B K Nallamothu

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. doi request reprint Comparison of clinical interpretation with visual assessment and quantitative coronary angiography in patients undergoing percutaneous coronary intervention in contemporary practice: the Assessing Angiography (A2) project
    Brahmajee K Nallamothu
    Ann Arbor VA Center for Clinical Management and Research and University of Michigan Health System, Ann Arbor, MI, USA
    Circulation 127:1793-800. 2013
  2. pmc Contemporary evidence: baseline data from the D2B Alliance
    Elizabeth H Bradley
    Section of Health Policy and Administration, School of Public Health, Yale University School of Medicine, New Haven, Connecticut, USA
    BMC Res Notes 1:23. 2008
  3. pmc Hospital variation in transfusion and infection after cardiac surgery: a cohort study
    Mary A M Rogers
    Division of General Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    BMC Med 7:37. 2009
  4. ncbi request reprint Impact of patient risk on the hospital volume-outcome relationship in coronary artery bypass grafting
    Brahmajee K Nallamothu
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, 48109 0366, USA
    Arch Intern Med 165:333-7. 2005
  5. pmc Coronary revascularization at specialty cardiac hospitals and peer general hospitals in black Medicare beneficiaries
    Brahmajee K Nallamothu
    Health Services Research and Development Center of Excellence, Ann Arbor VA Medical Center, Ann Arbor, Mich, USA
    Circ Cardiovasc Qual Outcomes 1:116-22. 2008
  6. ncbi request reprint Clinical problem-solving. Double jeopardy
    Brahmajee K Nallamothu
    Health Services Research and Development Center of Excellence, Ann Arbor Veterans Affairs Medical Center, and the Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    N Engl J Med 353:75-80. 2005
  7. ncbi request reprint Skilled care requirements for elderly patients after coronary artery bypass grafting
    Brahmajee K Nallamothu
    Health Services Research and Development Center of Excellence, Ann Arbor Veterans Affairs Medical Center, Ann Arbor, Michigan 48109, USA
    J Am Geriatr Soc 53:1133-7. 2005
  8. ncbi request reprint Recent trends in hospital utilization for acute myocardial infarction and coronary revascularization in the United States
    Brahmajee K Nallamothu
    VA Health Services Research and Development Center of Excellence, Ann Arbor VA Medical Center, Ann Arbor, Michigan, USA
    Am J Cardiol 99:749-53. 2007
  9. doi request reprint Door-to-balloon times in hospitals within the get-with-the-guidelines registry after initiation of the door-to-balloon (D2B) Alliance
    Brahmajee K Nallamothu
    Ann Arbor VA Medical Center, Michigan, USA
    Am J Cardiol 103:1051-5. 2009
  10. doi request reprint Beyond the randomized clinical trial: the role of effectiveness studies in evaluating cardiovascular therapies
    Brahmajee K Nallamothu
    Health Services Research and Development Center of Excellence, Ann Arbor VA Medical Center, Ann Arbor, MI, USA
    Circulation 118:1294-303. 2008

Research Grants

  1. Impact of Specialty Hospitals on Procedure Utilization
    Brahmajee Nallamothu; Fiscal Year: 2005

Detail Information

Publications82

  1. doi request reprint Comparison of clinical interpretation with visual assessment and quantitative coronary angiography in patients undergoing percutaneous coronary intervention in contemporary practice: the Assessing Angiography (A2) project
    Brahmajee K Nallamothu
    Ann Arbor VA Center for Clinical Management and Research and University of Michigan Health System, Ann Arbor, MI, USA
    Circulation 127:1793-800. 2013
    ..Despite the potential implications of such findings, no large-scale efforts to measure or improve clinical interpretation were subsequently undertaken...
  2. pmc Contemporary evidence: baseline data from the D2B Alliance
    Elizabeth H Bradley
    Section of Health Policy and Administration, School of Public Health, Yale University School of Medicine, New Haven, Connecticut, USA
    BMC Res Notes 1:23. 2008
    ..This study presents data on (1) the prevalence of evidence-based strategies in U.S. hospitals that participated in the D2B Alliance and (2) identifies key hospital characteristics associated with their use...
  3. pmc Hospital variation in transfusion and infection after cardiac surgery: a cohort study
    Mary A M Rogers
    Division of General Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    BMC Med 7:37. 2009
    ..Concomitant with this re-examination have been reports showing variability in the use of specific blood components. This investigation was designed to assess hospital variation in blood use and outcomes in cardiac surgery patients...
  4. ncbi request reprint Impact of patient risk on the hospital volume-outcome relationship in coronary artery bypass grafting
    Brahmajee K Nallamothu
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, 48109 0366, USA
    Arch Intern Med 165:333-7. 2005
    ..We assessed (1) whether in-hospital mortality rates differ across lower- and higher-volume hospitals by expected surgical risk and (2) whether high-risk patients are more likely to undergo CABG at low-volume centers...
  5. pmc Coronary revascularization at specialty cardiac hospitals and peer general hospitals in black Medicare beneficiaries
    Brahmajee K Nallamothu
    Health Services Research and Development Center of Excellence, Ann Arbor VA Medical Center, Ann Arbor, Mich, USA
    Circ Cardiovasc Qual Outcomes 1:116-22. 2008
    ..Critics have raised concerns that specialty cardiac hospitals exacerbate racial disparities in cardiovascular care, but empirical data are limited...
  6. ncbi request reprint Clinical problem-solving. Double jeopardy
    Brahmajee K Nallamothu
    Health Services Research and Development Center of Excellence, Ann Arbor Veterans Affairs Medical Center, and the Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    N Engl J Med 353:75-80. 2005
  7. ncbi request reprint Skilled care requirements for elderly patients after coronary artery bypass grafting
    Brahmajee K Nallamothu
    Health Services Research and Development Center of Excellence, Ann Arbor Veterans Affairs Medical Center, Ann Arbor, Michigan 48109, USA
    J Am Geriatr Soc 53:1133-7. 2005
    ..To examine the extent to which elderly individuals use various skilled care facilities after coronary artery bypass grafting (CABG)...
  8. ncbi request reprint Recent trends in hospital utilization for acute myocardial infarction and coronary revascularization in the United States
    Brahmajee K Nallamothu
    VA Health Services Research and Development Center of Excellence, Ann Arbor VA Medical Center, Ann Arbor, Michigan, USA
    Am J Cardiol 99:749-53. 2007
    ..In conclusion, the number and rates of hospitalization for AMI and coronary revascularization in the United States are decreasing...
  9. doi request reprint Door-to-balloon times in hospitals within the get-with-the-guidelines registry after initiation of the door-to-balloon (D2B) Alliance
    Brahmajee K Nallamothu
    Ann Arbor VA Medical Center, Michigan, USA
    Am J Cardiol 103:1051-5. 2009
    ..These improvements were broad and not limited to hospitals that joined the D2B Alliance...
  10. doi request reprint Beyond the randomized clinical trial: the role of effectiveness studies in evaluating cardiovascular therapies
    Brahmajee K Nallamothu
    Health Services Research and Development Center of Excellence, Ann Arbor VA Medical Center, Ann Arbor, MI, USA
    Circulation 118:1294-303. 2008
  11. ncbi request reprint Broken bodies, broken hearts? Limitations of the trauma system as a model for regionalizing care for ST-elevation myocardial infarction in the United States
    Brahmajee K Nallamothu
    Health Services Research and Development Center of Excellence, VA Medical Center, Ann Arbor, MI, USA
    Am Heart J 152:613-8. 2006
    ..In this article, we briefly review the current status of trauma systems in the United States and describe why the regionalization of STEMI care may require different methods of healthcare organization...
  12. ncbi request reprint Opening of specialty cardiac hospitals and use of coronary revascularization in medicare beneficiaries
    Brahmajee K Nallamothu
    VA Health Services Research and Development Center of Excellence, Ann Arbor, Mich, USA
    JAMA 297:962-8. 2007
    ..Although proponents argue that specialty cardiac hospitals provide high-quality cost-efficient care, strong financial incentives for physicians at these facilities could result in greater procedure utilization...
  13. ncbi request reprint Acute myocardial infarction and congestive heart failure outcomes at specialty cardiac hospitals
    Brahmajee K Nallamothu
    Health Services Research and Development Center of Excellence, Ann Arbor VA Medical Center, and Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Mich, USA
    Circulation 116:2280-7. 2007
    ..Outcomes of patients with acute myocardial infarction (AMI) and congestive heart failure (CHF) at specialty cardiac hospitals are uncertain...
  14. ncbi request reprint Is acetylcysteine effective in preventing contrast-related nephropathy? A meta-analysis
    Brahmajee K Nallamothu
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0311, USA
    Am J Med 117:938-47. 2004
    ..Although previous meta-analyses have concluded that acetylcysteine is beneficial, the recent availability of additional trials calls for reassessment of current evidence...
  15. pmc Operator experience and carotid stenting outcomes in Medicare beneficiaries
    Brahmajee K Nallamothu
    Center for Healthcare Outcomes and Policy, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    JAMA 306:1338-43. 2011
    ..Although the efficacy of carotid stenting has been established in clinical trials, outcomes of the procedure based on operator experience are less certain in clinical practice...
  16. ncbi request reprint Homocyst(e)ine and coronary heart disease: pharmacoeconomic support for interventions to lower hyperhomocyst(e)inaemia
    Brahmajee K Nallamothu
    Department of Internal Medicine, University of Michigan Medical School, B1F245 University Hospital, Ann Arbor, MI 49109 0022, USA
    Pharmacoeconomics 20:429-42. 2002
    ....
  17. ncbi request reprint Coronary artery bypass grafting in octogenarians: clinical and economic outcomes at community-based healthcare facilities
    Brahmajee K Nallamothu
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, USA
    Am J Manag Care 8:749-55. 2002
    ..Results of recent studies from high-volume academic centers suggest that coronary artery bypass grafting (CABG) is becoming safer to perform in octogenarians. Similar data from community-based facilities do not exist...
  18. ncbi request reprint Electron-beam computed tomography in the diagnosis of coronary artery disease: a meta-analysis
    B K Nallamothu
    B1F245, Division of General Medicine, University Hospital, Ann Arbor, MI 48109 0022, USA
    Arch Intern Med 161:833-8. 2001
    ..Before its clinical use is justified, however, the overall accuracy of EBCT must be better defined...
  19. pmc Coronary artery bypass grafting in Native Americans: a higher risk of death compared to other ethnic groups?
    B K Nallamothu
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109 0022, USA
    J Gen Intern Med 16:554-9. 2001
    ..While the efficacy and safety of coronary artery bypass grafting (CABG) has been established in several clinical trials, little is known about its outcomes in Native Americans...
  20. ncbi request reprint Potential clinical and economic effects of homocyst(e)ine lowering
    B K Nallamothu
    Division of General Medicine, University of Michigan Medical Center, 3116 Taubman Center, Ann Arbor, MI 48109 0376, USA
    Arch Intern Med 160:3406-12. 2000
    ..However, the benefits expected from lowering homocyst(e)ine levels with folic acid and vitamin B(12) supplementation have yet to be demonstrated in clinical trials...
  21. ncbi request reprint Relation between hospital specialization with primary percutaneous coronary intervention and clinical outcomes in ST-segment elevation myocardial infarction: National Registry of Myocardial Infarction-4 analysis
    Brahmajee K Nallamothu
    Health Services Research and Development Center of Excellence, Ann Arbor VA Medical Center, Ann Arbor, Michigan, USA
    Circulation 113:222-9. 2006
    ..Whether a greater level of hospital specialization with PPCI is associated with better quality of care is unknown...
  22. ncbi request reprint The role of hospital volume in coronary artery bypass grafting: is more always better?
    B K Nallamothu
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0366, USA
    J Am Coll Cardiol 38:1923-30. 2001
    ..The goal of this study was to determine whether outcomes of nonemergent coronary artery bypass grafting (CABG) differed between low- and high-volume hospitals in patients at different levels of surgical risk...
  23. ncbi request reprint Syncope in acute aortic dissection: diagnostic, prognostic, and clinical implications
    Brahmajee K Nallamothu
    University of Michigan Medical School, Ann Arbor, Michigan, USA
    Am J Med 113:468-71. 2002
    ..Syncope is a well-recognized symptom of acute aortic dissection, often indicating the development of dangerous complications such as cardiac tamponade...
  24. pmc Association of door-to-balloon time and mortality in patients > or =65 years with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention
    Saif S Rathore
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Cardiol 104:1198-203. 2009
    ....
  25. doi request reprint Trends in acute reperfusion therapy for ST-segment elevation myocardial infarction from 1999 to 2006: we are getting better but we have got a long way to go
    Kim A Eagle
    University of Michigan Cardiovascular Center, Ann Arbor, MI 48109 0477, USA
    Eur Heart J 29:609-17. 2008
    ..Many patients who are eligible for acute reperfusion therapy receive it after substantial delays or not at all. We wanted to determine whether over the years more patients are receiving reperfusion therapy...
  26. doi request reprint Primary percutaneous coronary intervention expansion to hospitals without on-site cardiac surgery in Michigan: a geographic information systems analysis
    Jeremy W Buckley
    University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Am Heart J 155:668-72. 2008
    ..In 2005, Michigan expanded primary percutaneous coronary intervention (P-PCI) capability to 12 hospitals without on-site cardiac surgery. We determined the potential impact of this expansion on geographic access to P-PCI for patients...
  27. ncbi request reprint Allogeneic blood transfusions explain increased mortality in women after coronary artery bypass graft surgery
    Mary A M Rogers
    Division of General Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0429, USA
    Am Heart J 152:1028-34. 2006
    ..Because allogeneic blood transfusions are more common in women and have been associated with immunomodulation, the impact of transfusion on sex differences in infection and mortality was examined...
  28. ncbi request reprint Incremental benefit and cost-effectiveness of high-dose statin therapy in high-risk patients with coronary artery disease
    Paul S Chan
    University of Michigan Department of Internal Medicine, Ann Arbor, MI, USA
    Circulation 115:2398-409. 2007
    ..However, the actual benefit and cost-effectiveness of high-dose statin therapy are unknown...
  29. doi request reprint Commentary: the role of percutaneous coronary intervention in ST-segment-elevation myocardial infarction
    Eric R Bates
    CVC Cardiovascular Medicine, 1500 E Medical Center Dr, Ann Arbor, MI 48109 5869, USA
    Circulation 118:567-73. 2008
  30. ncbi request reprint Safety of carotid artery stenting for symptomatic carotid artery disease: a meta-analysis
    Hitinder S Gurm
    Division of Cardiovascular Medicine, University of Michigan Health System, 2A 394, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0311, USA
    Eur Heart J 29:113-9. 2008
    ..We performed a meta-analysis to systematically evaluate currently available data by comparing CAS with CEA in patients with symptomatic carotid artery disease...
  31. pmc Acute reperfusion therapy in ST-elevation myocardial infarction from 1994-2003
    Brahmajee K Nallamothu
    Health Services Research and Development Center of Excellence, Ann Arbor VA Medical Center, Ann Arbor, Mich, USA
    Am J Med 120:693-9. 2007
    ..Appropriate utilization of acute reperfusion therapy is not a national performance measure for ST-elevation myocardial infarction at this time, and the extent of its contemporary use among ideal patients is unknown...
  32. doi request reprint The University of Michigan Specialist-Hospitalist Allied Research Program: jumpstarting hospital medicine research
    Scott A Flanders
    Hospitalist Program, Division of General Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    J Hosp Med 3:308-13. 2008
    ..Ideally, a successful hospital-based clinical research program will need to partner hospitalists with specialists...
  33. ncbi request reprint Vasodilator therapy in patients with aortic insufficiency: a systematic review
    Ali Mahajerin
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0366, USA
    Am Heart J 153:454-61. 2007
    ..The use of vasodilators to improve long-term outcomes in asymptomatic patients with chronic aortic insufficiency (AI) is controversial...
  34. pmc Interhospital transfers among Medicare beneficiaries admitted for acute myocardial infarction at nonrevascularization hospitals
    Theodore J Iwashyna
    Department of Internal Medicine, University of Michigan Medical School, 300 North Ingalls, Ann Arbor, MI 48109 5419, USA
    Circ Cardiovasc Qual Outcomes 3:468-75. 2010
    ....
  35. ncbi request reprint Times to treatment in transfer patients undergoing primary percutaneous coronary intervention in the United States: National Registry of Myocardial Infarction (NRMI)-3/4 analysis
    Brahmajee K Nallamothu
    Health Services Research and Development Center for Excellence, Ann Arbor Veterans Affairs Medical Center, Ann Arbor, Mich, USA
    Circulation 111:761-7. 2005
    ..Accordingly, we sought to describe patterns of times to treatment in patients undergoing interhospital transfer for primary PCI in the United States...
  36. ncbi request reprint Percutaneous coronary intervention versus fibrinolytic therapy in acute myocardial infarction: is timing (almost) everything?
    Brahmajee K Nallamothu
    Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0366, USA
    Am J Cardiol 92:824-6. 2003
    ..Interventional cardiology laboratories endeavoring to achieve the benefits of primary percutaneous coronary intervention seen in randomized clinical trials should aim to match their short door-to-balloon times...
  37. doi request reprint Thirty-day outcomes in Medicare patients with heart failure at heart transplant centers
    Scott L Hummel
    Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Mich 48109 5853, USA
    Circ Heart Fail 3:244-52. 2010
    ..However, their overall performance has not previously been evaluated in a broad population of elderly patients with heart failure, many of whom are not transplant candidates...
  38. doi request reprint Are changes in carotid intima-media thickness related to risk of nonfatal myocardial infarction? A critical review and meta-regression analysis
    Zachary D Goldberger
    Department of Internal Medicine, Division of Cardiology, University of Michigan Health System, Ann Arbor, MI, USA
    Am Heart J 160:701-14. 2010
    ..However, it remains unclear whether changes in CIMT that result from these therapies correlate with nonfatal myocardial infarction (MI)...
  39. pmc Use of medical imaging procedures with ionizing radiation in children: a population-based study
    Adam L Dorfman
    Department of Pediatrics, Division of Pediatric Cardiology, University of Michigan Health Systems, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Arch Pediatr Adolesc Med 165:458-64. 2011
    ..To determine population-based rates of the use of diagnostic imaging procedures with ionizing radiation in children, stratified by age and sex...
  40. ncbi request reprint Effect of statin use in patients with acute coronary syndromes and a serum low-density lipoprotein<or=80 mg/dl
    Thomas T Tsai
    Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Am J Cardiol 96:1491-3. 2005
    ..0% vs 9.5%, p=0.005). These results suggest that patients who have an acute coronary syndrome and a low-density lipoprotein cholesterol level<or=80 mg/dl in the absence of statin therapy may benefit from such therapy at discharge...
  41. ncbi request reprint Contribution of infection to increased mortality in women after cardiac surgery
    Mary A M Rogers
    Division of General Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0429, USA
    Arch Intern Med 166:437-43. 2006
    ..Explanations for this sex difference are controversial. The objective of this study was to assess whether infection contributes to the increased risk of mortality in women...
  42. ncbi request reprint When zebras run with horses: the diagnostic dilemma of acute aortic dissection complicated by myocardial infarction
    Brahmajee K Nallamothu
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    J Interv Cardiol 15:297-9. 2002
    ..in this comment on two key aspects of the case: (1) How commonly do acute aortic dissections lead to myocardial ischemia and MI? and (2) When should clinicians consider ruling out acute aortic dissection in the setting of acute MI?..
  43. ncbi request reprint Spontaneous hemopericardium in a patient with hemophilia B: a case report and review of the literature
    Dee Dee Wang
    University of Michigan Health System, Ann Arbor, MI 48109 5368, USA
    J Invasive Cardiol 20:E296-300. 2008
    ..We review the clinical challenges raised by this group of patients undergoing cardiac procedures and present a stepwise approach to optimal management during the periprocedural period...
  44. doi request reprint Racial differences in admissions to high-quality hospitals for coronary heart disease
    Ioana Popescu
    Department of Internal Medicine, The University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52240, USA
    Arch Intern Med 170:1209-15. 2010
    ..Research increasingly shows that blacks with coronary heart disease (CHD) are treated at lower-quality hospitals. Little is known about racial differences in admission to high-quality hospitals...
  45. ncbi request reprint Area socioeconomic status and mortality after coronary artery bypass graft surgery: the role of hospital volume
    Catherine Kim
    Division of General Internal Medicine, Department of Medicine, University of Michigan, Ann Arbor, MI, USA
    Am Heart J 154:385-90. 2007
    ..Individuals of low socioeconomic status (SES) have reduced access to coronary artery bypass graft surgery (CABG). It is unknown if low-SES CABG patients have reduced access to hospitals with better outcomes...
  46. pmc Differences in patient survival after acute myocardial infarction by hospital capability of performing percutaneous coronary intervention: implications for regionalization
    Jersey Chen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8017, USA
    Arch Intern Med 170:433-9. 2010
    ..Whether regionalization will improve outcomes depends in part on the magnitude of existing differences in outcomes between PCI and non-PCI hospitals within the same health care region...
  47. ncbi request reprint Prognostic implication of activated partial thromboplastin time after reteplase or half-dose reteplase plus abciximab: results from the GUSTO-V trial
    Brahmajee K Nallamothu
    University of Michigan Medical Center, Ann Arbor, MI, USA
    Eur Heart J 26:1506-12. 2005
    ....
  48. pmc Regionalization of ST-segment elevation acute coronary syndromes care: putting a national policy in proper perspective
    Saif S Rathore
    Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Am Coll Cardiol 47:1346-9. 2006
    ..Clearer evidence of the benefits and discussion of potential harms are needed before adopting a national STEMI regionalization policy...
  49. ncbi request reprint Potential impact of the HIPAA privacy rule on data collection in a registry of patients with acute coronary syndrome
    David Armstrong
    Division of Cardiovascular Medicine, Department of Internal Medicine, and the Cardiovascular Center of the University of Michigan Health System, and Health Services Research and Development Center of Excellence, Ann Arbor, USA
    Arch Intern Med 165:1125-9. 2005
    ..Implementation of the Health Insurance Portability and Accountability Act (HIPAA) Privacy Rule has the potential to affect data collection in outcomes research...
  50. ncbi request reprint Driving times and distances to hospitals with percutaneous coronary intervention in the United States: implications for prehospital triage of patients with ST-elevation myocardial infarction
    Brahmajee K Nallamothu
    Health Services Research and Development Center of Excellence, Ann Arbor VA Medical Center, Ann Arbor, Michigan, USA
    Circulation 113:1189-95. 2006
    ..Accordingly, we determined the proportion of the adult population in the United States with timely access to PCI hospitals using driving times and distances...
  51. ncbi request reprint Rates of infection for single-lumen versus multilumen central venous catheters: a meta-analysis
    Cameron Dezfulian
    Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    Crit Care Med 31:2385-90. 2003
    ..Our objective was to determine the risk of catheter-related bloodstream infection (CRBSI) and catheter colonization in multilumen catheters compared with single-lumen catheters...
  52. ncbi request reprint Time to treatment in primary percutaneous coronary intervention
    Brahmajee K Nallamothu
    Health Services Research and Development Center of Excellence, Ann Arbor Veterans Affairs Medical Center, and the Department of Internal Medicine, Division of Cardiovascular Disease, University of Michigan Medical School, Ann Arbor, USA
    N Engl J Med 357:1631-8. 2007
  53. ncbi request reprint Meta-analysis of randomized trials of drug-eluting stents versus bare metal stents in patients with diabetes mellitus
    Thomas F Boyden
    University Michigan Medical School, Ann Arbor VA Medical Center, Ann Arbor, Michigan, USA
    Am J Cardiol 99:1399-402. 2007
    ..001). DES use is associated with a marked decrease in in-stent restenosis and target lesion revascularization in patients with diabetes. In conclusion, the analysis supports the current widespread use of DESs in these high-risk patients...
  54. ncbi request reprint Prognostic implication of troponin I elevation after percutaneous coronary intervention
    Brahmajee K Nallamothu
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Am J Cardiol 91:1272-4. 2003
  55. doi request reprint Current role of sodium bicarbonate-based preprocedural hydration for the prevention of contrast-induced acute kidney injury: a meta-analysis
    Shea E Hogan
    Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109 5853, USA
    Am Heart J 156:414-21. 2008
    ..The purpose of this meta-analysis is to compare the effectiveness of normal saline (NS) versus sodium bicarbonate hydration (NaHCO(3)) for prevention of contrast-induced AKI...
  56. ncbi request reprint Should coronary artery bypass grafting be regionalized?
    Brahmajee K Nallamothu
    Health Services Research and Development Center of Excellence, Ann Arbor Veterans Affairs Medical Center, Ann Arbor, Michigan, USA
    Ann Thorac Surg 80:1572-81. 2005
  57. ncbi request reprint Long-term prognostic implication of extracardiac vascular disease in patients undergoing percutaneous coronary intervention
    Brahmajee K Nallamothu
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Am J Cardiol 92:964-6. 2003
    ..0 to 2.0, p = 0.029). When extracardiac vascular disease was separated into cerebrovascular disease and peripheral vascular disease, cerebrovascular disease was less common but was associated with a trend towards worse survival...
  58. ncbi request reprint Primary percutaneous coronary intervention versus fibrinolytic therapy in acute myocardial infarction: does the choice of fibrinolytic agent impact on the importance of time-to-treatment?
    Brahmajee K Nallamothu
    Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0366, USA
    Am J Cardiol 94:772-4. 2004
    ..When a substantial delay in initiating primary PCI is likely, reperfusion therapy with second- or third-generation fibrinolytic agents should be strongly considered...
  59. ncbi request reprint Do physicians examine patients in contact isolation less frequently? A brief report
    Sanjay Saint
    Ann Arbor Department of Veterans Affairs Medical Center, USA
    Am J Infect Control 31:354-6. 2003
    ..We assessed whether patients who are hospitalized and placed under contact precautions are examined less often by second- and third-year medical residents (ie, senior medical residents), and attending physicians during morning rounds...
  60. doi request reprint An early invasive strategy versus ischemia-guided management after fibrinolytic therapy for ST-segment elevation myocardial infarction: a meta-analysis of contemporary randomized controlled trials
    Harindra C Wijeysundera
    Department of Medicine, Division of Cardiology, Schulich Heart Center, Sunnybrook Health Sciences Center, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 156:564-572, 572.e1-2. 2008
    ....
  61. ncbi request reprint Coronary artery bypass surgery, hospital volume, and risk
    Brahmajee K Nallamothu
    Circulation 108:e6-7; author reply e6-7. 2003
  62. ncbi request reprint Hospital quality for acute myocardial infarction: correlation among process measures and relationship with short-term mortality
    Elizabeth H Bradley
    Department of Epidemiology and Public Health, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Conn 06520 8088, USA
    JAMA 296:72-8. 2006
    ....
  63. ncbi request reprint Hospital delays in reperfusion for ST-elevation myocardial infarction: implications when selecting a reperfusion strategy
    Duane S Pinto
    TIMI Study Group and the Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, 185 Pilgrim Rd, Boston, MA 02115, USA
    Circulation 114:2019-25. 2006
    ..We also hypothesized that in addition to PPCI delays, patient risk factors would significantly modulate the relative survival advantage of PPCI over fibrinolysis...
  64. ncbi request reprint Strategies for reducing the door-to-balloon time in acute myocardial infarction
    Elizabeth H Bradley
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    N Engl J Med 355:2308-20. 2006
    ..However, few hospitals meet this objective. We sought to identify hospital strategies that were significantly associated with a faster door-to-balloon time...
  65. ncbi request reprint Summary of evidence regarding hospital strategies to reduce door-to-balloon times for patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention
    Elizabeth H Bradley
    Section of Health Policy and Administration, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA
    Crit Pathw Cardiol 6:91-7. 2007
    ..In conclusion, although evidence of "what works" is based on observational studies rather than randomized trials, there is evidence on effective interventions to reduce door-to-balloon time...
  66. pmc Cardiac Certificate of Need regulations and the availability and use of revascularization services
    Vivian Ho
    Baker Institute for Public Policy, Rice University, Houston, TX 77005, USA
    Am Heart J 154:767-75. 2007
    ..We assessed the association between cardiac CON regulations, availability of revascularization facilities, and revascularization rates...
  67. ncbi request reprint Volume and outcome
    Brahmajee K Nallamothu
    N Engl J Med 347:693-6; author reply 693-6. 2002
  68. pmc Impact of delay in door-to-needle time on mortality in patients with ST-segment elevation myocardial infarction
    Robert L McNamara
    Department of Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA
    Am J Cardiol 100:1227-32. 2007
    ..87, respectively; p for trend <0.001). In conclusion, timely administration of fibrinolytic therapy continues to significantly impact on mortality in the modern era, particularly in patients presenting early after symptom onset...
  69. ncbi request reprint Use of the electrocardiogram in optimizing reperfusion for ST-elevation myocardial infarction: a new role for an old tool?
    Christos Kasapis
    Eur Heart J 28:2957-9. 2007
  70. doi request reprint Delayed time to defibrillation after in-hospital cardiac arrest
    Paul S Chan
    Saint Luke s Mid America Heart Institute, Kansas City, MO 64111, USA
    N Engl J Med 358:9-17. 2008
    ..However, empirical data on the prevalence of delayed defibrillation in the United States and its effect on survival are limited...
  71. ncbi request reprint Certificate of need regulation and cardiac catheterization appropriateness after acute myocardial infarction
    Joseph S Ross
    Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, One Gustave L Levy Pl, Box 1070, New York, NY 10029, USA
    Circulation 115:1012-9. 2007
    ..Our objective was to examine whether rates of appropriate cardiac catheterization after admission for acute myocardial infarction varied between states with and without CON regulation of cardiac catheterization...
  72. ncbi request reprint Rescue angioplasty or repeat fibrinolysis after failed fibrinolytic therapy for ST-segment myocardial infarction: a meta-analysis of randomized trials
    Harindra C Wijeysundera
    Division of Cardiology, Schulich Heart Centre and Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    J Am Coll Cardiol 49:422-30. 2007
    ....
  73. pmc Delay in presentation and reperfusion therapy in ST-elevation myocardial infarction
    Henry H Ting
    Division of Cardiovascular Diseases and Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Am J Med 121:316-23. 2008
    ..We studied the relationship between longer delays from symptom onset to hospital presentation and the use of any reperfusion therapy, door-to-balloon time, and door-to-drug time...
  74. pmc Time-to-reperfusion in patients undergoing interhospital transfer for primary percutaneous coronary intervention in the U.S: an analysis of 2005 and 2006 data from the National Cardiovascular Data Registry
    Anjan Chakrabarti
    J Am Coll Cardiol 51:2442-3. 2008
  75. doi request reprint Do specialty cardiac hospitals have greater adherence to acute myocardial infarction and heart failure process measures? An empirical assessment using Medicare quality measures: quality of care in cardiac specialty hospitals
    Ioana Popescu
    The Center for Research in Implementation of Innovative Strategies in Practice, Iowa City VA Medical Center, Iowa City, IA, USA
    Am Heart J 156:155-60. 2008
    ..Supporters of specialty hospitals claim these facilities provide better patient care; however, empirical data on quality of care in specialty hospitals are limited...
  76. ncbi request reprint Prognostic utility of microvolt T-wave alternans in risk stratification of patients with ischemic cardiomyopathy
    Theodore Chow
    The Lindner Clinical Trial Center at the Christ Hospital and the Ohio Heart and Vascular Center, Cincinnati, Ohio, USA
    J Am Coll Cardiol 47:1820-7. 2006
    ..The purpose of this study was to assess if microvolt T-wave alternans (MTWA) is an independent predictor of mortality in patients with ischemic cardiomyopathy...
  77. ncbi request reprint Admission body temperature and mortality in elderly patients hospitalized for heart failure
    Brahmajee K Nallamothu
    J Am Coll Cardiol 47:2563-4. 2006
  78. doi request reprint Implementation and integration of prehospital ECGs into systems of care for acute coronary syndrome: a scientific statement from the American Heart Association Interdisciplinary Council on Quality of Care and Outcomes Research, Emergency Cardiovascular Ca
    Henry H Ting
    Circulation 118:1066-79. 2008
  79. ncbi request reprint Keeping apples and oranges separate: reassessing clinical trials that use composite end points as their primary outcome
    Paul S Chan
    J Am Coll Cardiol 48:850; author reply 851-2. 2006
  80. doi request reprint Factors associated with longer time from symptom onset to hospital presentation for patients with ST-elevation myocardial infarction
    Henry H Ting
    Division of Cardiovascular Diseases and Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Arch Intern Med 168:959-68. 2008
    ..Previous studies have demonstrated the effects of single factors, such as age, sex, and race, with longer delays from symptom onset to hospital presentation in patients with ST-elevation myocardial infarction...
  81. ncbi request reprint Comparing hospital performance in door-to-balloon time between the Hospital Quality Alliance and the National Cardiovascular Data Registry
    Brahmajee K Nallamothu
    J Am Coll Cardiol 50:1517-9. 2007
  82. ncbi request reprint Development of systems of care for ST-elevation myocardial infarction patients: gaps, barriers, and implications
    Brahmajee K Nallamothu
    Circulation 116:e68-72. 2007

Research Grants3

  1. Impact of Specialty Hospitals on Procedure Utilization
    Brahmajee Nallamothu; Fiscal Year: 2005
    ....