Nakamura M, Nara T. Gene regulation of mammalian desaturases. Biochem Soc Trans. 2002;30:1076-9 pubmed
..Available data suggest that the induction of desaturases by PPs may be a compensatory response to an increased demand for unsaturated fatty acids because PPs increase fatty acid degradation and induce proliferation of peroxisomes. ..
Nakamura M, Nara T. Essential fatty acid synthesis and its regulation in mammals. Prostaglandins Leukot Essent Fatty Acids. 2003;68:145-50 pubmed
..Recent studies have demonstrated a critical role of peroxisomal beta-oxidation in DHA synthesis, and identified acyl CoA oxidase and D-bifunctional protein as the key enzymes. ..
Nakamura M, Nara T. Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. Annu Rev Nutr. 2004;24:345-76 pubmed
..Combinations of multiple transcription factors achieve this sophisticated differential regulation. ..