 414 VA Medical Center, Woodland Avenue, Philadelphia, PA 19104, USA
    Exp Mol Pathol 81:202-10. 2006
    ..Nonalcoholic fatty liver disease (NAFLD) is a common hepatic condition that may progress to end-stage liver disease. High-fat diets in animals reproduce many of the features found in nonalcoholic steatohepatitis...
  7. ncbi request reprint Animal models of alcoholic liver disease--focus on the intragastric feeding model
    Amin A Nanji
    Department of Pathology, University of Pennsylvania, Philadelphia, USA
    Alcohol Res Health 27:325-30. 2003
    ..This model allows scientists to rigorously control an animal's consumption of both alcohol and dietary nutrients and is providing important information on the mechanisms of injury of alcoholic liver disease...
  8. doi request reprint A voluntary oral ethanol-feeding rat model associated with necroinflammatory liver injury
    George L Tipoe
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China
    Alcohol Clin Exp Res 32:669-82. 2008
    ....
  9. ncbi request reprint Expression of hepatocyte growth factor and its receptor c-met, correlates with severity of pathological injury in experimental alcoholic liver disease
    El Nasir Lalani
    Department of Histopathology, Imperial College School of Medicine, Hammersmith Campus, London, UK
    Int J Mol Med 15:811-7. 2005
    ..Thus, up-regulation of HGF and c-met occurred in the presence of the necrosis and inflammation suggesting that HGF may be acting to protect against liver injury or accelerate the regenerative process...
  10. doi request reprint A voluntary oral-feeding rat model for pathological alcoholic liver injury
    George L Tipoe
    Department of Anatomy, The University of Hong Kong, Hong Kong, SAR China
    Methods Mol Biol 447:11-31. 2008
    ....
  11. ncbi request reprint Lysosomal leakage and lack of adaptation of hepatoprotective enzyme contribute to enhanced susceptibility to ethanol-induced liver injury in female rats
    Terrence M Donohue
    Liver Study Unit, VA Nebraska, Western Iowa Health Care Network, Omaha, Nebraska 68105, USA
    Alcohol Clin Exp Res 31:1944-52. 2007
    ..Here, we determined whether differential liver injury occurred in male and female rats after feeding these animals liquid diets containing either ethanol or isocaloric dextrose with fish oil as the sole source of lipid...
  12. ncbi request reprint Pathogenesis of alcoholic liver disease--recent advances
    Amin A Nanji
    Department of Pathology and Center for the Study of Liver Diseases, The University of Hong Kong and Queen Mary Hospital
    Alcohol Clin Exp Res 26:731-6. 2002
    ..French...
  13. ncbi request reprint Green tea polyphenols prevent toxin-induced hepatotoxicity in mice by down-regulating inducible nitric oxide-derived prooxidants
    Ju Hua Chen
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA
    Am J Clin Nutr 80:742-51. 2004
    ..Green tea polyphenols have both antioxidant and antiinflammatory properties...
  14. ncbi request reprint Role of apoptosis in alcoholic liver injury
    Hiromasa Ishii
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Alcohol Clin Exp Res 27:1207-12. 2003
    ..C. Fernández-Checa; (4) Toxicity of ethanol in HepG2 cells that express CYP2E1, by A.I. Cederbaum; (5) Is alcohol-enhanced liver apoptosis a pathogenic factor in alcoholic liver disease? by I.V. Deaciuc...
  15. ncbi request reprint Liver asialoglycoprotein receptor levels correlate with severity of alcoholic liver damage in rats
    Carol A Casey
    Liver Study Unit, Department of Internal Medicine and Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha NE 68198, USA
    J Appl Physiol 96:76-80. 2004
    ..These results demonstrate that a correlation exists between the progression of alcohol-associated liver injury, as defined by the severity of liver pathology, and an ethanol-induced decline in ASGP-R content...
  16. pmc Endothelial nitric oxide synthase is a critical factor in experimental liver fibrosis
    Tung Ming Leung
    Department of Pathology and Laboratory Medicine, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada
    Int J Exp Pathol 89:241-50. 2008
    ..Our results showed that the reduced eNOS expression in CCl(4)-treated mice was reversed by L-arginine. Furthermore, L-arginine also reversed the reduced AP-1 activity, an eNOS promoter...
  17. ncbi request reprint Another animal model for nonalcoholic steatohepatitis: how close to the human condition?
    Amin A Nanji
    Am J Clin Nutr 79:350-1. 2004
  18. ncbi request reprint Decreased proteasome activity is associated with increased severity of liver pathology and oxidative stress in experimental alcoholic liver disease
    Terrence M Donohue
    Liver Study Unit, The Omaha Department of Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
    Alcohol Clin Exp Res 28:1257-63. 2004
    ..This study examined the relationship of proteasome activity and content with ethanol-induced oxidative stress and the degree of liver injury...
  19. ncbi request reprint Expression and functions of vasoactive substances regulated by hypoxia-inducible factor-1 in chronic hypoxemia
    George L Tipoe
    Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Cardiovasc Hematol Agents Med Chem 4:199-218. 2006
    ..In conclusion, the adaptive response to long-term hypoxemia involves compensatory mechanisms mediated by expressing significant levels of HIF-1alpha and vasoactive substances regulated by HIF-1...
  20. ncbi request reprint Macrophage migration inhibitory factor expression correlates with inflammatory changes in human chronic hepatitis B infection
    Hai Ying Zhang
    Department of Medicine, The University of Hong Kong, Hong Kong, SAR, China
    Liver Int 25:571-9. 2005
    ..Macrophage migration inhibitory factor (MIF) has emerged to be a pivotal cytokine in immune-mediated diseases...
  21. ncbi request reprint Induction of CYP3A by ethanol in multiple in vitro and in vivo models
    Dennis E Feierman
    Department of Anesthesiology, The Mount Sinai Medical Center, New York, New York 10029 6574, USA
    Alcohol Clin Exp Res 27:981-8. 2003
    ..Because ethanol is used widely, its potential interaction with CYP3A is of great interest. The effects of ethanol on CYP3A content and activity were assessed in different in vivo and in vitro models...
  22. ncbi request reprint Role of Kupffer cells in alcoholic hepatitis
    Amin A Nanji
    Department of Pathology and Center for the Study of Liver Diseases, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Alcohol 27:13-5. 2002
    ..Inflammatory cytokines and cyclooxygenase-2 are up-regulated in response to binding of NF-kappa B. A combined role for tumor necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 is important in the pathogenesis of alcoholic hepatitis...
  23. ncbi request reprint L-Buthionine (S,R) sulfoximine depletes hepatic glutathione but protects against ethanol-induced liver injury
    Terrence M Donohue
    Liver Study Unit, U S Department of Veterans Affairs Medical Center, University of Nebraska Medical Center, Omaha, Nebraska 68105, USA
    Alcohol Clin Exp Res 31:1053-60. 2007
    ..Here we investigated whether treatment with BSO enhanced ethanol-induced liver injury in mice...