C W Nager

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc A randomized trial of urodynamic testing before stress-incontinence surgery
    Charles W Nager
    University of California at San Diego, La Jolla, CA 92037 1300, USA
    N Engl J Med 366:1987-97. 2012
  2. pmc Preoperative voiding detrusor pressures do not predict stress incontinence surgery outcomes
    Anna C Kirby
    Reproductive Medicine, University of California San Diego, San Diego, CA, USA
    Int Urogynecol J 22:657-63. 2011
  3. pmc Urethral sleeve sensor: a non-withdrawal method to measure maximum urethral pressure
    Jasmine Tan-Kim
    Department of Reproductive Medicine, Division of Female Pelvic Medicine and Reconstructive Surgery, University of California, San Diego, La Jolla, CA, USA
    Int Urogynecol J 21:685-91. 2010
  4. ncbi Correlation of urethral closure pressure, leak-point pressure and incontinence severity measures
    C W Nager
    Department of Reproductive Medicine, University of California, San Diego Medical Center, 92103 8433, USA
    Int Urogynecol J Pelvic Floor Dysfunct 12:395-400. 2001
  5. ncbi Reference urodynamic values for stress incontinent women
    C W Nager
    UCSD Women s Pelvic Medicine Center, La Jolla, California
    Neurourol Urodyn 26:333-40. 2007
  6. pmc Process for development of multicenter urodynamic studies
    Charles W Nager
    University of California, San Diego, Women s Pelvic Medicine Center, San Diego, California, USA
    Urology 69:63-7; discussion 67-8. 2007
  7. doi Urodynamic measures do not predict stress continence outcomes after surgery for stress urinary incontinence in selected women
    Charles W Nager
    University of California, San Diego, California, USA
    J Urol 179:1470-4. 2008
  8. pmc Incontinence pessaries: size, POPQ measures, and successful fitting
    Charles W Nager
    Department of Reproductive Medicine, University of California, San Diego, San Diego, CA, USA
    Int Urogynecol J Pelvic Floor Dysfunct 20:1023-8. 2009
  9. pmc Design of the Value of Urodynamic Evaluation (ValUE) trial: A non-inferiority randomized trial of preoperative urodynamic investigations
    Charles W Nager
    Department of Reproductive Medicine, University of California, San Diego, San Diego, CA, United States
    Contemp Clin Trials 30:531-9. 2009
  10. doi Baseline urodynamic predictors of treatment failure 1 year after mid urethral sling surgery
    Charles W Nager
    Department of Reproductive Medicine, University of California San Diego, San Diego, California 92037, USA
    J Urol 186:597-603. 2011

Research Grants

  1. Pelvic Floor Disorders Network
    Charles Nager; Fiscal Year: 2007

Detail Information

Publications45

  1. pmc A randomized trial of urodynamic testing before stress-incontinence surgery
    Charles W Nager
    University of California at San Diego, La Jolla, CA 92037 1300, USA
    N Engl J Med 366:1987-97. 2012
    ..Urodynamic studies are commonly performed in women before surgery for stress urinary incontinence, but there is no good evidence that they improve outcomes...
  2. pmc Preoperative voiding detrusor pressures do not predict stress incontinence surgery outcomes
    Anna C Kirby
    Reproductive Medicine, University of California San Diego, San Diego, CA, USA
    Int Urogynecol J 22:657-63. 2011
    ..The aim of this study was to determine whether preoperative voiding detrusor pressures were associated with postoperative outcomes after stress incontinence surgery...
  3. pmc Urethral sleeve sensor: a non-withdrawal method to measure maximum urethral pressure
    Jasmine Tan-Kim
    Department of Reproductive Medicine, Division of Female Pelvic Medicine and Reconstructive Surgery, University of California, San Diego, La Jolla, CA, USA
    Int Urogynecol J 21:685-91. 2010
    ....
  4. ncbi Correlation of urethral closure pressure, leak-point pressure and incontinence severity measures
    C W Nager
    Department of Reproductive Medicine, University of California, San Diego Medical Center, 92103 8433, USA
    Int Urogynecol J Pelvic Floor Dysfunct 12:395-400. 2001
    ..MUCP and LPP correlate modestly with each other and both are comparable in predicting incontinence severity. Either can be used as the urodynamic measure to assess intrinsic sphincter deficiency...
  5. ncbi Reference urodynamic values for stress incontinent women
    C W Nager
    UCSD Women s Pelvic Medicine Center, La Jolla, California
    Neurourol Urodyn 26:333-40. 2007
    ..To determine reference urodynamic values for preoperative urodynamic studies in women undergoing surgery for pure or predominant stress urinary incontinence (SUI)...
  6. pmc Process for development of multicenter urodynamic studies
    Charles W Nager
    University of California, San Diego, Women s Pelvic Medicine Center, San Diego, California, USA
    Urology 69:63-7; discussion 67-8. 2007
    ..Multicenter UDSs can have considerable variations in testing procedures, training, equipment, and reviewer biases...
  7. doi Urodynamic measures do not predict stress continence outcomes after surgery for stress urinary incontinence in selected women
    Charles W Nager
    University of California, San Diego, California, USA
    J Urol 179:1470-4. 2008
    ..We determined the prognostic value of preoperative urodynamic results in patients with stress urinary incontinence...
  8. pmc Incontinence pessaries: size, POPQ measures, and successful fitting
    Charles W Nager
    Department of Reproductive Medicine, University of California, San Diego, San Diego, CA, USA
    Int Urogynecol J Pelvic Floor Dysfunct 20:1023-8. 2009
    ..The aim of the study was to determine whether successful incontinence pessary fitting or pessary size can be predicted by specific POPQ measurements in women without advanced pelvic organ prolapse...
  9. pmc Design of the Value of Urodynamic Evaluation (ValUE) trial: A non-inferiority randomized trial of preoperative urodynamic investigations
    Charles W Nager
    Department of Reproductive Medicine, University of California, San Diego, San Diego, CA, United States
    Contemp Clin Trials 30:531-9. 2009
    ....
  10. doi Baseline urodynamic predictors of treatment failure 1 year after mid urethral sling surgery
    Charles W Nager
    Department of Reproductive Medicine, University of California San Diego, San Diego, California 92037, USA
    J Urol 186:597-603. 2011
    ..We determined whether baseline urodynamic study variables predict failure after mid urethral sling surgery...
  11. ncbi Testing in women with lower urinary tract dysfunction
    Charles W Nager
    Department of Reproductive Medicine Ob Gyn, Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Surgery, UCSD Medical Center, San Diego, California, USA
    Clin Obstet Gynecol 47:53-69. 2004
  12. doi Prevalence and co-occurrence of pelvic floor disorders in community-dwelling women
    Jean M Lawrence
    Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA
    Obstet Gynecol 111:678-85. 2008
    ..To assess the effect of age on prevalence of pelvic floor disorders and report the co-occurrence of these conditions in community-dwelling women...
  13. ncbi Are sexual activity and satisfaction affected by pelvic floor disorders? Analysis of a community-based survey
    Emily S Lukacz
    Department of Reproductive Medicine, University of California, San Diego, Medical Center, San Diego, CA, USA
    Am J Obstet Gynecol 197:88.e1-6. 2007
    ..The purpose of this study was to assess the relationship between pelvic floor disorders and sexual activity and satisfaction...
  14. ncbi A comparison of two models of gynecology service consultation to the emergency department in an academic medical center
    D Yvette LaCoursiere
    Department of Reproductive Medicine, University of California San Diego, 200 W Arbor, San Diego, CA 92103, USA
    Am J Obstet Gynecol 188:1166-8. 2003
    ..This study was undertaken to determine differences in resource use and outcomes when emergency department (ED) physicians consult the gynecology service routinely versus selectively...
  15. ncbi The effects of the tension-free vaginal tape on voiding function: a prospective evaluation
    Emily S Lukacz
    Department of Reproductive Medicine, UCSD Medical Center, 200 West Arbor Drive, 8433, San Diego, CA 92103, USA
    Int Urogynecol J Pelvic Floor Dysfunct 15:32-8; discussion 38. 2004
    ..We concluded that the TVT sling reduces maximum flow rates without clinically significant effects on detrusor pressure, residual urine or subjective voiding...
  16. ncbi Epidemiology of prolapse and incontinence questionnaire: validation of a new epidemiologic survey
    Emily S Lukacz
    Female pelvic Medicine and Reconstructive Surgery Department of Reproductive Medicine, University of California, San Diego, La Jolla, 92037, USA
    Int Urogynecol J Pelvic Floor Dysfunct 16:272-84. 2005
    ..EPIQ is a psychometrically validated screening instrument that may identify women at high risk of having pelvic floor disorders in large undiagnosed populations...
  17. ncbi Parity, mode of delivery, and pelvic floor disorders
    Emily S Lukacz
    Women s Pelvic Medicine Center, University of California, San Diego, La Jolla, California 92037, USA
    Obstet Gynecol 107:1253-60. 2006
    ..This study aimed to assess the associations between parity, mode of delivery, and pelvic floor disorders...
  18. doi Paracervical compared with intracervical lidocaine for suction curettage: a randomized controlled trial
    Jennifer L Mankowski
    Department of Reproductive Medicine, University of California, San Diego Medical Center, San Diego, California, USA
    Obstet Gynecol 113:1052-7. 2009
    ..To estimate the efficacy of paracervical compared with intracervical administration of local anesthesia during first-trimester suction curettage...
  19. pmc Prevalence and risk factors for mesh erosion after laparoscopic-assisted sacrocolpopexy
    Jasmine Tan-Kim
    Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA
    Int Urogynecol J 22:205-12. 2011
    ..The purpose of this study is to identify risk factors for mesh erosion in women undergoing minimally invasive sacrocolpopexy (MISC). We hypothesize that erosion is higher in subjects undergoing concomitant hysterectomy...
  20. ncbi Seeking healthcare for pelvic floor disorders: a population-based study
    Michelle Morrill
    Department of Women s Pelvic Medicine, University of California, San Diego, School of Medicine, San Diego, CA 92037, USA
    Am J Obstet Gynecol 197:86.e1-6. 2007
    ..The purpose of this study was to identify characteristics that are associated with seeking care for pelvic floor disorders (PFD)...
  21. doi Prevalence and degree of bother from pelvic floor disorders in obese women
    Emily L Whitcomb
    Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Reproductive Medicine, University of California, San Diego, CA, USA
    Int Urogynecol J Pelvic Floor Dysfunct 20:289-94. 2009
    ..Degree of bother did not vary by degree of obesity. Prevalence of PFD increases with higher degrees of obesity...
  22. ncbi The vaginal pressure profile
    Noelani M Guaderrama
    Department of Reproductive Medicine, Internal Medicine and Radiology, Division of Female Pelvic Medicine and Reconstructive Surgery, The Pelvic Floor Function and Disorder Group, University of California, San Diego, California 92037, USA
    Neurourol Urodyn 24:243-7. 2005
    ..To describe the vaginal pressure profile in asymptomatic nulliparous women...
  23. pmc Vaginal high-pressure zone assessed by dynamic 3-dimensional ultrasound images of the pelvic floor
    Sung Ae Jung
    Pelvic Floor Function and Disorder Group, University of California, San Diego, School of Medicine, San Diego, CA, USA
    Am J Obstet Gynecol 197:52.e1-7. 2007
    ..The purpose of this study was to determine the shape and characteristics of the vaginal high-pressure zone (HPZ) by imaging a compliant fluid-filled bag that had been placed in the vaginal HPZ with the 3-dimensional ultrasound system...
  24. doi Midurethral slings for stress urinary incontinence
    Amy R Kane
    Department of Reproductive Medicine, University of California, San Diego, California, USA
    Clin Obstet Gynecol 51:124-35. 2008
    ..Retropubic and transobturator approaches will be reviewed along with a review of efficacy, comparative studies, complications, and use in many different clinical situations...
  25. ncbi Predictive value of prolapse symptoms: a large database study
    Jasmine S Tan
    UCSD Medical Center, San Diego, CA 92037, USA
    Int Urogynecol J Pelvic Floor Dysfunct 16:203-9; discussion 209. 2005
    ..Digital assistance for fecal evacuation is no more common with massive posterior prolapse than with moderate posterior prolapse. Patient report of a bulge is a valuable screening tool for POP and should prompt a careful exam...
  26. ncbi Evidence for the innervation of pelvic floor muscles by the pudendal nerve
    Noelani M Guaderrama
    Departments of Reproductive Medicine, Internal Medicine, Radiology, and Neurology, The Pelvic Floor Function and Disorder Group, University of California, San Diego, San Diego, California 92161, USA
    Obstet Gynecol 106:774-81. 2005
    ..To evaluate whether the pudendal nerve innervates the levator ani muscles by assessing the effect of pudendal nerve blockade on pelvic floor muscle function...
  27. ncbi The effects of the tension-free vaginal tape on proximal urethral position: a prospective, longitudinal evaluation
    Emily S Lukacz
    Female Pelvic Medicine and Reconstructive Surgery, UCSD Department of Reproductive Medicine, 200 West Arbor Drive, 8433, San Diego, CA 92103, USA
    Int Urogynecol J Pelvic Floor Dysfunct 14:179-84; discussion 184. 2003
    ..Unchanged resting Q-tip angles confirm the tension-free concept and there appears to be no shrinkage or tightening of the sling. We concluded that the success of the TVT is not due to proximal urethral support...
  28. ncbi Effects of pelvic floor muscle contraction on anal canal pressure
    Bikram S Padda
    Univ of California San Diego, La Jolla, CA 92161, USA
    Am J Physiol Gastrointest Liver Physiol 292:G565-71. 2007
    ..We propose that pelvic floor contraction plays an important role in the fecal continence mechanism by increasing anal canal pressure...
  29. ncbi The reliability of puborectalis muscle measurements with 3-dimensional ultrasound imaging
    Milena M Weinstein
    Pelvic Floor Function and Disorder Group, University of California, San Diego, School of Medicine, San Diego, CA, USA
    Am J Obstet Gynecol 197:68.e1-6. 2007
    ....
  30. pmc Urinary frequency in community-dwelling women: what is normal?
    Emily S Lukacz
    Division of Women s Pelvic Medicine, Department of Reproductive Medicine, University of California San Diego, San Diego, CA, USA
    Am J Obstet Gynecol 200:552.e1-7. 2009
    ..The objective of the study was to assess urinary frequency in community-dwelling women...
  31. doi Pelvic fracture with complete urethrovaginal complex avulsion
    Keisha Y Dyer
    University of California San Diego, La Jolla, California, USA
    Obstet Gynecol 116:533-5. 2010
    ..The anatomic support of the urethra is controversial. We present a case of an intact urethra and vagina avulsing from the symphysis pubis after pelvic fracture...
  32. ncbi The use of Visual Analog Scale in urogynecologic research: a psychometric evaluation
    Emily S Lukacz
    Department of Reproductive Medicine, Division of Female Pelvic Medicine and Reconstructive Surgery, University of California, San Diego, USA
    Am J Obstet Gynecol 191:165-70. 2004
    ..The purpose of this study was to assess the validity of Visual Analog Scales in urogynecologic research...
  33. ncbi Functional correlates of anal canal anatomy: puborectalis muscle and anal canal pressure
    Jianmin Liu
    The Pelvic Floor Function and Disease Group, University of California, San Diego, La Jolla 92161, USA
    Am J Gastroenterol 101:1092-7. 2006
    ..Role of the puborectalis muscle (PRM) in the genesis of anal canal pressure is not known...
  34. pmc Transperineal three-dimensional ultrasound imaging for detection of anatomic defects in the anal sphincter complex muscles
    Milena M Weinstein
    The Pelvic Floor Function and Disorder Group, University of California, San Diego, California, USA
    Clin Gastroenterol Hepatol 7:205-11. 2009
    ..Our goal was to determine the reliability of the 3D-US imaging technique in detecting morphologic defects in the IAS, EAS, and PRM...
  35. doi Closure mechanism of the anal canal in women: assessed by three-dimensional ultrasound imaging
    Sung Ae Jung
    Division of Gastroenterology, Pelvic Floor Function and Diseases Group, University of California, San Diego, California 92161, USA
    Dis Colon Rectum 51:932-9. 2008
    ..To describe the functional correlates of anal canal anatomy using 3 dimensional ultrasound imaging...
  36. ncbi Determinants of patient satisfaction after the tension-free vaginal tape procedure
    Tracie L Davis
    Department of Reproductive Medicine, University of California, San Dieg, USA
    Am J Obstet Gynecol 191:176-81. 2004
    ..This study was undertaken to compare patient satisfaction with subjective and objective measures of success...
  37. ncbi Bulking agents for stress urinary incontinence: short-term results and complications in a randomized comparison of periurethral and transurethral injections
    Jane A Schulz
    St George s Hospital, London, UK
    Int Urogynecol J Pelvic Floor Dysfunct 15:261-5. 2004
    ..We conclude that both periurethral and transurethral methods of bulking agent injection for stress urinary incontinence are equally efficacious, with minimal morbidity...
  38. ncbi Anal incontinence in women presenting for gynecologic care: prevalence, risk factors, and impact upon quality of life
    Muriel K Boreham
    Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, University of Texas Southwesten Medical Center, Dallas, USA
    Am J Obstet Gynecol 192:1637-42. 2005
    ..The purpose of this study was to estimate the prevalence and impact upon quality of life of anal incontinence (AI) in women aged 18 to 65...
  39. ncbi A comparative study of water perfusion catheters and microtip transducer catheters for urethral pressure measurements
    Annette Kuhn
    Department of Urogynaecology, Frauenklinik, Effingerstr 102, Inselspital, 3011, Bern, Switzerland
    Int Urogynecol J Pelvic Floor Dysfunct 18:931-5. 2007
    ..70 to 0.80. This study confirms that both water perfusion catheters and microtip transducers have excellent or very good reproducibility with an acceptable intraindividual variation for both methods...
  40. pmc Prevalence of symptomatic pelvic floor disorders in US women
    Ingrid Nygaard
    Department of Obstetrics and Gynecology, University of Utah School of Medicine, 30 N 1900 E, Salt Lake City, UT 84132 2209, USA
    JAMA 300:1311-6. 2008
    ..No national prevalence estimates derived from the same population-based sample exists for multiple pelvic floor disorders in women in the United States...
  41. ncbi Quality of life in women with stress urinary incontinence
    Sharon L Tennstedt
    New England Research Institutes, 9 Galen Street, Watertown, MA 02472, USA
    Int Urogynecol J Pelvic Floor Dysfunct 18:543-9. 2007
    ..Health and sociodemographic factors associated with lower incontinence-related QoL included current tobacco use, younger age, lower socioeconomic status, and Hispanic ethnicity...
  42. ncbi Pelvic floor disorders, diabetes, and obesity in women: findings from the Kaiser Permanente Continence Associated Risk Epidemiology Study
    Jean M Lawrence
    Department of Research and Evaluation, Kaiser Permanente Southern California, 100 S Los Robles, 2nd Floor, Pasadena CA 91101, USA
    Diabetes Care 30:2536-41. 2007
    ..We examined associations between obesity and diabetes and female pelvic floor disorders (PFDs), stress urinary incontinence (SUI), overactive bladder (OAB), and anal incontinence (AI) in community-dwelling women...
  43. ncbi Prevalence and risk factors of fecal incontinence in women undergoing stress incontinence surgery
    Alayne D Markland
    Division of Gerontology, Geriatrics, and Palliative Care, Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35233, USA
    Am J Obstet Gynecol 197:662.e1-7. 2007
    ..The objective of the study was to determine the prevalence and identify potential risk factors for monthly fecal incontinence (FI) in women presenting for stress urinary incontinence (UI) surgery...
  44. pmc Behavioral therapy to enable women with urge incontinence to discontinue drug treatment: a randomized trial
    Kathryn L Burgio
    University of Alabama at Birmingham and Department of Veterans Affairs, Birmingham, Alabama 35233, USA
    Ann Intern Med 149:161-9. 2008
    ..Women with urge urinary incontinence are commonly treated with antimuscarinic medications, but many discontinue therapy...
  45. ncbi Determinants of vaginal length
    Jasmine S Tan
    University of California San Diego Medical Center, USA
    Am J Obstet Gynecol 195:1846-50. 2006
    ..The purpose of this study was to describe quantitatively the associations between total vaginal length and demographic, historic, and physical characteristics...

Research Grants3

  1. Pelvic Floor Disorders Network
    Charles Nager; Fiscal Year: 2007
    ..We believe that the PFDN will benefit greatly by the proven ability of the San Diego Clinical Site's demonstrated energy, skills, and leadership. ..