JEAN LEE NAKAMURA

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi The epidermal growth factor receptor in malignant gliomas: pathogenesis and therapeutic implications
    Jean L Nakamura
    University of California, San Francisco, Department of Radiation Oncology, 1600 Divisadero Street, Suite H1031, San Francisco, CA 94143, USA
    Expert Opin Ther Targets 11:463-72. 2007
  2. ncbi Glioma invasiveness responds variably to irradiation in a co-culture model
    Jean L Nakamura
    Department of Radiation Oncology, University of California San Francisco, San Francisco, CA 94143, USA
    Int J Radiat Oncol Biol Phys 69:880-6. 2007
  3. ncbi PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas
    Jean L Nakamura
    Department of Radiation Oncology, The University of California, San Francisco, CA 94143, USA
    J Neurooncol 71:215-22. 2005
  4. doi Gamma Knife radiosurgery for brain metastases from primary breast cancer
    Norbert Kased
    Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA 94143 0226, USA
    Int J Radiat Oncol Biol Phys 75:1132-40. 2009
  5. pmc S6K1 plays a key role in glial transformation
    Jean L Nakamura
    Department of Radiation Oncology, University of California, San Francisco, California 94143, USA
    Cancer Res 68:6516-23. 2008
  6. ncbi A dosimetric comparison between Gamma Knife and CyberKnife treatment plans for trigeminal neuralgia
    Martina Descovich
    Department of Radiation Oncology, University of California, San Francisco, California, USA
    J Neurosurg 113:199-206. 2010
  7. ncbi Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanism
    Alexander R Gottschalk
    Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94143 1708, USA
    Int J Radiat Oncol Biol Phys 63:1221-7. 2005
  8. ncbi Inhibition of phosphatidylinositol-3-kinase causes cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent mechanism
    Alexander R Gottschalk
    Radiation Oncology, University of California, 1600 Divisadero St, San Francisco, CA 94143, USA
    Int J Radiat Oncol Biol Phys 61:1183-8. 2005
  9. pmc mTOR-independent translational control of the extrinsic cell death pathway by RalA
    Amith Panner
    UCSF Cancer Center, 2340 Sutter St, Rm N219, San Francisco, CA 94115 0875, USA
    Mol Cell Biol 26:7345-57. 2006
  10. ncbi Gamma knife radiosurgery for brainstem metastases: the UCSF experience
    Norbert Kased
    Department of Radiation Oncology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0226, USA
    J Neurooncol 86:195-205. 2008

Research Grants

  1. The role of mTOR in Ras mediated gliomagenesis
    JEAN NAKAMURA; Fiscal Year: 2007

Detail Information

Publications11

  1. ncbi The epidermal growth factor receptor in malignant gliomas: pathogenesis and therapeutic implications
    Jean L Nakamura
    University of California, San Francisco, Department of Radiation Oncology, 1600 Divisadero Street, Suite H1031, San Francisco, CA 94143, USA
    Expert Opin Ther Targets 11:463-72. 2007
    ....
  2. ncbi Glioma invasiveness responds variably to irradiation in a co-culture model
    Jean L Nakamura
    Department of Radiation Oncology, University of California San Francisco, San Francisco, CA 94143, USA
    Int J Radiat Oncol Biol Phys 69:880-6. 2007
    ....
  3. ncbi PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas
    Jean L Nakamura
    Department of Radiation Oncology, The University of California, San Francisco, CA 94143, USA
    J Neurooncol 71:215-22. 2005
    ..Thus PI3-kinase dysregulation may contribute to the notable radioresistance of GM tumors and inhibition of PKB/Akt offers an excellent target to enhance radiosensitivity...
  4. doi Gamma Knife radiosurgery for brain metastases from primary breast cancer
    Norbert Kased
    Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA 94143 0226, USA
    Int J Radiat Oncol Biol Phys 75:1132-40. 2009
    ..The relative roles of stereotactic radiosurgery (SRS) vs. whole brain radiotherapy (WBRT) in the treatment of patients with brain metastases from breast cancer remain undefined. In this study, we reviewed our experience with these patients...
  5. pmc S6K1 plays a key role in glial transformation
    Jean L Nakamura
    Department of Radiation Oncology, University of California, San Francisco, California 94143, USA
    Cancer Res 68:6516-23. 2008
    ..These findings implicate the mTOR-S6K pathway as a critical mediator of glial cell transformation...
  6. ncbi A dosimetric comparison between Gamma Knife and CyberKnife treatment plans for trigeminal neuralgia
    Martina Descovich
    Department of Radiation Oncology, University of California, San Francisco, California, USA
    J Neurosurg 113:199-206. 2010
    ..A comparison between Gamma Knife and CyberKnife treatment plans obtained with this method is presented...
  7. ncbi Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanism
    Alexander R Gottschalk
    Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94143 1708, USA
    Int J Radiat Oncol Biol Phys 63:1221-7. 2005
    ..To identify whether inhibition of phosphatidylinositol-3-kinase (PI3K) causes increased radiosensitivity through inhibition of protein kinase B (PKB), implicating PKB as an important therapeutic target in prostate cancer...
  8. ncbi Inhibition of phosphatidylinositol-3-kinase causes cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent mechanism
    Alexander R Gottschalk
    Radiation Oncology, University of California, 1600 Divisadero St, San Francisco, CA 94143, USA
    Int J Radiat Oncol Biol Phys 61:1183-8. 2005
    ..To identify whether inhibition of phosphatidylinositol-3-kinase (PI3K) causes apoptosis through inhibition of protein kinase B (PKB), implicating PKB as an important therapeutic target in prostate cancer...
  9. pmc mTOR-independent translational control of the extrinsic cell death pathway by RalA
    Amith Panner
    UCSF Cancer Center, 2340 Sutter St, Rm N219, San Francisco, CA 94115 0875, USA
    Mol Cell Biol 26:7345-57. 2006
    ....
  10. ncbi Gamma knife radiosurgery for brainstem metastases: the UCSF experience
    Norbert Kased
    Department of Radiation Oncology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0226, USA
    J Neurooncol 86:195-205. 2008
    ..To assess clinical and imaging outcomes in patients treated with Gamma Knife stereotactic radiosurgery (SRS) for brainstem metastases...
  11. ncbi Comparison of intensity-modulated radiosurgery with gamma knife radiosurgery for challenging skull base lesions
    Jean L Nakamura
    Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA 94143, USA
    Int J Radiat Oncol Biol Phys 55:99-109. 2003
    ..To quantitatively compare intensity-modulated radiosurgery (IMRS) using 3-mm mini-multileaf collimation with gamma knife radiosurgery (GKRS) plans for irregularly shaped skull base lesions in direct proximity to organs at risk (OAR)...

Research Grants2

  1. The role of mTOR in Ras mediated gliomagenesis
    JEAN NAKAMURA; Fiscal Year: 2007
    ..The UCSF Department of Radiation Oncology strongly supports the career development activities outlined and has committed clinical and laboratory resources to support the PI's transition to independence. ..