Research Topics
| Nguyen Hai NamSummaryAffiliation: University of Rhode Island Country: USA Publications
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Detail Information
Publications
New constituents from Crinum latifolium with inhibitory effects against tube-like formation of human umbilical venous endothelial cellsNguyen Hai Nam
College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
Nat Prod Res 18:485-91. 2004..Other compounds, including cycloartenol (1), 4',7-dihydroxy-3'-methoxyflavan (3), 4',7-dihydroxyflavan (4), and 2',4',7-trihydroxydihydrochalcone (5) were found to be nearly inactive...- Naturally occurring NF-kappaB inhibitorsNguyen Hai Nam
University of Pharmacy, 13 15 Le Thanh Tong, Hanoi, Vietnam
Mini Rev Med Chem 6:945-51. 2006..In this mini-review we will discuss the medicinal chemistry of these compounds with regards to the NF-kappaB inhibition... - Synthesis and Biological Evaluation of A Series of (Benzo[d]thiazol-2-yl)cyclohexanecarboxamides and (Benzo[d]thiazol-2-yl)cyclohexanecarbothioamidesNguyen Hai Nam
Department of Pharmaceutical Chemistry, Hanoi University of Pharmacy, 13 15 Le Thanh Tong, Hanoi, Vietnam
Med Chem 6:159-64. 2010.... - Synthesis and biological evaluation of a series of 2-(substitutedphenyl)benzothiazolesNguyen Hai Nam
Department of Pharmaceutical Chemistry, Hanoi University of Pharmacy, 13 15 Le Thanh Tong, Hanoi, Vietnam
Med Chem 7:127-34. 2011..07-13.21 μg/ml). Brominated and nitrated derivatives (1k, 1l, respectively) of 1e exhibited even more potent cytotoxicity... - Combretastatin-chalcone hybrids: synthesis and cytotoxicityNguyen Hai Nam
Department of Pharmaceutical Chemistry, Hanoi University of Pharmacy, 13 15 Le Thanh Tong, Hanoi, Vietnam
Med Chem 3:373-7. 2007..all-trans-1-(2,5-Dihydroxyphenyl)-5-(4-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-2,4-pentanediene-1-one (3a) was the most potent compound from this series... - Reactions of solid-supported reagents and solid supports with alcohols and phenols through their hydroxyl functional groupNguyen-Hai Nam
Department of Biomedical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02881, USA
J Comb Chem 5:479-546. 2003 
Benzothiazole-containing hydroxamic acids as histone deacetylase inhibitors and antitumor agentsDao Thi Kim Oanh
Hanoi University of Pharmacy, 13 15 Le Thanh Tong, Hanoi, Viet Nam
Bioorg Med Chem Lett 21:7509-12. 2011..81 μg/ml, almost equipotent to SAHA...- Synthesis and evaluation of biological activities of a series of (6-substituted benzothiazol-2-yl)acrylamidesNam Nguyen-Hai
Department of Pharmaceutical Chemistry, Hanoi University of Pharmacy, 13 15 Le Thanh Tong, Hanoi, Vietnam
Med Chem 7:727-31. 2011..66 μg/ml. The synthesized compounds also exhibited some antifungal effects against Apergillus niger... - Combretastatin A-4 analogues as antimitotic antitumor agentsNguyen Hai Nam
Department of Biomedical Sciences, College of Pharmacy, University of Rhode Island, RI 02881, USA
Curr Med Chem 10:1697-722. 2003..In this paper, the structure-activity relationships and pharmacological properties of the CA-4 derivatives as a class of potent antimitotic anticancer agents are reviewed and discussed... - Synthesis and anti-tumor activity of novel combretastatins: combretocyclopentenones and related analoguesNguyen-Hai Nam
College of Pharmacy, Chungnam National University, Taejon 305-764, Republic of Korea
Bioorg Med Chem Lett 12:1955-8. 2002..Compounds 8a-c, 8e and 9a showed strong cytotoxicity with IC(50) values in the range of 8-34ng/mL. Compound 8e exhibited significant anti-tumor activity in BDF1 mice bearing Lewis lung carcinoma cells with an inhibition ratio of 59%... 
Synthesis and evaluation of tripodal peptide analogues for cellular delivery of phosphopeptidesGuofeng Ye
Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island 02881, USA
J Med Chem 50:3604-17. 2007..These studies suggest that amphipathic tripodal peptide analogues, such as LPA4, can be used for cellular delivery of phosphopeptides...- Solid-phase binding assays of peptides using EGFP-Src SH2 domain fusion protein and biotinylated Src SH2 domainGuofeng Ye
Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, 41 Lower College Road, Kingston, RI 02881, USA
Bioorg Med Chem Lett 15:4994-7. 2005..These solid-phase binding assays may have potential applications for the screening of peptides for the Src kinases SH2 domains... - Furo-1,2-naphthoquinones from Crataegus pinnatifida with ICAM-1 expression inhibition activityByung-Sun Min
Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea
Planta Med 70:1166-9. 2004..The two compounds 1 and 2 showed significant inhibitory activity with IC50 values of 33 and 90 microM, respectively, against the expression of intercellular adhesion molecule-1 (ICAM-1)... - Carboxylic acid and phosphate ester derivatives of fluconazole: synthesis and antifungal activitiesNguyen-Hai Nam
Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, 41 Lower College Road, Kingston, RI 02881, USA
Bioorg Med Chem 12:6255-69. 2004..These results demonstrate the potential of these antifungal agents for further development as sustained-release topical antifungal chemotherapeutic agents... - Synthesis and cytotoxicity of 2,5-dihydroxychalcones and related compoundsNguyen-Hai Nam
College of Pharmacy, Chungnam National University, Taejon 305-764, Korea
Arch Pharm Res 27:581-8. 2004..Among the synthesized compounds, 2'-chloro-2, 5-dihydroxychalcone (9) was most potent, with an IC50 value as low as 0.31 microg/mL. This compound also exhibited a significant cytotoxic selectivity toward HUVEC... - Conformationally constrained peptide analogues of pTyr-Glu-Glu-Ile as inhibitors of the Src SH2 domain bindingNguyen-Hai Nam
Department of Biomedical Sciences, University of Rhode Island, Kingston, RI 02881, USA
J Med Chem 47:3131-41. 2004..These constrained peptides can serve as novel templates for the design of small and nonpeptidic inhibitors of the Src SH2 domain... - 2,3-dibenzylbutyrolactones and 1,2,3,4-tetrahydro-2-naphthoic acid gamma-lactones: structure and activity relationship in cytotoxic activityYong Kim
College of Pharmacy, Chungnam National University, Daejeon, Korea
Arch Pharm Res 25:240-9. 2002..In TNL series, presence of 3,4-dioxy group in ring A and 2-methoxy group in ring C was essential for the enhancement of the activity... - Preliminary structure-antiangiogenic activity relationships of 4-senecioyloxymethyl-6,7-dimethoxycoumarinNguyen Hai Nam
College of Pharmacy, Chungnam National University, Taejon, Republic of Korea
Bioorg Med Chem Lett 12:2345-8. 2002..We have also synthesized compound 12, an analogue of 6d, with equipotency and improved water solubility... - Water soluble prodrugs of the antitumor agent 3-[(3-amino-4-methoxy)phenyl]-2-(3,4,5-trimethoxyphenyl)cyclopent-2-ene-1-oneNguyen Hai Nam
College of Pharmacy, Chungnam National University, Taejon 305 764, South Korea
Bioorg Med Chem 11:1021-9. 2003..The similar approaches may be used to improve water solubility and bioactivity of other poorly soluble aromatic amines... - Cytotoxic 2',5'-dihydroxychalcones with unexpected antiangiogenic activityNguyen-Hai Nam
College of Pharmacy, Chungnam National University, Taejon, 305-764, South Korea
Eur J Med Chem 38:179-87. 2003..When administered into BDF1 mice bearing Lewis lung carcinoma cells at 50 mg kg(-1) day(-1), 2-3 was found to inhibit the growth of tumor mass by 60.5%... - Antiangiogenic activity of lupeol from Bombax ceibaYoung Jae You
College of Pharmacy, Chungnam National University, Taejon 305 764, Korea
Phytother Res 17:341-4. 2003..At 50 and 30 microg/mL lupeol showed a marked inhibitory activity on HUVEC tube formation while it did not affect the growth of tumor cell lines such as SK-MEL-2, A549, and B16-F10 melanoma... - Inhibitory effect of Adonis amurensis components on tube-like formation of human umbilical venous cellsYoung Jae You
College of Pharmacy, Chungnam National University, Taejon 305 764, South Korea
Phytother Res 17:568-70. 2003..Cymarin and cymarol exhibited potent cytotoxicity against a human solid tumor cell line A549 (human lung carcinoma), while being inactive on murine leukemic cells (L1210)... - Synthesis and cytotoxic activity of A-ring modified betulinic acid derivativesYoung-Jae You
College of Pharmacy, Chungnam National University, Taejon 305-764, South Korea
Bioorg Med Chem Lett 13:3137-40. 2003..Especially, the compounds bearing 1-ene-3-oxo with electron-withdrawing groups at C2 showed strong cytotoxicity... - Design of tetrapeptide ligands as inhibitors of the Src SH2 domainNguyen-Hai Nam
Department of Biomedical Sciences, College of Pharmacy, The University of Rhode Island, Kingston, RI 02881, USA
Bioorg Med Chem 12:779-87. 2004..Overall, these results provided the structure-activity relationships for some FEEI and YEEI derivatives designed as Src SH2 domain inhibitors... - Alkyl and carboxylalkyl esters of 4'-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxic, and antitumor activityYoung-Jae You
College of Pharmacy, Chungnam National University, Taejon 305-764, South Korea
Eur J Med Chem 39:189-93. 2004..Among 19 esters, esters of propanoic acid, tetradecanedioic acid, 13-carboxyundecanoic acid, and hexadecanedioic acid improved the antitumor activity compared with that of the starting compounds, DDPT... - Synthesis and cytotoxicity of 3,4-diaryl-2(5H)-furanonesYong Kim
College of Pharmacy, Chungnam National University, Taejon 305-764, Republic of Korea
Bioorg Med Chem Lett 12:719-22. 2002....