Michael A Nalesnik

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Growth factor pathways in development and progression of hepatocellular carcinoma
    Michael Andrew Nalesnik
    Department of Pathology, University of Pittsburgh Medical Center, Montefiore Hospital, Pittsburgh, PA 15213, USA
    Front Biosci (Schol Ed) 4:1487-515. 2012
  2. doi request reprint Hepatobiliary effects of 90yttrium microsphere therapy for unresectable hepatocellular carcinoma
    Michael A Nalesnik
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Hum Pathol 40:125-34. 2009
  3. doi request reprint Donor-transmitted malignancies in organ transplantation: assessment of clinical risk
    M A Nalesnik
    Division of Transplantation and Hepatic Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Transplant 11:1140-7. 2011
  4. pmc Low-dose carbon monoxide inhibits progressive chronic allograft nephropathy and restores renal allograft function
    Atsunori Nakao
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Physiol Renal Physiol 297:F19-26. 2009
  5. doi request reprint Lymphoproliferative disorders and de novo malignancies in intestinal and multivisceral recipients: improved outcomes with new outlooks
    Kareem M Abu-Elmagd
    Department of Surgery, Thomas E Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Transplantation 88:926-34. 2009
  6. pmc Relative contribution of direct and indirect allorecognition in developing tolerance after liver transplantation
    Hideyoshi Toyokawa
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Liver Transpl 14:346-57. 2008
  7. ncbi request reprint Heart allograft protection with low-dose carbon monoxide inhalation: effects on inflammatory mediators and alloreactive T-cell responses
    Atsunori Nakao
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Transplantation 81:220-30. 2006
  8. pmc The loss of renal dendritic cells and activation of host adaptive immunity are long-term effects of ischemia/reperfusion injury following syngeneic kidney transplantation
    Kikumi S Ozaki
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Kidney Int 81:1015-25. 2012
  9. pmc Simultaneous bone marrow and intestine transplantation promotes marrow-derived hematopoietic stem cell engraftment and chimerism
    Atsunori Nakao
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Blood 108:1413-20. 2006
  10. doi request reprint EBV-positive extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue in the posttransplant setting: a distinct type of posttransplant lymphoproliferative disorder?
    Sarah E Gibson
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA
    Am J Surg Pathol 35:807-15. 2011

Detail Information

Publications42

  1. ncbi request reprint Growth factor pathways in development and progression of hepatocellular carcinoma
    Michael Andrew Nalesnik
    Department of Pathology, University of Pittsburgh Medical Center, Montefiore Hospital, Pittsburgh, PA 15213, USA
    Front Biosci (Schol Ed) 4:1487-515. 2012
    ..Review of available information indicates that redundancies and interactions among these signaling pathways must be taken into account if they are to be exploited to block and reverse HCC growth and spread...
  2. doi request reprint Hepatobiliary effects of 90yttrium microsphere therapy for unresectable hepatocellular carcinoma
    Michael A Nalesnik
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Hum Pathol 40:125-34. 2009
    ..The pathologist should be aware of these changes to distinguish them from the diffuse "radiation hepatitis" associated with older forms of radiotherapy...
  3. doi request reprint Donor-transmitted malignancies in organ transplantation: assessment of clinical risk
    M A Nalesnik
    Division of Transplantation and Hepatic Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Transplant 11:1140-7. 2011
    ..This resource document is tailored to clinical practice in the United States and should aid clinical decision making in the difficult circumstance of an organ donor with potential or proven neoplasia...
  4. pmc Low-dose carbon monoxide inhibits progressive chronic allograft nephropathy and restores renal allograft function
    Atsunori Nakao
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Physiol Renal Physiol 297:F19-26. 2009
    ..The study demonstrates that CO is able to inhibit progression of fibroinflammatory process of CAN, restore renal allograft function, and improve survival even when the treatment is started after CAN is diagnosed...
  5. doi request reprint Lymphoproliferative disorders and de novo malignancies in intestinal and multivisceral recipients: improved outcomes with new outlooks
    Kareem M Abu-Elmagd
    Department of Surgery, Thomas E Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Transplantation 88:926-34. 2009
    ..To improve outcome, innovative management and immunosuppressant strategies were sequentially evolved...
  6. pmc Relative contribution of direct and indirect allorecognition in developing tolerance after liver transplantation
    Hideyoshi Toyokawa
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Liver Transpl 14:346-57. 2008
    ..In conclusion, the study suggests that host cells with phagocytic activity could play significant roles in developing LT tolerance...
  7. ncbi request reprint Heart allograft protection with low-dose carbon monoxide inhalation: effects on inflammatory mediators and alloreactive T-cell responses
    Atsunori Nakao
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Transplantation 81:220-30. 2006
    ..We hypothesized in this study that low concentration CO would be beneficial for organ allografts, which frequently undergo several types of injury such as ischemia/reperfusion, alloimmune reaction, and inflammation..
  8. pmc The loss of renal dendritic cells and activation of host adaptive immunity are long-term effects of ischemia/reperfusion injury following syngeneic kidney transplantation
    Kikumi S Ozaki
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Kidney Int 81:1015-25. 2012
    ..Renal-resident dendritic cells might function as a protective regulatory network...
  9. pmc Simultaneous bone marrow and intestine transplantation promotes marrow-derived hematopoietic stem cell engraftment and chimerism
    Atsunori Nakao
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Blood 108:1413-20. 2006
    ..These findings suggest that intestine allograft supports simultaneously infused donor (syngeneic to organ grafts) marrow stem cell engraftment, differentiation, and persistence of chimerism...
  10. doi request reprint EBV-positive extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue in the posttransplant setting: a distinct type of posttransplant lymphoproliferative disorder?
    Sarah E Gibson
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA
    Am J Surg Pathol 35:807-15. 2011
    ..Whether their distinctive subcutaneous/soft tissue localization and IgA positivity are uniform features will require identification of additional cases...
  11. doi request reprint Posttransplant adenoviral enteropathy in patients with small bowel transplantation
    Oyedele A Adeyi
    Department of Pathology, University of Pittsburgh Medical Center, Presbyterian Hospital, Pittsburgh, PA, USA
    Arch Pathol Lab Med 132:703-5. 2008
    ..The identification of characteristic viral inclusions in the surface or crypt epithelium points to the diagnosis of adenoviral enteropathy, in spite of the increased crypt apoptosis...
  12. ncbi request reprint 3D-confocal structural analysis of bone marrow-derived renal tubular cells during renal ischemia/reperfusion injury
    Hideyoshi Toyokawa
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Lab Invest 86:72-82. 2006
    ..The actual frequency in 3D analysis was approximately one-fourth of that seen in 2D analysis. 3D confocal imaging precisely detected BM-derived tubular epithelial cells and could be useful to study BMC contribution to tissue repair...
  13. ncbi request reprint Gene expression profiling of Epstein-Barr virus-positive and -negative monomorphic B-cell posttransplant lymphoproliferative disorders
    Fiona E Craig
    Division of Hematopathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Diagn Mol Pathol 16:158-68. 2007
    ..By contrast, EBV- PTLD lacked viral-associated changes suggesting that they are biologically distinct...
  14. ncbi request reprint Donor graft adenoviral iNOS gene transfer ameliorates rat liver transplant preservation injury and improves survival
    Takashi Kaizu
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Hepatology 43:464-73. 2006
    ..Downregulation of ICAM-1 mRNA and neutrophil infiltration may be associated with the mechanisms by which AdiNOS pretreatment confer the protection against transplant-associated hepatic I/R injury...
  15. ncbi request reprint Histopathologic characteristics of human intestine allograft acute rejection in patients pretreated with thymoglobulin or alemtuzumab
    Tong Wu
    Department of Pathology, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Gastroenterol 101:1617-24. 2006
    ....
  16. pmc Neuroendocrine carcinoma of the extrahepatic bile duct: case report and literature review
    Eizaburo Sasatomi
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, United States
    World J Gastroenterol 19:4616-23. 2013
    ..The patient died 21 d after the operation. NEC of the bile duct is an aggressive neoplasm, and its biological characteristics remain to be better defined. ..
  17. pmc Gene deletions and amplifications in human hepatocellular carcinomas: correlation with hepatocyte growth regulation
    Michael A Nalesnik
    Department of Pathology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15241, USA
    Am J Pathol 180:1495-508. 2012
    ....
  18. pmc Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic development
    Pallavi B Limaye
    Department of Pathology, Division of Transplantation Pathology, Montefiore University Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2582, USA
    Lab Invest 88:865-72. 2008
    ....
  19. pmc Tolerogenic immunosuppression for organ transplantation
    Thomas E Starzl
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Lancet 361:1502-10. 2003
    ..We aimed to apply these principles in recipients of renal and extrarenal organ transplants...
  20. ncbi request reprint A schema for histologic grading of small intestine allograft acute rejection
    Tong Wu
    Department of Pathology, Thomas E Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Transplantation 75:1241-8. 2003
    ..The primary goal of this study was to develop a histologic grading system for the diagnosis of small bowel allograft acute rejection...
  21. ncbi request reprint Chimerism and tolerance in rat recipients of intestinal allografts from ALS-treated donors with and without adjunct naïve-donor-strain bone-marrow cells
    Atsunori Nakao
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, PA 15213, USA
    Transplantation 75:1575-81. 2003
    ....
  22. doi request reprint Multiple hepatic adenomas associated with liver steatosis at CT and MRI: a case-control study
    Alessandro Furlan
    Department of Radiology, University of Pittsburgh Medical Center Presbyterian Campus, Pittsburgh, PA, USA
    AJR Am J Roentgenol 191:1430-5. 2008
    ..The objective of our study was to investigate the relationship between hepatic adenoma and liver steatosis...
  23. ncbi request reprint Unresectable hepatocellular carcinoma with a solitary metastasis to the mandible
    Ryan Li
    University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am Surg 74:346-9. 2008
    ..Radiotherapy has been used to palliate mandibular metastases; however, surgical intervention proved to be very effective in managing this patient's disease...
  24. ncbi request reprint Clinicopathologic characteristics of post-transplant lymphoproliferative disorders
    Michael A Nalesnik
    Department of Pathology, University of Pittsburgh Medical Center, PA 15261, USA
    Recent Results Cancer Res 159:9-18. 2002
    ..Continued individual and multi-institutional studies are essential for progress in these areas...
  25. ncbi request reprint Exogenous IL-6 inhibits acute inflammatory responses and prevents ischemia/reperfusion injury after intestinal transplantation
    Kei Kimizuka
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Am J Transplant 4:482-94. 2004
    ..These results show that IL-6 is effective in protecting the intestine from cold I/R injury by maintaining graft blood flow and reducing pro-inflammatory cytokine up-regulation and neutrophil infiltration...
  26. ncbi request reprint Plasma cell tumors in transplant patients
    Michael A Nalesnik
    University of Pittsburgh Medical Center, PA, USA
    Blood 121:1247-9. 2013
    ..1) Might this represent a separate pathway for PTLD development?..
  27. ncbi request reprint De novo malignancies after intestinal and multivisceral transplantation
    Kareem M Abu-Elmagd
    Thomas E Starzl Transplantation Institute, Pittsburgh, PA 15213, USA
    Transplantation 77:1719-25. 2004
    ..With more than a decade of clinical experience, this report is the first to address the risk of de novo cancer after intestinal transplantation...
  28. ncbi request reprint Long-term function and morphology of intestinal autografts and allografts in outbred dogs
    Kotaro Iwanami
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Transplant 3:1083-90. 2003
    ..Results also indicate that these allografts experienced low-grade chronic rejection as evidenced in the submucosa and muscle layers, despite the lack of clinical symptoms...
  29. ncbi request reprint Minimal evidence of transdifferentiation from recipient bone marrow to parenchymal cells in regenerating and long-surviving human allografts
    Tong Wu
    Division of Transplant Pathology, Thomas E Starzl Transplant Institute, University of Pittsburgh Medical Center, Pittsburgh, Pittsburgh, PA, USA
    Am J Transplant 3:1173-81. 2003
    ..Because of the extremely low frequency, interpretation was difficult. Regardless of these results, a more vigorous search for conditions that promote transdifferentiation is warranted...
  30. ncbi request reprint Morphology and function of canine small intestinal autografts: with particular interest in the influence of ex vivo graft irradiation
    Takashi Ishikawa
    Thomas, E, Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Gastrointest Surg 7:662-71. 2003
    ..Graft irradiation did not induce further defects in intestinal function or cause histopathologic abnormalities...
  31. ncbi request reprint Protective effects of ex vivo graft radiation and tacrolimus on syngeneic transplanted rat small bowel motility
    Nicolas T Schwarz
    Department of Surgery, University of Pittsburgh Medical Center, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Surgery 131:413-23. 2002
    ....
  32. ncbi request reprint Posttransplant lymphoproliferative disorders presenting at sites of previous surgical intervention
    Cataldo Doria
    Department of Surgery, University of Pittsburgh, Thomas E Starzl Transplantation Institute, 4th Floor, Falk Clinic, 3601 Fifth Avenue, Pittsburgh, PA 15213
    Transplantation 75:1066-9. 2003
    ..PTLD should be included in the differential diagnosis when clinical signs and symptoms localize to anastomotic sites, surgical incision sites, or sites of longstanding catheter placement in immunosuppressed organ transplant recipients...
  33. ncbi request reprint Low-dose carbon monoxide inhalation prevents development of chronic allograft nephropathy
    Joao Seda Neto
    Thomas E Starzl Transplantation Institute, Department of Surgery, E1555 Biomedical Science Tower, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Physiol Renal Physiol 290:F324-34. 2006
    ..In conclusion, inhaled CO at a low concentration efficiently abrogates chronic fibroinflammatory changes associated with CAN and improves long-term renal allograft function...
  34. ncbi request reprint Spontaneous rupture of hepatic artery aneurysm associated with polyarteritis nodosa
    Brodie A Parent
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am Surg 76:1416-9. 2010
    ..The review revealed 17 published cases of ruptured PAN-related intrahepatic aneurysms. We conclude that unexplained findings of visceral arterial aneurysms should prompt investigations for vasculitis as the etiology...
  35. ncbi request reprint Impact of Epstein-Barr virus in monomorphic B-cell posttransplant lymphoproliferative disorders: a histogenetic study
    Lawrence R Johnson
    Department of Pathology, Division of Hematopathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 30:1604-12. 2006
    ..The lack of a demonstrable correlation with survival may relate to the relatively small number of cases studied...
  36. doi request reprint Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors
    Masahiro Shuda
    Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Int J Cancer 125:1243-9. 2009
    ..As with some of the other human polyomaviruses, lymphocytes may serve as a tissue reservoir for MCV infection, but hematolymphoid malignancies associated with MCC are unlikely to be caused by MCV...
  37. pmc NOD.c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogenetically models human primary biliary cirrhosis
    Junichiro Irie
    Division of Rheumatology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Exp Med 203:1209-19. 2006
    ..Using a congenic mapping approach, we define the first ABD (Abd) locus, Abd1. These results identify the NOD.c3c4 mouse as the first spontaneous mouse model of PBC...
  38. doi request reprint Altered liver morphology after portal vein thrombosis: not always cirrhosis
    Mitchell E Tublin
    Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Dig Dis Sci 53:2784-8. 2008
    ..Awareness of this appearance after primary portal vein thrombosis may prevent an erroneous diagnosis of cirrhosis...
  39. ncbi request reprint Carcinoid of the extra-hepatic bile duct: a case report with long-term follow-up and review of literature
    Niraj J Gusani
    Department of Surgery, Liver Pancreas Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am Surg 74:87-90. 2008
    ..Complete excision with clear margins seems to provide the best chance of obtaining long-term survival and cure...
  40. ncbi request reprint Protective effect of carbon monoxide inhalation for cold-preserved small intestinal grafts
    Atsunori Nakao
    University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Surgery 134:285-92. 2003
    ..This study investigated cytoprotective efficacy of CO at a low concentration on cold ischemia/reperfusion (I/R) injury of transplanted intestine...
  41. ncbi request reprint Protection of transplant-induced renal ischemia-reperfusion injury with carbon monoxide
    Joao Seda Neto
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, E1555 Biomedical Science Tower, Pittsburgh, PA 15213, USA
    Am J Physiol Renal Physiol 287:F979-89. 2004
    ..5 from 25 days in untreated controls. The study demonstrates that exposure of kidney graft recipients to CO at a low concentration can impart significant protective effects against renal I/R injury and improve function of renal grafts...
  42. pmc Carbon monoxide inhalation protects rat intestinal grafts from ischemia/reperfusion injury
    Atsunori Nakao
    Thomas E Starzl Transplantation Institute, Departments of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Pathol 163:1587-98. 2003
    ..Perioperative CO inhalation at a low concentration resulted in protection against ischemia/reperfusion injury to intestinal grafts with prolonged cold preservation...