Ulhas P Naik

Summary

Affiliation: University of Delaware
Country: USA

Publications

  1. pmc Junctional adhesion molecule-A regulates vascular endothelial growth factor receptor-2 signaling-dependent mouse corneal wound healing
    Sharmila Chatterjee
    Department of Biological Sciences, University of Delaware, Newark, Delaware, United States of America
    PLoS ONE 8:e63674. 2013
  2. pmc Calcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cells
    John C Kostyak
    Department of Biological Sciences, University of Delaware, Newark, Delaware, United States of America
    PLoS ONE 6:e14513. 2011
  3. pmc JAM-A protects from thrombosis by suppressing integrin αIIbβ3-dependent outside-in signaling in platelets
    Meghna U Naik
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    Blood 119:3352-60. 2012
  4. pmc Probabilistic modeling and analysis of the effects of extra-cellular matrix density on the sizes, shapes, and locations of integrin clusters in adherent cells
    Erik S Welf
    Department of Chemical Engineering, 150 Academy St, Colburn Lab, University of Delaware, Newark, Delaware 19716, USA
    BMC Biophys 4:15. 2011
  5. pmc Calcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cells
    Meghna U Naik
    Delaware Cardiovascular Research Center, University of Delaware, Newark, DE 19716, USA
    Int J Cancer 128:587-96. 2011
  6. doi request reprint CIB1 deficiency results in impaired thrombosis: the potential role of CIB1 in outside-in signaling through integrin alpha IIb beta 3
    M U Naik
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    J Thromb Haemost 7:1906-14. 2009
  7. pmc Putting the brakes on cancer cell migration: JAM-A restrains integrin activation
    Ulhas P Naik
    Department of Biological Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, Delaware 19716, USA
    Cell Adh Migr 2:249-51. 2008
  8. ncbi request reprint Characterization and chromosomal localization of JAM-1, a platelet receptor for a stimulatory monoclonal antibody
    U P Naik
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    J Cell Sci 114:539-47. 2001
  9. ncbi request reprint Junctional adhesion molecule-A-induced endothelial cell migration on vitronectin is integrin alpha v beta 3 specific
    Meghna U Naik
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    J Cell Sci 119:490-9. 2006
  10. ncbi request reprint Essential role of junctional adhesion molecule-1 in basic fibroblast growth factor-induced endothelial cell migration
    Meghna U Naik
    Department of Biological Sciences, University of Delaware, 329 Wolf Hall, Newark, DE 19716, USA
    Arterioscler Thromb Vasc Biol 23:2165-71. 2003

Research Grants

  1. Role of JAM Family in Angiogenesis
    Ulhas P Naik; Fiscal Year: 2010
  2. ROLE OF JAM-1 IN CELL ADHESION AND MIGRATION
    Ulhas Naik; Fiscal Year: 2003
  3. Role of JAM Family in Angiogenesis
    Ulhas Naik; Fiscal Year: 2007
  4. Modulation of integrin function by cytoplasmic signals
    Ulhas Naik; Fiscal Year: 2007

Collaborators

Detail Information

Publications31

  1. pmc Junctional adhesion molecule-A regulates vascular endothelial growth factor receptor-2 signaling-dependent mouse corneal wound healing
    Sharmila Chatterjee
    Department of Biological Sciences, University of Delaware, Newark, Delaware, United States of America
    PLoS ONE 8:e63674. 2013
    ..Our results suggest that in the absence of Jam-A, the VEGF-A/VEGFR-2 pathway is upregulated, thereby augmenting wound induced corneal inflammation, angiogenesis, and myofibroblast accumulation leading to scarring...
  2. pmc Calcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cells
    John C Kostyak
    Department of Biological Sciences, University of Delaware, Newark, Delaware, United States of America
    PLoS ONE 6:e14513. 2011
    ..Furthermore, PMA treatment augmented the interaction between CIB1 and Plk3, which depended on the duration of treatment. These data suggest that CIB1 is involved in regulating endomitosis, perhaps through its interaction with Plk3...
  3. pmc JAM-A protects from thrombosis by suppressing integrin αIIbβ3-dependent outside-in signaling in platelets
    Meghna U Naik
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    Blood 119:3352-60. 2012
    ..We conclude that JAM-A normally limits platelet accumulation by inhibiting integrin outside-in signaling thus preventing premature platelet activation...
  4. pmc Probabilistic modeling and analysis of the effects of extra-cellular matrix density on the sizes, shapes, and locations of integrin clusters in adherent cells
    Erik S Welf
    Department of Chemical Engineering, 150 Academy St, Colburn Lab, University of Delaware, Newark, Delaware 19716, USA
    BMC Biophys 4:15. 2011
    ..abstract:..
  5. pmc Calcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cells
    Meghna U Naik
    Delaware Cardiovascular Research Center, University of Delaware, Newark, DE 19716, USA
    Int J Cancer 128:587-96. 2011
    ..Thus, in addition to Plk3, CIB1 may be a potential biomarker and target for therapeutic intervention of breast cancer...
  6. doi request reprint CIB1 deficiency results in impaired thrombosis: the potential role of CIB1 in outside-in signaling through integrin alpha IIb beta 3
    M U Naik
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    J Thromb Haemost 7:1906-14. 2009
    ..How outside-in signaling through alpha(IIb)beta(3) regulates hemostasis and thrombosis is not well understood. We have previously shown that CIB1 is involved in regulating alpha(IIb)beta(3) function...
  7. pmc Putting the brakes on cancer cell migration: JAM-A restrains integrin activation
    Ulhas P Naik
    Department of Biological Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, Delaware 19716, USA
    Cell Adh Migr 2:249-51. 2008
    ..The molecular mechanism of this function of JAM-A is beyond its well-characterized barrier function at the tight junction. Our results point out that JAM-A differentially regulates migration of endothelial and cancer cells...
  8. ncbi request reprint Characterization and chromosomal localization of JAM-1, a platelet receptor for a stimulatory monoclonal antibody
    U P Naik
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    J Cell Sci 114:539-47. 2001
    ..JAM-1 is a single copy gene, which is constitutively expressed on various tissues and cells, and may be involved in cell to cell adhesion through homophilic interaction...
  9. ncbi request reprint Junctional adhesion molecule-A-induced endothelial cell migration on vitronectin is integrin alpha v beta 3 specific
    Meghna U Naik
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    J Cell Sci 119:490-9. 2006
    ..Taken together, these results suggest that signaling through JAM-A is necessary for alpha(v)beta(3)-dependent HUVEC migration and implicate JAM-A in the regulation of vascular function...
  10. ncbi request reprint Essential role of junctional adhesion molecule-1 in basic fibroblast growth factor-induced endothelial cell migration
    Meghna U Naik
    Department of Biological Sciences, University of Delaware, 329 Wolf Hall, Newark, DE 19716, USA
    Arterioscler Thromb Vasc Biol 23:2165-71. 2003
    ....
  11. ncbi request reprint Association of CIB with GPIIb/IIIa during outside-in signaling is required for platelet spreading on fibrinogen
    Ulhas P Naik
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    Blood 102:1355-62. 2003
    ..These data suggest that formation of the CIB-GPIIb/IIIa complex may be necessary for initiation of downstream signaling events, such as ADP secretion, that lead to platelet spreading...
  12. ncbi request reprint Calcium-and integrin-binding protein regulates focal adhesion kinase activity during platelet spreading on immobilized fibrinogen
    Meghna U Naik
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    Blood 102:3629-36. 2003
    ..Taken together, our results suggest that CIB regulates platelet spreading through the regulation of FAK activation...
  13. doi request reprint Attenuation of junctional adhesion molecule-A is a contributing factor for breast cancer cell invasion
    Meghna U Naik
    Deparment of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    Cancer Res 68:2194-203. 2008
    ..Furthermore, loss of JAM-A could be used as a biomarker for aggressive breast cancer...
  14. ncbi request reprint Deletion of JAM-A causes morphological defects in the corneal epithelium
    Liang I Kang
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    Int J Biochem Cell Biol 39:576-85. 2007
    ..In summary, JAM-A is expressed in the corneal epithelium where it appears to regulate cell shape...
  15. ncbi request reprint Junctional adhesion molecules in angiogenesis
    Tejal U Naik
    Charter School of Wilmington, Delaware, USA
    Front Biosci 13:258-62. 2008
    ..This review focuses on a recently identified novel cell adhesion molecule, Junctional Adhesion Molecule A, and its role in the process of regulating angiogenesis...
  16. pmc Calcium- and integrin-binding protein 1 regulates megakaryocyte ploidy, adhesion, and migration
    John C Kostyak
    Department of Biological Sciences, University of Delaware, Newark, USA
    Blood 119:838-46. 2012
    ..05), when plated on fibrinogen. These data suggest that CIB1 plays a dual role in megakaryopoiesis, initially by negatively regulating TPO signaling and later by augmenting proplatelet production...
  17. pmc Contra-regulation of calcium- and integrin-binding protein 1-induced cell migration on fibronectin by PAK1 and MAP kinase signaling
    Meghna U Naik
    Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, USA
    J Cell Biochem 112:3289-99. 2011
    ..Furthermore, CIB1-induced cell migration is dependent on MAP kinase signaling and its function is attenuated by PAK1...
  18. ncbi request reprint Fibroblast growth factor-2 failed to induce angiogenesis in junctional adhesion molecule-A-deficient mice
    Vesselina G Cooke
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    Arterioscler Thromb Vasc Biol 26:2005-11. 2006
    ..Whether JAM-A is involved in FGF-2-induced angiogenesis in vivo is not known. We used JAM-A null mice to conclusively determine the role of JAM-A in FGF-2-induced neovascularization...
  19. ncbi request reprint Signaling through JAM-1 and alphavbeta3 is required for the angiogenic action of bFGF: dissociation of the JAM-1 and alphavbeta3 complex
    Meghna U Naik
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    Blood 102:2108-14. 2003
    ..In addition, blockage of either JAM-1 or alphavbeta3 inhibits bFGF-induced MAP kinase activation. Thus, our results suggest that signaling through JAM-1 and alphavbeta3 is necessary for bFGF-induced angiogenesis...
  20. pmc CASK interacts with PMCA4b and JAM-A on the mouse sperm flagellum to regulate Ca2+ homeostasis and motility
    Rolands G Aravindan
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    J Cell Physiol 227:3138-50. 2012
    ..The decreased motility is likely due to the collateral net deficit in ATP observed in nulls. Our data indicate that Ca(2+) homeostasis in sperm is maintained by the relative ratios of CASK-PMCA4b and CASK-JAM-A interactions...
  21. pmc JAM-A is present in mammalian spermatozoa where it is essential for normal motility
    Minghai Shao
    Department of Biological Sciences, 219 McKinly Lab, University of Delaware, Newark, DE 19716, USA
    Dev Biol 313:246-55. 2008
    ....
  22. ncbi request reprint JAM-A expression during embryonic development
    James J Parris
    Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, USA
    Dev Dyn 233:1517-24. 2005
    ..Thus, JAM-A is prominently expressed in embryonic vasculature and the epithelial components of several organ systems and may have an important role in their development...
  23. pmc Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progression
    Meghna U Naik
    Delaware Cardiovascular Research Center, Department of Biological Sciences, University of Delaware, Newark, DE 19716, United States
    Int J Biochem Cell Biol 43:120-9. 2011
    ..These results suggest that CIB1 tightly regulates Plk3 activity during cell division and that either over- or underexpression results in a multinucleated phenotype...
  24. ncbi request reprint OptiRNAi, an RNAi design tool
    Wenwu Cui
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    Comput Methods Programs Biomed 75:67-73. 2004
    ..Thus, OptiRNAi is an efficient and user friendly tool for RNAi design based on criteria that are more stringent than other available tools...
  25. ncbi request reprint Cytoplasmic binding partners of the platelet integrin alphaIIb beta3
    Melissa A Bonner
    Delaware Biotechnology Institute, Newark, DE, USA
    Front Biosci 12:2038-49. 2007
    ..In the present work, we explore known cytoplasmic binding partners of the integrin alphaIIb beta3 and their effect on alphaIIb beta3, focusing on CIB1...
  26. doi request reprint Formulation of a Peptide nucleic Acid based nucleic Acid delivery construct
    Peter G Millili
    Department of Chemical Engineering, Department of Biological Sciences, Department of Chemistry and Biochemistry, and Delaware Biotechnology Institute, University of Delaware, Newark, Delaware 19716, and Department of Pharmaceutical Research, Development, Merck Research Laboratories, West Point, Pennsylvania 19486
    Bioconjug Chem 21:445-55. 2010
    ..These findings suggest that DNA prePEGylation by the PNA-based strategy might provide a way to circumvent cytotoxicity and formulation issues related to the use of PEI for in vivo gene delivery. ..
  27. pmc A spatial model for integrin clustering as a result of feedback between integrin activation and integrin binding
    Erik S Welf
    Department of Chemical Engineering, University of Delaware, Newark, Delaware, USA
    Biophys J 103:1379-89. 2012
    ....
  28. pmc The crystal structure of calcium- and integrin-binding protein 1: insights into redox regulated functions
    Chad J Blamey
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    Protein Sci 14:1214-21. 2005
    ..The potential enzymatic activity of CIB1 is discussed and suggests a mechanism by which it regulates a wide variety of proteins in cells in addition to platelets...
  29. pmc Structural and functional consequences of poly(ethylene glycol) inclusion on DNA condensation for gene delivery
    Peter G Millili
    Department of Chemical Engineering, University of Delaware, Newark, Delaware 19716, USA
    Microsc Res Tech 73:866-77. 2010
    ..These studies provide new information on the role of PEG in delivery vehicle design and lay the foundation for future work aimed at elucidating the details of the intracellular transport of PEGylated polyplexes...
  30. doi request reprint Application of 1D blood flow models of the human arterial network to differential pressure predictions
    David A Johnson
    Department of Chemical Engineering, University of Delaware, Newark, DE 19716, USA
    J Biomech 44:869-76. 2011
    ..This suggests the possibility of using the model in interpreting multiple pressure data of healthy/diseased individuals...
  31. ncbi request reprint JAM-A is both essential and inhibitory to development of hepatic polarity in WIF-B cells
    Lelita T Braiterman
    Department of Cell Biology, Johns Hopkins University School of Medicine, 725 N Wolfe St, Baltimore, MD 21205, USA
    Am J Physiol Gastrointest Liver Physiol 294:G576-88. 2008
    ..Importantly, formation/maintenance of TJs and the apical domain in hepatic cells are linked, unlike simple epithelia...

Research Grants12

  1. Role of JAM Family in Angiogenesis
    Ulhas P Naik; Fiscal Year: 2010
    ..Further, elucidation of the role of JAM-A in endothelial cell proliferation and migration leading to angiogenesis will open up a mew line of investigation that is important in tumerigenesis and vascular biology. ..
  2. ROLE OF JAM-1 IN CELL ADHESION AND MIGRATION
    Ulhas Naik; Fiscal Year: 2003
    ..Characterizing the cell adhesion function of this novel protein will open up a new line of investigation that is important in inflammatory diseases and vascular biology. ..
  3. Role of JAM Family in Angiogenesis
    Ulhas Naik; Fiscal Year: 2007
    ..Further, elucidation of the role of JAM-A in endothelial cell proliferation and migration leading to angiogenesis will open up a new line of investigation that is important in tumorigenesis and vascular biology. ..
  4. Modulation of integrin function by cytoplasmic signals
    Ulhas Naik; Fiscal Year: 2007
    ..Further, characterization of CIB and its interactions with integrin alphaIIb-beta3 and Plk3 may help in delineating the mechanisms by which cytoplasmic signals modulate integrin function. ..