Jean L Nakamura

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Radiotherapy-induced malignancies: review of clinical features, pathobiology, and evolving approaches for mitigating risk
    Steve Braunstein
    Department of Radiation Oncology, University of California San Francisco San Francisco, CA, USA
    Front Oncol 3:73. 2013
  2. pmc Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice
    Jean L Nakamura
    Department of Radiation Oncology, University of California, San Francisco, California 94158, USA
    Cancer Res 71:106-15. 2011
  3. pmc S6K1 plays a key role in glial transformation
    Jean L Nakamura
    Department of Radiation Oncology, University of California, San Francisco, California 94143, USA
    Cancer Res 68:6516-23. 2008
  4. doi request reprint Prognostic factors for survival in patients treated with stereotactic radiosurgery for recurrent brain metastases after prior whole brain radiotherapy
    Jorge A Caballero
    Stanford University School of Medicine, Stanford, CA, USA
    Int J Radiat Oncol Biol Phys 83:303-9. 2012
  5. ncbi request reprint Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanism
    Alexander R Gottschalk
    Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94143 1708, USA
    Int J Radiat Oncol Biol Phys 63:1221-7. 2005
  6. ncbi request reprint Inhibition of phosphatidylinositol-3-kinase causes cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent mechanism
    Alexander R Gottschalk
    Radiation Oncology, University of California, 1600 Divisadero St, San Francisco, CA 94143, USA
    Int J Radiat Oncol Biol Phys 61:1183-8. 2005
  7. ncbi request reprint Glioma invasiveness responds variably to irradiation in a co-culture model
    Jean L Nakamura
    Department of Radiation Oncology, University of California San Francisco, San Francisco, CA 94143, USA
    Int J Radiat Oncol Biol Phys 69:880-6. 2007
  8. pmc mTOR-independent translational control of the extrinsic cell death pathway by RalA
    Amith Panner
    UCSF Cancer Center, 2340 Sutter St, Rm N219, San Francisco, CA 94115 0875, USA
    Mol Cell Biol 26:7345-57. 2006
  9. doi request reprint High-precision volume-staged Gamma Knife surgery and equivalent hypofractionation dose schedules for treating large arteriovenous malformations
    Shannon Fogh
    Department of Radiation Oncology, University of California, San Francisco, California 94143, USA
    J Neurosurg 117:115-9. 2012
  10. pmc Genetically mediated Nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasms
    Grace Choi
    Department of Radiation Oncology, University of California, San Francisco, San Francisco, California, USA
    Cancer Res 72:6425-34. 2012

Detail Information

Publications16

  1. pmc Radiotherapy-induced malignancies: review of clinical features, pathobiology, and evolving approaches for mitigating risk
    Steve Braunstein
    Department of Radiation Oncology, University of California San Francisco San Francisco, CA, USA
    Front Oncol 3:73. 2013
    ..The goal of this review is to discuss epidemiologic, modeling, and radiotherapy delivery data, where these lines of research intersect and their potential impact on patient care...
  2. pmc Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice
    Jean L Nakamura
    Department of Radiation Oncology, University of California, San Francisco, California 94158, USA
    Cancer Res 71:106-15. 2011
    ..This technique for administering focal fractionated irradiation will facilitate mechanistic and translational studies of SMNs...
  3. pmc S6K1 plays a key role in glial transformation
    Jean L Nakamura
    Department of Radiation Oncology, University of California, San Francisco, California 94143, USA
    Cancer Res 68:6516-23. 2008
    ..These findings implicate the mTOR-S6K pathway as a critical mediator of glial cell transformation...
  4. doi request reprint Prognostic factors for survival in patients treated with stereotactic radiosurgery for recurrent brain metastases after prior whole brain radiotherapy
    Jorge A Caballero
    Stanford University School of Medicine, Stanford, CA, USA
    Int J Radiat Oncol Biol Phys 83:303-9. 2012
    ..To evaluate prognostic factors for survival after stereotactic radiosurgery (SRS) for new, progressive, or recurrent brain metastases (BM) after prior whole brain radiotherapy (WBRT)...
  5. ncbi request reprint Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanism
    Alexander R Gottschalk
    Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94143 1708, USA
    Int J Radiat Oncol Biol Phys 63:1221-7. 2005
    ..To identify whether inhibition of phosphatidylinositol-3-kinase (PI3K) causes increased radiosensitivity through inhibition of protein kinase B (PKB), implicating PKB as an important therapeutic target in prostate cancer...
  6. ncbi request reprint Inhibition of phosphatidylinositol-3-kinase causes cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent mechanism
    Alexander R Gottschalk
    Radiation Oncology, University of California, 1600 Divisadero St, San Francisco, CA 94143, USA
    Int J Radiat Oncol Biol Phys 61:1183-8. 2005
    ..To identify whether inhibition of phosphatidylinositol-3-kinase (PI3K) causes apoptosis through inhibition of protein kinase B (PKB), implicating PKB as an important therapeutic target in prostate cancer...
  7. ncbi request reprint Glioma invasiveness responds variably to irradiation in a co-culture model
    Jean L Nakamura
    Department of Radiation Oncology, University of California San Francisco, San Francisco, CA 94143, USA
    Int J Radiat Oncol Biol Phys 69:880-6. 2007
    ....
  8. pmc mTOR-independent translational control of the extrinsic cell death pathway by RalA
    Amith Panner
    UCSF Cancer Center, 2340 Sutter St, Rm N219, San Francisco, CA 94115 0875, USA
    Mol Cell Biol 26:7345-57. 2006
    ....
  9. doi request reprint High-precision volume-staged Gamma Knife surgery and equivalent hypofractionation dose schedules for treating large arteriovenous malformations
    Shannon Fogh
    Department of Radiation Oncology, University of California, San Francisco, California 94143, USA
    J Neurosurg 117:115-9. 2012
    ....
  10. pmc Genetically mediated Nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasms
    Grace Choi
    Department of Radiation Oncology, University of California, San Francisco, San Francisco, California, USA
    Cancer Res 72:6425-34. 2012
    ..Nf1 heterozygosity confers broad susceptibility to genotoxin-induced tumorigenesis, and this paradigm serves as an experimental platform for future studies of SMNs...
  11. ncbi request reprint PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas
    Jean L Nakamura
    Department of Radiation Oncology, The University of California, San Francisco, CA 94143, USA
    J Neurooncol 71:215-22. 2005
    ..Thus PI3-kinase dysregulation may contribute to the notable radioresistance of GM tumors and inhibition of PKB/Akt offers an excellent target to enhance radiosensitivity...
  12. ncbi request reprint A dosimetric comparison between Gamma Knife and CyberKnife treatment plans for trigeminal neuralgia
    Martina Descovich
    Department of Radiation Oncology, University of California, San Francisco, California, USA
    J Neurosurg 113:199-206. 2010
    ..A comparison between Gamma Knife and CyberKnife treatment plans obtained with this method is presented...
  13. doi request reprint Gamma Knife radiosurgery for brain metastases from primary breast cancer
    Norbert Kased
    Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA 94143 0226, USA
    Int J Radiat Oncol Biol Phys 75:1132-40. 2009
    ..The relative roles of stereotactic radiosurgery (SRS) vs. whole brain radiotherapy (WBRT) in the treatment of patients with brain metastases from breast cancer remain undefined. In this study, we reviewed our experience with these patients...
  14. ncbi request reprint The epidermal growth factor receptor in malignant gliomas: pathogenesis and therapeutic implications
    Jean L Nakamura
    University of California, San Francisco, Department of Radiation Oncology, 1600 Divisadero Street, Suite H1031, San Francisco, CA 94143, USA
    Expert Opin Ther Targets 11:463-72. 2007
    ....
  15. ncbi request reprint Gamma knife radiosurgery for brainstem metastases: the UCSF experience
    Norbert Kased
    Department of Radiation Oncology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0226, USA
    J Neurooncol 86:195-205. 2008
    ..To assess clinical and imaging outcomes in patients treated with Gamma Knife stereotactic radiosurgery (SRS) for brainstem metastases...
  16. ncbi request reprint Comparison of intensity-modulated radiosurgery with gamma knife radiosurgery for challenging skull base lesions
    Jean L Nakamura
    Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA 94143, USA
    Int J Radiat Oncol Biol Phys 55:99-109. 2003
    ..To quantitatively compare intensity-modulated radiosurgery (IMRS) using 3-mm mini-multileaf collimation with gamma knife radiosurgery (GKRS) plans for irregularly shaped skull base lesions in direct proximity to organs at risk (OAR)...