Research Topics
Species | Maki NakayamaSummaryAffiliation: University of Colorado Denver Country: USA Publications
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Detail Information
Publications
Germline TRAV5D-4 T-cell receptor sequence targets a primary insulin peptide of NOD miceMaki Nakayama
Barbara Davis Center for Childhood Diabetes, University of ColoradoSchool of Medicine, Aurora, CO, USA
Diabetes 61:857-65. 2012..Targeting primary autoantigenic peptides by simple germline-encoded TCR motifs may underlie enhanced susceptibility to the development of autoimmune diabetes...
Insulin as a key autoantigen in the development of type 1 diabetesMaki Nakayama
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
Diabetes Metab Res Rev 27:773-7. 2011..Given multiple similarities between diabetes of NOD mice and man, targeting insulin and insulin-reactive T cells may provide opportunities to develop robust immunotherapies...- Conserved T cell receptor alpha-chain induces insulin autoantibodiesMasakazu Kobayashi
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 105:10090-4. 2008..We suggest that a major part of the mystery as to why islet autoimmunity develops relates to recognition of a primary insulin peptide by a conserved alpha chain T cell receptor... - Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunityMaki Nakayama
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center UCHSC, Aurora, CO 80045 6511, USA
J Clin Invest 117:1835-43. 2007..Our findings demonstrate dependence on B16 alanine versus tyrosine of insulin B:9-23 for both the initial priming and the effector phase of NOD anti-islet autoimmunity... 
Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockoutJean M Jasinski
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, P O Box 6511, MS B140, Aurora, CO 80045 6511, USA
Diabetes 55:1978-84. 2006..scid mouse. The current study demonstrates that the BDC12-4.1 TCR is sufficient to cause diabetes at NOD backcross 1, bypassing polygenic inhibition of insulitis and diabetogenesis...- Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chainsLi Zhang
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
J Autoimmun 33:42-9. 2009.... - Type 1 diabetes: chronic progressive autoimmune diseaseLi Zhang
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver Health Sciences Center, Aurora, CO 80010, USA
Novartis Found Symp 292:85-94; discussion 94-8, 122-9, 202-3. 2008..Given the ability to predict type 1A diabetes trials at all stages of the disorder to prevent beta cell destruction are now possible... - Deleting islet autoimmunityEdwin Liu
Barbara Davis Center for Childhood Diabetes, Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, CO, USA
Cell Biochem Biophys 48:177-82. 2007..In this article, we review current literature regarding insulin as an autoantigen and potential approaches to deleting insulin-reactive T cells through the use of peptide vaccines and targeted T cell receptor immunizations... - Pancreatic autoimmunity induction with insulin B:9-23 peptide and viral mimics in the NZB mouseDevasenan Devendra
Barbara Davis Center for Childhood Diabetes, P O Box 6511, Aurora, CO 80010, USA
Ann N Y Acad Sci 1079:135-7. 2006..We demonstrate insulin autoimmunity in the NZB mouse using the insulin peptide B:9-23 and viral mimics. The reason for the protection from diabetes despite the presence of autoimmunity is currently not established... - Prime role for an insulin epitope in the development of type 1 diabetes in NOD miceMaki Nakayama
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Nature 435:220-3. 2005.... - Comparison of insulin autoantibody: polyethylene glycol and micro-IAA 1-day and 7-day assaysNaru Babaya
Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045 6511, USA
Diabetes Metab Res Rev 25:665-70. 2009..Our standard micro-IAA assay (mIAA) utilizes precipitation with proteins A/G and 1-day incubation (1-day mIAA), but is less sensitive compared to the CIAA assay... - Gamma delta T cell receptors confer autonomous responsiveness to the insulin-peptide B:9-23Li Zhang
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
J Autoimmun 34:478-84. 2010..This study reveals a novel specificity for gammadelta TCRs, and raises the possibility that gammadelta T cells become involved in islet-specific autoimmunity... - Insulin as an autoantigen in NOD/human diabetesLi Zhang
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Box B140, Building M20, 1775 N Ursula St, P O Box 6511, Aurora, CO 80045 6511, USA
Curr Opin Immunol 20:111-8. 2008.... - Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentationAaron W Michels
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
J Immunol 187:5921-30. 2011..These studies present a novel method for identifying small molecules capable of both stimulating and inhibiting T cell responses, with potentially therapeutic applications... - The stages of type 1A diabetesNaru Babaya
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 12801 East 17th Avenue, Aurora, CO 80010-1763, USA
Ann N Y Acad Sci 1051:194-204. 2005..We can also readily prevent the disorder in animal models. A major goal is safe prevention in man, and for this we will almost certainly need a better understanding of pathogenesis, coupled with rigorous clinical trials... - Interferon-alpha as a mediator of polyinosinic:polycytidylic acid-induced type 1 diabetesDevasenan Devendra
Barbara Davis Center for Childhood Diabetes, 4200 East 9th Ave, Box B140, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Diabetes 54:2549-56. 2005.... - The anti-insulin trimolecular complex in type 1 diabetesAaron W Michels
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
Curr Opin Endocrinol Diabetes Obes 17:329-34. 2010..Description of the immunologic components needed for autoimmune diabetes... - Establishment of native insulin-negative NOD mice and the methodology to distinguish specific insulin knockout genotypes and a B:16 alanine preproinsulin transgeneMaki Nakayama
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B-140, Denver, CO 80262, USA
Ann N Y Acad Sci 1037:193-8. 2004..Four B:16 alanine transgenic founders were produced directly in NOD mice and, by intercrossing, initial live native insulin-negative B:16 alanine transgenic mice have been generated...