Nguyen Hai Nam

Summary

Affiliation: University of Rhode Island
Country: USA

Publications

  1. ncbi New constituents from Crinum latifolium with inhibitory effects against tube-like formation of human umbilical venous endothelial cells
    Nguyen Hai Nam
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Nat Prod Res 18:485-91. 2004
  2. ncbi Naturally occurring NF-kappaB inhibitors
    Nguyen Hai Nam
    University of Pharmacy, 13 15 Le Thanh Tong, Hanoi, Vietnam
    Mini Rev Med Chem 6:945-51. 2006
  3. ncbi Synthesis and Biological Evaluation of A Series of (Benzo[d]thiazol-2-yl)cyclohexanecarboxamides and (Benzo[d]thiazol-2-yl)cyclohexanecarbothioamides
    Nguyen Hai Nam
    Department of Pharmaceutical Chemistry, Hanoi University of Pharmacy, 13 15 Le Thanh Tong, Hanoi, Vietnam
    Med Chem 6:159-64. 2010
  4. ncbi Combretastatin-chalcone hybrids: synthesis and cytotoxicity
    Nguyen Hai Nam
    Department of Pharmaceutical Chemistry, Hanoi University of Pharmacy, 13 15 Le Thanh Tong, Hanoi, Vietnam
    Med Chem 3:373-7. 2007
  5. ncbi Synthesis and biological evaluation of a series of 2-(substitutedphenyl)benzothiazoles
    Nguyen Hai Nam
    Department of Pharmaceutical Chemistry, Hanoi University of Pharmacy, 13 15 Le Thanh Tong, Hanoi, Vietnam
    Med Chem 7:127-34. 2011
  6. ncbi New benzothiazole/thiazole-containing hydroxamic acids as potent histone deacetylase inhibitors and antitumor agents
    Truong Thanh Tung
    Department of Pharmaceutical Chemistry, Hanoi University of Pharmacy, 13 15 Le Thanh Tong, Hanoi, Vietnam
    Med Chem 9:1051-7. 2013
  7. doi Novel isatin-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents
    Nguyen Hai Nam
    Hanoi University of Pharmacy, 13 15 Le Thanh Tong, Hanoi, Viet Nam Electronic address
    Eur J Med Chem 70:477-86. 2013
  8. ncbi Reactions of solid-supported reagents and solid supports with alcohols and phenols through their hydroxyl functional group
    Nguyen Hai Nam
    Department of Biomedical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02881, USA
    J Comb Chem 5:479-546. 2003
  9. doi Benzothiazole-containing hydroxamic acids as histone deacetylase inhibitors and antitumor agents
    Dao Thi Kim Oanh
    Hanoi University of Pharmacy, 13 15 Le Thanh Tong, Hanoi, Viet Nam
    Bioorg Med Chem Lett 21:7509-12. 2011
  10. ncbi Synthesis and evaluation of biological activities of a series of (6-substituted benzothiazol-2-yl)acrylamides
    Nam Nguyen-Hai
    Department of Pharmaceutical Chemistry, Hanoi University of Pharmacy, 13 15 Le Thanh Tong, Hanoi, Vietnam
    Med Chem 7:727-31. 2011

Collaborators

  • Jin Tae Hong
  • S Sardari
  • K Parang
  • Young Jae You
  • Yong Kim
  • Byung Zun Ahn
  • Dao Thi Kim Oanh
  • Guofeng Ye
  • Truong Thanh Tung
  • Sang Bae Han
  • Byung Woo Han
  • Sang Ho Park
  • Van Thi My Hue
  • Nam Nguyen-Hai
  • Gongqin Sun
  • Byung Sun Min
  • Youngsoo Kim
  • Phan Thi Phuong Dung
  • Thi Phuong Dung Phan
  • The Cuòng Tran
  • Hoang Le
  • Thi Hien Tran
  • Dinh Chau Phan
  • Hyun Jung Kim
  • Hoang Van Hai
  • Hyung Sook Kim
  • Thanh Hieu Doan
  • Ali Saleh
  • Anil Kumar
  • Dinesh B Shenoy
  • Mansoor M Amiji
  • Xiaofeng Lin
  • Marina Ayrapetov
  • Seong Cheol Bang
  • Hyun Ju Jun
  • KiHwan Bae
  • Min Kyun Na
  • Sam Sik Kang
  • Ha Thi Thanh Huong
  • Jung Hee Kim
  • Hyeong Kyu Lee
  • Ki Hwan Bae

Detail Information

Publications28

  1. ncbi New constituents from Crinum latifolium with inhibitory effects against tube-like formation of human umbilical venous endothelial cells
    Nguyen Hai Nam
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Nat Prod Res 18:485-91. 2004
    ..Other compounds, including cycloartenol (1), 4',7-dihydroxy-3'-methoxyflavan (3), 4',7-dihydroxyflavan (4), and 2',4',7-trihydroxydihydrochalcone (5) were found to be nearly inactive...
  2. ncbi Naturally occurring NF-kappaB inhibitors
    Nguyen Hai Nam
    University of Pharmacy, 13 15 Le Thanh Tong, Hanoi, Vietnam
    Mini Rev Med Chem 6:945-51. 2006
    ..In this mini-review we will discuss the medicinal chemistry of these compounds with regards to the NF-kappaB inhibition...
  3. ncbi Synthesis and Biological Evaluation of A Series of (Benzo[d]thiazol-2-yl)cyclohexanecarboxamides and (Benzo[d]thiazol-2-yl)cyclohexanecarbothioamides
    Nguyen Hai Nam
    Department of Pharmaceutical Chemistry, Hanoi University of Pharmacy, 13 15 Le Thanh Tong, Hanoi, Vietnam
    Med Chem 6:159-64. 2010
    ....
  4. ncbi Combretastatin-chalcone hybrids: synthesis and cytotoxicity
    Nguyen Hai Nam
    Department of Pharmaceutical Chemistry, Hanoi University of Pharmacy, 13 15 Le Thanh Tong, Hanoi, Vietnam
    Med Chem 3:373-7. 2007
    ..all-trans-1-(2,5-Dihydroxyphenyl)-5-(4-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-2,4-pentanediene-1-one (3a) was the most potent compound from this series...
  5. ncbi Synthesis and biological evaluation of a series of 2-(substitutedphenyl)benzothiazoles
    Nguyen Hai Nam
    Department of Pharmaceutical Chemistry, Hanoi University of Pharmacy, 13 15 Le Thanh Tong, Hanoi, Vietnam
    Med Chem 7:127-34. 2011
    ..07-13.21 μg/ml). Brominated and nitrated derivatives (1k, 1l, respectively) of 1e exhibited even more potent cytotoxicity...
  6. ncbi New benzothiazole/thiazole-containing hydroxamic acids as potent histone deacetylase inhibitors and antitumor agents
    Truong Thanh Tung
    Department of Pharmaceutical Chemistry, Hanoi University of Pharmacy, 13 15 Le Thanh Tong, Hanoi, Vietnam
    Med Chem 9:1051-7. 2013
    ..In vitro, compound 3a exhibited cytotoxicity equipotent to SAHA against five human cancer cell lines. In term of in vivo activity, compound 3a demonstrated equivalent efficacy to SAHA in mouse xenograft model. ..
  7. doi Novel isatin-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents
    Nguyen Hai Nam
    Hanoi University of Pharmacy, 13 15 Le Thanh Tong, Hanoi, Viet Nam Electronic address
    Eur J Med Chem 70:477-86. 2013
    ..Compounds 3a and 6a also bound to HDAC2 at the binding site with high binding affinity. These findings should encourage further elaboration with the isatin moiety to produce more potent HDAC inhibitors with potential anticancer activity...
  8. ncbi Reactions of solid-supported reagents and solid supports with alcohols and phenols through their hydroxyl functional group
    Nguyen Hai Nam
    Department of Biomedical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02881, USA
    J Comb Chem 5:479-546. 2003
  9. doi Benzothiazole-containing hydroxamic acids as histone deacetylase inhibitors and antitumor agents
    Dao Thi Kim Oanh
    Hanoi University of Pharmacy, 13 15 Le Thanh Tong, Hanoi, Viet Nam
    Bioorg Med Chem Lett 21:7509-12. 2011
    ..81 μg/ml, almost equipotent to SAHA...
  10. ncbi Synthesis and evaluation of biological activities of a series of (6-substituted benzothiazol-2-yl)acrylamides
    Nam Nguyen-Hai
    Department of Pharmaceutical Chemistry, Hanoi University of Pharmacy, 13 15 Le Thanh Tong, Hanoi, Vietnam
    Med Chem 7:727-31. 2011
    ..66 μg/ml. The synthesized compounds also exhibited some antifungal effects against Apergillus niger...
  11. ncbi Combretastatin A-4 analogues as antimitotic antitumor agents
    Nguyen Hai Nam
    Department of Biomedical Sciences, College of Pharmacy, University of Rhode Island, RI 02881, USA
    Curr Med Chem 10:1697-722. 2003
    ..In this paper, the structure-activity relationships and pharmacological properties of the CA-4 derivatives as a class of potent antimitotic anticancer agents are reviewed and discussed...
  12. ncbi Synthesis and anti-tumor activity of novel combretastatins: combretocyclopentenones and related analogues
    Nguyen Hai Nam
    College of Pharmacy, Chungnam National University, Taejon 305 764, Republic of Korea
    Bioorg Med Chem Lett 12:1955-8. 2002
    ..Compounds 8a-c, 8e and 9a showed strong cytotoxicity with IC(50) values in the range of 8-34ng/mL. Compound 8e exhibited significant anti-tumor activity in BDF1 mice bearing Lewis lung carcinoma cells with an inhibition ratio of 59%...
  13. pmc Synthesis and evaluation of tripodal peptide analogues for cellular delivery of phosphopeptides
    Guofeng Ye
    Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island 02881, USA
    J Med Chem 50:3604-17. 2007
    ..These studies suggest that amphipathic tripodal peptide analogues, such as LPA4, can be used for cellular delivery of phosphopeptides...
  14. ncbi Solid-phase binding assays of peptides using EGFP-Src SH2 domain fusion protein and biotinylated Src SH2 domain
    Guofeng Ye
    Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, 41 Lower College Road, Kingston, RI 02881, USA
    Bioorg Med Chem Lett 15:4994-7. 2005
    ..These solid-phase binding assays may have potential applications for the screening of peptides for the Src kinases SH2 domains...
  15. ncbi Furo-1,2-naphthoquinones from Crataegus pinnatifida with ICAM-1 expression inhibition activity
    Byung Sun Min
    Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea
    Planta Med 70:1166-9. 2004
    ..The two compounds 1 and 2 showed significant inhibitory activity with IC50 values of 33 and 90 microM, respectively, against the expression of intercellular adhesion molecule-1 (ICAM-1)...
  16. ncbi Carboxylic acid and phosphate ester derivatives of fluconazole: synthesis and antifungal activities
    Nguyen Hai Nam
    Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, 41 Lower College Road, Kingston, RI 02881, USA
    Bioorg Med Chem 12:6255-69. 2004
    ..These results demonstrate the potential of these antifungal agents for further development as sustained-release topical antifungal chemotherapeutic agents...
  17. ncbi Synthesis and cytotoxicity of 2,5-dihydroxychalcones and related compounds
    Nguyen Hai Nam
    College of Pharmacy, Chungnam National University, Taejon 305 764, Korea
    Arch Pharm Res 27:581-8. 2004
    ..Among the synthesized compounds, 2'-chloro-2, 5-dihydroxychalcone (9) was most potent, with an IC50 value as low as 0.31 microg/mL. This compound also exhibited a significant cytotoxic selectivity toward HUVEC...
  18. ncbi 2,3-dibenzylbutyrolactones and 1,2,3,4-tetrahydro-2-naphthoic acid gamma-lactones: structure and activity relationship in cytotoxic activity
    Yong Kim
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Arch Pharm Res 25:240-9. 2002
    ..In TNL series, presence of 3,4-dioxy group in ring A and 2-methoxy group in ring C was essential for the enhancement of the activity...
  19. ncbi Preliminary structure-antiangiogenic activity relationships of 4-senecioyloxymethyl-6,7-dimethoxycoumarin
    Nguyen Hai Nam
    College of Pharmacy, Chungnam National University, Taejon, Republic of Korea
    Bioorg Med Chem Lett 12:2345-8. 2002
    ..We have also synthesized compound 12, an analogue of 6d, with equipotency and improved water solubility...
  20. ncbi Water soluble prodrugs of the antitumor agent 3-[(3-amino-4-methoxy)phenyl]-2-(3,4,5-trimethoxyphenyl)cyclopent-2-ene-1-one
    Nguyen Hai Nam
    College of Pharmacy, Chungnam National University, Taejon 305 764, South Korea
    Bioorg Med Chem 11:1021-9. 2003
    ..The similar approaches may be used to improve water solubility and bioactivity of other poorly soluble aromatic amines...
  21. ncbi Cytotoxic 2',5'-dihydroxychalcones with unexpected antiangiogenic activity
    Nguyen Hai Nam
    College of Pharmacy, Chungnam National University, Taejon, 305 764, South Korea
    Eur J Med Chem 38:179-87. 2003
    ..When administered into BDF1 mice bearing Lewis lung carcinoma cells at 50 mg kg(-1) day(-1), 2-3 was found to inhibit the growth of tumor mass by 60.5%...
  22. ncbi Antiangiogenic activity of lupeol from Bombax ceiba
    Young Jae You
    College of Pharmacy, Chungnam National University, Taejon 305 764, Korea
    Phytother Res 17:341-4. 2003
    ..At 50 and 30 microg/mL lupeol showed a marked inhibitory activity on HUVEC tube formation while it did not affect the growth of tumor cell lines such as SK-MEL-2, A549, and B16-F10 melanoma...
  23. ncbi Inhibitory effect of Adonis amurensis components on tube-like formation of human umbilical venous cells
    Young Jae You
    College of Pharmacy, Chungnam National University, Taejon 305 764, South Korea
    Phytother Res 17:568-70. 2003
    ..Cymarin and cymarol exhibited potent cytotoxicity against a human solid tumor cell line A549 (human lung carcinoma), while being inactive on murine leukemic cells (L1210)...
  24. ncbi Synthesis and cytotoxic activity of A-ring modified betulinic acid derivatives
    Young Jae You
    College of Pharmacy, Chungnam National University, Taejon 305 764, South Korea
    Bioorg Med Chem Lett 13:3137-40. 2003
    ..Especially, the compounds bearing 1-ene-3-oxo with electron-withdrawing groups at C2 showed strong cytotoxicity...
  25. ncbi Design of tetrapeptide ligands as inhibitors of the Src SH2 domain
    Nguyen Hai Nam
    Department of Biomedical Sciences, College of Pharmacy, The University of Rhode Island, Kingston, RI 02881, USA
    Bioorg Med Chem 12:779-87. 2004
    ..Overall, these results provided the structure-activity relationships for some FEEI and YEEI derivatives designed as Src SH2 domain inhibitors...
  26. ncbi Alkyl and carboxylalkyl esters of 4'-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxic, and antitumor activity
    Young Jae You
    College of Pharmacy, Chungnam National University, Taejon 305 764, South Korea
    Eur J Med Chem 39:189-93. 2004
    ..Among 19 esters, esters of propanoic acid, tetradecanedioic acid, 13-carboxyundecanoic acid, and hexadecanedioic acid improved the antitumor activity compared with that of the starting compounds, DDPT...
  27. ncbi Conformationally constrained peptide analogues of pTyr-Glu-Glu-Ile as inhibitors of the Src SH2 domain binding
    Nguyen Hai Nam
    Department of Biomedical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    J Med Chem 47:3131-41. 2004
    ..These constrained peptides can serve as novel templates for the design of small and nonpeptidic inhibitors of the Src SH2 domain...
  28. ncbi Synthesis and cytotoxicity of 3,4-diaryl-2(5H)-furanones
    Yong Kim
    College of Pharmacy, Chungnam National University, Taejon 305 764, Republic of Korea
    Bioorg Med Chem Lett 12:719-22. 2002
    ....