M P Nair

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. ncbi request reprint Grape seed extract proanthocyanidins downregulate HIV-1 entry coreceptors, CCR2b, CCR3 and CCR5 gene expression by normal peripheral blood mononuclear cells
    Madhavan P Nair
    Departments of Medicine and Microbiology, Kaleida Health System, Buffalo General Hospital, Buffalo, NY, USA
    Biol Res 35:421-31. 2002
  2. ncbi request reprint Methamphetamine modulates DC-SIGN expression by mature dendritic cells
    Madhavan P N Nair
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York and Buffalo General Hospital, Kaleida Health System, 100 High Street, Buffalo, NY 14203, USA
    J Neuroimmune Pharmacol 1:296-304. 2006
  3. ncbi request reprint Association of drug abuse with inhibition of HIV-1 immune responses: studies with long-term of HIV-1 non-progressors
    Madhavan P N Nair
    Department of Medicine and Microbiology, State University of New York at Buffalo, Kaleida Health Buffalo General Hospital, 100 High Street, Buffalo, NY 14203, USA
    J Neuroimmunol 147:21-5. 2004
  4. ncbi request reprint Cocaine modulates dendritic cell-specific C type intercellular adhesion molecule-3-grabbing nonintegrin expression by dendritic cells in HIV-1 patients
    Madhavan P N Nair
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York and Buffalo General Hospital, 14203, USA
    J Immunol 174:6617-26. 2005
  5. ncbi request reprint The flavonoid, quercetin, differentially regulates Th-1 (IFNgamma) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells
    Madhavan P N Nair
    Departments of Medicine, Kaleida Health System, Buffalo General Hospital, Buffalo, NY 14203, USA
    Biochim Biophys Acta 1593:29-36. 2002
  6. pmc The flavonoid quercetin inhibits proinflammatory cytokine (tumor necrosis factor alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-kappa beta system
    Madhavan P Nair
    Department of Medicine and Microbiology, Kaleida Health System, Buffalo General Hospital, State University of New York at Buffalo, Buffalo, NY 14203, USA
    Clin Vaccine Immunol 13:319-28. 2006
  7. ncbi request reprint The stress hormone, cortisol, synergizes with HIV-1 gp-120 to induce apoptosis of normal human peripheral blood mononuclear cells
    - Nair MPN
    Department of Medicine, State University of New York at Buffalo, Buffalo General Hospital, NY 14203, USA
    Cell Mol Biol (Noisy-le-grand) 46:1227-38. 2000
  8. pmc Reversal of human immunodeficiency virus type 1 protein-induced inhibition of natural killer cell activity by alpha interferon and interleukin-2
    M P Nair
    Department of Medicine and Microbiology, Division of Allergy, Immunology and Rheumatology, and Buffalo General Hospital, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, New York 14203, USA
    Clin Diagn Lab Immunol 7:101-5. 2000
  9. pmc Cocaine differentially modulates chemokine production by mononuclear cells from normal donors and human immunodeficiency virus type 1-infected patients
    M P Nair
    State University of New York at Buffalo, Buffalo General Hospital, Buffalo, New York 14203, USA
    Clin Diagn Lab Immunol 7:96-100. 2000
  10. ncbi request reprint Effect of cocaine on chemokine and CCR-5 gene expression by mononuclear cells from normal donors and HIV-1 infected patients
    M P Nair
    Buffalo General Hospital, NY 14203, USA
    Adv Exp Med Biol 493:235-40. 2001

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Grape seed extract proanthocyanidins downregulate HIV-1 entry coreceptors, CCR2b, CCR3 and CCR5 gene expression by normal peripheral blood mononuclear cells
    Madhavan P Nair
    Departments of Medicine and Microbiology, Kaleida Health System, Buffalo General Hospital, Buffalo, NY, USA
    Biol Res 35:421-31. 2002
    ..Investigations of the mechanisms underlying the anti-HIV-1 effects of grape seed extracts may help to identify promising natural products useful in the prevention and/or amelioration of HIV-1 infection...
  2. ncbi request reprint Methamphetamine modulates DC-SIGN expression by mature dendritic cells
    Madhavan P N Nair
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York and Buffalo General Hospital, Kaleida Health System, 100 High Street, Buffalo, NY 14203, USA
    J Neuroimmune Pharmacol 1:296-304. 2006
    ..A better understanding of the role of DC-SIGN in HIV-1 infection may help to design novel therapeutic strategies against the progression of HIV-1 disease in the drug-using population...
  3. ncbi request reprint Association of drug abuse with inhibition of HIV-1 immune responses: studies with long-term of HIV-1 non-progressors
    Madhavan P N Nair
    Department of Medicine and Microbiology, State University of New York at Buffalo, Kaleida Health Buffalo General Hospital, 100 High Street, Buffalo, NY 14203, USA
    J Neuroimmunol 147:21-5. 2004
    ..Our results suggest that recreational drug use may reduce CTL and IL-16 expression and increase the expression of TGF-beta1 and CXCR4, all of which may facilitate progression of HIV infections...
  4. ncbi request reprint Cocaine modulates dendritic cell-specific C type intercellular adhesion molecule-3-grabbing nonintegrin expression by dendritic cells in HIV-1 patients
    Madhavan P N Nair
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York and Buffalo General Hospital, 14203, USA
    J Immunol 174:6617-26. 2005
    ..A better understanding of the role of DC-SIGN in HIV infection may help to design novel therapeutic strategies against the progression of HIV disease in the drug-using population...
  5. ncbi request reprint The flavonoid, quercetin, differentially regulates Th-1 (IFNgamma) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells
    Madhavan P N Nair
    Departments of Medicine, Kaleida Health System, Buffalo General Hospital, Buffalo, NY 14203, USA
    Biochim Biophys Acta 1593:29-36. 2002
    ..These results suggest that the beneficial immuno-stimulatory effects of quercetin may be mediated through the induction of Th-1 derived cytokine, IFNgamma, and inhibition of Th-2 derived cytokine, IL-4...
  6. pmc The flavonoid quercetin inhibits proinflammatory cytokine (tumor necrosis factor alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-kappa beta system
    Madhavan P Nair
    Department of Medicine and Microbiology, Kaleida Health System, Buffalo General Hospital, State University of New York at Buffalo, Buffalo, NY 14203, USA
    Clin Vaccine Immunol 13:319-28. 2006
    ..Our results provide direct evidence of the anti-inflammatory effects of quercetin by PBMC, which are mediated by the inhibition of the proinflammatory cytokine TNF-alpha via modulation of NF-kappabeta1 and Ikappabeta...
  7. ncbi request reprint The stress hormone, cortisol, synergizes with HIV-1 gp-120 to induce apoptosis of normal human peripheral blood mononuclear cells
    - Nair MPN
    Department of Medicine, State University of New York at Buffalo, Buffalo General Hospital, NY 14203, USA
    Cell Mol Biol (Noisy-le-grand) 46:1227-38. 2000
    ..The synergistic effect of cortisol and gp- 120 in inducing apoptosis of lymphocytes is consistent with a model proposing that stress-associated and circulating HIV-1 derived soluble products may cause progression of HIV infections...
  8. pmc Reversal of human immunodeficiency virus type 1 protein-induced inhibition of natural killer cell activity by alpha interferon and interleukin-2
    M P Nair
    Department of Medicine and Microbiology, Division of Allergy, Immunology and Rheumatology, and Buffalo General Hospital, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, New York 14203, USA
    Clin Diagn Lab Immunol 7:101-5. 2000
    ..The combined effect of IFN-alpha and IL-2 in enhancing NK cell activity may provide a novel therapeutic approach to the restoration of depressed NK cell activity observed in HIV-infected patients...
  9. pmc Cocaine differentially modulates chemokine production by mononuclear cells from normal donors and human immunodeficiency virus type 1-infected patients
    M P Nair
    State University of New York at Buffalo, Buffalo General Hospital, Buffalo, New York 14203, USA
    Clin Diagn Lab Immunol 7:96-100. 2000
    ....
  10. ncbi request reprint Effect of cocaine on chemokine and CCR-5 gene expression by mononuclear cells from normal donors and HIV-1 infected patients
    M P Nair
    Buffalo General Hospital, NY 14203, USA
    Adv Exp Med Biol 493:235-40. 2001
  11. pmc Differential effects of human immunodeficiency virus type 1 envelope protein gp120 on interferon production by mononuclear cells from adults and neonates
    M P Nair
    Department of Medicine and Microbiology, State University of New York at Buffalo, USA
    Clin Diagn Lab Immunol 2:434-8. 1995
    ..Increased suppression of IFN-alpha and IFN-gamma production by gp120 in neonates may partially explain their apparent increased susceptibility to the clinical progression of HIV infections compared with that of adults...
  12. ncbi request reprint Drug abuse and neuropathogenesis of HIV infection: role of DC-SIGN and IDO
    Madhavan P N Nair
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology and State University of New York and Buffalo General Hospital, Kaleida Health System 100 High Street, Buffalo, NY 14203, USA
    J Neuroimmunol 157:56-60. 2004
    ....
  13. pmc Proteomic analyses of methamphetamine (METH)-induced differential protein expression by immature dendritic cells (IDC)
    Jessica L Reynolds
    Department of Medicine, Division of Allergy, Immunology and Rheumatology, State University of New York at Buffalo, Buffalo General Hospital, Buffalo, NY 14203, USA
    Biochim Biophys Acta 1774:433-42. 2007
    ..Identification of unique, METH-induced proteins may help to develop novel markers for diagnostic, preventive and therapeutic targeting in METH using subjects...
  14. pmc Proteomic analysis of the effects of cocaine on the enhancement of HIV-1 replication in normal human astrocytes (NHA)
    Jessica L Reynolds
    Department of Medicine, Division of Allergy, Immunology and Rheumatology, State University of New York at Buffalo, Buffalo General Hospital, 100 High Street, Buffalo, NY 14203, USA
    Brain Res 1123:226-36. 2006
    ..Further, our results show for the first time that cocaine differentially regulates the expression of a number of proteins by NHA that may play a role in the neuropathogenesis of HIV-1 disease...
  15. ncbi request reprint Methamphetamine modulates gene expression patterns in monocyte derived mature dendritic cells: implications for HIV-1 pathogenesis
    Supriya D Mahajan
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, Buffalo General Hospital, Buffalo, New York 14203, USA
    Mol Diagn Ther 10:257-69. 2006
    ..This suggests that methamphetamine has a role as a cofactor in the pathogenesis of HIV-1...
  16. ncbi request reprint Morphine regulates gene expression of alpha- and beta-chemokines and their receptors on astroglial cells via the opioid mu receptor
    Supriya D Mahajan
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York and Buffalo General Hospital, Kaleida Health System, Buffalo, NY 14203, USA
    J Immunol 169:3589-99. 2002
    ..These effects of opioids appear to be mediated through the opioid mu receptor that we demonstrated on astroglial cells...
  17. pmc RNAi-directed inhibition of DC-SIGN by dendritic cells: prospects for HIV-1 therapy
    Madhavan P N Nair
    Department of Medicine, Division of Allergy, Immunology and Rheumatology, Buffalo General Hospital, 100 High Street, Buffalo, NY 14203, USA
    AAPS J 7:E572-8. 2005
    ..This effect may be mediated by modulation of p38 mitogen activated protein kinase (MAPK)...
  18. ncbi request reprint Morphine exacerbates HIV-1 viral protein gp120 induced modulation of chemokine gene expression in U373 astrocytoma cells
    Supriya D Mahajan
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York and Buffalo General Hospital, Kaleida Health, 100 High Street, Buffalo, NY 14203, USA
    Curr HIV Res 3:277-88. 2005
    ....
  19. ncbi request reprint Serum interferon inhibitor declines in patients with HIV-1 infection after a change in antiretroviral therapy
    Kailash C Chadha
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Immunol Invest 32:299-312. 2003
    ..Interferon inhibitor levels appear to decline as CD4 cell count rises and HIV-RNA levels fall. This suggests that interferon inhibitor may have a significant role in the host immune response to HIV infection...
  20. ncbi request reprint Morphine modulates chemokine gene regulation in normal human astrocytes
    Supriya D Mahajan
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York and Buffalo General Hospital, 310 Multi Research Building, Kaleida Health, 100 High Street, Buffalo, NY 14203, USA
    Clin Immunol 115:323-32. 2005
    ..These results support our hypothesis that opiates act as co-factors in the neuropathogenesis of HIV infection...
  21. pmc Prostate-specific antigen modulates the expression of genes involved in prostate tumor growth
    B Bindukumar
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Neoplasia 7:241-52. 2005
    ..Our data support the hypothesis that f-PSA plays a significant role in prostate tumor growth by regulating various proangiogenic and antiangiogenic growth factors...
  22. ncbi request reprint Gene expression of angiogenic factors correlates with metastatic potential of prostate cancer cells
    Ravikumar Aalinkeel
    Department of Medicine, Division of Allergy, Immunology and Rheumatology, State University of New York at Buffalo, 100 High Street, Buffalo, NY 14203, USA
    Cancer Res 64:5311-21. 2004
    ..These results support our hypothesis that metastatic potential of prostate cancer cells correlates with expression of proangiogenic factors...