Ken Nakamura

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc α-Synuclein and mitochondria: partners in crime?
    Ken Nakamura
    Gladstone Institute of Neurological Disease, 1650 Owens Street, San Francisco, CA 94158, USA
    Neurotherapeutics 10:391-9. 2013
  2. ncbi request reprint Effects of unilateral subthalamic and pallidal deep brain stimulation on fine motor functions in Parkinson's disease
    Ken Nakamura
    Department of Neurology, University of California, San Francisco, CA, USA
    Mov Disord 22:619-26. 2007
  3. pmc Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein
    Ken Nakamura
    Department of Neurology and Physiology, University of California, San Francisco, California 94158, USA
    J Biol Chem 286:20710-26. 2011
  4. ncbi request reprint A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1
    Nicholas T Hertz
    Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 154:737-47. 2013
  5. pmc Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies
    Gaia Skibinski
    Gladstone Institute of Neurological Disease, the Taube Koret Center for Neurodegenerative Disease Research, and the Hellman Family Foundation Program in Alzheimer s Disease Research, San Francisco, California 94158, Departments of Neurology, Physiology, and Graduate Programs in Neuroscience and Biomedical Sciences, University of California, San Francisco, California 94158, and Laboratory of Neurogenetics, National Institutes of Health, Bethesda, Maryland 20892
    J Neurosci 34:418-33. 2014
  6. pmc Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis
    Venu M Nemani
    Departments of Neurology and Physiology, Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 65:66-79. 2010
  7. doi request reprint The behavior of alpha-synuclein in neurons
    Doris L Fortin
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA
    Mov Disord 25:S21-6. 2010
  8. ncbi request reprint Energy failure: does it contribute to neurodegeneration?
    Divya Pathak
    Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA
    Ann Neurol 74:506-16. 2013
  9. doi request reprint Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria
    Ken Nakamura
    Graduate Program in Neuroscience, Department of Neurology, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 28:12305-17. 2008
  10. pmc Physiology versus pathology in Parkinson's disease
    Ken Nakamura
    Departments of Neurology and Physiology, University of California School of Medicine, 600 16th Street, GH N272B, San Francisco, CA 94158 2517, USA
    Proc Natl Acad Sci U S A 104:11867-8. 2007

Collaborators

Detail Information

Publications11

  1. pmc α-Synuclein and mitochondria: partners in crime?
    Ken Nakamura
    Gladstone Institute of Neurological Disease, 1650 Owens Street, San Francisco, CA 94158, USA
    Neurotherapeutics 10:391-9. 2013
    ..Understanding the functional consequences of synuclein's interactions with mitochondria is likely to provide important insights into disease pathophysiology, and may also reveal therapeutic strategies. ..
  2. ncbi request reprint Effects of unilateral subthalamic and pallidal deep brain stimulation on fine motor functions in Parkinson's disease
    Ken Nakamura
    Department of Neurology, University of California, San Francisco, CA, USA
    Mov Disord 22:619-26. 2007
    ..Our findings suggest that DBS of the STN or GPi results in a similar improvement in hand movements at short-term follow-up. Preoperative medication responsiveness predicts improvement in some but not other motor tasks...
  3. pmc Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein
    Ken Nakamura
    Department of Neurology and Physiology, University of California, San Francisco, California 94158, USA
    J Biol Chem 286:20710-26. 2011
    ..Synuclein thus exerts a primary and direct effect on the morphology of an organelle long implicated in the pathogenesis of Parkinson disease...
  4. ncbi request reprint A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1
    Nicholas T Hertz
    Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 154:737-47. 2013
    ..Discovery of neo-substrates for kinases could provide a heretofore-unappreciated modality for regulating kinase activity...
  5. pmc Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies
    Gaia Skibinski
    Gladstone Institute of Neurological Disease, the Taube Koret Center for Neurodegenerative Disease Research, and the Hellman Family Foundation Program in Alzheimer s Disease Research, San Francisco, California 94158, Departments of Neurology, Physiology, and Graduate Programs in Neuroscience and Biomedical Sciences, University of California, San Francisco, California 94158, and Laboratory of Neurogenetics, National Institutes of Health, Bethesda, Maryland 20892
    J Neurosci 34:418-33. 2014
    ..These findings suggest that LRRK2 levels are more important than kinase activity per se in predicting toxicity and implicate synuclein as a major mediator of LRRK2-induced neurodegeneration. ..
  6. pmc Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis
    Venu M Nemani
    Departments of Neurology and Physiology, Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 65:66-79. 2010
    ..Increased levels of alpha-synuclein thus produce a specific, physiological defect in synaptic vesicle recycling that precedes detectable neuropathology...
  7. doi request reprint The behavior of alpha-synuclein in neurons
    Doris L Fortin
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA
    Mov Disord 25:S21-6. 2010
    ..In addition to the presumed role of alpha-synuclein dynamics in synaptic function, changes in its physiological behavior may underlie the pathological changes associated with Parkinson's disease...
  8. ncbi request reprint Energy failure: does it contribute to neurodegeneration?
    Divya Pathak
    Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA
    Ann Neurol 74:506-16. 2013
    ..Here we review the current evidence that energy failure occurs in and contributes to neurodegenerative disease, and consider new approaches that may allow us to better address this central issue...
  9. doi request reprint Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria
    Ken Nakamura
    Graduate Program in Neuroscience, Department of Neurology, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 28:12305-17. 2008
    ..We find that the conformation of alpha-synuclein responds selectively to mitochondria, indicating a direct link between alpha-synuclein and an organelle strongly implicated in the pathogenesis of PD...
  10. pmc Physiology versus pathology in Parkinson's disease
    Ken Nakamura
    Departments of Neurology and Physiology, University of California School of Medicine, 600 16th Street, GH N272B, San Francisco, CA 94158 2517, USA
    Proc Natl Acad Sci U S A 104:11867-8. 2007
  11. pmc The ubiquitin ligase parkin mediates resistance to intracellular pathogens
    Paolo S Manzanillo
    Department of Microbiology and Immunology Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, San Francisco, California 94158, USA
    Nature 501:512-6. 2013
    ..Moreover, our work reveals an unexpected functional link between mitophagy and infectious disease. ..