Herbert T Nagasawa

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Novel, orally effective cyanide antidotes
    Herbert T Nagasawa
    Center for Drug Design, University of Minnesota, Minneapolis 55455, USA
    J Med Chem 50:6462-4. 2007
  2. pmc Cyanide toxicity in juvenile pigs and its reversal by a new prodrug, sulfanegen sodium
    Kumar G Belani
    Department of Anesthesiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Anesth Analg 114:956-61. 2012
  3. pmc Cyanide antidotes for mass casualties: water-soluble salts of the dithiane (sulfanegen) from 3-mercaptopyruvate for intramuscular administration
    Steven E Patterson
    Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Med Chem 56:1346-9. 2013
  4. pmc A novel paradigm for assessing efficacies of potential antidotes against neurotoxins in mice
    Daune L Crankshaw
    Center for Drug Design, Academic Health Center, University of Minnesota, MN, United States
    Toxicol Lett 175:111-7. 2007
  5. ncbi request reprint Double-prodrugs of L-cysteine: differential protection against acetaminophen-induced hepatotoxicity in mice
    Daune L Crankshaw
    Medical Research Laboratories, DVA Medical Center, Minneapolis, MN 55417, USA
    J Biochem Mol Toxicol 16:235-44. 2002
  6. ncbi request reprint Acetaminophen-induced suppression of hepatic AdoMet synthetase activity is attenuated by prodrugs of L-cysteine
    Frances N Shirota
    Medical Research Laboratories 151, VA Medical Center, Minneapolis, MN 55417, USA
    Toxicol Lett 132:1-8. 2002
  7. ncbi request reprint Hepatoprotection by L-cysteine-glutathione mixed disulfide, a sulfhydryl-modified prodrug of glutathione
    Lorelle I Berkeley
    Medical Research Laboratories, DVA Medical Center, Minneapolis, MN 55417, USA
    J Biochem Mol Toxicol 17:95-7. 2003
  8. ncbi request reprint p-Aminophenol-induced hepatotoxicity in hamsters: role of glutathione
    Xin Fu
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, USA
    J Biochem Mol Toxicol 18:154-61. 2004
  9. ncbi request reprint Donors of HNO
    Katrina M Miranda
    Department of Chemistry, University of Arizona, Tucson, 85721, USA
    Curr Top Med Chem 5:649-64. 2005

Collaborators

  • Steven E Patterson
  • Daune L Crankshaw
  • Kumar G Belani
  • Frances N Shirota
  • Katrina M Miranda
  • Xin Fu
  • Lorelle I Berkeley
  • Robert Vince
  • David S Beebe
  • Preeta George
  • Harpreet Singh
  • John P Toscano
  • Theresa S Chen
  • Mukunda B Ray
  • Walter M Williams
  • Jonathan F Cohen
  • Eugene G DeMaster
  • Don W Shoeman

Detail Information

Publications9

  1. pmc Novel, orally effective cyanide antidotes
    Herbert T Nagasawa
    Center for Drug Design, University of Minnesota, Minneapolis 55455, USA
    J Med Chem 50:6462-4. 2007
    ..These prodrugs of 3-MP are unique in being not only orally bioavailable, but may be administered up to an hour prior to cyanide as a prophylactic agent and are both rapid- or slow-acting when given parenterally...
  2. pmc Cyanide toxicity in juvenile pigs and its reversal by a new prodrug, sulfanegen sodium
    Kumar G Belani
    Department of Anesthesiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Anesth Analg 114:956-61. 2012
    ..In this study, we induced severe CN toxicity independently with SNP or sodium cyanide (NaCN) in a juvenile pig model to demonstrate reversal of severe CN toxicity with a new antidote, sulfanegen sodium, a prodrug of 3-mercaptopyruvate...
  3. pmc Cyanide antidotes for mass casualties: water-soluble salts of the dithiane (sulfanegen) from 3-mercaptopyruvate for intramuscular administration
    Steven E Patterson
    Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Med Chem 56:1346-9. 2013
    ..We report the discovery of the highly water-soluble sulfanegen triethanolamine as a promising lead for development as an IM injectable cyanide antidote...
  4. pmc A novel paradigm for assessing efficacies of potential antidotes against neurotoxins in mice
    Daune L Crankshaw
    Center for Drug Design, Academic Health Center, University of Minnesota, MN, United States
    Toxicol Lett 175:111-7. 2007
    ..This new test paradigm was found to be a powerful tool for assessing the efficacies of some novel antidotes against cyanide and should be equally applicable for evaluating putative antidotes for other neurotoxins...
  5. ncbi request reprint Double-prodrugs of L-cysteine: differential protection against acetaminophen-induced hepatotoxicity in mice
    Daune L Crankshaw
    Medical Research Laboratories, DVA Medical Center, Minneapolis, MN 55417, USA
    J Biochem Mol Toxicol 16:235-44. 2002
    ....
  6. ncbi request reprint Acetaminophen-induced suppression of hepatic AdoMet synthetase activity is attenuated by prodrugs of L-cysteine
    Frances N Shirota
    Medical Research Laboratories 151, VA Medical Center, Minneapolis, MN 55417, USA
    Toxicol Lett 132:1-8. 2002
    ....
  7. ncbi request reprint Hepatoprotection by L-cysteine-glutathione mixed disulfide, a sulfhydryl-modified prodrug of glutathione
    Lorelle I Berkeley
    Medical Research Laboratories, DVA Medical Center, Minneapolis, MN 55417, USA
    J Biochem Mol Toxicol 17:95-7. 2003
    ..Since the corresponding D-cysteine-glutathione disulfide was totally ineffective in this regard, an enzymatic mechanism that provides glutathione directly to cells is postulated...
  8. ncbi request reprint p-Aminophenol-induced hepatotoxicity in hamsters: role of glutathione
    Xin Fu
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, USA
    J Biochem Mol Toxicol 18:154-61. 2004
    ..PTCA also attenuated the PAP-induced elevations in plasma enzyme activities and hepatic necrosis. It was concluded that PAP hepatotoxicity is associated with depletion of hepatic GSH and can be prevented by PTCA...
  9. ncbi request reprint Donors of HNO
    Katrina M Miranda
    Department of Chemistry, University of Arizona, Tucson, 85721, USA
    Curr Top Med Chem 5:649-64. 2005
    ..This review provides a detailed discussion of the most commonly utilized donors of HNO as well as a guideline for the characterization of novel donors...