Maki Nakayama

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. pmc Germline TRAV5D-4 T-cell receptor sequence targets a primary insulin peptide of NOD mice
    Maki Nakayama
    Barbara Davis Center for Childhood Diabetes, University of ColoradoSchool of Medicine, Aurora, CO, USA
    Diabetes 61:857-65. 2012
  2. doi request reprint Insulin as a key autoantigen in the development of type 1 diabetes
    Maki Nakayama
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    Diabetes Metab Res Rev 27:773-7. 2011
  3. pmc Conserved T cell receptor alpha-chain induces insulin autoantibodies
    Masakazu Kobayashi
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 105:10090-4. 2008
  4. pmc Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity
    Maki Nakayama
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center UCHSC, Aurora, CO 80045 6511, USA
    J Clin Invest 117:1835-43. 2007
  5. ncbi request reprint Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout
    Jean M Jasinski
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, P O Box 6511, MS B140, Aurora, CO 80045 6511, USA
    Diabetes 55:1978-84. 2006
  6. doi request reprint Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Autoimmun 33:42-9. 2009
  7. ncbi request reprint Type 1 diabetes: chronic progressive autoimmune disease
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver Health Sciences Center, Aurora, CO 80010, USA
    Novartis Found Symp 292:85-94; discussion 94-8, 122-9, 202-3. 2008
  8. ncbi request reprint Deleting islet autoimmunity
    Edwin Liu
    Barbara Davis Center for Childhood Diabetes, Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, CO, USA
    Cell Biochem Biophys 48:177-82. 2007
  9. ncbi request reprint Pancreatic autoimmunity induction with insulin B:9-23 peptide and viral mimics in the NZB mouse
    Devasenan Devendra
    Barbara Davis Center for Childhood Diabetes, P O Box 6511, Aurora, CO 80010, USA
    Ann N Y Acad Sci 1079:135-7. 2006
  10. pmc Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
    Maki Nakayama
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Nature 435:220-3. 2005

Collaborators

Detail Information

Publications18

  1. pmc Germline TRAV5D-4 T-cell receptor sequence targets a primary insulin peptide of NOD mice
    Maki Nakayama
    Barbara Davis Center for Childhood Diabetes, University of ColoradoSchool of Medicine, Aurora, CO, USA
    Diabetes 61:857-65. 2012
    ..Targeting primary autoantigenic peptides by simple germline-encoded TCR motifs may underlie enhanced susceptibility to the development of autoimmune diabetes...
  2. doi request reprint Insulin as a key autoantigen in the development of type 1 diabetes
    Maki Nakayama
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    Diabetes Metab Res Rev 27:773-7. 2011
    ..Given multiple similarities between diabetes of NOD mice and man, targeting insulin and insulin-reactive T cells may provide opportunities to develop robust immunotherapies...
  3. pmc Conserved T cell receptor alpha-chain induces insulin autoantibodies
    Masakazu Kobayashi
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 105:10090-4. 2008
    ..We suggest that a major part of the mystery as to why islet autoimmunity develops relates to recognition of a primary insulin peptide by a conserved alpha chain T cell receptor...
  4. pmc Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity
    Maki Nakayama
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center UCHSC, Aurora, CO 80045 6511, USA
    J Clin Invest 117:1835-43. 2007
    ..Our findings demonstrate dependence on B16 alanine versus tyrosine of insulin B:9-23 for both the initial priming and the effector phase of NOD anti-islet autoimmunity...
  5. ncbi request reprint Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout
    Jean M Jasinski
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, P O Box 6511, MS B140, Aurora, CO 80045 6511, USA
    Diabetes 55:1978-84. 2006
    ..scid mouse. The current study demonstrates that the BDC12-4.1 TCR is sufficient to cause diabetes at NOD backcross 1, bypassing polygenic inhibition of insulitis and diabetogenesis...
  6. doi request reprint Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Autoimmun 33:42-9. 2009
    ....
  7. ncbi request reprint Type 1 diabetes: chronic progressive autoimmune disease
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver Health Sciences Center, Aurora, CO 80010, USA
    Novartis Found Symp 292:85-94; discussion 94-8, 122-9, 202-3. 2008
    ..Given the ability to predict type 1A diabetes trials at all stages of the disorder to prevent beta cell destruction are now possible...
  8. ncbi request reprint Deleting islet autoimmunity
    Edwin Liu
    Barbara Davis Center for Childhood Diabetes, Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, CO, USA
    Cell Biochem Biophys 48:177-82. 2007
    ..In this article, we review current literature regarding insulin as an autoantigen and potential approaches to deleting insulin-reactive T cells through the use of peptide vaccines and targeted T cell receptor immunizations...
  9. ncbi request reprint Pancreatic autoimmunity induction with insulin B:9-23 peptide and viral mimics in the NZB mouse
    Devasenan Devendra
    Barbara Davis Center for Childhood Diabetes, P O Box 6511, Aurora, CO 80010, USA
    Ann N Y Acad Sci 1079:135-7. 2006
    ..We demonstrate insulin autoimmunity in the NZB mouse using the insulin peptide B:9-23 and viral mimics. The reason for the protection from diabetes despite the presence of autoimmunity is currently not established...
  10. pmc Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
    Maki Nakayama
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Nature 435:220-3. 2005
    ....
  11. doi request reprint Comparison of insulin autoantibody: polyethylene glycol and micro-IAA 1-day and 7-day assays
    Naru Babaya
    Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045 6511, USA
    Diabetes Metab Res Rev 25:665-70. 2009
    ..Our standard micro-IAA assay (mIAA) utilizes precipitation with proteins A/G and 1-day incubation (1-day mIAA), but is less sensitive compared to the CIAA assay...
  12. pmc Gamma delta T cell receptors confer autonomous responsiveness to the insulin-peptide B:9-23
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Autoimmun 34:478-84. 2010
    ..This study reveals a novel specificity for gammadelta TCRs, and raises the possibility that gammadelta T cells become involved in islet-specific autoimmunity...
  13. pmc Insulin as an autoantigen in NOD/human diabetes
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Box B140, Building M20, 1775 N Ursula St, P O Box 6511, Aurora, CO 80045 6511, USA
    Curr Opin Immunol 20:111-8. 2008
    ....
  14. pmc Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation
    Aaron W Michels
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 187:5921-30. 2011
    ..These studies present a novel method for identifying small molecules capable of both stimulating and inhibiting T cell responses, with potentially therapeutic applications...
  15. ncbi request reprint The stages of type 1A diabetes
    Naru Babaya
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 12801 East 17th Avenue, Aurora, CO 80010 1763, USA
    Ann N Y Acad Sci 1051:194-204. 2005
    ..We can also readily prevent the disorder in animal models. A major goal is safe prevention in man, and for this we will almost certainly need a better understanding of pathogenesis, coupled with rigorous clinical trials...
  16. ncbi request reprint Interferon-alpha as a mediator of polyinosinic:polycytidylic acid-induced type 1 diabetes
    Devasenan Devendra
    Barbara Davis Center for Childhood Diabetes, 4200 East 9th Ave, Box B140, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Diabetes 54:2549-56. 2005
    ....
  17. doi request reprint The anti-insulin trimolecular complex in type 1 diabetes
    Aaron W Michels
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    Curr Opin Endocrinol Diabetes Obes 17:329-34. 2010
    ..Description of the immunologic components needed for autoimmune diabetes...
  18. ncbi request reprint Establishment of native insulin-negative NOD mice and the methodology to distinguish specific insulin knockout genotypes and a B:16 alanine preproinsulin transgene
    Maki Nakayama
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B 140, Denver, CO 80262, USA
    Ann N Y Acad Sci 1037:193-8. 2004
    ..Four B:16 alanine transgenic founders were produced directly in NOD mice and, by intercrossing, initial live native insulin-negative B:16 alanine transgenic mice have been generated...