Research Topics
Genomes and Genes | Ulhas P NaikSummaryAffiliation: University of Delaware Country: USA Publications
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Publications
JAM-A protects from thrombosis by suppressing integrin αIIbβ3-dependent outside-in signaling in plateletsMeghna U Naik
Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
Blood 119:3352-60. 2012..We conclude that JAM-A normally limits platelet accumulation by inhibiting integrin outside-in signaling thus preventing premature platelet activation...- Probabilistic modeling and analysis of the effects of extra-cellular matrix density on the sizes, shapes, and locations of integrin clusters in adherent cellsErik S Welf
Department of Chemical Engineering, 150 Academy St, Colburn Lab, University of Delaware, Newark, Delaware 19716, USA
BMC Biophys 4:15. 2011..abstract:.. - Calcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cellsMeghna U Naik
Delaware Cardiovascular Research Center, University of Delaware, Newark, DE 19716, USA
Int J Cancer 128:587-96. 2011..Thus, in addition to Plk3, CIB1 may be a potential biomarker and target for therapeutic intervention of breast cancer... 
CIB1 deficiency results in impaired thrombosis: the potential role of CIB1 in outside-in signaling through integrin alpha IIb beta 3M U Naik
Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
J Thromb Haemost 7:1906-14. 2009..How outside-in signaling through alpha(IIb)beta(3) regulates hemostasis and thrombosis is not well understood. We have previously shown that CIB1 is involved in regulating alpha(IIb)beta(3) function...- Putting the brakes on cancer cell migration: JAM-A restrains integrin activationUlhas P Naik
Department of Biological Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, Delaware 19716, USA
Cell Adh Migr 2:249-51. 2008..The molecular mechanism of this function of JAM-A is beyond its well-characterized barrier function at the tight junction. Our results point out that JAM-A differentially regulates migration of endothelial and cancer cells... 
Characterization and chromosomal localization of JAM-1, a platelet receptor for a stimulatory monoclonal antibodyU P Naik
Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
J Cell Sci 114:539-47. 2001..JAM-1 is a single copy gene, which is constitutively expressed on various tissues and cells, and may be involved in cell to cell adhesion through homophilic interaction...- Junctional adhesion molecule-A-induced endothelial cell migration on vitronectin is integrin alpha v beta 3 specificMeghna U Naik
Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
J Cell Sci 119:490-9. 2006..Taken together, these results suggest that signaling through JAM-A is necessary for alpha(v)beta(3)-dependent HUVEC migration and implicate JAM-A in the regulation of vascular function... - Calcium-and integrin-binding protein regulates focal adhesion kinase activity during platelet spreading on immobilized fibrinogenMeghna U Naik
Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
Blood 102:3629-36. 2003..Taken together, our results suggest that CIB regulates platelet spreading through the regulation of FAK activation... - Essential role of junctional adhesion molecule-1 in basic fibroblast growth factor-induced endothelial cell migrationMeghna U Naik
Department of Biological Sciences, University of Delaware, 329 Wolf Hall, Newark, DE 19716, USA
Arterioscler Thromb Vasc Biol 23:2165-71. 2003.... - Association of CIB with GPIIb/IIIa during outside-in signaling is required for platelet spreading on fibrinogenUlhas P Naik
Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
Blood 102:1355-62. 2003..These data suggest that formation of the CIB-GPIIb/IIIa complex may be necessary for initiation of downstream signaling events, such as ADP secretion, that lead to platelet spreading... - Calcium- and integrin-binding protein 1 regulates megakaryocyte ploidy, adhesion, and migrationJohn C Kostyak
Department of Biological Sciences, University of Delaware, Newark, USA
Blood 119:838-46. 2012..05), when plated on fibrinogen. These data suggest that CIB1 plays a dual role in megakaryopoiesis, initially by negatively regulating TPO signaling and later by augmenting proplatelet production... - Attenuation of junctional adhesion molecule-A is a contributing factor for breast cancer cell invasionMeghna U Naik
Deparment of Biological Sciences, University of Delaware, Newark, DE 19716, USA
Cancer Res 68:2194-203. 2008..Furthermore, loss of JAM-A could be used as a biomarker for aggressive breast cancer... - Contra-regulation of calcium- and integrin-binding protein 1-induced cell migration on fibronectin by PAK1 and MAP kinase signalingMeghna U Naik
Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, USA
J Cell Biochem 112:3289-99. 2011..Furthermore, CIB1-induced cell migration is dependent on MAP kinase signaling and its function is attenuated by PAK1... - Fibroblast growth factor-2 failed to induce angiogenesis in junctional adhesion molecule-A-deficient miceVesselina G Cooke
Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
Arterioscler Thromb Vasc Biol 26:2005-11. 2006..Whether JAM-A is involved in FGF-2-induced angiogenesis in vivo is not known. We used JAM-A null mice to conclusively determine the role of JAM-A in FGF-2-induced neovascularization... - Signaling through JAM-1 and alphavbeta3 is required for the angiogenic action of bFGF: dissociation of the JAM-1 and alphavbeta3 complexMeghna U Naik
Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
Blood 102:2108-14. 2003..In addition, blockage of either JAM-1 or alphavbeta3 inhibits bFGF-induced MAP kinase activation. Thus, our results suggest that signaling through JAM-1 and alphavbeta3 is necessary for bFGF-induced angiogenesis... - Deletion of JAM-A causes morphological defects in the corneal epitheliumLiang I Kang
Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
Int J Biochem Cell Biol 39:576-85. 2007..In summary, JAM-A is expressed in the corneal epithelium where it appears to regulate cell shape... - CASK interacts with PMCA4b and JAM-A on the mouse sperm flagellum to regulate Ca2+ homeostasis and motilityRolands G Aravindan
Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
J Cell Physiol 227:3138-50. 2012..The decreased motility is likely due to the collateral net deficit in ATP observed in nulls. Our data indicate that Ca(2+) homeostasis in sperm is maintained by the relative ratios of CASK-PMCA4b and CASK-JAM-A interactions... - JAM-A is present in mammalian spermatozoa where it is essential for normal motilityMinghai Shao
Department of Biological Sciences, 219 McKinly Lab, University of Delaware, Newark, DE 19716, USA
Dev Biol 313:246-55. 2008.... - JAM-A expression during embryonic developmentJames J Parris
Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, USA
Dev Dyn 233:1517-24. 2005..Thus, JAM-A is prominently expressed in embryonic vasculature and the epithelial components of several organ systems and may have an important role in their development... - Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progressionMeghna U Naik
Delaware Cardiovascular Research Center, Department of Biological Sciences, University of Delaware, Newark, DE 19716, United States
Int J Biochem Cell Biol 43:120-9. 2011..These results suggest that CIB1 tightly regulates Plk3 activity during cell division and that either over- or underexpression results in a multinucleated phenotype... - Cytoplasmic binding partners of the platelet integrin alphaIIb beta3Melissa A Bonner
Delaware Biotechnology Institute, Newark, DE, USA
Front Biosci 12:2038-49. 2007..In the present work, we explore known cytoplasmic binding partners of the integrin alphaIIb beta3 and their effect on alphaIIb beta3, focusing on CIB1... - Structural and functional consequences of poly(ethylene glycol) inclusion on DNA condensation for gene deliveryPeter G Millili
Department of Chemical Engineering, University of Delaware, Newark, Delaware 19716, USA
Microsc Res Tech 73:866-77. 2010..These studies provide new information on the role of PEG in delivery vehicle design and lay the foundation for future work aimed at elucidating the details of the intracellular transport of PEGylated polyplexes... - The crystal structure of calcium- and integrin-binding protein 1: insights into redox regulated functionsChad J Blamey
Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
Protein Sci 14:1214-21. 2005..The potential enzymatic activity of CIB1 is discussed and suggests a mechanism by which it regulates a wide variety of proteins in cells in addition to platelets... - OptiRNAi, an RNAi design toolWenwu Cui
Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
Comput Methods Programs Biomed 75:67-73. 2004..Thus, OptiRNAi is an efficient and user friendly tool for RNAi design based on criteria that are more stringent than other available tools... - Calcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cellsJohn C Kostyak
Department of Biological Sciences, University of Delaware, Newark, Delaware, United States of America
PLoS ONE 6:e14513. 2011..Furthermore, PMA treatment augmented the interaction between CIB1 and Plk3, which depended on the duration of treatment. These data suggest that CIB1 is involved in regulating endomitosis, perhaps through its interaction with Plk3... - Application of 1D blood flow models of the human arterial network to differential pressure predictionsDavid A Johnson
Department of Chemical Engineering, University of Delaware, Newark, DE 19716, USA
J Biomech 44:869-76. 2011..This suggests the possibility of using the model in interpreting multiple pressure data of healthy/diseased individuals... - Junctional adhesion molecules in angiogenesisTejal U Naik
Charter School of Wilmington, Delaware, USA
Front Biosci 13:258-62. 2008..This review focuses on a recently identified novel cell adhesion molecule, Junctional Adhesion Molecule A, and its role in the process of regulating angiogenesis... - JAM-A is both essential and inhibitory to development of hepatic polarity in WIF-B cellsLelita T Braiterman
Department of Cell Biology, Johns Hopkins University School of Medicine, 725 N Wolfe St, Baltimore, MD 21205, USA
Am J Physiol Gastrointest Liver Physiol 294:G576-88. 2008..Importantly, formation/maintenance of TJs and the apical domain in hepatic cells are linked, unlike simple epithelia...
Research Grants
- Modulation of integrin function by cytoplasmic signalsUlhas Naik; Fiscal Year: 2007..Further, characterization of CIB and its interactions with integrin alphaIIb-beta3 and Plk3 may help in delineating the mechanisms by which cytoplasmic signals modulate integrin function. ..
- Role of JAM Family in AngiogenesisUlhas Naik; Fiscal Year: 2007..Further, elucidation of the role of JAM-A in endothelial cell proliferation and migration leading to angiogenesis will open up a new line of investigation that is important in tumorigenesis and vascular biology. ..
- ROLE OF JAM-1 IN CELL ADHESION AND MIGRATIONUlhas Naik; Fiscal Year: 2003..Characterizing the cell adhesion function of this novel protein will open up a new line of investigation that is important in inflammatory diseases and vascular biology. ..
- Role of JAM Family in AngiogenesisUlhas P Naik; Fiscal Year: 2010..Further, elucidation of the role of JAM-A in endothelial cell proliferation and migration leading to angiogenesis will open up a mew line of investigation that is important in tumerigenesis and vascular biology. ..