M T Nakamura

Summary

Affiliation: University of Illinois
Country: USA

Publications

  1. ncbi request reprint Metabolism and functions of highly unsaturated fatty acids: an update
    M T Nakamura
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Lipids 36:961-4. 2001
  2. ncbi request reprint Mechanisms of regulation of gene expression by fatty acids
    Manabu T Nakamura
    Department of Food Science and Human Nutrition and Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Lipids 39:1077-83. 2004
  3. ncbi request reprint Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases
    Manabu T Nakamura
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Annu Rev Nutr 24:345-76. 2004
  4. ncbi request reprint Essential fatty acid synthesis and its regulation in mammals
    M T Nakamura
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, 905 S Goodwin Avenue, Urbana, IL 61801, USA
    Prostaglandins Leukot Essent Fatty Acids 68:145-50. 2003
  5. ncbi request reprint Gene regulation of mammalian desaturases
    M T Nakamura
    Food Science and Human Nutrition, University of Illinois at Urbana Champaign, 905 S Goodwin Avenue, 61801, USA
    Biochem Soc Trans 30:1076-9. 2002
  6. ncbi request reprint The E-box like sterol regulatory element mediates the suppression of human Delta-6 desaturase gene by highly unsaturated fatty acids
    Takayuki Y Nara
    Division of Nutritional Sciences, University of Illinois at Urbana Champaign, 61801, Urbana, IL, USA
    Biochem Biophys Res Commun 296:111-7. 2002
  7. ncbi request reprint Delayed induction of delta-6 and delta-5 desaturases by a peroxisome proliferator
    Wei Song He
    Department of Food Science and Human Nutrition, Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Biochem Biophys Res Commun 299:832-8. 2002
  8. ncbi request reprint Peroxisome proliferator-activated receptor alpha is required for feedback regulation of highly unsaturated fatty acid synthesis
    Yue Li
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Lipid Res 46:2432-40. 2005
  9. ncbi request reprint Induction of overlapping genes by fasting and a peroxisome proliferator in pigs: evidence of functional PPARalpha in nonproliferating species
    Yewon Cheon
    Division of Nutritional Sciences, Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, 905 South Goodwin Ave, Bevier Hall 439, Urbana, IL, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1525-35. 2005
  10. ncbi request reprint Dietary lycopene downregulates carotenoid 15,15'-monooxygenase and PPAR-gamma in selected rat tissues
    Susan Zaripheh
    Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA
    J Nutr 136:932-8. 2006

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Metabolism and functions of highly unsaturated fatty acids: an update
    M T Nakamura
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Lipids 36:961-4. 2001
    ..Another likely mechanism is that HUFA suppress genes for fatty acid synthesis by reducing both mRNA and protein maturation of sterol regulatory element binding protein-1...
  2. ncbi request reprint Mechanisms of regulation of gene expression by fatty acids
    Manabu T Nakamura
    Department of Food Science and Human Nutrition and Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Lipids 39:1077-83. 2004
    ..It is yet to be determined whether FA regulate other transcription factors such as liver-X receptor, hepatocyte nuclear factor 4, and carbohydrate response element binding protein...
  3. ncbi request reprint Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases
    Manabu T Nakamura
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Annu Rev Nutr 24:345-76. 2004
    ..Combinations of multiple transcription factors achieve this sophisticated differential regulation...
  4. ncbi request reprint Essential fatty acid synthesis and its regulation in mammals
    M T Nakamura
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, 905 S Goodwin Avenue, Urbana, IL 61801, USA
    Prostaglandins Leukot Essent Fatty Acids 68:145-50. 2003
    ..Recent studies have demonstrated a critical role of peroxisomal beta-oxidation in DHA synthesis, and identified acyl CoA oxidase and D-bifunctional protein as the key enzymes...
  5. ncbi request reprint Gene regulation of mammalian desaturases
    M T Nakamura
    Food Science and Human Nutrition, University of Illinois at Urbana Champaign, 905 S Goodwin Avenue, 61801, USA
    Biochem Soc Trans 30:1076-9. 2002
    ..Available data suggest that the induction of desaturases by PPs may be a compensatory response to an increased demand for unsaturated fatty acids because PPs increase fatty acid degradation and induce proliferation of peroxisomes...
  6. ncbi request reprint The E-box like sterol regulatory element mediates the suppression of human Delta-6 desaturase gene by highly unsaturated fatty acids
    Takayuki Y Nara
    Division of Nutritional Sciences, University of Illinois at Urbana Champaign, 61801, Urbana, IL, USA
    Biochem Biophys Res Commun 296:111-7. 2002
    ..Because HUFA are primarily incorporated into phospholipids (PL), our results suggest that the primary role of SREBP-1c in liver is the regulation of fatty acid supply for PL rather than for triglycerides...
  7. ncbi request reprint Delayed induction of delta-6 and delta-5 desaturases by a peroxisome proliferator
    Wei Song He
    Department of Food Science and Human Nutrition, Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Biochem Biophys Res Commun 299:832-8. 2002
    ..Taken together, this study supports our hypothesis and suggests that peroxisome proliferation and induction of fatty acid oxidation enzymes are the major mechanisms of the induction of HUFA synthesis by PP...
  8. ncbi request reprint Peroxisome proliferator-activated receptor alpha is required for feedback regulation of highly unsaturated fatty acid synthesis
    Yue Li
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Lipid Res 46:2432-40. 2005
    ..Our study suggests that PPARalpha, together with SREBP-1c, senses HUFA status and confers pathway-specific induction of HUFA synthesis by essential fatty acid-deficient diets...
  9. ncbi request reprint Induction of overlapping genes by fasting and a peroxisome proliferator in pigs: evidence of functional PPARalpha in nonproliferating species
    Yewon Cheon
    Division of Nutritional Sciences, Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, 905 South Goodwin Ave, Bevier Hall 439, Urbana, IL, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1525-35. 2005
    ..In conclusion, PPARalpha is likely to play a central role in adaptation to fasting in pig liver as in rats and mice...
  10. ncbi request reprint Dietary lycopene downregulates carotenoid 15,15'-monooxygenase and PPAR-gamma in selected rat tissues
    Susan Zaripheh
    Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA
    J Nutr 136:932-8. 2006
    ..These data suggest that lycopene may play an important role in the modulation of beta-carotene, retinoid, and/or lipid metabolism...
  11. ncbi request reprint A reduced carbohydrate, increased protein diet stabilizes glycemic control and minimizes adipose tissue glucose disposal in rats
    Jamie I Baum
    Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Nutr 136:1855-61. 2006
    ....
  12. pmc Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration
    Chad K Stroud
    Division of Nutritional Sciences, Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Lipid Res 50:1870-80. 2009
    ....
  13. pmc Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta-6 desaturase-null mice
    Manuel Roqueta-Rivera
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Lipid Res 51:360-7. 2010
    ..In conclusion, DHA was capable of restoring all observed impairment in male reproduction, whereas 22:4n6 formed from dietary AA may act as an inferior substitute for DHA...
  14. doi request reprint Replacing dietary glucose with fructose increases ChREBP activity and SREBP-1 protein in rat liver nucleus
    Hyun Young Koo
    Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Biochem Biophys Res Commun 390:285-9. 2009
    ..In conclusion, the gene induction by dietary fructose is likely to be mediated in part by simultaneously increased ChREBP activity, SREBP-1 and possibly FoxO1 protein in nucleus...
  15. ncbi request reprint NF-Y involvement in the polyunsaturated fat inhibition of fatty acid synthase gene transcription
    Margarita Teran-Garcia
    Division of Nutritional Sciences, University of Texas, Austin 78712, USA
    Biochem Biophys Res Commun 290:1295-9. 2002
    ..Interestingly, the distal PUFA-RR(FAS) has many similarities to the PUFA-RR of l-pyruvate kinase gene while the proximal PUFA-RR(FAS) is comparable to the PUFA-RR of the S14 and stearoyl-CoA desaturase genes...
  16. ncbi request reprint Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element
    Chongren Tang
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge 70808, USA
    J Lipid Res 44:686-95. 2003
    ....
  17. doi request reprint Dietary fructose induces a wide range of genes with distinct shift in carbohydrate and lipid metabolism in fed and fasted rat liver
    Hyun Young Koo
    Division of Nutritional Sciences, University of Illinois at Urbana Champaign, 905 S Goodwin Avenue, Urbana, IL 61801, USA
    Biochim Biophys Acta 1782:341-8. 2008
    ..In conclusion, fructose feeding induced a broader range of genes than previously identified with simultaneous increase in glycogen and triglycerides in liver. The induction may be in part mediated by ChREBP...
  18. pmc Hepatocyte nuclear factor-4alpha contributes to carbohydrate-induced transcriptional activation of hepatic fatty acid synthase
    Aaron W Adamson
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Biochem J 399:285-95. 2006
    ..The findings support the broader view that HNF-4alpha is an integral component of the hepatic nutrient sensing system that co-ordinates transcriptional responses to transitions between nutritional states...
  19. ncbi request reprint Serum testosterone is reduced following short-term phytofluene, lycopene, or tomato powder consumption in F344 rats
    Jessica K Campbell
    Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Nutr 136:2813-9. 2006
    ..Overall, results illustrate that short-term intake of tomato carotenoids significantly alters androgen status, which may partially be a mechanism by which tomato intake reduces prostate cancer risk...