Robert Nakamoto

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Rotational coupling in the F0F1 ATP synthase
    R K Nakamoto
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville 22906, USA
    Annu Rev Biophys Biomol Struct 28:205-34. 1999
  2. ncbi request reprint Molecular mechanisms of rotational catalysis in the F(0)F(1) ATP synthase
    R K Nakamoto
    Department of Molecular Physiology and Biological Physics, University of Virginia, P O Box 10011, Charlottesville, VA 22906 0011, USA
    Biochim Biophys Acta 1458:289-99. 2000
  3. ncbi request reprint Mitochondria in nonalcoholic fatty liver disease
    Stephen H Caldwell
    Division of Gastroenterology and Hepatology, University of Virginia Health System, PO Box 800708, Charlottesville, VA 22908, USA
    Clin Liver Dis 8:595-617, x. 2004
  4. ncbi request reprint Determination of the partial reactions of rotational catalysis in F1-ATPase
    Joanne A Baylis Scanlon
    Department of Molecular Physiology and Biological Physics, University of Virginia, P O Box 800736, Charlottesville, Virginia 22908 0736, USA
    Biochemistry 46:8785-97. 2007
  5. pmc The rotary mechanism of the ATP synthase
    Robert K Nakamoto
    Department of Molecular Physiology and Biological Physics, University of Virginia, P O Box 800736, Charlottesville, VA 22908 0736, USA
    Arch Biochem Biophys 476:43-50. 2008
  6. pmc A rotor-stator cross-link in the F1-ATPase blocks the rate-limiting step of rotational catalysis
    Joanne A Baylis Scanlon
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 283:26228-40. 2008
  7. ncbi request reprint F0 cysteine, bCys21, in the Escherichia coli ATP synthase is involved in regulation of potassium uptake and molecular hydrogen production in anaerobic conditions
    Nelli Mnatsakanyan
    Department of Biophysics, Yerevan State University, 1 Alex Manougian Street, 375049 Yerevan, Armenia
    Biosci Rep 22:421-30. 2002
  8. pmc Special issue on transport ATPases
    Giuseppe Inesi
    Arch Biochem Biophys 476:1-2. 2008

Research Grants

  1. Transport of Vitamin B12 in E. Coli
    Robert Nakamoto; Fiscal Year: 2007
  2. Linking functions of the FOF1 ATP Synthase
    Robert Nakamoto; Fiscal Year: 2005
  3. LINKING FUNCTIONS OF THE FOF1 SYNTHASE
    Robert Nakamoto; Fiscal Year: 2001

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Rotational coupling in the F0F1 ATP synthase
    R K Nakamoto
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville 22906, USA
    Annu Rev Biophys Biomol Struct 28:205-34. 1999
    ..Mutational analyses have shown that the rotor subunits are responsible for coupling and in doing so transmit specific conformational information between transport and catalysis...
  2. ncbi request reprint Molecular mechanisms of rotational catalysis in the F(0)F(1) ATP synthase
    R K Nakamoto
    Department of Molecular Physiology and Biological Physics, University of Virginia, P O Box 10011, Charlottesville, VA 22906 0011, USA
    Biochim Biophys Acta 1458:289-99. 2000
    ..Amino acid replacements in the transport domain also affect the steady state catalytic transition state indicating that rotation is involved in coupling to transport...
  3. ncbi request reprint Mitochondria in nonalcoholic fatty liver disease
    Stephen H Caldwell
    Division of Gastroenterology and Hepatology, University of Virginia Health System, PO Box 800708, Charlottesville, VA 22908, USA
    Clin Liver Dis 8:595-617, x. 2004
    ..The prominent role of mitochondrial dysfunction in NAFL provides a new and exciting paradigm in which to view this disorder, its complications, and potential dietary and pharmacologic intervention...
  4. ncbi request reprint Determination of the partial reactions of rotational catalysis in F1-ATPase
    Joanne A Baylis Scanlon
    Department of Molecular Physiology and Biological Physics, University of Virginia, P O Box 800736, Charlottesville, Virginia 22908 0736, USA
    Biochemistry 46:8785-97. 2007
    ..P., Leslie, A. G. W., Lutter, R., and Walker, J. E. (1994) Nature 370, 621-628)...
  5. pmc The rotary mechanism of the ATP synthase
    Robert K Nakamoto
    Department of Molecular Physiology and Biological Physics, University of Virginia, P O Box 800736, Charlottesville, VA 22908 0736, USA
    Arch Biochem Biophys 476:43-50. 2008
    ..This review addresses the role of rotation in catalysis of ATP synthesis/hydrolysis and the transport of protons or sodium...
  6. pmc A rotor-stator cross-link in the F1-ATPase blocks the rate-limiting step of rotational catalysis
    Joanne A Baylis Scanlon
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 283:26228-40. 2008
    ..This analysis provides additional insights into how the enzyme achieves efficient coupling and implicates the betaGlu-381 residue for proper formation of the rate-limiting transition state involving gamma subunit rotation...
  7. ncbi request reprint F0 cysteine, bCys21, in the Escherichia coli ATP synthase is involved in regulation of potassium uptake and molecular hydrogen production in anaerobic conditions
    Nelli Mnatsakanyan
    Department of Biophysics, Yerevan State University, 1 Alex Manougian Street, 375049 Yerevan, Armenia
    Biosci Rep 22:421-30. 2002
    ..These results indicate a role for the F0 subunit bCys21 in the functionality of F0F1 and coupling to other membranous activities under fermentative conditions...
  8. pmc Special issue on transport ATPases
    Giuseppe Inesi
    Arch Biochem Biophys 476:1-2. 2008

Research Grants16

  1. Transport of Vitamin B12 in E. Coli
    Robert Nakamoto; Fiscal Year: 2007
    ..Reconstitution of the translational regulatory process in vitro will allow detailed probing of changes in RNA secondary structure and the role of transcript . ..
  2. Linking functions of the FOF1 ATP Synthase
    Robert Nakamoto; Fiscal Year: 2005
    ....
  3. LINKING FUNCTIONS OF THE FOF1 SYNTHASE
    Robert Nakamoto; Fiscal Year: 2001
    ..These mutations affect cells with high metabolic rates, and in particular usually appear as neurodegenerative disorders. ..