NIRINJINI N NAIDOO

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc The endoplasmic reticulum stress response in aging and age-related diseases
    Marishka K Brown
    Center for Sleep and Circadian Neurobiology, University of Pennsylvania Philadelphia, PA, USA
    Front Physiol 3:263. 2012
  2. doi request reprint Roles of endoplasmic reticulum and energetic stress in disturbed sleep
    Nirinjini Naidoo
    Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Neuromolecular Med 14:213-9. 2012
  3. pmc Role of Homer proteins in the maintenance of sleep-wake states
    Nirinjini Naidoo
    Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e35174. 2012
  4. pmc Potential of proteomics as a bioanalytic technique for quantifying sleepiness
    Nirinjini Naidoo
    Center for Sleep and Circadian Neurobiology, Division of Sleep Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Clin Sleep Med 7:S28-30. 2011
  5. pmc Endoplasmic reticulum stress in wake-active neurons progresses with aging
    Nirinjini Naidoo
    Division of Sleep Medicine, Center for Sleep and Circadian Neurobiology, School of Medicine, University of Pennsylvania, 125 S 31st Street, Philadelphia, PA 19104, USA
    Aging Cell 10:640-9. 2011
  6. ncbi request reprint The endoplasmic reticulum stress response and aging
    Nirinjini Naidoo
    University of Pennsylvania School of Medicine, Center for Sleep and Respiratory Neurobiology, Philadelphia, PA 19104, USA
    Rev Neurosci 20:23-37. 2009
  7. doi request reprint ER and aging-Protein folding and the ER stress response
    Nirinjini Naidoo
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States
    Ageing Res Rev 8:150-9. 2009
  8. pmc Cellular stress/the unfolded protein response: relevance to sleep and sleep disorders
    Nirinjini Naidoo
    University of Pennsylvania School of Medicine, Center for Sleep and Respiratory Neurobiology, Division of Sleep Medicine, 125 South 31st Street, Suite 2100, Philadelphia, PA 19104, USA
    Sleep Med Rev 13:195-204. 2009
  9. ncbi request reprint Sleep deprivation induces the unfolded protein response in mouse cerebral cortex
    Nirinjini Naidoo
    Division of Sleep Medicine Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurochem 92:1150-7. 2005
  10. pmc Aging impairs the unfolded protein response to sleep deprivation and leads to proapoptotic signaling
    Nirinjini Naidoo
    Division of Sleep Medicine and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 28:6539-48. 2008

Research Grants

  1. Age and Sleep Effects on ER Protein Function
    Nirinjini Naidoo; Fiscal Year: 2005

Collaborators

Detail Information

Publications22

  1. pmc The endoplasmic reticulum stress response in aging and age-related diseases
    Marishka K Brown
    Center for Sleep and Circadian Neurobiology, University of Pennsylvania Philadelphia, PA, USA
    Front Physiol 3:263. 2012
    ..This review will discuss age-related changes in the ER stress response and the role of the UPR in age-related diseases...
  2. doi request reprint Roles of endoplasmic reticulum and energetic stress in disturbed sleep
    Nirinjini Naidoo
    Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Neuromolecular Med 14:213-9. 2012
    ..Sleep research pertinent to these specific pathways will be discussed...
  3. pmc Role of Homer proteins in the maintenance of sleep-wake states
    Nirinjini Naidoo
    Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e35174. 2012
    ..Sustained behaviors of the sleep/wake cycle are created by molecular pathways that are distinct from those for arousal or short bouts, and implicate an evolutionarily-conserved role for Homer in sustaining these behaviors...
  4. pmc Potential of proteomics as a bioanalytic technique for quantifying sleepiness
    Nirinjini Naidoo
    Center for Sleep and Circadian Neurobiology, Division of Sleep Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Clin Sleep Med 7:S28-30. 2011
    ..A variety of proteonomic techniques are available which are being used in a current sleep deprivation study of monozygotic and dizygotic twin pairs we are performing...
  5. pmc Endoplasmic reticulum stress in wake-active neurons progresses with aging
    Nirinjini Naidoo
    Division of Sleep Medicine, Center for Sleep and Circadian Neurobiology, School of Medicine, University of Pennsylvania, 125 S 31st Street, Philadelphia, PA 19104, USA
    Aging Cell 10:640-9. 2011
    ..We have identified an age-related unfolded protein response injury to and dysfunction of wake neurons. It is anticipated that these changes contribute to sleep/wake fragmentation and cognitive impairment in aging...
  6. ncbi request reprint The endoplasmic reticulum stress response and aging
    Nirinjini Naidoo
    University of Pennsylvania School of Medicine, Center for Sleep and Respiratory Neurobiology, Philadelphia, PA 19104, USA
    Rev Neurosci 20:23-37. 2009
    ..There is also considerable evidence of oxidative damage. There are suggestions that an impaired UPR may contribute to the acceleration of neurodegenerative disorders...
  7. doi request reprint ER and aging-Protein folding and the ER stress response
    Nirinjini Naidoo
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States
    Ageing Res Rev 8:150-9. 2009
    ..This review will highlight age-related changes in the protein folding machinery and in the UPR...
  8. pmc Cellular stress/the unfolded protein response: relevance to sleep and sleep disorders
    Nirinjini Naidoo
    University of Pennsylvania School of Medicine, Center for Sleep and Respiratory Neurobiology, Division of Sleep Medicine, 125 South 31st Street, Suite 2100, Philadelphia, PA 19104, USA
    Sleep Med Rev 13:195-204. 2009
    ....
  9. ncbi request reprint Sleep deprivation induces the unfolded protein response in mouse cerebral cortex
    Nirinjini Naidoo
    Division of Sleep Medicine Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurochem 92:1150-7. 2005
    ..These changes are first observed after 6 h of induced wakefulness. Thus, prolonging wakefulness beyond a certain duration induces the UPR indicating a physiological limit to wakefulness...
  10. pmc Aging impairs the unfolded protein response to sleep deprivation and leads to proapoptotic signaling
    Nirinjini Naidoo
    Division of Sleep Medicine and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 28:6539-48. 2008
    ....
  11. ncbi request reprint A role for the molecular chaperone protein BiP/GRP78 in Drosophila sleep homeostasis
    Nirinjini Naidoo
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Sleep 30:557-65. 2007
    ..We then sought to establish a key role for BiP in the homeostatic process of sleep by contrasting recovery sleep in models of over- and under-expression of BiP...
  12. doi request reprint Eif-2a protects brainstem motoneurons in a murine model of sleep apnea
    Yan Zhu
    Center for Sleep and Neurobiology and Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 28:2168-78. 2008
    ..It is anticipated that obstructive sleep apnea results in endoplasmic reticulum injury involving motoneurons, whereas a critical balance of phosphorylated eIF-2a should minimize motoneuronal injury in obstructive sleep apnea...
  13. pmc Changes in components of energy regulation in mouse cortex with increases in wakefulness
    Elena V Nikonova
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 3403, USA
    Sleep 33:889-900. 2010
    ..We hypothesized that energy depletion could be a mechanism leading to difficulty maintaining wakefulness and assessed changes in components of the electron transport chain...
  14. ncbi request reprint Proteomic analysis of the effects and interactions of sleep deprivation and aging in mouse cerebral cortex
    Aaron C Pawlyk
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA
    J Neurochem 103:2301-13. 2007
    ..The identity and characteristics of these proteins relevant to sleep and aging are discussed...
  15. doi request reprint Molecular mechanisms of sleep and wakefulness
    Miroslaw Mackiewicz
    Center for Sleep and Respiratory Neurobiology, Division of Sleep Medicine Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann N Y Acad Sci 1129:335-49. 2008
    ..Identification of genes regulating sleep has the potential for translational studies to elucidate the genetics of sleep and response to sleep deprivation in humans...
  16. ncbi request reprint Multiple mechanisms limit the duration of wakefulness in Drosophila brain
    John E Zimmerman
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Physiol Genomics 27:337-50. 2006
    ....
  17. ncbi request reprint Macromolecule biosynthesis: a key function of sleep
    Miroslaw Mackiewicz
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 3403, USA
    Physiol Genomics 31:441-57. 2007
    ..We postulate that during sleep there is a rebuilding of multiple key cellular components in preparation for subsequent wakefulness...
  18. pmc Relationships among dietary nutrients and subjective sleep, objective sleep, and napping in women
    Michael A Grandner
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Sleep Med 11:180-4. 2010
    ..To describe which dietary nutrient variables are related to subjective and objective habitual sleep and subjective and objective napping...
  19. pmc The energy hypothesis of sleep revisited
    Matthew T Scharf
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Translational Research Building, Suite 2100, 125 S 31st Street, Philadelphia, PA 19104 3403, USA
    Prog Neurobiol 86:264-80. 2008
    ....
  20. pmc AMP-activated protein kinase phosphorylation in brain is dependent on method of killing and tissue preparation
    Matthew T Scharf
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 3403, USA
    J Neurochem 105:833-41. 2008
    ..These results demonstrate that alpha-AMPK phosphorylation is dependent on method of killing and tissue preparation and that alpha-AMPK phosphorylation can increase in a manner that does not reflect biological alterations...
  21. pmc Mechanisms of sleep-dependent consolidation of cortical plasticity
    Sara J Aton
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuron 61:454-66. 2009
    ..These findings demonstrate that synaptic strengthening via NMDAR and PKA activity is a key step in sleep-dependent consolidation of ODP...
  22. pmc Conservation of sleep: insights from non-mammalian model systems
    John E Zimmerman
    Center for Sleep and Respiratory Neurobiology, Department of Medicine, University of Pennsylvania School of Medicine, 125 South 31st Street, Philadelphia, PA 19104, USA
    Trends Neurosci 31:371-6. 2008
    ....

Research Grants2

  1. Age and Sleep Effects on ER Protein Function
    Nirinjini Naidoo; Fiscal Year: 2005
    ..We will use 2-D DIGE, as well as oxidation assays and mass spectrometry, to identify proteins that are altered by aging and sleep deprivation in the ER. ..