Affiliation: University of Arkansas for Medical Sciences
Nagarajan U, Ojcius D, Stahl L, Rank R, Darville T. Chlamydia trachomatis induces expression of IFN-gamma-inducible protein 10 and IFN-beta independent of TLR2 and TLR4, but largely dependent on MyD88. J Immunol. 2005;175:450-60 pubmed
..Furthermore, the intracellular pathways that lead to chlamydial-induced IFN-beta function through TANK-binding kinase mediated phosphorylation and nuclear translocation of IFN regulatory factor-3. ..
Nagarajan U, Prantner D, Sikes J, Andrews C, Goodwin A, Nagarajan S, et al
. Type I interferon signaling exacerbates Chlamydia muridarum genital infection in a murine model. Infect Immun. 2008;76:4642-8 pubmed publisher
..These data suggest that type I IFNs exacerbate C. muridarum genital infection through an inhibition of the chlamydial-specific CD4 T-cell response...
Prantner D, Sikes J, Hennings L, Savenka A, Basnakian A, Nagarajan U. Interferon regulatory transcription factor 3 protects mice from uterine horn pathology during Chlamydia muridarum genital infection. Infect Immun. 2011;79:3922-33 pubmed publisher
..These data suggest that IRF3 has a role in protection from uterine horn pathology that is independent of its function in IFN-? expression...
Nagarajan U, Sikes J, Yeruva L, Prantner D. Significant role of IL-1 signaling, but limited role of inflammasome activation, in oviduct pathology during Chlamydia muridarum genital infection. J Immunol. 2012;188:2866-75 pubmed publisher
..The data also suggest an IL-1-independent role for ASC in adaptive immunity during genital chlamydial infection. ..